DOI: 10.1016/j.ydbio.2003.09.024. The minibrain kinase homolog, mbk-2, is required for spindle positioning and asymmetric cell division in early C. elegans embryos

The minibrain kinase homolog, mbk-2, is required for spindle positioning and asymmetric cell division in early C. elegans embryos

10.1016/j.ydbio.2003.09.024

Crossref journal-article

Elsevier BV

Developmental Biology (78)

Bibliography

Ming Pang, K., Ishidate, T., Nakamura, K., Shirayama, M., Trzepacz, C., Schubert, C. M., Priess, J. R., & Mello, C. C. (2004). The minibrain kinase homolog, mbk-2, is required for spindle positioning and asymmetric cell division in early C. elegans embryos. Developmental Biology, 265(1), 127â139.

Authors 8

Ka Ming Pang (first)
Takao Ishidate (additional)
Kuniaki Nakamura (additional)
Masaki Shirayama (additional)
Chris Trzepacz (additional)
Charlotte M Schubert (additional)
James R Priess (additional)
Craig C Mello (additional)

References 43 Referenced 66

10.1093/hmg/10.18.1915 / Hum. Mol. Genet. / Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome by Altafaj (2001)
10.1093/emboj/20.5.1064 / EMBO J. / Fission yeast Pom1p kinase activity is cell cycle regulated and essential for cellular symmetry during growth and division by Bahler (2001)
10.1101/gad.12.9.1356 / Genes Dev. / Pom1p, a fission yeast protein kinase that provides positional information for both polarized growth and cytokinesis by Bahler (1998)
10.1093/genetics/77.1.71 / Genetics / The genetics of Caenorhabditis elegans by Brenner (1974)
10.1083/jcb.126.1.199 / J. Cell Biol. / Localization of the mei-1 gene product of Caenorhaditis elegans, a meiotic-specific spindle component by Clark-Maguire (1994)
10.1126/science.1084146 / Science / Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryos by Colombo (2003)
10.1242/dev.00284 / Development / Polarization of the C. elegans zygote proceeds via distinct establishment and maintenance phases by Cuenca (2003)
10.1093/genetics/150.1.119 / Genetics / Genetic and molecular characterization of the Caenorhabditis elegans gene, mel-26, a postmeiotic negative regulator of mei-1, a meiotic-specific spindle component by Dow (1998)
10.1038/nature01887 / Nature / Exclusion of germ plasm proteins from somatic lineages by cullin-dependent degradation by DeRenzo (2003)
10.1016/0092-8674(95)90187-6 / Cell / Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos by Etemad-Moghadam (1995)
10.1038/35888 / Nature / Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans by Fire (1998)
10.1128/MCB.22.18.6636-6647.2002 / Mol. Cell. Biol. / Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice by Fotaki (2002)
10.1101/gad.3.9.1336 / Genes Dev. / Loss of Ras activity in Saccharomyces cerevisiae is suppressed by disruptions of a new kinase gene, YAKI, whose product may act downstream of the cAMP-dependent protein kinase by Garrett (1989)
{'key': '10.1016/j.ydbio.2003.09.024_BIB14', 'first-page': '4045', 'article-title': 'The Saccharomyces cerevisiae YAK1 gene encodes a protein kinase that is induced by arrest early in the cell cycle', 'volume': '11', 'author': 'Garrett', 'year': '1991', 'journal-title': 'Mol. Cell. Biol.'} / Mol. Cell. Biol. / The Saccharomyces cerevisiae YAK1 gene encodes a protein kinase that is induced by arrest early in the cell cycle by Garrett (1991)
10.1038/35060092 / Nat. Cell Biol. / Distinct roles for Galpha and Gbetagamma in regulating spindle position and orientation in Caenorhabditis elegans embryos by Gotta (2001)
10.1016/S0960-9822(03)00371-3 / Curr. Biol. / Asymmetrically distributed C. elegans homologs of AGS3/PINS control spindle position in the early embryo by Gotta (2003)
10.1038/35054572 / Nature / Polarity controls forces governing asymmetric spindle positioning in the Caenorhabditis elegans embryo by Grill (2001)
