DOI: 10.1017/s0317167100042992. Experimental Porphyric Neuropathy: A Preliminary Report

Experimental Porphyric Neuropathy: A Preliminary Report

10.1017/s0317167100042992

Crossref journal-article

Cambridge University Press (CUP)

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques (56)

Abstract

SUMMARY:An experimental model for the study of porphyric neuropathy is presented. Injection of either tetraphenylporphinesulfonate (TPPS), hematoporphyrin derivative (HpD), or delta-aminolevulinic acid (ALA) into mice resulted in markedly decreased motor nerve conduction velocity (MNCV). The MNCV returned to normal within one week following the injection of large doses of A LA, and within three weeks following the injection of close to lethal doses of HpD. hut there was no recovery of nerve function within 60 days following injection of substantially smaller doses of TPPS. Ultrastructural examination of motor nerves at various times following TPPS injection revealed the gradual development of structural abnormalities. Ultrastructional examination of the same nerves after a single dose of either A LA or Hp D failed to demonstrate any abnormalities.The present observations call for precaution as to the use of TPPS as photosensitizer in human cancer treatment.

Bibliography

Sima, A. A. F., Kennedy, J. C., Blakeslee, D., & Robertson, D. M. (1981). Experimental Porphyric Neuropathy: A Preliminary Report. Canadian Journal of Neurological Sciences / Journal Canadien Des Sciences Neurologiques, 8(2), 105â114.

Authors 4

Anders A.F. Sima (first)
James C. Kennedy (additional)
Dennis Blakeslee (additional)
David M. Robertson (additional)

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Dates

Type	When
Created	9 years, 1 month ago (July 28, 2016, 3:34 a.m.)
Deposited	6 years, 3 months ago (May 25, 2019, 12:13 p.m.)
Indexed	1 year, 10 months ago (Oct. 27, 2023, 2:19 p.m.)
Issued	44 years, 3 months ago (May 1, 1981)
Published	44 years, 3 months ago (May 1, 1981)
Published Online	9 years, 11 months ago (Sept. 18, 2015)
Published Print	44 years, 3 months ago (May 1, 1981)

Funders 0

None

BibTeX

@article{Sima_1981, title={Experimental Porphyric Neuropathy: A Preliminary Report}, volume={8}, ISSN={2057-0155}, url={http://dx.doi.org/10.1017/s0317167100042992}, DOI={10.1017/s0317167100042992}, number={2}, journal={Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques}, publisher={Cambridge University Press (CUP)}, author={Sima, Anders A.F. and Kennedy, James C. and Blakeslee, Dennis and Robertson, David M.}, year={1981}, month=may, pages={105–114} }

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