DOI: 10.1017/s0033291700017608. Schizophrenia and the brain: a prospective clinico-neuropathological study

Schizophrenia and the brain: a prospective clinico-neuropathological study

10.1017/s0033291700017608

Crossref journal-article

Cambridge University Press (CUP)

Psychological Medicine (56)

Abstract

SynopsisThe neuropathological results from a prospective, systematically assessed, series of 56 schizophrenic patients and 56 age- and sex-matched normal controls have been presented.When compared with the normal controls, the brains of the schizophrenic subjects showed a significant reduction in brain weight and brain length with a concomitant increase in ventricular size. (All findings relate to measurements made after formalin fixation). In addition, the brains of the schizophrenic patients contained significantly more non-specific focal pathology and fibrillary gliosis than the controls.After exclusion of cases with moderate and severe Alzheimer-type change, cerebro-vascular disease and all forms of focal pathology, the structural brain changes (i.e. decrease in brain weight and brain length) continued to distinguish the schizophrenia group from the controls. Furthermore, an analysis of the clinical data showed that the structural brain changes were correlated in the schizophrenic patients with a measurement of pre-morbid function.The findings and their possible aetiological implications have been discussed.

Bibliography

Bruton, C. J., Crow, T. J., Frith, C. D., Johnstone, E. C., Owens, D. G. C., & Roberts, G. W. (1990). Schizophrenia and the brain: a prospective clinico-neuropathological study. Psychological Medicine, 20(2), 285â304.

Authors 6

C. J. Bruton (first)
T. J. Crow (additional)
C. D. Frith (additional)
E. C. Johnstone (additional)
D. G. C. Owens (additional)
G. W. Roberts (additional)

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Dates

Type	When
Created	16 years, 1 month ago (July 9, 2009, 6:21 a.m.)
Deposited	6 years, 3 months ago (May 18, 2019, 1:22 p.m.)
Indexed	3 days, 14 hours ago (Sept. 3, 2025, 7:02 a.m.)
Issued	35 years, 4 months ago (May 1, 1990)
Published	35 years, 4 months ago (May 1, 1990)
Published Online	16 years, 1 month ago (July 9, 2009)
Published Print	35 years, 4 months ago (May 1, 1990)

Funders 0

None

BibTeX

@article{Bruton_1990, title={Schizophrenia and the brain: a prospective clinico-neuropathological study}, volume={20}, ISSN={1469-8978}, url={http://dx.doi.org/10.1017/s0033291700017608}, DOI={10.1017/s0033291700017608}, number={2}, journal={Psychological Medicine}, publisher={Cambridge University Press (CUP)}, author={Bruton, C. J. and Crow, T. J. and Frith, C. D. and Johnstone, E. C. and Owens, D. G. C. and Roberts, G. W.}, year={1990}, month=may, pages={285–304} }

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