10.1016/0092-8674(95)90082-9 / Cell / par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed by Guo (1995)
{'key': '10.1016/j.ydbio.2003.09.024_BIB19', 'first-page': '2.1', 'article-title': 'Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins', 'volume': '3', 'author': 'Jones', 'year': '2002', 'journal-title': 'Genome Biol.'} / Genome Biol. / Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins by Jones (2002)
10.1016/S0092-8674(00)81605-0 / Cell / PGL-1, a predicted RNA-binding component of germ granules, is essential for fertility in C. elegans by Kawasaki (1998)
10.1016/S0092-8674(00)80844-2 / Cell / PARsing embryonic polarity by Kemphues (2000)
10.1074/jbc.271.7.3488 / J. Biol. Chem. / Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII by Kentrup (1996)
10.1126/science.1067765 / Science / Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway by Kurz (2002)
10.1016/0092-8674(95)90100-0 / Cell / pop-1 encodes an HMG box protein required for the specification of a mesoderm precursor in early C. elegans embryos by Lin (1995)
10.1016/0092-8674(92)90542-K / Cell / The pie-1 and mex-1 genes and maternal control of blastomere identity in early C. elegans embryos by Mello (1992)
10.1126/science.1072162 / Science / Anterior–posterior polarity in C. elegans and Drosophila—PARallels and differences by Pellettieri (2002)
10.1016/S0960-9822(03)00336-1 / Curr. Biol. / Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans by Pintard (2003)
10.1093/genetics/163.2.571 / Genetics / Characterization of Caenorhabditis elegans homologs of the down syndrome candidate gene DYRK1A by Raich (2003)
10.1016/S1097-2765(00)00043-5 / Mol. Cell / PIE-1 localization to the germ lineage depends on two distinct mechanisms that act on separate domains in the PIE-1 protein by Reese (2000)
10.1016/S0092-8674(00)80531-0 / Cell / Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos by Rocheleau (1997)
10.1016/S0092-8674(00)80784-9 / Cell / WRM-1 activates the LIT-1 protein kinase to transduce anterior/posterior polarity signals in C. elegans by Rocheleau (1999)
10.1146/annurev.genet.32.1.521 / Annu. Rev. Genet. / Early patterning of the C. elegans embryo by Rose (1998)
10.1016/S1097-2765(00)80246-4 / Mol. Cell / MEX-5 and MEX-6 function to establish soma/germline asymmetry in early C. elegans embryos by Schubert (2000)
10.1038/ng0597-28 / Nat. Genet. / Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome by Smith (1997)
10.1242/dev.125.12.2291 / Development / YakA, a protein kinase required for the transition from growth to development in Dictyostelium by Souza (1998)
10.1101/gad.14.9.1072 / Genes Dev. / MEI-1/MEI-2 katanin-like microtubule severing activity is required for Caenorhabditis elegans meiosis by Srayko (2000)
10.1101/gad.1081203 / Genes Dev. / A complex of LIN-5 and GPR proteins regulates G protein signaling and spindle function in C. elegans by Srinivasan (2003)
10.1242/dev.125.18.3607 / Development / Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans by Tabuse (1998)
10.1016/0896-6273(95)90286-4 / Neuron / Minibrain: a new protein kinase family involved in postembryonic neurogenesis in Drosophila by Tejedor (1995)
10.1242/dev.129.19.4469 / Development / LET-99 determines spindle position and is asymmetrically enriched in response to PAR polarity cues in C. elegans embryos by Tsou (2002)
10.1074/jbc.273.52.35260 / J. Biol. Chem. / Role of the COOH-terminal domains of meprin A in folding, secretion, and activity of the metalloendopeptidase by Tsukuba (1998)
10.1038/35040562 / Nature / Polarization of the anterior-posterior axis of C. elegans is a microtubule-directed process by Wallenfang (2000)
10.1073/pnas.91.22.10717 / Proc. Natl. Acad. Sci. U. S. A. / The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila by Zollman (1994)

