DOI: 10.1017/s0033583500000123. Electrically gated ionic channels in lipid bilayers

Electrically gated ionic channels in lipid bilayers

10.1017/s0033583500000123

Crossref journal-article

Cambridge University Press (CUP)

Quarterly Reviews of Biophysics (56)

Abstract

The generation of action potentials in nerve and muscle requires cell membranes with steeply voltage-dependent ionic permeabilities. The voltage-dependent, ion-selective pathways responsible for excitation have been characterized for numerous excitable tissues such as nerve axon, muscle, electric organ, algae and epithelia (Aidley, 1971; Hodgkin, 1964; Cole, 1968). The process of activating ionic pathways by some stimulus, such as a change in membrane potential, is called gating.

Bibliography

Ehrenstein, G., & Lecar, H. (1977). Electrically gated ionic channels in lipid bilayers. Quarterly Reviews of Biophysics, 10(1), 1â34.

Authors 2

Gerald Ehrenstein (first)
Harold Lecar (additional)

References 76 Referenced 310

10.1038/262698a0
10.1085/jgp.60.1.72
10.1016/0005-2736(74)90092-3
10.1021/bi00723a001
10.1016/S0022-2836(62)80110-7
10.1016/0005-2736(73)90323-4
10.1038/255496a0
{'key': 'S0033583500000123_ref069', 'first-page': '97', 'article-title': 'Membrane shot noise in electrically depolarized nodes of Ranvier', 'volume': '341', 'author': 'Siebenga', 'year': '1972', 'journal-title': 'Pflügers Arch. ges. Physiol.'} / Pflügers Arch. ges. Physiol. / Membrane shot noise in electrically depolarized nodes of Ranvier by Siebenga (1972)
10.1016/B978-1-4831-9971-9.50010-9
{'key': 'S0033583500000123_ref062', 'first-page': '67', 'article-title': 'Methods for the formation of single bimolecular lipid membranes in aqueous solution', 'author': 'Mueller', 'year': '1963', 'journal-title': 'J. Phys. Chem.'} / J. Phys. Chem. / Methods for the formation of single bimolecular lipid membranes in aqueous solution by Mueller (1963)
10.1016/0005-2736(72)90415-4
10.1038/217713a0
10.1073/pnas.68.8.1907
10.1016/0005-2736(76)90185-1
10.1111/j.1749-6632.1975.tb31484.x
{'key': 'S0033583500000123_ref047', 'volume-title': 'The, Bimolecular Lipid Membrane', 'author': 'Jain', 'year': '1972'} / The, Bimolecular Lipid Membrane by Jain (1972)
{'key': 'S0033583500000123_ref063', 'first-page': '75', 'volume-title': 'MTP Int. Rev. Sci.', 'volume': '3', 'author': 'Mueller', 'year': '1975'} / MTP Int. Rev. Sci. by Mueller (1975)
{'key': 'S0033583500000123_ref020', 'first-page': '253', 'article-title': 'Dynamical electrical characteristics of the squid axon membrane', 'volume': '3', 'author': 'Cole', 'year': '1949', 'journal-title': 'Archs Sci. Physiol.'} / Archs Sci. Physiol. / Dynamical electrical characteristics of the squid axon membrane by Cole (1949)
10.1016/S0006-3495(75)85856-5
10.1073/pnas.69.6.1610
10.1098/rstb.1975.0021
10.1007/BF01867907
10.1161/01.CIR.26.5.1167
{'key': 'S0033583500000123_ref041', 'volume-title': 'Membranes – A Series of Advances', 'volume': '3', 'author': 'Hille', 'year': '1975'} / Membranes – A Series of Advances by Hille (1975)
10.1146/annurev.bb.01.060172.002023
10.1002/jss.400020504
{'key': 'S0033583500000123_ref018', 'first-page': '917', 'article-title': 'Investigation of a single channel of conductance in a lipid bilayer', 'volume': '216', 'author': 'Borisova', 'year': '1974', 'journal-title': 'Reports of the Academy of the USSR'} / Reports of the Academy of the USSR / Investigation of a single channel of conductance in a lipid bilayer by Borisova (1974)
10.1016/0005-2736(76)90454-5
{'key': 'S0033583500000123_ref065', 'first-page': '154', 'article-title': 'Agonist-induced discrete conductance changes in frog muscle', 'volume': '16', 'author': 'Neher', 'year': '1976', 'journal-title': 'Biophys. J.'} / Biophys. J. / Agonist-induced discrete conductance changes in frog muscle by Neher (1976)
10.1113/jphysiol.1973.sp010410
{'key': 'S0033583500000123_ref001', 'volume-title': 'The Physiology of Excitable cells', 'author': 'Aidley', 'year': '1971'} / The Physiology of Excitable cells by Aidley (1971)
10.1146/annurev.pc.25.100174.000303
