DOI: 10.1017/s0022029900025796. Synthesis, effectiveness and metabolic fate in cows of the caesium complexing compound ammonium ferric hexacyanoferrate labelled with <sup>14</sup>C

Synthesis, effectiveness and metabolic fate in cows of the caesium complexing compound ammonium ferric hexacyanoferrate labelled with 14C

10.1017/s0022029900025796

Crossref journal-article

Cambridge University Press (CUP)

Journal of Dairy Research (56)

Abstract

SummaryAdding ammonium ferric hexacyanoferrate (AFCF) to cows' fodder produced after the Chernobyl nuclear accident prevented milk contamination by increasing the faecal elimination of 137Cs. Synthesis of ammonium ferric hexa[14C]-cyanoferrate (AF14CF) and its purification were performed for the study of the metabolic fate of this complex, and the evaluation of the possible release of cyanide. The stability of this colloidal product, tested by anaerobic incubation in rumen juice in vitro, showed no release of free cyanide from AF14CF, but hexacyanoferrate was identified in the rumen juice and 0·13% of the added radioactivity was converted to labelled CO2. AF14CF administered per os to two cows showed a nearly quantitative excretion of radioactivity in faeces during the first 3 d (91–95%). A very low but significant level of radioactivity appeared in plasma, blood cells, expired CO2 and was detected in organs taken 9 d after administration. Total cumulative radioactivity in urine and milk amounted to 0·19–0·47% and 0·068–0·071% respectively for the two cows. Labelled hexacyanoferrate and thiocyanate were identified in the urine and also in faeces. In spite of this relative instability of AFCF in the rumen of cows, the poor absorption of AF14CF degradation products showed that AFCF constitutes an efficient and safe food additive to prevent the absorption of radioactive caesium from ruminant feed and its secretion in milk.

Bibliography

Arnaud, M. J., Clement, C., Getaz, F., Tannhauser, F., Schoenegge, R., Blum, J., & Giese, W. (1988). Synthesis, effectiveness and metabolic fate in cows of the caesium complexing compound ammonium ferric hexacyanoferrate labelled with 14C. Journal of Dairy Research, 55(1), 1â13.

Authors 7

Maurice J. Arnaud (first)
Charles Clement (additional)
Françoise Getaz (additional)
Fritz Tannhauser (additional)
Rainer Schoenegge (additional)
Jürg Blum (additional)
Werner Giese (additional)

