DOI: 10.1016/j.toxlet.2009.09.012. In vitro and in vivo genotoxicity tests on fullerene C60 nanoparticles

In vitro and in vivo genotoxicity tests on fullerene C60 nanoparticles

10.1016/j.toxlet.2009.09.012

Crossref journal-article

Elsevier BV

Toxicology Letters (78)

Bibliography

Shinohara, N., Matsumoto, K., Endoh, S., Maru, J., & Nakanishi, J. (2009). In vitro and in vivo genotoxicity tests on fullerene C60 nanoparticles. Toxicology Letters, 191(2â3), 289â296.

Authors 5

Naohide Shinohara (first)
Kyomu Matsumoto (additional)
Shigehisa Endoh (additional)
Junko Maru (additional)
Junko Nakanishi (additional)

References 41 Referenced 99

10.1021/ja010202a / J. Am. Chem. Soc. / Stable colloidal dispersions of fullerenes in polar organic solvents by Alargova (2001)
10.1016/0165-1161(75)90046-1 / Mutat. Res. / Methods for detecting carcinogens and mutagens with Salmonella/mammalian-microsome mutagenicity test by Ames (1975)
10.1039/C39920000604 / J. Chem. Soc. Chem. Commun. / C60 embedded in gamma-cyclodextrin—a water-soluble fullerene by Andersson (1992)
10.1021/j100154a006 / J. Phys. Chem. / Photophysical properties of C60 by Arbogast (1991)
10.1016/S0940-2993(96)80068-6 / Exp. Toxicol. Pathol. / Comparison of immunological effects of fullerene C-60 and raw soot from fullerene production on alveolar macrophages and macrophage-like cells in vitro by Baierl (1996)
10.1002/anie.199424621 / Angew. Chem.-Int. / Fullerene-oligonucleotide conjugates—photoinduced sequence-specific DNA cleavage by Boutorine (1994)
10.1021/la053293o / Langmuir / Characterizing the impact of preparation method on fullerene cluster structure and chemistry by Brant (2006)
10.1021/ja01269a023 / J. Am. Chem. Soc. / Adsorption of gases in multimolecular layers by Brunauer (1938)
10.1016/0921-8777(94)00043-6 / Mutat. Res. / The kinetics of repair of oxidative DNA damage (strand breaks and oxidized pyrimidines) in human cells by Collins (1995)
10.1021/la010651o / Langmuir / Stable dispersions of fullerenes, C60 and C70, in water: preparation and characterization by Deguchi (2001)
{'key': '10.1016/j.toxlet.2009.09.012_bib11', 'series-title': 'Mutagenicity Test in Industrial Safety and Health Law: Test Guideline and GLP [in Japanese]', 'author': 'Department of Labor, Safety, and Health, Industrial Health Division', 'year': '1995'} / Mutagenicity Test in Industrial Safety and Health Law: Test Guideline and GLP [in Japanese] by Department of Labor, Safety, and Health, Industrial Health Division (1995)
10.1021/es0609708 / Environ. Sci. Technol. / Stable colloidal dispersions of C-60 fullerenes in water: evidence for genotoxicity by Dhawan (2006)
10.1021/es048099n / Environ. Sci. Technol. / C-60 in water: nanocrystal formation and microbial response by Fortner (2005)
10.1016/0165-1161(94)90037-X / Mutat. Res. / Recommendations for the performance of bacterial mutation assays by Gatehouse (1994)
10.1021/nl051866b / Nano Lett. / [60]Fullerene is a powerful antioxidant in vivo with no acute or subacute toxicity by Gharbi (2005)
10.1080/17435390802464986 / Nanotoxicology / Genotoxicity of engineered nanomaterials: A critical review by Gonzales (2008)
10.1021/ar990144m / Acc. Chem. Res. / Excited-state properties of C60 fullerene derivatives by Guldi (2000)
10.1289/ehp.9757 / Environ. Health Perspect. / Attributing effects of aqueous C-60 nano-aggregates to tetrahydrofuran decomposition products in larval zebrafish by assessment of gene expression by Henry (2007)
10.1016/0008-6223(95)00213-8 / Carbon / Solubility of C60 in alcohols and alkanes by Heymann (1996)
10.1021/es702172w / Environ. Sci. Technol. / Mechanisms of photochemistry and reactive oxygen production by fullerene suspensions in water by Hotze (2008)
10.1021/es048729l / Environ. Sci. Technol. / Cytotoxicity of carbon nanomaterials: single-wall nanotube, multi-wall nanotube, and fullerene by Jia (2005)
Kolosnjaj, J., Szwarc, H., Moussa, F., 2007. Toxicity studies of fullerenes and derivatives. Advances in Experimental Medicine and Biology, vol. 620 (Bio-applications of nanoparticles), pp. 168–180. (10.1007/978-0-387-76713-0_13)
