DOI: 10.1016/j.tox.2008.09.014. Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO2 nanoparticles

Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO2 nanoparticles

10.1016/j.tox.2008.09.014

Crossref journal-article

Elsevier BV

Toxicology (78)

Bibliography

Wang, J., Liu, Y., Jiao, F., Lao, F., Li, W., Gu, Y., Li, Y., Ge, C., Zhou, G., Li, B., Zhao, Y., Chai, Z., & Chen, C. (2008). Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO2 nanoparticles. Toxicology, 254(1â2), 82â90.

Authors 13

Jiangxue Wang (first)
Ying Liu (additional)
Fang Jiao (additional)
Fang Lao (additional)
Wei Li (additional)
Yiqun Gu (additional)
Yufeng Li (additional)
Cuicui Ge (additional)
Guoqiang Zhou (additional)
Bai Li (additional)
Yuliang Zhao (additional)
Zhifang Chai (additional)
Chunying Chen (additional)

References 46 Referenced 359

10.1046/j.1365-2249.2003.02104.x / Clin. Exp. Immunol. / Oxygen free radicals and systemic autoimmunity by Ahsan (2003)
10.1016/S1470-2045(06)70651-9 / Lancet Oncol. / Carcinogenicity of carbon black, titanium dioxide, and talc by Baan (2006)
10.1038/nrd1330 / Nat. Rev. Drug Discov. / Neurodegenerative diseases and oxidative stress by Barnham (2004)
10.1093/toxsci/kfh019 / Toxicol. Sci. / Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles by Bermudez (2004)
10.1016/S0967-2109(02)00070-4 / Cardiovasc. Surg. / The pathophysiology of skeletal muscle ischemia and the reperfusion syndrome: a review by Blaisdell (2002)
10.1023/B:CACO.0000036188.23970.22 / Cancer Cause Control / Mortality among workers employed in the titanium dioxide production industry in Europe by Boffetta (2004)
10.1016/0003-2697(76)90527-3 / Anal. Biochem. / A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein–dye binding by Bradford (1976)
10.1016/j.neuro.2004.08.003 / Neurotoxicology / Particulate matter in polluted air may increase biomarkers of inflammation in mouse brain by Campbell (2005)
10.1073/pnas.0600997103 / Proc. Natl. Acad. Sci. U.S.A. / Role of target geometry in phagocytosis by Champion (2006)
10.1006/taap.2000.9088 / Toxicol. Appl. Pharmacol. / Influence of particle solubility on the delivery of inhaled manganese to the rat brain: manganese sulfate and manganese tetroxide pharmacokinetics following repeated (14-day) exposure by Dorman (2001)
10.1080/08958370490439687 / Inhal. Toxicol. / Nasal toxicity of manganese sulfate and manganese phosphate in young male rats following subchronic (13-week) inhalation exposure by Dorman (2004)
10.1016/S0014-5793(97)01356-2 / FEBS Lett. / Chemical oxidation and DNA damage catalysed by inorganic sunscreen ingredients by Dunford (1995)
10.1289/ehp.9030 / Environ. Health Perspect. / Translocation of inhaled ultrafine manganese oxide particles to the central nervous system by Elder (2006)
10.1016/j.aquatox.2007.07.009 / Aquat. Toxicol. / Toxicity of titanium dioxide nanoparticles to rainbow trout (Oncorhynchus mykiss): gill injury, oxidative stress, and other physiological effects by Federici (2007)
10.1016/S1010-6030(97)00229-3 / J. Photochem. Photobiol. A: Chem. / In vitro photochemical damage to DNA, RNA and their bases by an inorganic sunscreen agent on exposure to UVA and UVB radiation by Hidaka (1997)
10.1186/1465-9921-6-106 / Resp. Res. / Effects of nano particles on antigen-related airway inflammation in mice by Inoue (2005)
{'key': '10.1016/j.tox.2008.09.014_bib17', 'first-page': '1', 'article-title': 'Human respiratory model for radiological protection', 'volume': '24', 'author': 'International Commission on Radiological Protection', 'year': '1994', 'journal-title': 'Ann. ICRP'} / Ann. ICRP / Human respiratory model for radiological protection by International Commission on Radiological Protection (1994)
10.1088/0957-4484/19/14/145102 / Nanotechnology / Translocation of fullerenic nanoparticles into lysosome via the pathway of clathrin-mediated endocytosis by Li (2008)
10.1021/es060589n / Environ. Sci. Technol. / Titanium dioxide (P25) produces reactive oxygen species in immortalized brain microglia (BV2): implications for nanoparticle neurotoxicity by Long (2006)
10.1289/ehp.10216 / Envrion. Health Perspect. / Nanosize titanium dioxide stimulates reactive oxygen species in brain microglia and damages neurons in vitro by Long (2007)
