DOI: 10.1016/j.tins.2005.09.011. Molecular basis of programmed cell death involved in neurodegeneration

Molecular basis of programmed cell death involved in neurodegeneration

10.1016/j.tins.2005.09.011

Crossref journal-article

Elsevier BV

Trends in Neurosciences (78)

Bibliography

Krantic, S., Mechawar, N., Reix, S., & Quirion, R. (2005). Molecular basis of programmed cell death involved in neurodegeneration. Trends in Neurosciences, 28(12), 670â676.

Authors 4

Slavica Krantic (first)
Naguib Mechawar (additional)
Stéphanie Reix (additional)
Rémi Quirion (additional)

References 75 Referenced 117

10.1038/sj.cdd.4401108 / Cell Death Differ. / Cycling at the interface between neurodevelopment and neurodegeneration by Nguyen (2002)
10.1038/35085008 / Nat. Rev. Mol. Cell Biol. / Four deaths and a funeral: from caspases to alternative mechanisms by Leist (2001)
10.1016/j.semcdb.2005.02.006 / Sem. Cell. Dev. Biol / Beyond proliferation – cell cycle control of neuronal survival and differentiation in the developing mammalian brain by Becker (2005)
10.1023/A:1025682611389 / Neurochem. Res. / Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis by Rego (2003)
10.1172/JCI200318182 / J. Clin. Invest. / Oxidative stress, cell cycle, and neurodegeneration by Klein (2003)
10.1038/sj.onc.1207514 / Oncogene / Caspase-independent cell death? by Lockshin (2004)
10.1038/ni0503-416 / Nat. Immunol. / Caspase-independent cell death in T-lymphocytes by Jäättelä (2003)
10.1038/35037710 / Nature / The biochemistry of apoptosis by Hengartner (2000)
10.1038/17135 / Nature / Molecular characterization of mitochondrial apoptosis inducing factor by Susin (1999)
10.1038/35069004 / Nature / Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death by Joza (2001)
10.1038/sj.onc.1207279 / Oncogene / AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis by Cande (2004)
10.1126/science.1076194 / Science / Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans by Wang (2002)
10.1016/S0960-9822(99)80425-4 / Curr. Biol. / Interdigital cell death can occur through a necrotic and caspase-independent pathway by Chautan (1999)
10.1074/jbc.275.7.5131 / J. Biol. Chem. / Direct cleavage by calcium-activated protease calpain can lead to inactivation of caspases by Chua (2000)
10.1146/annurev.biochem.69.1.217 / Annu. Rev. Biochem. / Apoptosis signaling by Strasser (2000)
10.1084/jem.185.8.1481 / J. Exp. Med. / Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis by Leist (1997)
10.1006/excr.1999.4514 / Exp. Cell Res. / Inhibition of mitochondrial ATP generation by nitric oxide switches apoptosis to necrosis by Leist (1999)
10.1093/gerona/56.11.B475 / J. Gerontol. A Biol. Sci. Med. Sci. / Apoptosis and aging: role of the mitochondria by Pollack (2001)
10.1016/j.nbd.2003.07.006 / Neurobiol. Dis. / Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and Alzheimer's disease by Zhao (2003)
10.1089/08977150260190410 / J. Neurotrauma / Rapid subcellular redistribution of Bax precedes caspase-3 and endonuclease activation during excitotoxic neuronal apoptosis in rat brain by Lok (2002)
10.1016/j.bbrc.2004.07.118 / Biochem. Biophys. Res. Commun. / Caspase-12 cleavage and increased oxidative stress during motoneuron degeneration in transgenic mouse model of ALS by Wootz (2004)
10.1002/ana.410440710 / Ann. Neurol. / Autosomal dominant Parkinson's disease and α-synuclein by Polymeropoulos (1998)
10.1111/j.1471-4159.2004.02728.x / J. Neurochem. / Over-expression of α-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of α-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson's disease by Yamada (2004)
10.1016/S0969-9961(02)00019-0 / Neurobiol. Dis. / Fas and Fas ligand are associated with neuritic degeneration in the AD brain and participate in β-amyloid-induced neuronal death by Su (2003)
10.1083/jcb.200110119 / J. Cell Biol. / Selective cytotoxicity of intracellular amyloid β peptide1-42 through p53 and Bax in cultured primary human neurons by Zhang (2002)
10.1096/fj.04-2637fje / FASEB J. / Intracellular Aβ42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease by Ohyagi (2005)
10.1096/fj.04-3258fje / FASEB J. / BimEL up-regulation potentiates AIF translocation and cell death in response to MPTP by Liou (2005)