Dates

Type	When
Created	21 years, 9 months ago (Nov. 15, 2003, 7:01 a.m.)
Deposited	2 years, 6 months ago (Feb. 21, 2023, 2:34 a.m.)
Indexed	3 months, 1 week ago (May 25, 2025, 9:42 a.m.)
Issued	21 years, 8 months ago (Jan. 1, 2004)
Published	21 years, 8 months ago (Jan. 1, 2004)
Published Print	21 years, 8 months ago (Jan. 1, 2004)

Funders 0

None

BibTeX

@article{Ming_Pang_2004, title={The minibrain kinase homolog, mbk-2, is required for spindle positioning and asymmetric cell division in early C. elegans embryos}, volume={265}, ISSN={0012-1606}, url={http://dx.doi.org/10.1016/j.ydbio.2003.09.024}, DOI={10.1016/j.ydbio.2003.09.024}, number={1}, journal={Developmental Biology}, publisher={Elsevier BV}, author={Ming Pang, Ka and Ishidate, Takao and Nakamura, Kuniaki and Shirayama, Masaki and Trzepacz, Chris and Schubert, Charlotte M and Priess, James R and Mello, Craig C}, year={2004}, month=jan, pages={127–139} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        5,
        25
      ]
    ],
    "date-time": "2025-05-25T13:42:19Z",
    "timestamp": 1748180539658
  },
  "reference-count": 43,
  "publisher": "Elsevier BV",
  "issue": "1",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2004,
            1,
            1
          ]
        ],
        "date-time": "2004-01-01T00:00:00Z",
        "timestamp": 1072915200000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2013,
            8,
            22
          ]
        ],
        "date-time": "2013-08-22T00:00:00Z",
        "timestamp": 1377129600000
      },
      "content-version": "vor",
      "delay-in-days": 3521,
      "URL": "http://www.elsevier.com/open-access/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2004,
            1,
            1
          ]
        ],
        "date-time": "2004-01-01T00:00:00Z",
        "timestamp": 1072915200000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-017"
    },
    {
      "start": {
        "date-parts": [
          [
            2004,
            1,
            1
          ]
        ],
        "date-time": "2004-01-01T00:00:00Z",
        "timestamp": 1072915200000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-037"
    },
    {
      "start": {
        "date-parts": [
          [
            2004,
            1,
            1
          ]
        ],
        "date-time": "2004-01-01T00:00:00Z",
        "timestamp": 1072915200000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-012"
    },
    {
      "start": {
        "date-parts": [
          [
            2004,
            1,
            1
          ]
        ],
        "date-time": "2004-01-01T00:00:00Z",
        "timestamp": 1072915200000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-029"
    },
    {
      "start": {
        "date-parts": [
          [
            2004,
            1,
            1
          ]
        ],
        "date-time": "2004-01-01T00:00:00Z",
        "timestamp": 1072915200000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-004"
    }
  ],
  "content-domain": {
    "domain": [
      "elsevier.com",
      "sciencedirect.com"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        2004,
        1
      ]
    ]
  },
  "DOI": "10.1016/j.ydbio.2003.09.024",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2003,
        11,
        15
      ]
    ],
    "date-time": "2003-11-15T12:01:05Z",
    "timestamp": 1068897665000
  },
  "page": "127-139",
  "update-policy": "http://dx.doi.org/10.1016/elsevier_cm_policy",
  "source": "Crossref",
  "is-referenced-by-count": 66,
  "title": "The minibrain kinase homolog, mbk-2, is required for spindle positioning and asymmetric cell division in early C. elegans embryos",
  "prefix": "10.1016",
  "volume": "265",
  "author": [
    {
      "given": "Ka",
      "family": "Ming Pang",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Takao",
      "family": "Ishidate",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Kuniaki",
      "family": "Nakamura",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Masaki",
      "family": "Shirayama",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Chris",
      "family": "Trzepacz",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Charlotte M",
      "family": "Schubert",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "James R",
      "family": "Priess",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Craig C",
      "family": "Mello",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "1915",
      "DOI": "10.1093/hmg/10.18.1915",
      "article-title": "Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome",
      "volume": "10",
      "author": "Altafaj",
      "year": "2001",
      "journal-title": "Hum. Mol. Genet."
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "1064",
