DOI: 10.1017/s0016672300002895. A comparison of some biological characteristics of the mouse-passaged scrapie agents, 22A and ME7

A comparison of some biological characteristics of the mouse-passaged scrapie agents, 22A and ME7

10.1017/s0016672300002895

Crossref journal-article

Hindawi Limited

Genetical Research (98)

Abstract

Two mouse-adapted scrapie agents of different sheep origin were compared. The titre, reached in the brains of mice in the terminal stage of scrapie, is of the same order for both agents. There is a threefold difference between the incubation periods of the two agents in some mouse strains, of which C57 is one, and in this strain incubation of the 22A agent, given as a large dose by a peripheral route, occupies almost the whole life-span.The most fundamental difference between the agents concerns the reversal of the ranking of incubation periods, typically in the VM and C57 mouse strams: incubation of ME7 in VM takes almost twice as long as in C57, whereas most sub-lines of 22A take half as long in VM as in C57. The implications of this type of host-genotype, agent-strain interaction are discussed in terms of the possible nature of agent differences, the possibility of latent infection and the consequences for scrapie eradication programmes.

Bibliography

Dickinson, A. G., & Meikle, V. M. H. (1969). A comparison of some biological characteristics of the mouse-passaged scrapie agents, 22A and ME7. Genetical Research, 13(2), 213â225.

Authors 2

A. G. Dickinson (first)
Veronica M. H. Meikle (additional)

References 12 Referenced 100

10.1016/S0368-1742(63)80018-1
10.1016/S0007-1935(17)50172-4
10.1016/S0034-5288(18)34700-3 / Rea. vet. Sci. / The relative susceptibility of sheep, goats and mice to two types of the goat scrapie agent by Pattison (1966)
10.1016/S0034-5288(18)34525-9 / Res. vet. Sci. / Modification of a strain of mouse-adapted scrapie by passage through rats by Pattison (1968)
10.1016/0021-9975(68)90007-8
10.1016/0021-9975(69)90022-X
10.1093/oxfordjournals.bmb.a070533
10.1016/S0034-5288(18)34840-9 / Res. vet. Sci. / Observations on the comparative infectivity of cellular fractions derived from homogenates of mouse-scrapie brain by Hunter (1963)
10.1038/hdy.1965.64
10.1038/hdy.1964.31
10.1016/0021-9975(68)90005-4
10.1038/2161310a0

Dates

Type	When
Created	15 years, 11 months ago (Sept. 17, 2009, 3:55 a.m.)
Deposited	4 years, 8 months ago (Dec. 31, 2020, 5:46 p.m.)
Indexed	3 weeks, 3 days ago (Aug. 7, 2025, 4:36 p.m.)
Issued	56 years, 5 months ago (April 1, 1969)
Published	56 years, 5 months ago (April 1, 1969)
Published Online	16 years, 4 months ago (April 14, 2009)
Published Print	56 years, 5 months ago (April 1, 1969)

Funders 0

None

BibTeX

@article{Dickinson_1969, title={A comparison of some biological characteristics of the mouse-passaged scrapie agents, 22A and ME7}, volume={13}, ISSN={1469-5073}, url={http://dx.doi.org/10.1017/s0016672300002895}, DOI={10.1017/s0016672300002895}, number={2}, journal={Genetical Research}, publisher={Hindawi Limited}, author={Dickinson, A. G. and Meikle, Veronica M. H.}, year={1969}, month=apr, pages={213–225} }

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