10.1016/S0002-9440(10)65460-0 / Am. J. Pathol. / Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease by Stadelmann (1999)
10.1111/j.1471-4159.2005.03187.x / J. Neurochem. / mTOR/p70S6k signalling alteration by Aβ exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer's disease by Lafay-Chebassier (2005)
10.1074/jbc.275.16.11553 / J. Biol. Chem. / E2F1 mediates death of β-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase-3 by Giovanni (2000)
10.1111/j.1471-4159.2004.02451.x / J. Neurochem. / mGluR5 activation reduces β-amyloid-induced cell death in primary neuronal cultures and attenuates translocation of cytochrome c and apoptosis-inducing factor by Movsesyan (2004)
10.1016/S0168-0102(98)00111-4 / Neurosci. Res. / Novel non-apoptotic morphological changes in neurons of the mouse hippocampus following transient hypoxic-ischemia by Fukuda (1999)
10.1523/JNEUROSCI.16-19-06134.1996 / J. Neurosci. / Neuronal death in substantia nigra of weaver mouse occurs late in development and is not apoptotic by Oo (1996)
10.1016/S0021-9258(18)63504-5 / J. Biol. Chem. / Superoxide dismutase. An enzymatic function for erythrocuprein (hemocuprein) by McCord (1969)
10.1016/S0021-9258(18)54740-2 / J. Biol. Chem. / Detection of catalase in rat heart mitochondria by Radi (1991)
10.1016/j.freeradbiomed.2004.05.034 / Free Radic. Biol. Med. / Mitochondrial superoxide: production, biological effects and activation of uncoupling proteins by Brand (2004)
10.1074/jbc.M407707200 / J. Biol. Chem. / Peroxiredoxin III, a mitochondrion-specific peroxidase, regulates apoptotic signaling by mitochondria by Chang (2004)
10.1016/S0143-4160(03)00141-6 / Cell Calcium / Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity by Arundine (2003)
10.1038/364535a0 / Nature / NMDA-dependent superoxide production and neurotoxicity by Lafon-Cazal (1993)
10.1097/00004647-199601000-00013 / J. Cereb. Blood Flow Metab. / Short therapeutic window for MK-801 in transient focal cerebral ischemia in normotensive rats by Margaill (1996)
10.1016/S0197-4580(00)00220-7 / Neurobiol. Aging / Cell cycle regulators in neuronal death evoked by excitotoxic stress: implications for neurodegeneration and its treatment by Park (2000)
10.1016/S0891-5849(02)01327-8 / Free Radic. Biol. Med. / Nitric oxide-induced mitochondrial dysfunction: implications for neurodegeneration by Stewart (2003)
10.1111/j.1469-7793.2001.0147j.x / J. Physiol. / Exploration of the role of reactive oxygen species in glutamate neurotoxicity in rat hippocampal neurons in culture by Vergun (2001)
{'key': '10.1016/j.tins.2005.09.011_bib44', 'first-page': '373', 'article-title': 'Poly(ADP-ribose) polymerase inhibition protect neurons and the white matter and regulates the translocation of apoptosis-inducing factor in stroke', 'volume': '13', 'author': 'Komjati', 'year': '2004', 'journal-title': 'Int. J. Mol. Med.'} / Int. J. Mol. Med. / Poly(ADP-ribose) polymerase inhibition protect neurons and the white matter and regulates the translocation of apoptosis-inducing factor in stroke by Komjati (2004)
10.1523/JNEUROSCI.3461-04.2004 / J. Neurosci. / Apoptosis-Inducing Factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal cell death by Wang (2004)
10.1093/emboj/cdg423 / EMBO J. / Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization by Arnoult (2003)
10.1523/JNEUROSCI.4261-04.2005 / J. Neurosci. / Apoptosis-inducing factor is a key factor in neuronal cell death propagated by Bax-dependent and Bax-independent mechanisms by Cheung (2005)
10.2174/1566524043479158 / Curr. Mol. Med. / Excitotoxic versus apoptotic mechanism of neuronal cell death in perinatal hypoxia/ischemia by Young (2004)
10.1126/science.7901908 / Science / Oxidative stress, glutamate, and neurodegenerative disorders by Coyle (1993)
10.1006/exnr.1999.7190 / Exp. Neurol. / ALS-linked Cu/Zn SOD mutation increases vulnerability of motor neurons to excitotoxicity by a mechanism involving increased oxidative stress and perturbed calcium homeostasis by Kruman (1999)