10.1021/es062146p / Environ. Sci. Technol. / Behavioral and physiological changes in Daphnia magna when exposed to nanoparticle suspensions (titanium dioxide, Nano-C60, and C60HxC70Hx) by Lovern (2007)
10.1016/S0300-483X(00)00306-1 / Toxicology / Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology by Matés (2000)
10.1016/S1383-5718(97)00126-5 / Mutat. Res. / The photogenotoxicity of titanium dioxide particles by Nakagawa (1997)
10.1126/science.1114397 / Science / Toxic potential of materials at the nanolevel by Nel (2006)
Oberdörster, G., Finkelstein, J.N., Johnston, C., Gelein, R., Cox, C., Baggs, R., Elder, A.C., 2000. Acute pulmonary effects of ultrafine particles in rats and mice. Health Effects Institute Research Report 96.
10.1186/1743-8977-2-8 / Part. Fibre Toxicol. / Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy by Oberdörster (2005)
10.1289/ehp.7339 / Environ. Health Perspect. / Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles by Oberdörster (2005)
10.1080/08958370490439597 / Inhal. Toxicol. / Translocation of inhaled ultrafine particles to the brain by Oberdörster (2004)
10.1023/A:1016131310025 / J. Mater. Sci. Mater. Med. / An experimental study of the dissemination of titanium and zirconium in the body by Olmedo (2002)
10.1006/faat.1997.2390 / Fund. Appl. Toxicol. / Intratracheal inhalation vs. intratracheal instillation: differences in particle effects by Osier (1997)
10.1289/ehp.7696 / Environ. Health Perspect. / Time course of gene expression of inflammatory mediators in rat lung after diesel exhaust particle exposure by Rao (2005)
10.1016/S0149-7634(05)80152-6 / Neurosci. Biobehav. Rev. / Involvement of cytokines in acute neurodegeneration in the CNS by Rothwell (1993)
10.1021/nl0489586 / Nano Lett. / The differential cytotoxicity of water-soluble fullerenes by Sayes (2004)
10.1126/science.1094823 / Science / How viruses enter animal cells by Smith (2004)
{'issue': '3', 'key': '10.1016/j.tox.2008.09.014_bib35', 'first-page': '140', 'article-title': 'Intranasal delivery: an approach to bypass the blood brain barrier', 'volume': '36', 'author': 'Talegaonkar', 'year': '2004', 'journal-title': 'Educ. Forum'} / Educ. Forum / Intranasal delivery: an approach to bypass the blood brain barrier by Talegaonkar (2004)
10.1016/j.biomaterials.2006.05.045 / Biomaterials / Differential inflammatory macrophage response to rutile and titanium particles by Vallés (2006)
10.1073/pnas.96.17.9879 / Proc. Natl. Acad. Sci. U.S.A. / A new mechanism of neurodegeneration: a proinflammatory cytokine inhibits receptor signaling by a survival peptide by Venters (1999)
10.2106/00004623-200102000-00007 / J. Bone Joint Surg. / The effects of particulate wear debris cytokines, and growth factors on the functions of MG-63 osteoblasts by Vermes (2001)
10.1016/S0891-5849(97)00068-3 / Free Rad. Biol. Med. / Oxidative damage to nucleic acids photosensitized by titanium dioxide by Wamer (1997)
Wang, J.X., Chen, C.Y. Liu, Y., Jiao, F., Li, W., Lao, F., Li, Y.F., Li, B., Zhou, G.Q., Ge, C.C., Gao, Y.X., Zhao, Y.L., Chai, Z.F., 2008. Potential neurological lesion after nasal instillation of TiO2 Nanoparticles in the anatase and rutile crystal phases. Toxicol. Lett. doi:10.1016/j.toxlet.2008.10.001. (10.1016/j.toxlet.2008.10.001)
10.1016/j.bcp.2005.12.001 / Biochem. Pharmacol. / Antioxidative function and biodistribution of [Gd@C82(OH)22]n nanoparticles in tumor-bearing mice by Wang (2006)
10.1007/s10967-007-0617-z / J. Radioanal. Nucl. Chem. / Distribution of TiO2 particles in the olfactory bulb of mice after nasal inhalation using microbeam SRXRF mapping techniques by Wang (2007)
10.1016/j.toxlet.2006.12.001 / Toxicol. Lett. / Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration by Wang (2007)
10.1093/toxsci/kfi331 / Toxicol. Sci. / Comparative pulmonary toxicity inhalation and instillation studies with different TiO2 particle formulations: impact of surface treatments on particle toxicity by Warheit (2005)
10.1016/j.toxlet.2007.04.008 / Toxicol. Lett. / Development f a base of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management by Warheit (2007)
10.1016/j.tox.2006.11.002 / Toxicology / Pulmonary toxicity study in rats with three forms of ultrafine-TiO2 particles: differential responses related to surface properties by Warheit (2007)

