DOI: 10.1017/s0952523800000730. Effects of synaptic blocking agents on the depolarizing responses of turtle cones evoked by surround illumination

Effects of synaptic blocking agents on the depolarizing responses of turtle cones evoked by surround illumination

10.1017/s0952523800000730

Crossref journal-article

Maximum Academic Press

Visual Neuroscience (27968)

Abstract

AbstractThe effects of synaptic blocking agents on the antagonistic surround of the receptive field of cone photoreceptors were studied intracellular recording in the retina of hte turtle (Pseudemys scripta elegans) Illumination of a cone's receptive-field surround typically evoked a hybriid depolarizing response composed of two componests: (1) the graded synaptic feedback depolarization and (2) the prolonged depolarization a distinctive, intrinsic response of the cone. The locus of action of synaptic blocking agents was analyzed by comparing their effects on the light-evoked response of horizontal cells, the hybrid cone depolarization evoked by surround illumination, and the pure prolonged depolarization evoked by intracellular current injection.The excitatory amino-acid antagonists, d-O-phosphoserine (DOS) and kynurenic acid (KynA), suppressed the light responses of horizontal cells and eliminated the surround-evoked, hybrid cone depolarization without affecting the prolonged depolarization evoked by current injection. Cobalt at 5–10 mM suppressed horizontal cell responses and thereby eliminated surround-evoked cone depolarizations. Cobalt (5–10 mM) also blocked the current-evoked prolonged depolarization, suggesting that the intrinsic cone mechanisms responsible for the prolonged depolarization are likely to be calcium-dependent.Various GABA agonists and antagonists were found to have no effect on the surround-evoked depolarizations of cones. In contrast, a very low concentration of cobalt (0.5 mM) selectively suppressed the light-evoked feedback depolarization of cones without affecting horizontal cell responses or the current-evoked prolonged depolarization. Cobalt at 0.5 mM thus blocks the light-evoked action of the cone feedback synapse while sparing feedforward synaptic transmission from cones to horizontal cells. The implications of the present work for the possible neurotransmitters used at these synapses is discussed.

Bibliography

Thoreson, W. B., & Burkhardt, D. A. (1990). Effects of synaptic blocking agents on the depolarizing responses of turtle cones evoked by surround illumination. Visual Neuroscience, 5(6), 571â583.

Authors 2

Wallace B. Thoreson (first)
Dwight A. Burkhardt (additional)