{'key': '10.1016/j.tins.2005.09.011_bib51', 'first-page': '332', 'article-title': 'Comparison of pathological alterations in ALS and a murine transgenic model: pathogenetic implications', 'volume': '3', 'author': 'Dal Canto', 'year': '1995', 'journal-title': 'Clin. Neurosci.'} / Clin. Neurosci. / Comparison of pathological alterations in ALS and a murine transgenic model: pathogenetic implications by Dal Canto (1995)
10.1097/00005072-199804000-00006 / J. Neuropathol. Exp. Neurol. / Protein nitration in Parkinson's disease by Good (1998)
10.1111/j.1749-6632.2003.tb07471.x / Ann. N. Y. Acad. Sci. / Apoptosis-Inducing Factor and PARP-mediated injury in the MPTP mouse model of Parkinson's disease by Wang (2003)
10.1038/sj.emboj.7600461 / EMBO J. / AIF deficiency compromises oxidative phosphorylation by Vahsen (2004)
10.1038/nature01034 / Nature / The harlequin mouse mutation down-regulates apoptosis-inducing factor by Klein (2002)
10.1016/0092-8674(93)90636-5 / Cell / Mammalian G1 cyclins by Sherr (1993)
10.1097/00001756-199703030-00037 / NeuroReport / c-Jun and cyclin D1 proteins as mediators of neuronal death after a focal ischaemic insult by Guegan (1997)
10.1523/JNEUROSCI.21-14-05045.2001 / J. Neurosci. / Mild cerebral ischemia induces loss of cyclin-dependent kinase inhibitors and activation of cell cycle machinery before delayed neuronal cell death by Katchanov (2001)
10.1046/j.1460-9568.1999.00434.x / Eur. J. Neurosci. / Increased cyclin D1 in vulnerable neurons in the hippocampus after ischemia and epilepsy: a modulator of in vivo programmed cell death? by Timsit (1999)
10.1523/JNEUROSCI.3883-04.2004 / J. Neurosci. / Hypoxia–ischemia induced DNA synthesis without cell proliferation in dying neurons in adult rodent brain by Kuan (2004)
10.1523/JNEUROSCI.23-06-02131.2003 / J. Neurosci. / Cell cycle regulators in the neuronal death pathway of amyotrophic lateral sclerosis caused by mutant superoxide dismutase 1 by Nguyen (2003)
10.1523/JNEUROSCI.18-03-00830.1998 / J. Neurosci. / Multiple pathways of neuronal death induced by DNA damaging agents, NGF deprivation and oxidative stress by Park (1998)
10.1002/syn.10307 / Synapse / Gene expression profiling in the midbrain of striatal 6-hydroxydopamine-injected mice by Iwata (2004)
10.1007/978-3-7091-6842-4_8 / J. Neural Transm. Suppl. / Induction of mitosis-related genes during dopamine-triggered apoptosis in sympathetic neurons by Shirvan (1997)
10.1006/excr.1999.4504 / Exp. Cell Res. / MPP+ inhibits proliferation of PC12 cells by a p21 (WAF1/CIP1)-dependent pathway and induces cell death in cells lacking p21 (WAF1/CIP1) by Soldner (1999)
10.1096/fasebj.13.15.2225 / FASEB J. / Mitotic signaling by β-amyloid causes neuronal death by Copani (1999)
10.1523/JNEUROSCI.23-07-02557.2003 / J. Neurosci. / Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease by Yang (2003)
10.1007/s007020050104 / J. Neural Transm. / Neuronal expression of cyclin dependent kinase inhibitors of the INK4 family in Alzheimer's disease by Arendt (1998)
{'key': '10.1016/j.tins.2005.09.011_bib69', 'first-page': '273', 'article-title': 'Copper/zinc superoxide dismutase expression in the human central nervous system. Correlation with selective neuronal vulnerability', 'volume': '148', 'author': 'Bergeron', 'year': '1996', 'journal-title': 'Am. J. Pathol.'} / Am. J. Pathol. / Copper/zinc superoxide dismutase expression in the human central nervous system. Correlation with selective neuronal vulnerability by Bergeron (1996)
10.1002/jnr.20210 / J. Neurosci. Res. / Oxidative-stress-induced death in the nervous system: cell cycle dependent or independent? by Langley (2004)
10.1016/S0896-6273(04)00017-0 / Neuron / Cell cycle activation linked to neuronal cell death by DNA damage by Kruman (2004)
10.1128/MCB.20.5.1562-1570.2000 / Mol. Cell. Biol. / Terminally differentiated human neurons repair transcribed genes but display attenuated global DNA repair and modulation of repair gene expression by Nouspikel (2000)
10.1038/sj.onc.1207532 / Oncogene / DNA damage-induced apoptosis by Norbury (2004)
10.1038/sj.cdd.4401465 / Cell Death Differ. / Paraptosis: mediation by MAP kinases and inhibition by AIP-1/Alix by Sperandio (2004)
10.1038/sj.onc.1202538 / Oncogene / Oncogenic Ras triggers cell suicide through the activation of a caspase-independent cell death program in human cancer cells by Chi (1999)