      "DOI": "10.1093/emboj/20.5.1064",
      "article-title": "Fission yeast Pom1p kinase activity is cell cycle regulated and essential for cellular symmetry during growth and division",
      "volume": "20",
      "author": "Bahler",
      "year": "2001",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "1356",
      "DOI": "10.1101/gad.12.9.1356",
      "article-title": "Pom1p, a fission yeast protein kinase that provides positional information for both polarized growth and cytokinesis",
      "volume": "12",
      "author": "Bahler",
      "year": "1998",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "71",
      "DOI": "10.1093/genetics/77.1.71",
      "article-title": "The genetics of Caenorhabditis elegans",
      "volume": "77",
      "author": "Brenner",
      "year": "1974",
      "journal-title": "Genetics"
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "199",
      "DOI": "10.1083/jcb.126.1.199",
      "article-title": "Localization of the mei-1 gene product of Caenorhaditis elegans, a meiotic-specific spindle component",
      "volume": "126",
      "author": "Clark-Maguire",
      "year": "1994",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "1957",
      "DOI": "10.1126/science.1084146",
      "article-title": "Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryos",
      "volume": "300",
      "author": "Colombo",
      "year": "2003",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "1255",
      "DOI": "10.1242/dev.00284",
      "article-title": "Polarization of the C. elegans zygote proceeds via distinct establishment and maintenance phases",
      "volume": "130",
      "author": "Cuenca",
      "year": "2003",
      "journal-title": "Development"
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "119",
      "DOI": "10.1093/genetics/150.1.119",
      "article-title": "Genetic and molecular characterization of the Caenorhabditis elegans gene, mel-26, a postmeiotic negative regulator of mei-1, a meiotic-specific spindle component",
      "volume": "150",
      "author": "Dow",
      "year": "1998",
      "journal-title": "Genetics"
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "685",
      "DOI": "10.1038/nature01887",
      "article-title": "Exclusion of germ plasm proteins from somatic lineages by cullin-dependent degradation",
      "volume": "424",
      "author": "DeRenzo",
      "year": "2003",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "743",
      "DOI": "10.1016/0092-8674(95)90187-6",
      "article-title": "Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos",
      "volume": "83",
      "author": "Etemad-Moghadam",
      "year": "1995",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "806",
      "DOI": "10.1038/35888",
      "article-title": "Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans",
      "volume": "391",
      "author": "Fire",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "6636",
      "DOI": "10.1128/MCB.22.18.6636-6647.2002",
      "article-title": "Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice",
      "volume": "22",
      "author": "Fotaki",
      "year": "2002",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "1336",
      "DOI": "10.1101/gad.3.9.1336",
      "article-title": "Loss of Ras activity in Saccharomyces cerevisiae is suppressed by disruptions of a new kinase gene, YAKI, whose product may act downstream of the cAMP-dependent protein kinase",
      "volume": "3",
      "author": "Garrett",
      "year": "1989",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB14",
      "first-page": "4045",
      "article-title": "The Saccharomyces cerevisiae YAK1 gene encodes a protein kinase that is induced by arrest early in the cell cycle",
      "volume": "11",
      "author": "Garrett",
      "year": "1991",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "297",
      "DOI": "10.1038/35060092",
      "article-title": "Distinct roles for Galpha and Gbetagamma in regulating spindle position and orientation in Caenorhabditis elegans embryos",
      "volume": "3",
      "author": "Gotta",
      "year": "2001",
      "journal-title": "Nat. Cell Biol."
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "1029",
      "DOI": "10.1016/S0960-9822(03)00371-3",
      "article-title": "Asymmetrically distributed C. elegans homologs of AGS3/PINS control spindle position in the early embryo",
      "volume": "13",
      "author": "Gotta",
      "year": "2003",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "630",
      "DOI": "10.1038/35054572",
      "article-title": "Polarity controls forces governing asymmetric spindle positioning in the Caenorhabditis elegans embryo",
      "volume": "409",
      "author": "Grill",
      "year": "2001",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "611",