10.1016/j.mrrev.2008.10.002 / Mut. Res.-Rev. Mu. Res. / Genotoxicity investigations on nanomaterials: Methods, preparation and characterization of test material, potential artifacts and limitations-Many questions, some answers by Landsiedel (2009)
10.1039/c39930001725 / J. Chem. Soc. Chem. Commun. / Amphiphilic derivatives of fullerenes formed by polymer modification by Manolova (1993)
10.1016/j.biomaterials.2007.09.002 / Biomaterials / The mechanism of cell-damaging reactive oxygen generation by colloidal fullerenes by Markovic (2007)
10.1039/a705494g / J. Chem. Soc. Faraday Trans. / Colloidal dispersions of fullerene C-60 in water: some properties and regularities of coagulation by electrolytes by Mchedlov-Petrossyan (1997)
{'key': '10.1016/j.toxlet.2009.09.012_bib27', 'series-title': 'A Revision of the Law Concerning the Examination and Regulation of Manufacture, etc., of Chemical Substances', 'author': 'Ministry of Economy, Trade, and Industry (METI), Japan', 'year': '2003'} / A Revision of the Law Concerning the Examination and Regulation of Manufacture, etc., of Chemical Substances by Ministry of Economy, Trade, and Industry (METI), Japan (2003)
10.1006/bbrc.2000.3715 / Biochem. Biophys. Res. Commun. / C60 carboxyfullerene exerts a protective activity against oxidative stress-induced apoptosis in human peripheral blood mononuclear cells by Monti (2000)
10.1016/j.tox.2006.05.001 / Toxicology / Preclinical studies on safety of fullerene upon acute oral administration and evaluation for no mutagenesis by Mori (2006)
{'key': '10.1016/j.toxlet.2009.09.012_bib30', 'series-title': 'OECD Guideline for the Testing of Chemicals: Mammalian Erythrocyte Micronucleus Test, No. 474', 'author': 'Organization for Economic Co-operation and Development (OECD)', 'year': '1997'} / OECD Guideline for the Testing of Chemicals: Mammalian Erythrocyte Micronucleus Test, No. 474 by Organization for Economic Co-operation and Development (OECD) (1997)
10.1021/j100115a049 / J. Phys. Chem. / Solubility of C60 in a variety of solvents by Ruoff (1993)
{'key': '10.1016/j.toxlet.2009.09.012_bib32', 'first-page': '53', 'article-title': 'Acute toxicity of fullerene C60 in aquatic organism', 'volume': '21', 'author': 'Seki', 'year': '2008', 'journal-title': 'Environ. Sci.'} / Environ. Sci. / Acute toxicity of fullerene C60 in aquatic organism by Seki (2008)
10.1093/carcin/17.10.2163 / Carcinogenesis / Mutagenicity of the fullerene C60-generated singlet oxygen dependent formation of lipid peroxides by Sera (1996)
10.1021/es802182f / Environ. Sci. Technol. / Is lipid peroxidation induced by the aqueous suspension of fullerene C60 nanoparticles in the brains of Cyprinus carpio? by Shinohara (2009)
{'key': '10.1016/j.toxlet.2009.09.012_bib35', 'series-title': 'Environmental Toxicology: Methods and Safety Evaluation [in Japanese]', 'article-title': 'Acute toxicity test', 'author': 'Takahashi', 'year': '1975'} / Environmental Toxicology: Methods and Safety Evaluation [in Japanese] / Acute toxicity test by Takahashi (1975)
10.1016/j.tox.2004.07.020 / Toxicology / Polysorbate 80 increases the susceptibility to oxidative stress in rat thymocytes by Tatsuishi (2005)
10.1021/ja00070a064 / J. Am. Chem. Soc. / Photoinduced biochemical-activity of fullerene carboxylic-acid by Tokuyama (1993)
10.1006/bbrc.1995.1126 / Biochem. Biophys. Res. Commun. / A novel promoting action of fullerene C60 on the chondrogenesis in rat embryonic limb bud cell culture system by Tsuchiya (1995)
10.3123/jems.27.7 / Environ. Mutagen Res. / Inhibitory effects of NADH/NADPH in S9 mix on photo-mutagenicity of thiabendazole following UVA-irradiation in E. coli by Watanabe-Akanuma (2005)
{'issue': '3', 'key': '10.1016/j.toxlet.2009.09.012_bib40', 'first-page': '1', 'article-title': 'Genotoxic responses to titanium dioxide nanoparticles and fullerene in gpt delta transgenic MEF cells', 'volume': '6', 'author': 'Xu', 'year': '2009', 'journal-title': 'Part. Fibre Toxicol.'} / Part. Fibre Toxicol. / Genotoxic responses to titanium dioxide nanoparticles and fullerene in gpt delta transgenic MEF cells by Xu (2009)
10.1021/jo961210q / J. Org. Chem. / Acridine adduct of [60]fullerene with enhanced DNA-cleaving activity by Yamakoshi (1996)

