DOI: 10.1017/s0016672300003335. XO mice

XO mice

10.1017/s0016672300003335

Crossref journal-article

Hindawi Limited

Genetical Research (98)

Abstract

The inactive-X hypothesis (Lyon, 1961) states that in the normal female mouse only one of the two X chromosomes is genetically active in each cell of the body other than the germ-cells, and that the choice of which X is to be inactivated occurs at an early stage of embryogenesis, and is at random in each cell. The descendants of these cells then abide by the decision so that females are mosaics for two lines of cells and may show a mosaic phenotype if they are heterozygous for a sex-linked gene. One requisite for the validity of this hypothesis is that only one X is necessary for the development of a normal female mouse, and evidence substantiating this supposition is the apparent normality of XO mice (Welshons & Russell, 1959; Cattanach, 1961a, b). On the other hand it has been suggested that XO mice are not fully viable (Russell, Russell & Gower, 1959), but no data on the comparative viability and growth of XO female mice have yet been reported. In the present communication data of this nature, collected in the process of setting up an XO stock, are presented and support the hypothesis that only one X chromosome is necessary for normal female mouse development.

Bibliography

Cattanach, B. M. (1962). XO mice. Genetical Research, 3(3), 487â490.

Authors 1

Bruce M. Cattanach (first)

References 5 Referenced 81

10.1038/190372a0
10.1073/pnas.45.4.560
10.1073/pnas.45.4.554
{'key': 'S0016672300003335_ref002', 'first-page': '165', 'article-title': 'A chemically-induced variegated-type position effect in the mouse', 'volume': '92', 'author': 'Cattanach', 'year': '1961', 'journal-title': 'Z. indukt. Vererb Abstamm.- u. Lehre'} / Z. indukt. Vererb Abstamm.- u. Lehre / A chemically-induced variegated-type position effect in the mouse by Cattanach (1961)
10.1017/S001667230000063X

Dates

Type	When
Created	15 years, 11 months ago (Sept. 17, 2009, 4:01 a.m.)
Deposited	4 years, 8 months ago (Dec. 31, 2020, 5:44 p.m.)
Indexed	1 year ago (Aug. 28, 2024, 9:55 a.m.)
Issued	62 years, 9 months ago (Nov. 1, 1962)
Published	62 years, 9 months ago (Nov. 1, 1962)
Published Online	16 years, 4 months ago (April 14, 2009)
Published Print	62 years, 9 months ago (Nov. 1, 1962)

Funders 0

None

BibTeX

@article{Cattanach_1962, title={XO mice}, volume={3}, ISSN={1469-5073}, url={http://dx.doi.org/10.1017/s0016672300003335}, DOI={10.1017/s0016672300003335}, number={3}, journal={Genetical Research}, publisher={Hindawi Limited}, author={Cattanach, Bruce M.}, year={1962}, month=nov, pages={487–490} }

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