10.1016/0005-2736(75)90154-6
10.1085/jgp.60.3.263
10.1085/jgp.65.4.421
10.1085/jgp.53.6.741
10.1007/BF01869983
10.1016/0005-2736(76)90389-8
10.1007/BF01868616
{'key': 'S0033583500000123_ref015', 'first-page': '1168', 'article-title': 'Untersuchungen zur Kinetik der Porenbildung durch Alamethicin in Lipidmembranen', 'volume': '79', 'author': 'Boheim', 'year': '1975', 'journal-title': 'Berichte der Bunsen-Gesellschaft für Physikalische Chemie.'} / Berichte der Bunsen-Gesellschaft für Physikalische Chemie. / Untersuchungen zur Kinetik der Porenbildung durch Alamethicin in Lipidmembranen by Boheim (1975)
10.1101/SQB.1965.030.01.040
{'key': 'S0033583500000123_ref051', 'volume-title': 'Introduction to Solid State Physics', 'author': 'Kittel', 'year': '1967'} / Introduction to Solid State Physics by Kittel (1967)
10.1016/0005-2736(75)90155-8
10.1007/BF01869820
10.1016/0005-2736(76)90186-3
10.1113/jphysiol.1975.sp010962
10.1038/242459a0
10.1007/BF01868573
10.1017/S0033583500001967
{'key': 'S0033583500000123_ref032', 'first-page': '377', 'volume-title': 'Membranes', 'volume': '2', 'author': 'Finkelstein', 'year': '1973'} / Membranes by Finkelstein (1973)
{'key': 'S0033583500000123_ref028', 'volume-title': 'Ion Transport Across Membranes – The Proceedings of a Joint US–USSR Conference', 'author': 'Ehrenstein', 'year': '1977'} / Ion Transport Across Membranes – The Proceedings of a Joint US–USSR Conference by Ehrenstein (1977)
10.1007/BF01867924
{'key': 'S0033583500000123_ref034', 'volume-title': 'Biological Engineering', 'author': 'Fitzhugh', 'year': '1969'} / Biological Engineering by Fitzhugh (1969)
10.1007/BF01868075
{'key': 'S0033583500000123_ref044', 'volume-title': 'The Conduction of the Nervous Impulse', 'author': 'Hodgkin', 'year': '1964'} / The Conduction of the Nervous Impulse by Hodgkin (1964)
10.1085/jgp.63.6.707
10.1525/9780520326514 / Membranes, Ions and Impulses by Cole (1968)
10.1126/science.948756
10.1016/0005-2736(76)90439-9
10.1016/S0006-3495(75)85869-3
10.1113/jphysiol.1976.sp011616
10.1085/jgp.67.6.731
10.1111/j.1749-6632.1975.tb31491.x
10.1016/S0022-5193(75)80130-5
10.1038/newbio246214a0
10.1085/jgp.55.1.119
10.1016/0022-5193(68)90163-X
10.1073/pnas.69.12.3742
10.1016/S0006-3495(75)85858-9
10.1113/jphysiol.1972.sp009918
10.1016/0005-2736(72)90178-2
{'key': 'S0033583500000123_ref066', 'volume-title': 'Mathematical Analysis of Random Noise', 'volume': '23 and 24', 'author': 'Rice', 'year': '1954'} / Mathematical Analysis of Random Noise by Rice (1954)
10.1152/physrev.1965.45.2.340
{'key': 'S0033583500000123_ref046', 'first-page': '129', 'article-title': 'Ionic currents underlying activity in the giant axon of the squid', 'volume': '3', 'author': 'Hodgkin', 'year': '1949', 'journal-title': 'Archs. Sci. Physiol.'} / Archs. Sci. Physiol. / Ionic currents underlying activity in the giant axon of the squid by Hodgkin (1949)
{'key': 'S0033583500000123_ref050', 'first-page': '28', 'article-title': 'Characteristics of the sodium gating current in the squid giant axon', 'volume': '233', 'author': 'Keynes', 'journal-title': 'J. Physiol.'} / J. Physiol. / Characteristics of the sodium gating current in the squid giant axon by Keynes
10.1113/jphysiol.1952.sp004764

Dates

Type	When
Created	16 years, 5 months ago (March 17, 2009, 12:07 p.m.)
Deposited	3 years, 10 months ago (Oct. 3, 2021, 5:21 a.m.)
Indexed	1 day, 19 hours ago (Aug. 26, 2025, 2:58 a.m.)
Issued	48 years, 6 months ago (Feb. 1, 1977)
Published	48 years, 6 months ago (Feb. 1, 1977)
Published Online	16 years, 5 months ago (March 17, 2009)
Published Print	48 years, 6 months ago (Feb. 1, 1977)

Funders 0

None

BibTeX

@article{Ehrenstein_1977, title={Electrically gated ionic channels in lipid bilayers}, volume={10}, ISSN={1469-8994}, url={http://dx.doi.org/10.1017/s0033583500000123}, DOI={10.1017/s0033583500000123}, number={1}, journal={Quarterly Reviews of Biophysics}, publisher={Cambridge University Press (CUP)}, author={Ehrenstein, Gerald and Lecar, Harold}, year={1977}, month=feb, pages={1–34} }

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