DOI: 10.1017/s0950268800048354. Insights into neutralization of animal viruses gained from study of influenza virus

Insights into neutralization of animal viruses gained from study of influenza virus

10.1017/s0950268800048354

Crossref journal-article

Cambridge University Press (CUP)

Epidemiology and Infection (56)

Abstract

SUMMARYIt has long been known that the binding of antibodies to viruses can result in a loss of infectivity, or neutralization, but little is understood of the mechanism or mechanisms of this process. This is probably because neutralization is a multifactorial phenomenon depending upon the nature of the virus itself, the particular antigenic site involved, the isotype of immunoglobulin and the ratio of virus to immunoglobulin (see below). Thus not only is it likely that neutralization of one virus will differ from another but that changing the circumstances of neutralization can change the mechanism itself. To give coherence to the topic we are concentrating this review on one virus, influenza type A which is itself well studied and reasonably well understood [1–3]. Reviews of the older literature can be found in references 4 to 7.

Bibliography

Outlaw, M. C., & Dimmock, N. J. (1991). Insights into neutralization of animal viruses gained from study of influenza virus. Epidemiology and Infection, 106(2), 205â220.

Authors 2

M. C. Outlaw (first)
N. J. Dimmock (additional)

References 56 Referenced 24

10.1016/S0042-6822(83)80015-4
{'key': 'S0950268800048354_ref007', 'first-page': '53', 'volume-title': 'Immunochemistry of viruses', 'author': 'Mandel', 'year': '1985'} / Immunochemistry of viruses by Mandel (1985)
10.1016/0167-5699(86)90169-6
10.1128/JVI.62.7.2209-2218.1988 / J Virol / Role of VP3 in human rotavirus internalization after target attachment via VP7 by Kukuhara (1988)
10.1016/0042-6822(83)90154-X
10.1099/0022-1317-70-8-2097
10.1159/000149531 / Intervirol / Influence of host cells on the infectivity and neutralizability of echovirus type 4 (Pesacek) by Kjellen (1984)
10.1099/0022-1317-70-10-2615
10.1016/0042-6822(81)90142-2
10.1099/0022-1317-70-3-639
10.1016/0042-6822(81)90535-3
10.1083/jcb.91.3.601
10.1016/0042-6822(76)90480-3
10.1128/JVI.54.1.7-13.1985 / J Virol / A monoclonal antibody that neutralizes poliovirus by crosslinking virions by Thomas (1985)
10.1016/0042-6822(63)90305-2
10.1128/JVI.63.1.36-42.1989 / J Virol / Inhibition of rhinovirus attachment by neutralizing monoclonal antibodies and their Fab fragments by Colonno (1989)
10.1016/0167-5699(86)90168-4
20. Taylor HP . The interaction of influenza virus with neutralizing antibody [PhD thesis]. University of Warwick, 1986.
10.1099/0022-1317-38-1-1
10.1099/0022-1317-70-3-625
10.1099/0022-1317-71-4-751
10.1084/jem.161.1.198
10.1007/BF01310871
{'key': 'S0950268800048354_ref005', 'first-page': '205', 'volume-title': 'Advances in virus research', 'volume': '23', 'author': 'Mandel', 'year': '1978'} / Advances in virus research by Mandel (1978)
10.1099/0022-1317-67-10-2247
{'key': 'S0950268800048354_ref045', 'first-page': '119', 'article-title': 'The role of influenza virus haemagglutinin in membrane fusion', 'volume': '4', 'author': 'Wharton', 'year': '1987', 'journal-title': 'Microbiol Sci'} / Microbiol Sci / The role of influenza virus haemagglutinin in membrane fusion by Wharton (1987)
{'key': 'S0950268800048354_ref023', 'first-page': '392', 'article-title': 'The red cell surface revisited', 'volume': '10', 'author': 'Viitala', 'year': '1985', 'journal-title': 'TIBS'} / TIBS / The red cell surface revisited by Viitala (1985)
10.1099/0022-1317-66-10-2279
10.1016/0264-410X(85)90110-0
10.1099/0022-1317-71-10-2313
10.1042/bj2180001
10.1016/0167-5699(86)90166-0
10.1128/JVI.61.5.1375-1383.1987 / J Virol / Role of receptor-binding activity of the viral haemagglutinin molecule in the presentation of influenza virus antigens to helper T cells by Eisenlohr (1987)
10.1021/bi00740a600
10.1016/0042-6822(90)90345-R
10.1099/0022-1317-58-2-373
10.1016/0264-410X(86)90042-3
10.1038/289373a0
10.1016/0042-6822(87)90466-1
10.1038/321244a0
10.1128/JVI.59.2.479-485.1986 / J Virol / Relationship between poliovirus neutralization and aggregation by Thomas (1986)
10.1016/0168-1702(86)90004-3
10.1099/0022-1317-66-12-2773
10.1038/326358a0
10.1099/0022-1317-58-1-37
10.1007/978-1-4613-3009-7_2 / Virus–host interactions. Comprehensive virology by Mandel (1979)
{'key': 'S0950268800048354_ref002', 'first-page': '70', 'article-title': 'Multiple mechanisms of neutralization of animal viruses', 'volume': '12', 'author': 'Dimmock', 'year': '1987', 'journal-title': 'TIBS'} / TIBS / Multiple mechanisms of neutralization of animal viruses by Dimmock (1987)
10.1016/0882-4010(88)90075-7
{'key': 'S0950268800048354_ref004', 'first-page': '1', 'article-title': 'Formation and dissociation of virus-antibody complexes with special reference to the neutralization process', 'volume': '10', 'author': 'Svehag', 'year': '1968', 'journal-title': 'Prog Med Virol'} / Prog Med Virol / Formation and dissociation of virus-antibody complexes with special reference to the neutralization process by Svehag (1968)
10.1128/JVI.59.1.37-44.1986 / J Virol / Neutralizing antibodies to visna lentivirus: mechanism of action and possible role in virus persistence by Kennedy-Stoskopf (1986)
10.1016/0042-6822(82)90313-0
10.1099/0022-1317-65-6-1015
10.1099/0022-1317-71-1-69
10.1099/0022-1317-58-2-283
10.1002/j.1460-2075.1988.tb02839.x / EMBO J / Human immunodeficiency virus infection of CD4- bearing cells occurs by a pH-independent mechanism by McClure (1988)
{'key': 'S0950268800048354_ref056', 'volume-title': 'Genetics of influenza viruses', 'author': 'Lamb', 'year': '1983'} / Genetics of influenza viruses by Lamb (1983)