      "DOI": "10.1016/0092-8674(95)90082-9",
      "article-title": "par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed",
      "volume": "81",
      "author": "Guo",
      "year": "1995",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB19",
      "first-page": "2.1",
      "article-title": "Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins",
      "volume": "3",
      "author": "Jones",
      "year": "2002",
      "journal-title": "Genome Biol."
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "635",
      "DOI": "10.1016/S0092-8674(00)81605-0",
      "article-title": "PGL-1, a predicted RNA-binding component of germ granules, is essential for fertility in C. elegans",
      "volume": "94",
      "author": "Kawasaki",
      "year": "1998",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "345",
      "DOI": "10.1016/S0092-8674(00)80844-2",
      "article-title": "PARsing embryonic polarity",
      "volume": "101",
      "author": "Kemphues",
      "year": "2000",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "3488",
      "DOI": "10.1074/jbc.271.7.3488",
      "article-title": "Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII",
      "volume": "271",
      "author": "Kentrup",
      "year": "1996",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "1294",
      "DOI": "10.1126/science.1067765",
      "article-title": "Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway",
      "volume": "295",
      "author": "Kurz",
      "year": "2002",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "599",
      "DOI": "10.1016/0092-8674(95)90100-0",
      "article-title": "pop-1 encodes an HMG box protein required for the specification of a mesoderm precursor in early C. elegans embryos",
      "volume": "83",
      "author": "Lin",
      "year": "1995",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "163",
      "DOI": "10.1016/0092-8674(92)90542-K",
      "article-title": "The pie-1 and mex-1 genes and maternal control of blastomere identity in early C. elegans embryos",
      "volume": "70",
      "author": "Mello",
      "year": "1992",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "1946",
      "DOI": "10.1126/science.1072162",
      "article-title": "Anterior\u2013posterior polarity in C. elegans and Drosophila\u2014PARallels and differences",
      "volume": "298",
      "author": "Pellettieri",
      "year": "2002",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "911",
      "DOI": "10.1016/S0960-9822(03)00336-1",
      "article-title": "Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans",
      "volume": "13",
      "author": "Pintard",
      "year": "2003",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "571",
      "DOI": "10.1093/genetics/163.2.571",
      "article-title": "Characterization of Caenorhabditis elegans homologs of the down syndrome candidate gene DYRK1A",
      "volume": "163",
      "author": "Raich",
      "year": "2003",
      "journal-title": "Genetics"
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "445",
      "DOI": "10.1016/S1097-2765(00)00043-5",
      "article-title": "PIE-1 localization to the germ lineage depends on two distinct mechanisms that act on separate domains in the PIE-1 protein",
      "volume": "6",
      "author": "Reese",
      "year": "2000",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "707",
      "DOI": "10.1016/S0092-8674(00)80531-0",
      "article-title": "Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos",
      "volume": "90",
      "author": "Rocheleau",
      "year": "1997",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "717",
      "DOI": "10.1016/S0092-8674(00)80784-9",
      "article-title": "WRM-1 activates the LIT-1 protein kinase to transduce anterior/posterior polarity signals in C. elegans",
      "volume": "97",
      "author": "Rocheleau",
      "year": "1999",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "521",
      "DOI": "10.1146/annurev.genet.32.1.521",
      "article-title": "Early patterning of the C. elegans embryo",
      "volume": "32",
      "author": "Rose",
      "year": "1998",
      "journal-title": "Annu. Rev. Genet."
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "671",
      "DOI": "10.1016/S1097-2765(00)80246-4",
      "article-title": "MEX-5 and MEX-6 function to establish soma/germline asymmetry in early C. elegans embryos",
      "volume": "5",
      "author": "Schubert",
      "year": "2000",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "28",
      "DOI": "10.1038/ng0597-28",
      "article-title": "Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome",
      "volume": "16",
      "author": "Smith",
      "year": "1997",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "2291",