Dates

Type	When
Created	19 years, 10 months ago (Oct. 11, 2005, 7:22 a.m.)
Deposited	4 years, 1 month ago (July 18, 2021, 9:51 a.m.)
Indexed	4 months, 3 weeks ago (April 12, 2025, 9:55 p.m.)
Issued	19 years, 9 months ago (Dec. 1, 2005)
Published	19 years, 9 months ago (Dec. 1, 2005)
Published Print	19 years, 9 months ago (Dec. 1, 2005)

Funders 0

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BibTeX

@article{Krantic_2005, title={Molecular basis of programmed cell death involved in neurodegeneration}, volume={28}, ISSN={0166-2236}, url={http://dx.doi.org/10.1016/j.tins.2005.09.011}, DOI={10.1016/j.tins.2005.09.011}, number={12}, journal={Trends in Neurosciences}, publisher={Elsevier BV}, author={Krantic, Slavica and Mechawar, Naguib and Reix, Stéphanie and Quirion, Rémi}, year={2005}, month=dec, pages={670–676} }

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      "year": "2001",
      "journal-title": "Nat. Rev. Mol. Cell Biol."
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      "first-page": "785",
      "DOI": "10.1172/JCI200318182",
      "article-title": "Oxidative stress, cell cycle, and neurodegeneration",
      "volume": "111",
      "author": "Klein",
      "year": "2003",
      "journal-title": "J. Clin. Invest."
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    {
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      "doi-asserted-by": "crossref",
      "first-page": "2766",
      "DOI": "10.1038/sj.onc.1207514",
      "article-title": "Caspase-independent cell death?",
      "volume": "23",
      "author": "Lockshin",
      "year": "2004",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "416",
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      "article-title": "Caspase-independent cell death in T-lymphocytes",
      "volume": "4",
      "author": "J\u00e4\u00e4ttel\u00e4",
      "year": "2003",
      "journal-title": "Nat. Immunol."
    },
    {
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      "doi-asserted-by": "crossref",
      "first-page": "770",
      "DOI": "10.1038/35037710",
      "article-title": "The biochemistry of apoptosis",
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      "author": "Hengartner",
      "year": "2000",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib9",
      "doi-asserted-by": "crossref",
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      "author": "Susin",
      "year": "1999",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib10",
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      "first-page": "549",
      "DOI": "10.1038/35069004",
      "article-title": "Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death",
      "volume": "410",
      "author": "Joza",
      "year": "2001",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib11",
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      "first-page": "1514",
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      "author": "Wang",
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    {
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      "volume": "9",
      "author": "Chautan",
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      "article-title": "Direct cleavage by calcium-activated protease calpain can lead to inactivation of caspases",
      "volume": "275",
      "author": "Chua",
      "year": "2000",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "217",
      "DOI": "10.1146/annurev.biochem.69.1.217",
      "article-title": "Apoptosis signaling",
      "volume": "69",
      "author": "Strasser",
      "year": "2000",
      "journal-title": "Annu. Rev. Biochem."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "1481",
      "DOI": "10.1084/jem.185.8.1481",
      "article-title": "Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis",
      "volume": "185",
      "author": "Leist",
      "year": "1997",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "396",
      "DOI": "10.1006/excr.1999.4514",
      "article-title": "Inhibition of mitochondrial ATP generation by nitric oxide switches apoptosis to necrosis",
      "volume": "249",
      "author": "Leist",
      "year": "1999",
