DOI: 10.1017/s0016672300017584. Allosuppressors in yeast

10.1017/s0016672300017584

Crossref journal-article

Wiley

Genetical Research (311)

Abstract

SUMMARYFive loci have been identified inSaccharomyces cerevisiaewhose function reduces suppressor activity in strains carrying ochre super-suppressor mutations. Recessive mutations which allow an increased level of suppression occur at these loci. In such mutants, termed allosuppressors, the serine-inserting suppressorSUPQ5suppresses ochre mutations in a [psi−] background and Class I tyrosine-inserting suppressors are lethal or have a reduced viability. Mutations at two allosuppressor loci,sal3 andsal4, have a lethal interaction with one another and with the extrachromosomal determinant [psi+]. This interaction is expressed in the absence of any suppressor mutation. All the mutant alleles of one allosuppressor locussal3 are cold sensitive. One allosuppressor mutation,sal4.2, is temperature-sensitive for growth, as well as for other aspects of its phenotypic expression; namely the expression ofSUPQ5and the lethal interactions with Class I super-suppressors, with [psi+] and withsal3. At low temperature (24 °C),sal3-sal4.2 double mutants weakly suppress the ochre mutationade2.1, but do not suppresshis5.2 orlys1.1. It is argued that the site of function of the products of these loci is ribosomal and that they are involved in chain termination at UAA codons. It is inferred that the [psi+] factor or its product affects protein synthesis by interaction with the ribosome.

Bibliography

Cox, B. S. (1977). Allosuppressors in yeast. Genetical Research, 30(2), 187â205.

Authors 1

B. S. Cox (first)

References 23 Referenced 47

10.1007/BF00338694
10.1017/S0016672300013173
10.1007/BF00267660
10.1093/genetics/50.3.435 / Genetics / Mitotic recombination and heteroallelic repair in Saccharomyces cerevisiae by Hurst (1964)
10.1093/genetics/60.4.735 / Genetics / Genetic mapping of nonsense suppressors in yeast by Hawthorne (1968)
10.1007/978-3-642-65848-8_1 / Current Topics in Microbiology and Immunology / Suppressor mutations in yeast by Hawthorne (1974)
10.1016/S0022-2836(66)80022-0
10.1038/hdy.1965.65
10.1128/JB.78.2.292-292.1959 / Journal of Bacteriology / Use of snail digestive juice in isolation of yeast spore tetrads by Johnston (1959)
10.1016/0092-8674(75)90178-6
10.1146/annurev.ge.04.120170.000543
10.1016/0022-2836(66)90066-0
10.1111/j.1469-8137.1962.tb06305.x
10.1093/genetics/56.4.641 / Genetics / Super-suppressors in Saccharomyces cerevisiae by Gilmore (1967)
10.1093/genetics/85.1.35 / Genetics / The effect of ochre suppression on meiosis and ascospore formation in Saccharomyces by Rothstein (1977)
10.1007/BF00268125
10.1038/hdy.1975.8
10.1038/hdy.1971.28
{'key': 'S0016672300017584_ref010', 'first-page': '563', 'article-title': 'Genetic modifiers of super-suppression in yeast', 'volume': '56', 'author': 'Hawthorne', 'year': '1967', 'journal-title': 'Genetics'} / Genetics / Genetic modifiers of super-suppression in yeast by Hawthorne (1967)
10.1016/0027-5107(74)90042-6
10.1016/0022-2836(75)90324-1
10.1016/0022-2836(71)90213-0
10.1038/hdy.1971.52

Dates

Type	When
Created	15 years, 11 months ago (Sept. 17, 2009, 3:45 a.m.)
Deposited	6 months, 3 weeks ago (Feb. 12, 2025, 1:54 a.m.)
Indexed	3 weeks, 5 days ago (Aug. 7, 2025, 5:05 p.m.)
Issued	47 years, 11 months ago (Oct. 1, 1977)
Published	47 years, 11 months ago (Oct. 1, 1977)
Published Online	16 years, 4 months ago (April 14, 2009)
Published Print	47 years, 11 months ago (Oct. 1, 1977)

Funders 0

None

BibTeX

@article{Cox_1977, title={Allosuppressors in yeast}, volume={30}, ISSN={1469-5073}, url={http://dx.doi.org/10.1017/s0016672300017584}, DOI={10.1017/s0016672300017584}, number={2}, journal={Genetical Research}, publisher={Wiley}, author={Cox, B. S.}, year={1977}, month=oct, pages={187–205} }

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