DOI: 10.1017/s0016672300012593. Pleiotropy of<i>p</i>-fluorophenylalanine-resistant and antibiotic hypersensitive mutants of<i>Pseudomonas aeruginosa</i>

Pleiotropy ofp-fluorophenylalanine-resistant and antibiotic hypersensitive mutants ofPseudomonas aeruginosa

10.1017/s0016672300012593

Crossref journal-article

Hindawi Limited

Genetical Research (98)

Abstract

SUMMARYMutants ofPseudomonas aeruginosaisolated as being resistant top-fluorophenylalanine (FPA-r) are pleiotropic, showing patterns of phenotypic alteration of host-controlled modification, growth rate at 37 and 43 °C, ability to grow on minimal medium, response to antibiotics and ribosomal characteristics. Alterations in host-controlled modification are also found in FPA-r mutants ofEscherichia coliB.The pleiotropy arising in these FPA-r mutants ofP. aeruginosaappears to result from alterations in the specificity of protein synthesis. Phenotypic variations in host-controlled modification of the type found in the FPA-r mutants may provide a method for the detection of suppressor mutations which act by miscoding.

Bibliography

Dunn, N. W., & Holloway, B. W. (1971). Pleiotropy ofp-fluorophenylalanine-resistant and antibiotic hypersensitive mutants ofPseudomonas aeruginosa. Genetical Research, 18(2), 185â197.

Authors 2

N. W. Dunn (first)
B. W. Holloway (additional)

References 28 Referenced 56

Waltho J. A. (1968). Genetic aspects of enzyme regulation in Pseudomonas aeruginosa. Ph.D. thesis, University of Melbourne.
10.1021/ac60177a025
10.1073/pnas.47.7.941
10.1128/JB.80.3.362-367.1960 / Journal of Bacteriology / Fertility factors and genetic linkage in Pseudomonas aeruginosa by Holloway (1960)
Holloway B. W. , Khishnapillai V. & Stanisich V. (1971). Pseudomonas genetics. Annual Review of Genetics (in the Press). (10.1146/annurev.ge.05.120171.002233)
10.1038/icb.1960.34
10.1128/JB.96.1.43-50.1968 / Journal of Bacteriology / Effect of mutation to streptomycin resistance on amber suppressor genes by Otsuji (1968)
{'key': 'S0016672300012593_ref016', 'first-page': '175', 'volume-title': 'Replication and Recombination of Genetical Material', 'author': 'Holloway', 'year': '1968'} / Replication and Recombination of Genetical Material by Holloway (1968)
10.1126/science.164.3883.1024
10.1016/S0022-2836(62)80059-X
10.1128/JB.91.3.1021-1028.1966 / Journal of Bacteriology / Effects of mutation to streptomycin resistance on the rate of translocation of mutant genetic information by Gartner (1966)
10.1016/0042-6822(65)90091-7
10.1016/S0022-2836(66)80173-0
10.1128/MMBR.33.3.419-443.1969 / Bacteriological Reviews / Genetics of Pseudomonas by Holloway (1969)
10.1101/SQB.1966.031.01.085
10.1016/S0021-9258(18)91269-X / Journal of Biological Chemistry / Demonstration of an altered amino-acyl ribonucleic acid synthetase in a mutant of Escherichia coli by Fangman (1964)
10.1017/S0016672300004158
10.1073/pnas.62.3.946
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10.1128/JB.96.5.1732-1741.1968 / Journal of Bacteriology / Control of pyrimidine biosynthesis in Pseudomonas aeruginosa by Isaac (1968)
10.1016/0042-6822(57)90006-5
10.1073/pnas.55.1.212
10.1017/S0016672300011678
10.1093/genetics/61.2.327 / Genetics / Conjugation in Pseudomonas aeruginosa by Stanisich (1969)
10.1016/S0022-2836(66)80267-X
10.1128/JB.92.1.35-42.1966 / Journal of Bacteriology / Suppression of fluorophenylalanine resistance by mutation to streptomycin resistance in Pseudomonas aeruginosa by Waltho (1966)
{'key': 'S0016672300012593_ref002', 'first-page': '255', 'article-title': 'Three genes that affect Escherichia coli ribosomes', 'volume': '30', 'author': 'Apirion', 'year': '1967', 'journal-title': 'Journal of Molecular Biology'} / Journal of Molecular Biology / Three genes that affect Escherichia coli ribosomes by Apirion (1967)
10.1016/0022-2836(68)90209-X

Dates

Type	When
Created	15 years, 11 months ago (Sept. 17, 2009, 3:52 a.m.)
Deposited	3 years, 10 months ago (Oct. 10, 2021, 6:52 p.m.)
Indexed	4 months, 3 weeks ago (April 12, 2025, 3:46 a.m.)
Issued	53 years, 11 months ago (Oct. 1, 1971)
Published	53 years, 11 months ago (Oct. 1, 1971)
Published Online	16 years, 4 months ago (April 14, 2009)
Published Print	53 years, 11 months ago (Oct. 1, 1971)

Funders 0

None

BibTeX

@article{Dunn_1971, title={Pleiotropy ofp-fluorophenylalanine-resistant and antibiotic hypersensitive mutants ofPseudomonas aeruginosa}, volume={18}, ISSN={1469-5073}, url={http://dx.doi.org/10.1017/s0016672300012593}, DOI={10.1017/s0016672300012593}, number={2}, journal={Genetical Research}, publisher={Hindawi Limited}, author={Dunn, N. W. and Holloway, B. W.}, year={1971}, month=oct, pages={185–197} }

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