      "DOI": "10.1242/dev.125.12.2291",
      "article-title": "YakA, a protein kinase required for the transition from growth to development in Dictyostelium",
      "volume": "125",
      "author": "Souza",
      "year": "1998",
      "journal-title": "Development"
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "1072",
      "DOI": "10.1101/gad.14.9.1072",
      "article-title": "MEI-1/MEI-2 katanin-like microtubule severing activity is required for Caenorhabditis elegans meiosis",
      "volume": "14",
      "author": "Srayko",
      "year": "2000",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "1225",
      "DOI": "10.1101/gad.1081203",
      "article-title": "A complex of LIN-5 and GPR proteins regulates G protein signaling and spindle function in C. elegans",
      "volume": "17",
      "author": "Srinivasan",
      "year": "2003",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "3607",
      "DOI": "10.1242/dev.125.18.3607",
      "article-title": "Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans",
      "volume": "125",
      "author": "Tabuse",
      "year": "1998",
      "journal-title": "Development"
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "287",
      "DOI": "10.1016/0896-6273(95)90286-4",
      "article-title": "Minibrain: a new protein kinase family involved in postembryonic neurogenesis in Drosophila",
      "volume": "14",
      "author": "Tejedor",
      "year": "1995",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "4469",
      "DOI": "10.1242/dev.129.19.4469",
      "article-title": "LET-99 determines spindle position and is asymmetrically enriched in response to PAR polarity cues in C. elegans embryos",
      "volume": "129",
      "author": "Tsou",
      "year": "2002",
      "journal-title": "Development"
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB44",
      "doi-asserted-by": "crossref",
      "first-page": "35260",
      "DOI": "10.1074/jbc.273.52.35260",
      "article-title": "Role of the COOH-terminal domains of meprin A in folding, secretion, and activity of the metalloendopeptidase",
      "volume": "273",
      "author": "Tsukuba",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB45",
      "doi-asserted-by": "crossref",
      "first-page": "89",
      "DOI": "10.1038/35040562",
      "article-title": "Polarization of the anterior-posterior axis of C. elegans is a microtubule-directed process",
      "volume": "408",
      "author": "Wallenfang",
      "year": "2000",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.ydbio.2003.09.024_BIB46",
      "doi-asserted-by": "crossref",
      "first-page": "10717",
      "DOI": "10.1073/pnas.91.22.10717",
      "article-title": "The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila",
      "volume": "91",
      "author": "Zollman",
      "year": "1994",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    }
  ],
  "container-title": "Developmental Biology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0012160603005761?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0012160603005761?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        2,
        21
      ]
    ],
    "date-time": "2023-02-21T07:34:30Z",
    "timestamp": 1676964870000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0012160603005761"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2004,
        1
      ]
    ]
  },
  "references-count": 43,
  "journal-issue": {
    "issue": "1",
    "published-print": {
      "date-parts": [
        [
          2004,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "S0012160603005761"
  ],
  "URL": "http://dx.doi.org/10.1016/j.ydbio.2003.09.024",
  "relation": {},
  "ISSN": [
    "0012-1606"
  ],
  "subject": [],
  "container-title-short": "Developmental Biology",
  "published": {
    "date-parts": [
      [
        2004,
        1
      ]
    ]
  },
  "assertion": [
    {
      "value": "Elsevier",
      "name": "publisher",
      "label": "This article is maintained by"
    },
    {
      "value": "The minibrain kinase homolog, mbk-2, is required for spindle positioning and asymmetric cell division in early C. elegans embryos",
      "name": "articletitle",
      "label": "Article Title"
    },
    {
      "value": "Developmental Biology",
      "name": "journaltitle",
      "label": "Journal Title"
    },
    {
      "value": "https://doi.org/10.1016/j.ydbio.2003.09.024",
      "name": "articlelink",
      "label": "CrossRef DOI link to publisher maintained version"
    },
    {
      "value": "converted-article",
      "name": "content_type",
      "label": "Content Type"
    },
    {
      "value": "Copyright \u00a9 2003 Elsevier Inc. All rights reserved.",
      "name": "copyright",
      "label": "Copyright"
    }
  ]
}