Dates

Type	When
Created	16 years, 10 months ago (Sept. 26, 2008, 4:51 a.m.)
Deposited	6 years, 3 months ago (May 14, 2019, 2:24 a.m.)
Indexed	3 weeks, 5 days ago (July 30, 2025, 11:11 a.m.)
Issued	16 years, 8 months ago (Dec. 1, 2008)
Published	16 years, 8 months ago (Dec. 1, 2008)
Published Print	16 years, 8 months ago (Dec. 1, 2008)

Funders 0

None

BibTeX

@article{Wang_2008, title={Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO2 nanoparticles}, volume={254}, ISSN={0300-483X}, url={http://dx.doi.org/10.1016/j.tox.2008.09.014}, DOI={10.1016/j.tox.2008.09.014}, number={1–2}, journal={Toxicology}, publisher={Elsevier BV}, author={Wang, Jiangxue and Liu, Ying and Jiao, Fang and Lao, Fang and Li, Wei and Gu, Yiqun and Li, Yufeng and Ge, Cuicui and Zhou, Guoqiang and Li, Bai and Zhao, Yuliang and Chai, Zhifang and Chen, Chunying}, year={2008}, month=dec, pages={82–90} }

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      "volume": "77",
      "author": "Bermudez",
      "year": "2004",
      "journal-title": "Toxicol. Sci."
    },
    {
      "issue": "6",
      "key": "10.1016/j.tox.2008.09.014_bib5",
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      "first-page": "620",
      "DOI": "10.1016/S0967-2109(02)00070-4",
      "article-title": "The pathophysiology of skeletal muscle ischemia and the reperfusion syndrome: a review",
      "volume": "10",
      "author": "Blaisdell",
      "year": "2002",
      "journal-title": "Cardiovasc. Surg."
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      "first-page": "697",
      "DOI": "10.1023/B:CACO.0000036188.23970.22",
      "article-title": "Mortality among workers employed in the titanium dioxide production industry in Europe",
      "volume": "15",
      "author": "Boffetta",
      "year": "2004",
      "journal-title": "Cancer Cause Control"
    },
    {
      "key": "10.1016/j.tox.2008.09.014_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "248",
      "DOI": "10.1016/0003-2697(76)90527-3",
      "article-title": "A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein\u2013dye binding",
      "volume": "72",
      "author": "Bradford",
      "year": "1976",
      "journal-title": "Anal. Biochem."
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    {
      "key": "10.1016/j.tox.2008.09.014_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "133",
      "DOI": "10.1016/j.neuro.2004.08.003",
      "article-title": "Particulate matter in polluted air may increase biomarkers of inflammation in mouse brain",
      "volume": "26",
      "author": "Campbell",
      "year": "2005",
      "journal-title": "Neurotoxicology"
    },
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      "doi-asserted-by": "crossref",
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      "DOI": "10.1073/pnas.0600997103",
      "article-title": "Role of target geometry in phagocytosis",
      "volume": "103",
      "author": "Champion",
      "year": "2006",
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      "volume": "170",
      "author": "Dorman",
      "year": "2001",
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      "author": "Dorman",
      "year": "2004",
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      "author": "Dunford",
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    {
      "issue": "8",
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      "doi-asserted-by": "crossref",
      "first-page": "1172",
      "DOI": "10.1289/ehp.9030",
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      "volume": "114",
      "author": "Elder",
      "year": "2006",
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      "key": "10.1016/j.tox.2008.09.014_bib14",
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      "year": "2007",
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      "volume": "111",
      "author": "Hidaka",
      "year": "1997",
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      "volume": "115",
      "author": "Long",
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      "volume": "41",
      "author": "Lovern",
      "year": "2007",
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    },
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      "DOI": "10.1016/S0300-483X(00)00306-1",
      "article-title": "Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology",
      "volume": "153",
      "author": "Mat\u00e9s",
      "year": "2000",
