DOI: 10.1017/s0033583500003061. Progress in high resolution atomic force microscopy in biology

Progress in high resolution atomic force microscopy in biology

10.1017/s0033583500003061

Crossref journal-article

Cambridge University Press (CUP)

Quarterly Reviews of Biophysics (56)

Abstract

The atomic force microscope (AFM) was invented by Binnig, Quate and Gerber less than 10 years ago (Binniget al. 1986). In their first prototype, a piece of goldfoil was used as the cantilever, with a crushed diamond tip mounted at the end. On the back of the cantilever, a tunnelling junction was used to monitor the deflection of the cantilever (the gold-foil) when the specimen was scanned with the tip in contact with the surface. Thus, the surface topography of the specimen was obtained with a resolution critically dependent on the sharpness of the tip provided the deformation of the specimen was not serious. Even with such a crude set-up, they managed to obtain a lateral resolution of ˜ 30 Å and a vertical resolution of better than 1 Å on an amorphous A12O3surface. The operating principle of such an instrument is deceptively simple. However, such an arrangement was inconvenient for routine operations and unsuitable for imaging hydrated specimens, because the tunnelling junction is easily contaminated in air and works poorly in aqueous solutions (Alexanderet al. 1989). As a result, the application of this type of AFM to biological samples was rare (Engel, 1991).

Bibliography

Shao, Z., & Yang, J. (1995). Progress in high resolution atomic force microscopy in biology. Quarterly Reviews of Biophysics, 28(2), 195â251.

Authors 2

Zhifeng Shao (first)
Jie Yang (additional)

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Dates

Type	When
Created	16 years, 5 months ago (March 17, 2009, 11:36 a.m.)
Deposited	3 years, 10 months ago (Oct. 3, 2021, 5:15 a.m.)
Indexed	11 months, 2 weeks ago (Sept. 9, 2024, 4:36 p.m.)
Issued	30 years, 3 months ago (May 1, 1995)
Published	30 years, 3 months ago (May 1, 1995)
Published Online	16 years, 5 months ago (March 17, 2009)
Published Print	30 years, 3 months ago (May 1, 1995)

Funders 0

None

BibTeX

@article{Shao_1995, title={Progress in high resolution atomic force microscopy in biology}, volume={28}, ISSN={1469-8994}, url={http://dx.doi.org/10.1017/s0033583500003061}, DOI={10.1017/s0033583500003061}, number={2}, journal={Quarterly Reviews of Biophysics}, publisher={Cambridge University Press (CUP)}, author={Shao, Zhifeng and Yang, Jie}, year={1995}, month=may, pages={195–251} }

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  "abstract": "<jats:p>The atomic force microscope (AFM) was invented by Binnig, Quate and Gerber less than 10 years ago (Binnig<jats:italic>et al</jats:italic>. 1986). In their first prototype, a piece of goldfoil was used as the cantilever, with a crushed diamond tip mounted at the end. On the back of the cantilever, a tunnelling junction was used to monitor the deflection of the cantilever (the gold-foil) when the specimen was scanned with the tip in contact with the surface. Thus, the surface topography of the specimen was obtained with a resolution critically dependent on the sharpness of the tip provided the deformation of the specimen was not serious. Even with such a crude set-up, they managed to obtain a lateral resolution of \u02dc 30 \u00c5 and a vertical resolution of better than 1 \u00c5 on an amorphous A1<jats:sub>2</jats:sub>O<jats:sub>3</jats:sub>surface. The operating principle of such an instrument is deceptively simple. However, such an arrangement was inconvenient for routine operations and unsuitable for imaging hydrated specimens, because the tunnelling junction is easily contaminated in air and works poorly in aqueous solutions (Alexander<jats:italic>et al</jats:italic>. 1989). As a result, the application of this type of AFM to biological samples was rare (Engel, 1991).</jats:p>",
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