DOI: 10.1017/s0022172400025109. The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice

The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice

10.1017/s0022172400025109

Crossref journal-article

Cambridge University Press (CUP)

Journal of Hygiene (56)

Abstract

SummaryThe pathogenicity for mice of two mutants of herpes simplex virus (type 1 and type 2), which fail to induce thymidine kinase, were compared with their respective parent strains. The mutants were much less virulent than the parents following either intracerebral or peripheral inoculation. The replication of the virus at the site of inoculation and its progression into the nervous system were studied. Following a very large inoculum in the ear, the type 1 mutant was found to establish a latent infection in the cervical dorsal root ganglia. Mice inoculated intracerebrally with small doses of the mutant viruses were solidly immune to challenge with lethal doses of the parent strain.

Bibliography

Field, H. J., & Wildy, P. (1978). The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice. Journal of Hygiene, 81(2), 267â277.

Authors 2

H. J. Field (first)
P. Wildy (additional)

References 18 Referenced 271

10.1038/257686a0
10.1099/0022-1317-26-2-159
10.1016/0042-6822(67)90015-3
{'key': 'S0022172400025109_ref005', 'first-page': '529', 'article-title': 'Resistance to intracerebral challenge in mice immunized against herpes simplex virus', 'volume': '53', 'author': 'Godfrey', 'year': '1972', 'journal-title': 'British Journal of Experimental Pathology'} / British Journal of Experimental Pathology / Resistance to intracerebral challenge in mice immunized against herpes simplex virus by Godfrey (1972)
10.1007/BF02026404
10.1084/jem.91.1.1
10.1099/0022-1317-24-3-465
10.1099/0022-1317-23-2-145
10.1099/0022-1317-28-3-341
10.1099/0022-1317-17-3-307
10.1007/BF01249353
{'key': 'S0022172400025109_ref004', 'first-page': '524', 'volume-title': 'Statistical Methods in Biological Assay', 'author': 'Finney', 'year': '1952'} / Statistical Methods in Biological Assay by Finney (1952)
10.1016/0042-6822(62)90112-5
10.1038/1951028a0
10.1016/0042-6822(77)90319-1
{'key': 'S0022172400025109_ref017', 'first-page': '399', 'article-title': 'Virus specific antigens in mammalian cells infected with herpes simplex virus', 'volume': '11', 'author': 'Watson', 'year': '1966', 'journal-title': 'Immunology'} / Immunology / Virus specific antigens in mammalian cells infected with herpes simplex virus by Watson (1966)
10.1128/IAI.12.1.166-172.1975 / Infection and Immunity / Role for cell-mediated immunity in the resistance of mice to subcutaneous herpes simplex virus infection by Oakes (1975)
10.1016/0042-6822(64)90070-4

Dates

Type	When
Created	16 years, 3 months ago (May 15, 2009, 5:44 a.m.)
Deposited	5 years, 3 months ago (May 18, 2020, 1:11 a.m.)
Indexed	3 weeks, 3 days ago (July 30, 2025, 10:14 a.m.)
Issued	46 years, 10 months ago (Oct. 1, 1978)
Published	46 years, 10 months ago (Oct. 1, 1978)
Published Online	16 years, 3 months ago (May 15, 2009)
Published Print	46 years, 10 months ago (Oct. 1, 1978)