References 74 Referenced 59

10.1038/314096a0
10.1016/0006-8993(86)90708-0
10.1152/jn.1989.61.1.162
10.1073/pnas.79.11.3671
10.1017/S0952523800012463
10.1016/0278-4327(86)90004-0
10.3181/00379727-158-40211
10.1113/jphysiol.1982.sp014069
10.1152/jn.1982.47.6.1057
10.1085/jgp.93.4.695
10.1113/jphysiol.1981.sp013544
10.1016/0006-8993(80)90697-6
10.1113/jphysiol.1988.sp017418
10.1007/BF00964548
{'key': 'S0952523800000730_ref014', 'first-page': '143', 'article-title': 'Excitatory amino acid receptors in the vertebrate central nervous system', 'volume': '40', 'author': 'Collingridge', 'year': '1989', 'journal-title': 'Pharmacological Reviews'} / Pharmacological Reviews / Excitatory amino acid receptors in the vertebrate central nervous system by Collingridge (1989)
10.1016/0165-0270(89)90034-4
{'key': 'S0952523800000730_ref042', 'first-page': '123', 'volume-title': 'Retinal Transmitters and Modulators: Models for the Brain, Vol. II', 'author': 'Miller', 'year': '1985'} / Retinal Transmitters and Modulators: Models for the Brain, Vol. II by Miller (1985)
10.1073/pnas.81.24.7961
10.1098/rspb.1980.0007
10.1016/0006-8993(83)91201-5
10.1016/0006-2952(85)90710-5
10.1016/0042-6989(83)90090-1
10.1126/science.1188380
10.1113/jphysiol.1986.sp016057
10.1126/science.2443977
10.1113/jphysiol.1971.sp009432
10.1016/0166-2236(87)90055-5
10.1016/0006-8993(72)90289-2
10.1152/jn.1977.40.1.53
10.1016/0042-6989(87)90151-9
{'key': 'S0952523800000730_ref009', 'first-page': '89', 'article-title': 'Model feedback mechanism between horizontal cells and photoreceptors of the vertebrate retina', 'volume': '9', 'author': 'Byzov', 'year': '1977', 'journal-title': 'Neirofiziologiya'} / Neirofiziologiya / Model feedback mechanism between horizontal cells and photoreceptors of the vertebrate retina by Byzov (1977)
10.1016/0042-6989(86)90069-6
10.1007/978-3-642-65340-7_14
10.1126/science.178.4062.767
10.1085/jgp.86.3.423
10.1038/341536a0
10.1085/jgp.89.6.959
10.1016/0006-8993(78)90743-6
{'key': 'S0952523800000730_ref019', 'first-page': '281', 'volume-title': 'In The S Potential', 'author': 'Drujan', 'year': '1982'} / In The S Potential by Drujan (1982)
{'key': 'S0952523800000730_ref020', 'first-page': '163', 'article-title': 'GABAA-and GABAB-mediated synaptic transmission ro conses in the tiger salamander retina', 'volume': '30', 'author': 'Eliasof', 'year': '1989', 'journal-title': 'Incestigative Ophthalmology and Visual Science'} / Incestigative Ophthalmology and Visual Science / GABAA-and GABAB-mediated synaptic transmission ro conses in the tiger salamander retina by Eliasof (1989)
{'key': 'S0952523800000730_ref021', 'first-page': '515', 'article-title': 'Colour-de-pendence of cone responses in the turtle retina', 'volume': '303', 'author': 'Fuortes', 'year': '1973', 'journal-title': 'Journal of Physiology'} / Journal of Physiology / Colour-de-pendence of cone responses in the turtle retina by Fuortes (1973)
10.1113/jphysiol.1974.sp010606
10.1016/0304-3940(79)96084-1
10.1038/268257a0
10.1098/rspb.1980.0008
10.1113/jphysiol.1986.sp016058
10.1021/jm00144a001
10.1007/978-1-4615-9382-9_14
10.1016/0042-6989(84)90047-6
10.1152/jn.1987.57.3.645
{'key': 'S0952523800000730_ref040', 'first-page': '344', 'article-title': 'Divalent cations modulate GABAa-receptor affinity and desensitization', 'volume': '14', 'author': 'Mielak', 'year': '1988', 'journal-title': 'Society for Neuroscience Abstracts'} / Society for Neuroscience Abstracts / Divalent cations modulate GABAa-receptor affinity and desensitization by Mielak (1988)
10.1113/jphysiol.1983.sp014497
10.1016/0166-2236(86)90061-5
{'key': 'S0952523800000730_ref044', 'first-page': '161', 'volume-title': 'Structure and Physiology of the Slow Inward Calcium Channel. Receptor Biochemistry and Methodology, Vol. 9', 'author': 'Miller', 'year': '1987'} / Structure and Physiology of the Slow Inward Calcium Channel. Receptor Biochemistry and Methodology, Vol. 9 by Miller (1987)
10.2170/jjphysiol.32.911
10.1113/jphysiol.1973.sp010385
10.1152/jn.1989.61.6.1097
10.1016/0042-6989(88)90147-2
10.1016/0278-4327(86)90009-X
10.1038/268259a0
10.1085/jgp.64.1.49
{'key': 'S0952523800000730_ref068', 'first-page': '161', 'article-title': 'Cellular mechanisms of surround antagonism in turtle cones', 'volume': '14', 'author': 'Thoreson', 'year': '1988', 'journal-title': 'Society for Neuroscience Abstracts'} / Society for Neuroscience Abstracts / Cellular mechanisms of surround antagonism in turtle cones by Thoreson (1988)
10.1152/jn.1983.49.4.1007
10.1523/JNEUROSCI.05-01-00224.1985
{'key': 'S0952523800000730_ref066', 'first-page': '1', 'article-title': 'Center-surround organization of Xenopus horizontal cells and its modification by γ-aminobutyric acid and strontium', 'volume': '47', 'author': 'Stone', 'year': '1987', 'journal-title': 'Experimental Biology'} / Experimental Biology / Center-surround organization of Xenopus horizontal cells and its modification by γ-aminobutyric acid and strontium by Stone (1987)
10.1152/jn.1991.65.1.96
{'key': 'S0952523800000730_ref052', 'first-page': '10', 'article-title': 'Participation of GABA in the sensitivity control of the OFF response in the trutle ERG', 'volume': '13', 'author': 'Penchev', 'year': '1987', 'journal-title': 'Acta Physiologica et Pharmacologica Bulgarica'} / Acta Physiologica et Pharmacologica Bulgarica / Participation of GABA in the sensitivity control of the OFF response in the trutle ERG by Penchev (1987)
10.1016/0006-8993(86)90723-7
10.1002/cne.902800103
{'key': 'S0952523800000730_ref048', 'first-page': '224', 'article-title': 'Does GABAergic feedback mediate the depolarizing photoresponses of “C-type” horizontal cells in the turtle retina?', 'volume': '29', 'author': 'Normann', 'year': '1988', 'journal-title': 'Investigative Ophthalmology and Visual Science'} / Investigative Ophthalmology and Visual Science / Does GABAergic feedback mediate the depolarizing photoresponses of “C-type” horizontal cells in the turtle retina? by Normann (1988)
10.2170/jjphysiol.32.927
10.1111/j.1471-4159.1987.tb05721.x
10.1098/rstb.1971.0101
10.1002/cne.902040305

Dates

Type	When
Created	16 years, 2 months ago (June 2, 2009, 8:19 a.m.)
Deposited	7 months, 3 weeks ago (Jan. 2, 2025, 2:58 p.m.)
Indexed	4 months ago (April 24, 2025, 12:48 a.m.)
Issued	34 years, 8 months ago (Dec. 1, 1990)
Published	34 years, 8 months ago (Dec. 1, 1990)
Published Online	16 years, 2 months ago (June 2, 2009)
Published Print	34 years, 8 months ago (Dec. 1, 1990)

Funders 0

None

BibTeX

@article{Thoreson_1990, title={Effects of synaptic blocking agents on the depolarizing responses of turtle cones evoked by surround illumination}, volume={5}, ISSN={1469-8714}, url={http://dx.doi.org/10.1017/s0952523800000730}, DOI={10.1017/s0952523800000730}, number={6}, journal={Visual Neuroscience}, publisher={Maximum Academic Press}, author={Thoreson, Wallace B. and Burkhardt, Dwight A.}, year={1990}, month=dec, pages={571–583} }

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