      "journal-title": "Exp. Cell Res."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "B475",
      "DOI": "10.1093/gerona/56.11.B475",
      "article-title": "Apoptosis and aging: role of the mitochondria",
      "volume": "56",
      "author": "Pollack",
      "year": "2001",
      "journal-title": "J. Gerontol. A Biol. Sci. Med. Sci."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "391",
      "DOI": "10.1016/j.nbd.2003.07.006",
      "article-title": "Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and Alzheimer's disease",
      "volume": "14",
      "author": "Zhao",
      "year": "2003",
      "journal-title": "Neurobiol. Dis."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "815",
      "DOI": "10.1089/08977150260190410",
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      "volume": "19",
      "author": "Lok",
      "year": "2002",
      "journal-title": "J. Neurotrauma"
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "281",
      "DOI": "10.1016/j.bbrc.2004.07.118",
      "article-title": "Caspase-12 cleavage and increased oxidative stress during motoneuron degeneration in transgenic mouse model of ALS",
      "volume": "322",
      "author": "Wootz",
      "year": "2004",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
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      "key": "10.1016/j.tins.2005.09.011_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "S63",
      "DOI": "10.1002/ana.410440710",
      "article-title": "Autosomal dominant Parkinson's disease and \u03b1-synuclein",
      "volume": "44",
      "author": "Polymeropoulos",
      "year": "1998",
      "journal-title": "Ann. Neurol."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "451",
      "DOI": "10.1111/j.1471-4159.2004.02728.x",
      "article-title": "Over-expression of \u03b1-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of \u03b1-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson's disease",
      "volume": "91",
      "author": "Yamada",
      "year": "2004",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "182",
      "DOI": "10.1016/S0969-9961(02)00019-0",
      "article-title": "Fas and Fas ligand are associated with neuritic degeneration in the AD brain and participate in \u03b2-amyloid-induced neuronal death",
      "volume": "12",
      "author": "Su",
      "year": "2003",
      "journal-title": "Neurobiol. Dis."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "519",
      "DOI": "10.1083/jcb.200110119",
      "article-title": "Selective cytotoxicity of intracellular amyloid \u03b2 peptide1-42 through p53 and Bax in cultured primary human neurons",
      "volume": "156",
      "author": "Zhang",
      "year": "2002",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "255",
      "DOI": "10.1096/fj.04-2637fje",
      "article-title": "Intracellular A\u03b242 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease",
      "volume": "19",
      "author": "Ohyagi",
      "year": "2005",
      "journal-title": "FASEB J."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "1350",
      "DOI": "10.1096/fj.04-3258fje",
      "article-title": "BimEL up-regulation potentiates AIF translocation and cell death in response to MPTP",
      "volume": "19",
      "author": "Liou",
      "year": "2005",
      "journal-title": "FASEB J."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "1459",
      "DOI": "10.1016/S0002-9440(10)65460-0",
      "article-title": "Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease",
      "volume": "155",
      "author": "Stadelmann",
      "year": "1999",
      "journal-title": "Am. J. Pathol."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "215",
      "DOI": "10.1111/j.1471-4159.2005.03187.x",
      "article-title": "mTOR/p70S6k signalling alteration by A\u03b2 exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer's disease",
      "volume": "94",
      "author": "Lafay-Chebassier",
      "year": "2005",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "11553",
      "DOI": "10.1074/jbc.275.16.11553",
      "article-title": "E2F1 mediates death of \u03b2-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase-3",
      "volume": "275",
      "author": "Giovanni",
      "year": "2000",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "1528",