      "journal-title": "Toxicology"
    },
    {
      "key": "10.1016/j.tox.2008.09.014_bib23",
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      "first-page": "125",
      "DOI": "10.1016/S1383-5718(97)00126-5",
      "article-title": "The photogenotoxicity of titanium dioxide particles",
      "volume": "394",
      "author": "Nakagawa",
      "year": "1997",
      "journal-title": "Mutat. Res."
    },
    {
      "issue": "3",
      "key": "10.1016/j.tox.2008.09.014_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "622",
      "DOI": "10.1126/science.1114397",
      "article-title": "Toxic potential of materials at the nanolevel",
      "volume": "311",
      "author": "Nel",
      "year": "2006",
      "journal-title": "Science"
    },
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      "DOI": "10.1186/1743-8977-2-8",
      "article-title": "Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy",
      "volume": "2",
      "author": "Oberd\u00f6rster",
      "year": "2005",
      "journal-title": "Part. Fibre Toxicol."
    },
    {
      "key": "10.1016/j.tox.2008.09.014_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "823",
      "DOI": "10.1289/ehp.7339",
      "article-title": "Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles",
      "volume": "113",
      "author": "Oberd\u00f6rster",
      "year": "2005",
      "journal-title": "Environ. Health Perspect."
    },
    {
      "issue": "6\u20137",
      "key": "10.1016/j.tox.2008.09.014_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "437",
      "DOI": "10.1080/08958370490439597",
      "article-title": "Translocation of inhaled ultrafine particles to the brain",
      "volume": "16",
      "author": "Oberd\u00f6rster",
      "year": "2004",
      "journal-title": "Inhal. Toxicol."
    },
    {
      "key": "10.1016/j.tox.2008.09.014_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "793",
      "DOI": "10.1023/A:1016131310025",
      "article-title": "An experimental study of the dissemination of titanium and zirconium in the body",
      "volume": "13",
      "author": "Olmedo",
      "year": "2002",
      "journal-title": "J. Mater. Sci. Mater. Med."
    },
    {
      "issue": "2",
      "key": "10.1016/j.tox.2008.09.014_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "220",
      "DOI": "10.1006/faat.1997.2390",
      "article-title": "Intratracheal inhalation vs. intratracheal instillation: differences in particle effects",
      "volume": "40",
      "author": "Osier",
      "year": "1997",
      "journal-title": "Fund. Appl. Toxicol."
    },
    {
      "issue": "5",
      "key": "10.1016/j.tox.2008.09.014_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "612",
      "DOI": "10.1289/ehp.7696",
      "article-title": "Time course of gene expression of inflammatory mediators in rat lung after diesel exhaust particle exposure",
      "volume": "113",
      "author": "Rao",
      "year": "2005",
      "journal-title": "Environ. Health Perspect."
    },
    {
      "key": "10.1016/j.tox.2008.09.014_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "217",
      "DOI": "10.1016/S0149-7634(05)80152-6",
      "article-title": "Involvement of cytokines in acute neurodegeneration in the CNS",
      "volume": "17",
      "author": "Rothwell",
      "year": "1993",
      "journal-title": "Neurosci. Biobehav. Rev."
    },
    {
      "issue": "10",
      "key": "10.1016/j.tox.2008.09.014_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "1881",
      "DOI": "10.1021/nl0489586",
      "article-title": "The differential cytotoxicity of water-soluble fullerenes",
      "volume": "4",
      "author": "Sayes",
      "year": "2004",
      "journal-title": "Nano Lett."
    },
    {
      "key": "10.1016/j.tox.2008.09.014_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "237",
      "DOI": "10.1126/science.1094823",
      "article-title": "How viruses enter animal cells",
      "volume": "304",
      "author": "Smith",
      "year": "2004",
      "journal-title": "Science"
    },
    {
      "issue": "3",
      "key": "10.1016/j.tox.2008.09.014_bib35",
      "first-page": "140",
      "article-title": "Intranasal delivery: an approach to bypass the blood brain barrier",
      "volume": "36",
      "author": "Talegaonkar",
      "year": "2004",
      "journal-title": "Educ. Forum"
    },
    {
      "key": "10.1016/j.tox.2008.09.014_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "5199",