References 33 Referenced 24

10.3168/jds.S0022-0302(69)86682-8
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{'key': 'S0022029900025796_ref029', 'first-page': '78', 'article-title': 'Determination of soluble cyanide in ferric ammonium ferrocyanide pigments', 'volume': '125', 'author': 'Thieman', 'year': '1979', 'journal-title': 'Drug and Cosmetic Industry'} / Drug and Cosmetic Industry / Determination of soluble cyanide in ferric ammonium ferrocyanide pigments by Thieman (1979)
Haselbach C. 1983 [Metabolism of the N-containing fraction of variously conserved forages by rumen microorganisms in vitro.] Eidgenössische Technische Hochschule, Zurich Dissertation No. 7257
10.1093/jat/9.3.112
{'key': 'S0022029900025796_ref022', 'first-page': '307', 'article-title': 'Enhancement of the excretion of radiocaesium in rats by ferric cyanoferrate(II)', 'volume': '7', 'author': 'Nigrovíc', 'year': '1963', 'journal-title': 'International Journal of Radiation Biology'} / International Journal of Radiation Biology / Enhancement of the excretion of radiocaesium in rats by ferric cyanoferrate(II) by Nigrovíc (1963)
{'key': 'S0022029900025796_ref014', 'first-page': '123', 'article-title': 'The use of cyanoferrates for the elimination of radiocaesium in rats and goats', 'volume': '134', 'author': 'Havliček', 'year': '1967', 'journal-title': 'Strahlentherapie'} / Strahlentherapie / The use of cyanoferrates for the elimination of radiocaesium in rats and goats by Havliček (1967)
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{'key': 'S0022029900025796_ref011', 'first-page': '191', 'article-title': 'The question of biological decontamination of highly radioactive milk given to pigs. 1. The behaviour of caesium-137 after daily dosage and under specific feeding conditions', 'volume': '11', 'author': 'Giese', 'year': '1970', 'journal-title': 'Zentralblatt für Veterinärmedicin'} / Zentralblatt für Veterinärmedicin / The question of biological decontamination of highly radioactive milk given to pigs. 1. The behaviour of caesium-137 after daily dosage and under specific feeding conditions by Giese (1970)
10.1016/S0015-6264(69)80419-0
10.3181/00379727-110-27461
{'key': 'S0022029900025796_ref002', 'first-page': '175', 'article-title': 'Evaluation of the effectiveness of colloidal and insoluble ferrihexacyanoferrates(II) in removing internally deposited radiocaesium', 'volume': '197', 'author': 'Bozorgzadéh', 'year': '1972', 'journal-title': 'Archives Internationales de Pharmacodynamie et de Thérapie'} / Archives Internationales de Pharmacodynamie et de Thérapie / Evaluation of the effectiveness of colloidal and insoluble ferrihexacyanoferrates(II) in removing internally deposited radiocaesium by Bozorgzadéh (1972)
{'key': 'S0022029900025796_ref019', 'first-page': '519', 'article-title': 'Diminution of radiocaesium body-burden in dogs and human beings by Prussian Blue', 'volume': '10', 'author': 'Madshus', 'year': '1966', 'journal-title': 'International Journal of Radiation Biology'} / International Journal of Radiation Biology / Diminution of radiocaesium body-burden in dogs and human beings by Prussian Blue by Madshus (1966)
{'key': 'S0022029900025796_ref005', 'first-page': '173', 'volume-title': 'Radioisotopes in Biology and Agriculture', 'author': 'Comar', 'year': '1955'} / Radioisotopes in Biology and Agriculture by Comar (1955)
{'key': 'S0022029900025796_ref010', 'first-page': '185', 'article-title': 'Comparative studies on caesium-137 elimination by various hexacyanoferrate complexes in the rat', 'volume': '11', 'author': 'Giese', 'year': '1970', 'journal-title': 'Zentralblatt für Veterinärmedizin'} / Zentralblatt für Veterinärmedizin / Comparative studies on caesium-137 elimination by various hexacyanoferrate complexes in the rat by Giese (1970)
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Giese W. 1971 [The in vitro and in vivo behaviour of radiocaesium and possibilities of reducing the radiation dosage.] Tierärztliche Hochschule Hannover, Habilitationsschrift
Senshu T. 1966 [In vitro studies on protein synthesis in rumen microorganisms.] Eidgenössische Technische Hochschule, Zurich Dissertation No. 3803
10.1039/an9790400525
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{'key': 'S0022029900025796_ref003', 'first-page': '55', 'article-title': 'A comparative study of the toxicity and efficacy of four ferrocyanides in decontamination of radioactive caesium-134', 'volume': '15', 'author': 'Brenot', 'year': '1967', 'journal-title': 'Pathologie et Biologie'} / Pathologie et Biologie / A comparative study of the toxicity and efficacy of four ferrocyanides in decontamination of radioactive caesium-134 by Brenot (1967)
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Dates

Type	When
Created	16 years, 2 months ago (June 5, 2009, 2:41 a.m.)
Deposited	6 years, 3 months ago (May 20, 2019, 12:24 p.m.)
Indexed	1 year, 10 months ago (Oct. 19, 2023, 2:58 a.m.)
Issued	37 years, 6 months ago (Feb. 1, 1988)
Published	37 years, 6 months ago (Feb. 1, 1988)
Published Online	16 years, 2 months ago (June 1, 2009)
Published Print	37 years, 6 months ago (Feb. 1, 1988)

Funders 0

None

BibTeX

@article{Arnaud_1988, title={Synthesis, effectiveness and metabolic fate in cows of the caesium complexing compound ammonium ferric hexacyanoferrate labelled with 14C}, volume={55}, ISSN={1469-7629}, url={http://dx.doi.org/10.1017/s0022029900025796}, DOI={10.1017/s0022029900025796}, number={1}, journal={Journal of Dairy Research}, publisher={Cambridge University Press (CUP)}, author={Arnaud, Maurice J. and Clement, Charles and Getaz, Françoise and Tannhauser, Fritz and Schoenegge, Rainer and Blum, Jürg and Giese, Werner}, year={1988}, month=feb, pages={1–13} }

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