      "DOI": "10.1111/j.1471-4159.2004.02451.x",
      "article-title": "mGluR5 activation reduces \u03b2-amyloid-induced cell death in primary neuronal cultures and attenuates translocation of cytochrome c and apoptosis-inducing factor",
      "volume": "89",
      "author": "Movsesyan",
      "year": "2004",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "49",
      "DOI": "10.1016/S0168-0102(98)00111-4",
      "article-title": "Novel non-apoptotic morphological changes in neurons of the mouse hippocampus following transient hypoxic-ischemia",
      "volume": "33",
      "author": "Fukuda",
      "year": "1999",
      "journal-title": "Neurosci. Res."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "6134",
      "DOI": "10.1523/JNEUROSCI.16-19-06134.1996",
      "article-title": "Neuronal death in substantia nigra of weaver mouse occurs late in development and is not apoptotic",
      "volume": "16",
      "author": "Oo",
      "year": "1996",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "6049",
      "DOI": "10.1016/S0021-9258(18)63504-5",
      "article-title": "Superoxide dismutase. An enzymatic function for erythrocuprein (hemocuprein)",
      "volume": "244",
      "author": "McCord",
      "year": "1969",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "22028",
      "DOI": "10.1016/S0021-9258(18)54740-2",
      "article-title": "Detection of catalase in rat heart mitochondria",
      "volume": "266",
      "author": "Radi",
      "year": "1991",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "755",
      "DOI": "10.1016/j.freeradbiomed.2004.05.034",
      "article-title": "Mitochondrial superoxide: production, biological effects and activation of uncoupling proteins",
      "volume": "37",
      "author": "Brand",
      "year": "2004",
      "journal-title": "Free Radic. Biol. Med."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "41975",
      "DOI": "10.1074/jbc.M407707200",
      "article-title": "Peroxiredoxin III, a mitochondrion-specific peroxidase, regulates apoptotic signaling by mitochondria",
      "volume": "279",
      "author": "Chang",
      "year": "2004",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "325",
      "DOI": "10.1016/S0143-4160(03)00141-6",
      "article-title": "Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity",
      "volume": "34",
      "author": "Arundine",
      "year": "2003",
      "journal-title": "Cell Calcium"
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "535",
      "DOI": "10.1038/364535a0",
      "article-title": "NMDA-dependent superoxide production and neurotoxicity",
      "volume": "364",
      "author": "Lafon-Cazal",
      "year": "1993",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "107",
      "DOI": "10.1097/00004647-199601000-00013",
      "article-title": "Short therapeutic window for MK-801 in transient focal cerebral ischemia in normotensive rats",
      "volume": "16",
      "author": "Margaill",
      "year": "1996",
      "journal-title": "J. Cereb. Blood Flow Metab."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "771",
      "DOI": "10.1016/S0197-4580(00)00220-7",
      "article-title": "Cell cycle regulators in neuronal death evoked by excitotoxic stress: implications for neurodegeneration and its treatment",
      "volume": "21",
      "author": "Park",
      "year": "2000",
      "journal-title": "Neurobiol. Aging"
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "287",
      "DOI": "10.1016/S0891-5849(02)01327-8",
      "article-title": "Nitric oxide-induced mitochondrial dysfunction: implications for neurodegeneration",
      "volume": "34",
      "author": "Stewart",
      "year": "2003",
      "journal-title": "Free Radic. Biol. Med."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "147",
      "DOI": "10.1111/j.1469-7793.2001.0147j.x",
      "article-title": "Exploration of the role of reactive oxygen species in glutamate neurotoxicity in rat hippocampal neurons in culture",
      "volume": "531",
      "author": "Vergun",
      "year": "2001",
      "journal-title": "J. Physiol."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib44",
      "first-page": "373",
