DOI: 10.1016/s0952-7915(99)00046-1. Tlr4: central component of the sole mammalian LPS sensor

Tlr4: central component of the sole mammalian LPS sensor

10.1016/s0952-7915(99)00046-1

Crossref journal-article

Elsevier BV

Current Opinion in Immunology (78)

Bibliography

Beutler, B. (2000). Tlr4: central component of the sole mammalian LPS sensor. Current Opinion in Immunology, 12(1), 20â26.

Authors 1

Bruce Beutler (first)

References 50 Referenced 604

10.1016/0167-5699(92)90198-G / Immunol Today / The immune system evolved to discriminate infectious nonself from noninfectious self by Janeway (1992)
10.1038/2191253a0 / Nature / Genetic control of leucocyte responses to endotoxin by Sultzer (1968)
10.4049/jimmunol.118.6.2088 / J Immunol / The response of recombinant inbred strains of mice to bacterial lipopolysaccharides by Watson (1977)
10.1007/BF01843983 / Immunogenetics / Genetic basis for unresponsiveness to lipopolysaccharide in C57BL/10Cr mice by Coutinho (1978)
10.4049/jimmunol.124.1.20 / J Immunol / Genetic control of susceptibility to Salmonella typhimurium in mice: role of the LPS gene by O’Brien (1980)
{'key': '10.1016/S0952-7915(99)00046-1_BIB6', 'first-page': '263', 'article-title': 'Genetic control of resistance to infection in mice', 'volume': '3', 'author': 'Rosenstreich', 'year': '1982', 'journal-title': 'CRC Crit Rev Immunol'} / CRC Crit Rev Immunol / Genetic control of resistance to infection in mice by Rosenstreich (1982)
10.1093/infdis/141.1.55 / J Infect Dis / The primary role of lymphoreticular cells in the mediation of host responses to bacterial endotoxin by Michalek (1980)
10.1126/science.1698311 / Science / CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein by Wright (1990)
10.4049/jimmunol.120.2.422 / J Immunol / The genetic mapping of a defective LPS response gene in C3H/HeJ mice by Watson (1978)
10.1006/geno.1996.0050 / Genomics / A high-resolution map in the chromosomal region surrounding the Lps locus by Qureshi (1996)
10.1006/bcmd.1998.0201 / Blood Cells Mol Dis / Genetic and physical mapping of the Lps locus- identification of the toll-4 receptor as a candidate gene in the critical region by Poltorak (1998)
10.1126/science.282.5396.2085 / Science / Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in TlR4 gene by Poltorak (1998)
10.1016/0092-8674(85)90274-0 / Cell / Establishment of dorsal-ventral polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product by Anderson (1985)
10.1016/S0092-8674(00)80172-5 / Cell / The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults by Lemaitre (1996)
10.1146/annurev.cellbio.12.1.393 / Annu Rev Cell Dev Biol / A conserved signaling pathway: the Drosophila toll-dorsal pathway by Belvin (1996)
10.1073/pnas.95.2.588 / Proc Natl Acad Sci USA / A family of human receptors structurally related to Drosophila Toll by Rock (1998)
10.1038/41131 / Nature / A human homologue of the Drosophila Toll, protein signals activation of adaptive immunity by Medzhitov (1997)
10.1091/mbc.4.8.767 / Mol Biol Cell / A conserved signal transduction pathway regulating the activity of the rel-like proteins dorsal and NF-kappa B by Wasserman (1993)
10.1084/jem.187.12.2097 / J Exp Med / The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6) by Muzio (1998)
10.1016/S1097-2765(00)80136-7 / Mol Cell / MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways by Medzhitov (1998)
10.1093/emboj/16.20.6120 / EMBO J / The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense by Williams (1997)
10.4049/jimmunol.121.5.1664 / J Immunol / Macrophage sensitivity to endotoxin. Genetic control by a single codominant gene by Rosenstreich (1978)
{'key': '10.1016/S0952-7915(99)00046-1_BIB23', 'first-page': '165', 'article-title': 'Evidence of the precision of genetic adaptation', 'volume': '43', 'author': 'Muller', 'year': '1948', 'journal-title': 'Harvey Lectures'} / Harvey Lectures / Evidence of the precision of genetic adaptation by Muller (1948)
10.1006/bcmd.1999.0262 / Blood Cells Mol Dis / Mutational analysis of Tlr4-mediated LPS signal transduction in macrophages by Du (1999)