Dates

Type	When
Created	16 years, 3 months ago (May 15, 2009, 5:13 a.m.)
Deposited	5 years, 3 months ago (May 18, 2020, 1:06 a.m.)
Indexed	4 months, 4 weeks ago (April 4, 2025, 4:43 p.m.)
Issued	34 years, 5 months ago (April 1, 1991)
Published	34 years, 5 months ago (April 1, 1991)
Published Online	16 years, 3 months ago (May 15, 2009)
Published Print	34 years, 5 months ago (April 1, 1991)

Funders 0

None

BibTeX

@article{Outlaw_1991, title={Insights into neutralization of animal viruses gained from study of influenza virus}, volume={106}, ISSN={1469-4409}, url={http://dx.doi.org/10.1017/s0950268800048354}, DOI={10.1017/s0950268800048354}, number={2}, journal={Epidemiology and Infection}, publisher={Cambridge University Press (CUP)}, author={Outlaw, M. C. and Dimmock, N. J.}, year={1991}, month=apr, pages={205–220} }

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    }
  },
  "alternative-id": [
    "S0950268800048354"
  ],
  "URL": "http://dx.doi.org/10.1017/S0950268800048354",
  "relation": {},
  "ISSN": [
    "0950-2688",
    "1469-4409"
  ],
  "subject": [],
  "container-title-short": "Epidemiol. Infect.",
  "published": {
    "date-parts": [
      [
        1991,
        4
      ]
    ]
  },
  "assertion": [
    {
      "value": "Cambridge University Press 1991",
      "name": "license",
      "label": "License",
      "group": {
        "name": "copyright_and_licensing",
        "label": "Copyright and Licensing"
      }
    }
  ]
}