DOI: 10.1017/s002217240001336x. An analysis of the complement-fixation reaction in influenza

An analysis of the complement-fixation reaction in influenza

10.1017/s002217240001336x

Crossref journal-article

Cambridge University Press (CUP)

Journal of Hygiene (56)

Abstract

1. An analysis of the complement-fixation reaction in influenza has been made by the use of chess-board experiments in which serial dilutions of antigen are tested against serial dilutions of serum with a constant dose of complement.2. The reaction has been shown to be a complex one, involving two different antigens, the virus elementary body and the soluble antigen.3. The soluble antigens of all strains of influenza virus A are identical, and different from the antigen of virus B.4. The elementary body is a complex of several different antigens, and differences in antigenic structure can be detected between different strains of virus A. All elementary body preparations, however, contain soluble antigen which may be an intrinsic part of the elementary body or may be adsorbed.5. The most suitable antigen for use in epidemiological studies is one containing chiefly soluble antigen, and a description is given of the method of preparation and use of such an antigen derived from infected mouse-lung tissue.The author wishes to express his indebtedness to Dr C. H. Andrewes for some of the strains of influenza virus used in this work.

Bibliography

Hoyle, L. (1945). An analysis of the complement-fixation reaction in influenza. Journal of Hygiene, 44(3), 170â178.

Authors 1

L. Hoyle (first)

References 12 Referenced 23

10.1002/path.1700440116
10.4049/jimmunol.41.4.383 / J. Immunol. by Eaton (1941)
10.1084/jem.73.5.581
10.4049/jimmunol.48.3.163 / J. Immunol. by Henle (1944)
10.1002/path.1700290412
10.4049/jimmunol.42.1.51 / J. Immunol. by Nigg (1941)
10.1017/S0022172400035233
10.1084/jem.72.3.233
10.1084/jem.78.5.347
10.3181/00379727-45-11862P
10.1038/icb.1937.25
10.1016/S0140-6736(00)77008-5

Dates

Type	When
Created	16 years, 3 months ago (May 15, 2009, 5:37 a.m.)
Deposited	1 year, 5 months ago (March 13, 2024, 7:11 a.m.)
Indexed	1 year ago (Sept. 6, 2024, 1:17 a.m.)
Issued	80 years ago (Sept. 1, 1945)
Published	80 years ago (Sept. 1, 1945)
Published Online	16 years, 3 months ago (May 15, 2009)
Published Print	80 years ago (Sept. 1, 1945)

Funders 0

None

BibTeX

@article{Hoyle_1945, title={An analysis of the complement-fixation reaction in influenza}, volume={44}, ISSN={0022-1724}, url={http://dx.doi.org/10.1017/s002217240001336x}, DOI={10.1017/s002217240001336x}, number={3}, journal={Journal of Hygiene}, publisher={Cambridge University Press (CUP)}, author={Hoyle, L.}, year={1945}, month=sep, pages={170–178} }

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