10.1038/26239 / Nature / Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling by Yang (1998)
10.1084/jem.188.11.2091 / J Exp Med / Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide by Kirschning (1998)
10.1056/NEJM199906103402312 / N Engl J Med / The toll of innate immunity on microbial pathogens by Modlin (1999)
10.4049/jimmunol.162.12.6971 / J Immunol / Cutting edge: cells that carry a null allele for toll-like receptor 2 are capable of responding to endotoxin by Heine (1999)
10.1016/S1074-7613(00)80119-3 / Immunity / Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components by Takeuchi (1999)
10.4049/jimmunol.162.7.3749 / J Immunol / Cutting edge: toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product by Hoshino (1999)
10.1084/jem.189.11.1777 / J Exp Med / MD-2, a molecule that confers lipopolysaccharide responsiveness on toll-like receptor 4 by Shimazu (1999)
10.1074/jbc.274.25.17406 / J Biol Chem / Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2 by Schwandner (1999)
10.4049/jimmunol.163.5.2382 / J Immunol / Inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2 by Hirschfeld (1999)
10.1126/science.285.5428.732 / Science / Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors by Brightbill (1999)
10.1126/science.285.5428.736 / Science / Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2 by Aliprantis (1999)
10.4049/jimmunol.163.1.1 / J Immunol / Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2 by Yoshimura (1999)
10.1084/jem.164.5.1791 / J Exp Med / The effect of interferon-γ on cachectin expression by mononuclear phagocytes: reversal of the lps-d (endotoxin resistance) phenotype by Beutler (1986)
10.1126/science.3754653 / Science / Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance by Beutler (1986)
10.1172/JCI114542 / J Clin Invest / Adaptation to bacterial lipopolysaccharide controls lipopolysaccharide-induced tumor necrosis factor production in rabbit macrophages by Mathison (1990)
10.1016/S0021-9258(19)38880-5 / J Biol Chem / Identification of lipopolysaccharide-binding proteins in 70Z/3 cells by photoaffinity cross-linking by Kirkland (1990)
10.1016/S0021-9258(19)74564-5 / J Biol Chem / Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14 by Han (1993)
10.1016/S1074-7613(00)80254-X / Immunity / Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice by Haziot (1996)
10.1084/jem.189.4.605 / J Exp Med / Toll, a new piece in the puzzle of innate immunity by Wright (1999)
10.1073/pnas.040565397 / Proc Natl Acad Sci USA / Physical contact between LPS and Tlr4 revealed by genetic complementation by Poltorak (2000)
10.1016/S0021-9258(18)55023-7 / J Biol Chem / Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes by Golenbock (1991)
10.1139/m66-143 / Can J Microbiol / Comparative studies on the toxicity of Escherichia coli lipopolysaccharide endotoxin in various animal species by Berczi (1966)
10.1016/S1074-7613(00)80086-2 / Immunity / Unresponsiveness of MyD88-deficient mice to endotoxin by Kawai (1999)
10.1016/S1074-7613(00)80596-8 / Immunity / Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function by Adachi (1998)
10.4049/jimmunol.158.8.3959 / J Immunol / Endotoxin and IL-1 hyporesponsiveness in a patient with recurrent bacterial infections by Kuhns (1997)
10.1172/JCI6709 / J Clin Invest / Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium by Frantz (1999)

Dates

Type	When
Created	23 years, 1 month ago (July 25, 2002, 9:44 p.m.)
Deposited	2 years, 4 months ago (April 16, 2023, 1:22 p.m.)
Indexed	1 month ago (Aug. 5, 2025, 8:54 a.m.)
Issued	25 years, 7 months ago (Feb. 1, 2000)
Published	25 years, 7 months ago (Feb. 1, 2000)
Published Print	25 years, 7 months ago (Feb. 1, 2000)

Funders 0

None

BibTeX

@article{Beutler_2000, title={Tlr4: central component of the sole mammalian LPS sensor}, volume={12}, ISSN={0952-7915}, url={http://dx.doi.org/10.1016/s0952-7915(99)00046-1}, DOI={10.1016/s0952-7915(99)00046-1}, number={1}, journal={Current Opinion in Immunology}, publisher={Elsevier BV}, author={Beutler, Bruce}, year={2000}, month=feb, pages={20–26} }

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