DOI: 10.1016/s0014-5793(98)01514-2. Positive feedback regulation of type I <i>IFN</i> genes by the IFN‐inducible transcription factor IRF‐7

Positive feedback regulation of type I IFN genes by the IFN‐inducible transcription factor IRF‐7

10.1016/s0014-5793(98)01514-2

Crossref journal-article

Wiley

FEBS Letters (311)

Abstract

The interferon regulatory factor (IRF) family of transcription factors regulate the interferon (IFN) system, among which IRF‐3 is involved in the virus‐induced IFN‐β gene expression. Here we show that another member IRF‐7 is critical for the IFN‐α gene induction. Unlike the IRF‐3 gene, the IRF‐7 gene is induced by IFNs through activation of the ISGF3 transcription factor, and IRF‐7 undergoes virus‐induced nuclear translocation. In cells lacking p48, an essential component of IFN stimulated gene factor 3 (ISGF3), ectopic expression of IRF‐7 but not IRF‐3 can rescue the deficiency to induce IFN‐α genes. These results indicate that IRF‐7 is a key factor in the positive feedback regulation of IFN‐α/β production.

Bibliography

Sato, M., Hata, N., Asagiri, M., Nakaya, T., Taniguchi, T., & Tanaka, N. (1998). Positive feedback regulation of type I IFN genes by the IFNâinducible transcription factor IRFâ7. FEBS Letters, 441(1), 106â110. Portico.

Authors 6

Mitsuharu Sato (first)
Naoki Hata (additional)
Masataka Asagiri (additional)
Takeo Nakaya (additional)
Tadatsugu Taniguchi (additional)
Nobuyuki Tanaka (additional)

References 30 Referenced 475

DeMaeyer E. and DeMaeyer-Guignard J. (1988) Interferons and Other Regulatory Cytokines Wiley New York NY.
Vilcek J. and Sen G.S. (1996) in: Fields Virology 3rd Edn. (Fields D.M. Knipe P.M. and Howley P.M. Eds.) pp. 375–399 Lippincott-Raven Philadelphia PA.
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Dates

Type	When
Created	23 years ago (July 25, 2002, 1:52 p.m.)
Deposited	1 year, 11 months ago (Sept. 16, 2023, 2:09 a.m.)
Indexed	2 weeks, 4 days ago (Aug. 6, 2025, 9:23 a.m.)
Issued	26 years, 8 months ago (Dec. 11, 1998)
Published	26 years, 8 months ago (Dec. 11, 1998)
Published Online	26 years, 7 months ago (Dec. 30, 1998)
Published Print	26 years, 8 months ago (Dec. 11, 1998)

Funders 0

None

BibTeX

@article{Sato_1998, title={Positive feedback regulation of type I IFN genes by the IFN‐inducible transcription factor IRF‐7}, volume={441}, ISSN={1873-3468}, url={http://dx.doi.org/10.1016/s0014-5793(98)01514-2}, DOI={10.1016/s0014-5793(98)01514-2}, number={1}, journal={FEBS Letters}, publisher={Wiley}, author={Sato, Mitsuharu and Hata, Naoki and Asagiri, Masataka and Nakaya, Takeo and Taniguchi, Tadatsugu and Tanaka, Nobuyuki}, year={1998}, month=dec, pages={106–110} }

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