DOI: 10.1017/s0016672300013732. The chromosomal integration of a β-lactamase gene derived from the P-type R-factor RP1 in<i>Escherichia coli</i>

The chromosomal integration of a β-lactamase gene derived from the P-type R-factor RP1 inEscherichia coli

10.1017/s0016672300013732

Crossref journal-article

Hindawi Limited

Genetical Research (98)

Abstract

The R-factor RP1, which carried the markersamp neo tet, confers resistance to penicillins by specifying the synthesis of Type IIIa β-lactamase. It was detected initially in a strain ofPseudomonas aeruginosa(Sykes & Richmond, 1970) and fragments spontaneously inPs. aeruginosastrain Ps 18 to give clones which carry only theampmarker. Such clones are said to carry the element RP 1–1 since they are still capable of specifying the transfer of ampicillin and carbenicillin resistance to appropriate recipients in mating experiments. However, unlike lines carrying RP 1, they contain no detectable extrachromosomal DNA (Ingramet al.1972), and the likely supposition is that theampgene in these clones has become integrated into the bacterial chromosome together with the regions necessary to allow such strains to act asampgene donors in mating experiments. It is probably cells ofPs. aeruginosain which theampgene has become integrated together with an RTF region that are responsible for the transfer of chromosomal markers reported by Holloway & Stanisich (1971).

Bibliography

Richmond, M. H., & Sykes, R. B. (1972). The chromosomal integration of a Î²-lactamase gene derived from the P-type R-factor RP1 inEscherichia coli. Genetical Research, 20(2), 231â237.

Authors 2

M. H. Richmond (first)
R. B. Sykes (additional)

References 16 Referenced 33

10.1111/j.1749-6632.1971.tb30652.x
10.1128/JB.95.3.1078-1089.1968 / Journal of Bacteriology / Effective elimination of drug resistance and sex factors in Escherichia coli by sodium dodecyl sulphate by Tomoeda (1968)
10.1038/226952a0
10.1146/annurev.mi.21.100167.003125
{'key': 'S0016672300013732_ref011', 'first-page': '31', 'volume-title': 'Advances in Microbiology Physiology', 'volume': '9', 'author': 'Richmond', 'year': '1973'} / Advances in Microbiology Physiology by Richmond (1973)
10.1017/S0016672300011769
10.1017/S0016672300012179 / Genetical Research / Chromosome transfer in Pseudomonas aeruginosa mediated by R factors by Holloway (1971)
10.1016/0006-291X(65)90855-7
10.1099/00221287-61-1-43
10.1111/j.1749-6632.1971.tb30659.x
10.1042/bj1050371
10.1111/j.1749-6632.1971.tb30661.x
10.1073/pnas.60.1.160
{'key': 'S0016672300013732_ref002', 'volume-title': 'Experiments in Microbial Genetics', 'author': 'Clowes', 'year': '1968'} / Experiments in Microbial Genetics by Clowes (1968)
10.1099/00221287-72-2-269
10.1128/MMBR.34.2.155-175.1970 / Bacteriological Reviews / Current linkage map of Escherichia coli by Taylor (1970)

Dates

Type	When
Created	15 years, 11 months ago (Sept. 17, 2009, 3:51 a.m.)
Deposited	4 years, 8 months ago (Dec. 31, 2020, 5:47 p.m.)
Indexed	1 year, 4 months ago (April 5, 2024, 4:59 a.m.)
Issued	52 years, 11 months ago (Oct. 1, 1972)
Published	52 years, 11 months ago (Oct. 1, 1972)
Published Online	16 years, 4 months ago (April 14, 2009)
Published Print	52 years, 11 months ago (Oct. 1, 1972)

Funders 0

None

BibTeX

@article{Richmond_1972, title={The chromosomal integration of a β-lactamase gene derived from the P-type R-factor RP1 inEscherichia coli}, volume={20}, ISSN={1469-5073}, url={http://dx.doi.org/10.1017/s0016672300013732}, DOI={10.1017/s0016672300013732}, number={2}, journal={Genetical Research}, publisher={Hindawi Limited}, author={Richmond, M. H. and Sykes, R. B.}, year={1972}, month=oct, pages={231–237} }

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