Dates

Type	When
Created	15 years, 11 months ago (Sept. 21, 2009, 12:09 a.m.)
Deposited	6 years, 3 months ago (May 22, 2019, 11:04 a.m.)
Indexed	6 days ago (Aug. 26, 2025, 2:28 a.m.)
Issued	15 years, 9 months ago (Dec. 1, 2009)
Published	15 years, 9 months ago (Dec. 1, 2009)
Published Print	15 years, 9 months ago (Dec. 1, 2009)

Funders 1

Evaluating risks associated with manufactured nanomaterials
Awards1
1. P06041

BibTeX

@article{Shinohara_2009, title={In vitro and in vivo genotoxicity tests on fullerene C60 nanoparticles}, volume={191}, ISSN={0378-4274}, url={http://dx.doi.org/10.1016/j.toxlet.2009.09.012}, DOI={10.1016/j.toxlet.2009.09.012}, number={2–3}, journal={Toxicology Letters}, publisher={Elsevier BV}, author={Shinohara, Naohide and Matsumoto, Kyomu and Endoh, Shigehisa and Maru, Junko and Nakanishi, Junko}, year={2009}, month=dec, pages={289–296} }

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      "volume": "28",
      "author": "Markovic",
      "year": "2007",
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      "author": "Monti",
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      "author": "Mori",
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      "DOI": "10.1021/j100115a049",
      "article-title": "Solubility of C60 in a variety of solvents",
      "volume": "97",
      "author": "Ruoff",
      "year": "1993",
      "journal-title": "J. Phys. Chem."
    },
    {
      "key": "10.1016/j.toxlet.2009.09.012_bib32",
      "first-page": "53",
      "article-title": "Acute toxicity of fullerene C60 in aquatic organism",
      "volume": "21",
      "author": "Seki",
      "year": "2008",
      "journal-title": "Environ. Sci."
    },
    {
      "key": "10.1016/j.toxlet.2009.09.012_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "2163",
      "DOI": "10.1093/carcin/17.10.2163",
      "article-title": "Mutagenicity of the fullerene C60-generated singlet oxygen dependent formation of lipid peroxides",
      "volume": "17",
      "author": "Sera",
      "year": "1996",
      "journal-title": "Carcinogenesis"
    },
    {
      "key": "10.1016/j.toxlet.2009.09.012_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "948",
      "DOI": "10.1021/es802182f",
      "article-title": "Is lipid peroxidation induced by the aqueous suspension of fullerene C60 nanoparticles in the brains of Cyprinus carpio?",
      "volume": "43",
      "author": "Shinohara",
      "year": "2009",
      "journal-title": "Environ. Sci. Technol."
    },
    {
      "key": "10.1016/j.toxlet.2009.09.012_bib35",
      "series-title": "Environmental Toxicology: Methods and Safety Evaluation [in Japanese]",
      "article-title": "Acute toxicity test",
      "author": "Takahashi",
      "year": "1975"
    },
    {
      "key": "10.1016/j.toxlet.2009.09.012_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "7",
      "DOI": "10.1016/j.tox.2004.07.020",
      "article-title": "Polysorbate 80 increases the susceptibility to oxidative stress in rat thymocytes",
      "volume": "207",
      "author": "Tatsuishi",
      "year": "2005",
      "journal-title": "Toxicology"
    },
    {
      "key": "10.1016/j.toxlet.2009.09.012_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "7918",
      "DOI": "10.1021/ja00070a064",
      "article-title": "Photoinduced biochemical-activity of fullerene carboxylic-acid",
      "volume": "115",
      "author": "Tokuyama",
      "year": "1993",
      "journal-title": "J. Am. Chem. Soc."
    },
    {
      "key": "10.1016/j.toxlet.2009.09.012_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "885",
      "DOI": "10.1006/bbrc.1995.1126",
      "article-title": "A novel promoting action of fullerene C60 on the chondrogenesis in rat embryonic limb bud cell culture system",
      "volume": "206",
      "author": "Tsuchiya",
      "year": "1995",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1016/j.toxlet.2009.09.012_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "7",
      "DOI": "10.3123/jems.27.7",
      "article-title": "Inhibitory effects of NADH/NADPH in S9 mix on photo-mutagenicity of thiabendazole following UVA-irradiation in E. coli",
      "volume": "27",
      "author": "Watanabe-Akanuma",
      "year": "2005",
      "journal-title": "Environ. Mutagen Res."
    },
    {
      "issue": "3",
      "key": "10.1016/j.toxlet.2009.09.012_bib40",
      "first-page": "1",
      "article-title": "Genotoxic responses to titanium dioxide nanoparticles and fullerene in gpt delta transgenic MEF cells",
      "volume": "6",
      "author": "Xu",
      "year": "2009",
      "journal-title": "Part. Fibre Toxicol."
    },
    {
      "key": "10.1016/j.toxlet.2009.09.012_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "7236",
      "DOI": "10.1021/jo961210q",
      "article-title": "Acridine adduct of [60]fullerene with enhanced DNA-cleaving activity",
      "volume": "61",
      "author": "Yamakoshi",
      "year": "1996",
      "journal-title": "J. Org. Chem."
    }
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