Abstract
1. Conditions are described under which the three types of live or formalin-inactivated poliomyelitis viruses can be concentrated 10–100 times in good yield, with elimination of approximately 90% of the extraneous protein normally present in poliovaccines.2. It was shown that 0·1–0·2 mg./ml. AlPO4almost quantitatively adsorbed the antigens, provided the adsorptions were carried out at a pH round about 5. Re-elution of the antigens occurred readily at pH 7–pH 8.3. No noticeable conversion of the ‘D-antigen’ to the ‘C-antigen’ occurred during the concentration.
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Dates
Type | When |
---|---|
Created | 16 years, 3 months ago (May 15, 2009, 4:45 a.m.) |
Deposited | 1 year, 5 months ago (March 13, 2024, 7:06 a.m.) |
Indexed | 11 months, 1 week ago (Sept. 13, 2024, 5:37 p.m.) |
Issued | 63 years, 5 months ago (March 1, 1962) |
Published | 63 years, 5 months ago (March 1, 1962) |
Published Online | 16 years, 3 months ago (May 15, 2009) |
Published Print | 63 years, 5 months ago (March 1, 1962) |
@article{Fantes_1962, title={Concentration and partial purification of poliomyelitis viruses}, volume={60}, ISSN={0022-1724}, url={http://dx.doi.org/10.1017/s0022172400039371}, DOI={10.1017/s0022172400039371}, number={1}, journal={Journal of Hygiene}, publisher={Cambridge University Press (CUP)}, author={Fantes, K. H.}, year={1962}, month=mar, pages={123–133} }