Trends and Challenges in Experimental Macromolecular Crystallography
10.1017/s0033583500005837
Crossref journal-article
Cambridge University Press (CUP)
Quarterly Reviews of Biophysics (56)
Abstract

Macromolecular X-ray crystallography underpins the vigorous field of structural molecular biology having yielded many protein, nucleic acid and virus structures in fine detail. The understanding of the recognition by these macromolecules, as receptors, of their cognate ligands involves the detailed study of the structural chemistry of their molecular interactions. Also these structural details underpin the rational design of novel inhibitors in modern drug discovery in the pharmaceutical industry. Moreover, from such structures the functional details can be inferred, such as the biological chemistry of enzyme reactivity. There is then a vast number and range of types of biological macromolecules that potentially could be studied. The completion of the protein primary sequencing of the yeast genome, and the human genome sequencing project comprising some 105proteins that is underway, raises expectations for equivalent three dimensional structural databases.

Bibliography

Chayen, N. E., Boggon, T. J., Cassetta, A., Deacon, A., Gleichmann, T., Habash, J., Harrop, S. J., Helliwell, J. R., Nieh, Y. P., Peterson, M. R., Raftery, J., Snell, E. H., Hädener, A., Niemann, A. C., Siddons, D. P., Stojanoff, V., Thompson, A. W., Ursby, T., & Wulff, M. (1996). Trends and Challenges in Experimental Macromolecular Crystallography. Quarterly Reviews of Biophysics, 29(3), 227–278.

Authors 19
  1. N. E. Chayen (first)
  2. T. J. Boggon (additional)
  3. A. Cassetta (additional)
  4. A. Deacon (additional)
  5. T. Gleichmann (additional)
  6. J. Habash (additional)
  7. S. J. Harrop (additional)
  8. J. R. Helliwell (additional)
  9. Y. P. Nieh (additional)
  10. M. R. Peterson (additional)
  11. J. Raftery (additional)
  12. E. H. Snell (additional)
  13. A. Hädener (additional)
  14. A. C. Niemann (additional)
  15. D. P. Siddons (additional)
  16. V. Stojanoff (additional)
  17. A. W. Thompson (additional)
  18. T. Ursby (additional)
  19. M. Wulff (additional)
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Dates
Type When
Created 16 years, 5 months ago (March 17, 2009, 11:29 a.m.)
Deposited 3 years, 11 months ago (Oct. 3, 2021, 5:15 a.m.)
Indexed 1 year, 2 months ago (June 29, 2024, 7:32 p.m.)
Issued 29 years, 1 month ago (Aug. 1, 1996)
Published 29 years, 1 month ago (Aug. 1, 1996)
Published Online 16 years, 5 months ago (March 17, 2009)
Published Print 29 years, 1 month ago (Aug. 1, 1996)
Funders 0

None

@article{Chayen_1996, title={Trends and Challenges in Experimental Macromolecular Crystallography}, volume={29}, ISSN={1469-8994}, url={http://dx.doi.org/10.1017/s0033583500005837}, DOI={10.1017/s0033583500005837}, number={3}, journal={Quarterly Reviews of Biophysics}, publisher={Cambridge University Press (CUP)}, author={Chayen, N. E. and Boggon, T. J. and Cassetta, A. and Deacon, A. and Gleichmann, T. and Habash, J. and Harrop, S. J. and Helliwell, J. R. and Nieh, Y. P. and Peterson, M. R. and Raftery, J. and Snell, E. H. and Hädener, A. and Niemann, A. C. and Siddons, D. P. and Stojanoff, V. and Thompson, A. W. and Ursby, T. and Wulff, M.}, year={1996}, month=aug, pages={227–278} }