DOI: 10.1017/s0007114599000264. Hypovitaminosis D in an Italian population of healthy subjects and hospitalized patients

Hypovitaminosis D in an Italian population of healthy subjects and hospitalized patients

10.1017/s0007114599000264

Crossref journal-article

Cambridge University Press (CUP)

British Journal of Nutrition (56)

Abstract

The present study aimed to investigate the prevalence and seasonal variation of hypovitaminosis D (defined as serum 25-hydroxyvitamin D level below 30 nmol/l) among healthy subjects and hospitalized patients living in central Italy. We studied 297 subjects, 131 in February 1997 and 166 in July 1997, subdivided into four groups: (a) young healthy blood donors; (b) healthy postmenopausal women; (c) inpatients with various medical diseases and (d) inpatients engaged in long-term rehabilitation programmes because of various neurological disorders. In all subjects and patients serum levels of 25-hydroxyvitamin D were measured by radioimmunoassay. We found a significant seasonal variation (P< 0·0001) of serum 25-hydroxyvitamin D levels, mean values being higher in summer in all groups, except in patients with a longer hospitalization time (group (d)). In each group, a significantly higher prevalence of hypovitaminosis D was found in winter compared with summer time (P< 0·001), being unexpectedly high in postmenopausal women (winter 32 % and summer 4·5 %); furthermore, in both seasons, inpatients were characterized by the highest incidences of hypovitaminosis, particularly those in group (d) (winter 82·3 % and summer 57·8 %). The results of the present study emphasize the importance of 25-hydroxyvitamin D measurement, and the need to increase vitamin D intake in Italy; foodstuff fortification and supplement use must be considered in order to prevent negative effects of vitamin D deficiency on skeletal integrity.

Bibliography

Romagnoli, E., Caravella, P., Scarnecchia, L., Martinez, P., & Minisola, S. (1999). Hypovitaminosis D in an Italian population of healthy subjects and hospitalized patients. British Journal of Nutrition, 81(2), 133â137.

Authors 5

Elisabetta Romagnoli (first)
Patrizia Caravella (additional)
Liliana Scarnecchia (additional)
Paolo Martinez (additional)
Salvatore Minisola (additional)

References 32 Referenced 43

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{'key': 'S0007114599000264_ref023', 'first-page': '13', 'article-title': 'Incidenza di ipovitaminosi D nel Nord Italia (Incidence of hypovitaminosis D in northern Italy)', 'volume': '4', 'author': 'Rossini', 'year': '1990', 'journal-title': 'Italian Journal of Mineral and Electrolyte Metabolism'} / Italian Journal of Mineral and Electrolyte Metabolism / Incidenza di ipovitaminosi D nel Nord Italia (Incidence of hypovitaminosis D in northern Italy) by Rossini (1990)
10.1111/j.1532-5415.1997.tb03094.x
10.1093/ajcn/66.4.929
10.1007/s001980050030
10.1056/NEJM198912283212602
{'key': 'S0007114599000264_ref002', 'first-page': '3', 'article-title': 'High prevalence of vitamin D deficiency among free-living postmenopausal women in Northern Italy', 'volume': '11', 'author': 'Bettica', 'year': '1997', 'journal-title': 'Italian Journal of Mineral and Electrolyte Metabolism'} / Italian Journal of Mineral and Electrolyte Metabolism / High prevalence of vitamin D deficiency among free-living postmenopausal women in Northern Italy by Bettica (1997)
10.1001/jama.1995.03530210037027
{'key': 'S0007114599000264_ref013', 'first-page': '301', 'article-title': 'Hypovitaminosis D in the healthy elderly', 'volume': '49', 'author': 'Keane', 'year': '1995', 'journal-title': 'British Journal of Clinical Practice'} / British Journal of Clinical Practice / Hypovitaminosis D in the healthy elderly by Keane (1995)
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{'key': 'S0007114599000264_ref026', 'volume-title': 'Dietary intakes: calcium, phosphorus, magnesium, vitamin D, and fluoride', 'year': '1997'} / Dietary intakes: calcium, phosphorus, magnesium, vitamin D, and fluoride (1997)
10.1056/NEJM199803193381209
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10.1093/geronj/38.1.19
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{'key': 'S0007114599000264_ref032', 'first-page': '68', 'article-title': 'Seasonal variation of biochemical indexes of bone turnover: results of a population based study', 'volume': '83', 'author': 'Woitge', 'year': '1998', 'journal-title': 'Journal of Clinical Endocrinology and Metabolism'} / Journal of Clinical Endocrinology and Metabolism / Seasonal variation of biochemical indexes of bone turnover: results of a population based study by Woitge (1998)
10.7326/0003-4819-124-4-199602150-00003
10.1056/NEJM199803193381201
10.1007/BF02509538
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10.1007/BF01623764
{'key': 'S0007114599000264_ref005', 'first-page': '1129', 'article-title': 'Healthy elderly French women living at home have secondary hyperparathyroidism and high bone turnover in winter', 'volume': '81', 'author': 'Chapuy', 'year': '1996', 'journal-title': 'Journal of Clinical Endocrinology and Metabolism'} / Journal of Clinical Endocrinology and Metabolism / Healthy elderly French women living at home have secondary hyperparathyroidism and high bone turnover in winter by Chapuy (1996)
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10.1093/clinchem/39.3.529 / Clinical Chemistry / Determination of vitamin D status by radioimmunoassay with 125I-labeled tracer by Hollis (1993)
10.1016/S0140-6736(95)91266-5

Dates

Type	When
Created	6 years, 3 months ago (May 10, 2019, 3:12 p.m.)
Deposited	4 years, 8 months ago (Dec. 12, 2020, 6:09 a.m.)
Indexed	1 month, 2 weeks ago (July 23, 2025, 8:50 a.m.)
Issued	26 years, 7 months ago (Feb. 1, 1999)
Published	26 years, 7 months ago (Feb. 1, 1999)
Published Online	18 years, 5 months ago (March 9, 2007)
Published Print	26 years, 7 months ago (Feb. 1, 1999)

Funders 0

None

BibTeX

@article{Romagnoli_1999, title={Hypovitaminosis D in an Italian population of healthy subjects and hospitalized patients}, volume={81}, ISSN={1475-2662}, url={http://dx.doi.org/10.1017/s0007114599000264}, DOI={10.1017/s0007114599000264}, number={2}, journal={British Journal of Nutrition}, publisher={Cambridge University Press (CUP)}, author={Romagnoli, Elisabetta and Caravella, Patrizia and Scarnecchia, Liliana and Martinez, Paolo and Minisola, Salvatore}, year={1999}, month=feb, pages={133–137} }

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