Classification of macromolecular assemblies studied as ‘single particles’
10.1017/s0033583500005564
Crossref journal-article
Cambridge University Press (CUP)
Quarterly Reviews of Biophysics (56)
Abstract

In order to study proteins that do not occur in two- or three-dimensionally ordered form, one may take two different approaches: either search for conditions that induce the formation of crystals, and proceed with the established methods of X-ray or electron crystallography, or attempt to study the molecules in the form of single particles with the EM. Although many proteins have been successfully crystallized, and some general recipes for inducing ordered arrangement have been found (Mannella, 1984; Uzgiris & Kornberg, 1983), there exists a large number of proteins and protein assemblies that have resisted such attempts for a long time. Furthermore, there are macromolecular assemblies, associated with membranes and engaged in switching or gating, whose function is tied to their occurrence in isolated form, and hence are best studied without extraction from the membrane. For these reasons, the single-particle approach to the study of macromolecular structure (Franket al.1978, 1981; Radermacheret al.1987a, b; for recent reviews, see Franket al.1985, 1988e; Frank, 1989) has found numerous applications after initial technical and conceptual hurdles were overcome. Although atomic resolution cannot be achieved with this approach for a variety of reasons, a quantitative description of architecture on the quaternary level is nevertheless possible, as exemplified in the 3D studies of ribosomal particles (overviews, see Franket al.1988a) and, most recently, the junctional channel complex (Wagenknechtet al.1989a).

Bibliography

Frank, J. (1990). Classification of macromolecular assemblies studied as ‘single particles.’ Quarterly Reviews of Biophysics, 23(3), 281–329.

Authors 1
  1. Joachim Frank (first)
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Dates
Type When
Created 16 years, 5 months ago (March 17, 2009, 11:54 a.m.)
Deposited 6 months, 3 weeks ago (Feb. 8, 2025, 8:20 a.m.)
Indexed 6 months, 3 weeks ago (Feb. 8, 2025, 8:40 a.m.)
Issued 35 years, 1 month ago (Aug. 1, 1990)
Published 35 years, 1 month ago (Aug. 1, 1990)
Published Online 16 years, 5 months ago (March 17, 2009)
Published Print 35 years, 1 month ago (Aug. 1, 1990)
Funders 0

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@article{Frank_1990, title={Classification of macromolecular assemblies studied as ‘single particles’}, volume={23}, ISSN={1469-8994}, url={http://dx.doi.org/10.1017/s0033583500005564}, DOI={10.1017/s0033583500005564}, number={3}, journal={Quarterly Reviews of Biophysics}, publisher={Cambridge University Press (CUP)}, author={Frank, Joachim}, year={1990}, month=aug, pages={281–329} }