Funders 0

None

BibTeX

@article{Field_1978, title={The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice}, volume={81}, ISSN={0022-1724}, url={http://dx.doi.org/10.1017/s0022172400025109}, DOI={10.1017/s0022172400025109}, number={2}, journal={Journal of Hygiene}, publisher={Cambridge University Press (CUP)}, author={Field, H. J. and Wildy, P.}, year={1978}, month=oct, pages={267–277} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        30
      ]
    ],
    "date-time": "2025-07-30T14:14:26Z",
    "timestamp": 1753884866902
  },
  "reference-count": 18,
  "publisher": "Cambridge University Press (CUP)",
  "issue": "2",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2009,
            5,
            15
          ]
        ],
        "date-time": "2009-05-15T00:00:00Z",
        "timestamp": 1242345600000
      },
      "content-version": "unspecified",
      "delay-in-days": 11184,
      "URL": "https://www.cambridge.org/core/terms"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1978,
        10
      ]
    ]
  },
  "abstract": "<jats:title>Summary</jats:title><jats:p>The pathogenicity for mice of two mutants of herpes simplex virus (type 1 and type 2), which fail to induce thymidine kinase, were compared with their respective parent strains. The mutants were much less virulent than the parents following either intracerebral or peripheral inoculation. The replication of the virus at the site of inoculation and its progression into the nervous system were studied. Following a very large inoculum in the ear, the type 1 mutant was found to establish a latent infection in the cervical dorsal root ganglia. Mice inoculated intracerebrally with small doses of the mutant viruses were solidly immune to challenge with lethal doses of the parent strain.</jats:p>",
  "DOI": "10.1017/s0022172400025109",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2009,
        5,
        15
      ]
    ],
    "date-time": "2009-05-15T09:44:55Z",
    "timestamp": 1242380695000
  },
  "page": "267-277",
  "source": "Crossref",
  "is-referenced-by-count": 271,
  "title": "The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice",
  "prefix": "10.1017",
  "volume": "81",
  "author": [
    {
      "given": "H. J.",
      "family": "Field",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "P.",
      "family": "Wildy",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "56",
  "published-online": {
    "date-parts": [
      [
        2009,
        5,
        15
      ]
    ]
  },
  "reference": [
    {
      "key": "S0022172400025109_ref012",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/257686a0"
    },
    {
      "key": "S0022172400025109_ref015",
      "doi-asserted-by": "publisher",
      "DOI": "10.1099/0022-1317-26-2-159"
    },
    {
      "key": "S0022172400025109_ref008",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0042-6822(67)90015-3"
    },
    {
      "key": "S0022172400025109_ref005",
      "first-page": "529",
      "article-title": "Resistance to intracerebral challenge in mice immunized against herpes simplex virus",
      "volume": "53",
      "author": "Godfrey",
      "year": "1972",
      "journal-title": "British Journal of Experimental Pathology"
    },
    {
      "key": "S0022172400025109_ref010",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF02026404"
    },
    {
      "key": "S0022172400025109_ref001",
      "doi-asserted-by": "publisher",
      "DOI": "10.1084/jem.91.1.1"
    },
    {
      "key": "S0022172400025109_ref007",
      "doi-asserted-by": "publisher",
      "DOI": "10.1099/0022-1317-24-3-465"
    },
    {
      "key": "S0022172400025109_ref003",
      "doi-asserted-by": "publisher",
      "DOI": "10.1099/0022-1317-23-2-145"
    },
    {
      "key": "S0022172400025109_ref006",
      "doi-asserted-by": "publisher",
      "DOI": "10.1099/0022-1317-28-3-341"
    },
    {
      "key": "S0022172400025109_ref014",
      "doi-asserted-by": "publisher",
      "DOI": "10.1099/0022-1317-17-3-307"
    },
    {
      "key": "S0022172400025109_ref018",
      "doi-asserted-by": "publisher",
      "DOI": "10.1007/BF01249353"
    },
    {
      "key": "S0022172400025109_ref004",
      "first-page": "524",
      "volume-title": "Statistical Methods in Biological Assay",
      "author": "Finney",
      "year": "1952"
    },
    {
      "key": "S0022172400025109_ref016",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0042-6822(62)90112-5"
    },
    {
      "key": "S0022172400025109_ref013",
      "doi-asserted-by": "publisher",
      "DOI": "10.1038/1951028a0"
    },
    {
      "key": "S0022172400025109_ref009",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0042-6822(77)90319-1"
    },
    {
      "key": "S0022172400025109_ref017",
      "first-page": "399",
      "article-title": "Virus specific antigens in mammalian cells infected with herpes simplex virus",
      "volume": "11",
      "author": "Watson",
      "year": "1966",
      "journal-title": "Immunology"
    },
    {
      "key": "S0022172400025109_ref011",
      "doi-asserted-by": "crossref",
      "first-page": "166",
      "DOI": "10.1128/IAI.12.1.166-172.1975",
      "article-title": "Role for cell-mediated immunity in the resistance of mice to subcutaneous herpes simplex virus infection",
      "volume": "12",
      "author": "Oakes",
      "year": "1975",
      "journal-title": "Infection and Immunity"
    },
    {
      "key": "S0022172400025109_ref002",
      "doi-asserted-by": "publisher",
      "DOI": "10.1016/0042-6822(64)90070-4"
    }
  ],
  "container-title": "Journal of Hygiene",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0022172400025109",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2020,
        5,
        18
      ]
    ],
    "date-time": "2020-05-18T05:11:24Z",
    "timestamp": 1589778684000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.cambridge.org/core/product/identifier/S0022172400025109/type/journal_article"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1978,
        10
      ]
    ]
  },
  "references-count": 18,
  "journal-issue": {
    "issue": "2",
    "published-print": {
      "date-parts": [
        [
          1978,
          10
        ]
      ]
    }
  },
  "alternative-id": [
    "S0022172400025109"
  ],
  "URL": "http://dx.doi.org/10.1017/S0022172400025109",
  "relation": {},
  "ISSN": [
    "0022-1724"
  ],
  "subject": [],
  "container-title-short": "J. Hyg.",
  "published": {
    "date-parts": [
      [
        1978,
        10
      ]
    ]
  }
}