      "DOI": "10.1016/j.biomaterials.2006.05.045",
      "article-title": "Differential inflammatory macrophage response to rutile and titanium particles",
      "volume": "27",
      "author": "Vall\u00e9s",
      "year": "2006",
      "journal-title": "Biomaterials"
    },
    {
      "key": "10.1016/j.tox.2008.09.014_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "9879",
      "DOI": "10.1073/pnas.96.17.9879",
      "article-title": "A new mechanism of neurodegeneration: a proinflammatory cytokine inhibits receptor signaling by a survival peptide",
      "volume": "96",
      "author": "Venters",
      "year": "1999",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "10.1016/j.tox.2008.09.014_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "201",
      "DOI": "10.2106/00004623-200102000-00007",
      "article-title": "The effects of particulate wear debris cytokines, and growth factors on the functions of MG-63 osteoblasts",
      "volume": "83",
      "author": "Vermes",
      "year": "2001",
      "journal-title": "J. Bone Joint Surg."
    },
    {
      "key": "10.1016/j.tox.2008.09.014_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "851",
      "DOI": "10.1016/S0891-5849(97)00068-3",
      "article-title": "Oxidative damage to nucleic acids photosensitized by titanium dioxide",
      "volume": "23",
      "author": "Wamer",
      "year": "1997",
      "journal-title": "Free Rad. Biol. Med."
    },
    {
      "key": "10.1016/j.tox.2008.09.014_bib40",
      "doi-asserted-by": "crossref",
      "unstructured": "Wang, J.X., Chen, C.Y. Liu, Y., Jiao, F., Li, W., Lao, F., Li, Y.F., Li, B., Zhou, G.Q., Ge, C.C., Gao, Y.X., Zhao, Y.L., Chai, Z.F., 2008. Potential neurological lesion after nasal instillation of TiO2 Nanoparticles in the anatase and rutile crystal phases. Toxicol. Lett. doi:10.1016/j.toxlet.2008.10.001.",
      "DOI": "10.1016/j.toxlet.2008.10.001"
    },
    {
      "key": "10.1016/j.tox.2008.09.014_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "872",
      "DOI": "10.1016/j.bcp.2005.12.001",
      "article-title": "Antioxidative function and biodistribution of [Gd@C82(OH)22]n nanoparticles in tumor-bearing mice",
      "volume": "71",
      "author": "Wang",
      "year": "2006",
      "journal-title": "Biochem. Pharmacol."
    },
    {
      "issue": "3",
      "key": "10.1016/j.tox.2008.09.014_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "527",
      "DOI": "10.1007/s10967-007-0617-z",
      "article-title": "Distribution of TiO2 particles in the olfactory bulb of mice after nasal inhalation using microbeam SRXRF mapping techniques",
      "volume": "272",
      "author": "Wang",
      "year": "2007",
      "journal-title": "J. Radioanal. Nucl. Chem."
    },
    {
      "key": "10.1016/j.tox.2008.09.014_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "176",
      "DOI": "10.1016/j.toxlet.2006.12.001",
      "article-title": "Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration",
      "volume": "168",
      "author": "Wang",
      "year": "2007",
      "journal-title": "Toxicol. Lett."
    },
    {
      "issue": "2",
      "key": "10.1016/j.tox.2008.09.014_bib44",
      "doi-asserted-by": "crossref",
      "first-page": "514",
      "DOI": "10.1093/toxsci/kfi331",
      "article-title": "Comparative pulmonary toxicity inhalation and instillation studies with different TiO2 particle formulations: impact of surface treatments on particle toxicity",
      "volume": "88",
      "author": "Warheit",
      "year": "2005",
      "journal-title": "Toxicol. Sci."
    },
    {
      "key": "10.1016/j.tox.2008.09.014_bib45",
      "doi-asserted-by": "crossref",
      "first-page": "99",
      "DOI": "10.1016/j.toxlet.2007.04.008",
      "article-title": "Development f a base of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management",
      "volume": "171",
      "author": "Warheit",
      "year": "2007",
      "journal-title": "Toxicol. Lett."
    },
    {
      "key": "10.1016/j.tox.2008.09.014_bib46",
      "doi-asserted-by": "crossref",
      "first-page": "90",
      "DOI": "10.1016/j.tox.2006.11.002",
      "article-title": "Pulmonary toxicity study in rats with three forms of ultrafine-TiO2 particles: differential responses related to surface properties",
      "volume": "230",
      "author": "Warheit",
      "year": "2007",
      "journal-title": "Toxicology"
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