      "article-title": "Poly(ADP-ribose) polymerase inhibition protect neurons and the white matter and regulates the translocation of apoptosis-inducing factor in stroke",
      "volume": "13",
      "author": "Komjati",
      "year": "2004",
      "journal-title": "Int. J. Mol. Med."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib45",
      "doi-asserted-by": "crossref",
      "first-page": "10963",
      "DOI": "10.1523/JNEUROSCI.3461-04.2004",
      "article-title": "Apoptosis-Inducing Factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal cell death",
      "volume": "24",
      "author": "Wang",
      "year": "2004",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib46",
      "doi-asserted-by": "crossref",
      "first-page": "4385",
      "DOI": "10.1093/emboj/cdg423",
      "article-title": "Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization",
      "volume": "22",
      "author": "Arnoult",
      "year": "2003",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib47",
      "doi-asserted-by": "crossref",
      "first-page": "1324",
      "DOI": "10.1523/JNEUROSCI.4261-04.2005",
      "article-title": "Apoptosis-inducing factor is a key factor in neuronal cell death propagated by Bax-dependent and Bax-independent mechanisms",
      "volume": "25",
      "author": "Cheung",
      "year": "2005",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib48",
      "doi-asserted-by": "crossref",
      "first-page": "77",
      "DOI": "10.2174/1566524043479158",
      "article-title": "Excitotoxic versus apoptotic mechanism of neuronal cell death in perinatal hypoxia/ischemia",
      "volume": "4",
      "author": "Young",
      "year": "2004",
      "journal-title": "Curr. Mol. Med."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib49",
      "doi-asserted-by": "crossref",
      "first-page": "689",
      "DOI": "10.1126/science.7901908",
      "article-title": "Oxidative stress, glutamate, and neurodegenerative disorders",
      "volume": "262",
      "author": "Coyle",
      "year": "1993",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib50",
      "doi-asserted-by": "crossref",
      "first-page": "28",
      "DOI": "10.1006/exnr.1999.7190",
      "article-title": "ALS-linked Cu/Zn SOD mutation increases vulnerability of motor neurons to excitotoxicity by a mechanism involving increased oxidative stress and perturbed calcium homeostasis",
      "volume": "160",
      "author": "Kruman",
      "year": "1999",
      "journal-title": "Exp. Neurol."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib51",
      "first-page": "332",
      "article-title": "Comparison of pathological alterations in ALS and a murine transgenic model: pathogenetic implications",
      "volume": "3",
      "author": "Dal Canto",
      "year": "1995",
      "journal-title": "Clin. Neurosci."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib52",
      "doi-asserted-by": "crossref",
      "first-page": "338",
      "DOI": "10.1097/00005072-199804000-00006",
      "article-title": "Protein nitration in Parkinson's disease",
      "volume": "57",
      "author": "Good",
      "year": "1998",
      "journal-title": "J. Neuropathol. Exp. Neurol."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib53",
      "doi-asserted-by": "crossref",
      "first-page": "132",
      "DOI": "10.1111/j.1749-6632.2003.tb07471.x",
      "article-title": "Apoptosis-Inducing Factor and PARP-mediated injury in the MPTP mouse model of Parkinson's disease",
      "volume": "991",
      "author": "Wang",
      "year": "2003",
      "journal-title": "Ann. N. Y. Acad. Sci."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib54",
      "doi-asserted-by": "crossref",
      "first-page": "4679",
      "DOI": "10.1038/sj.emboj.7600461",
      "article-title": "AIF deficiency compromises oxidative phosphorylation",
      "volume": "23",
      "author": "Vahsen",
      "year": "2004",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib55",
      "doi-asserted-by": "crossref",
      "first-page": "367",
      "DOI": "10.1038/nature01034",
      "article-title": "The harlequin mouse mutation down-regulates apoptosis-inducing factor",
      "volume": "419",
      "author": "Klein",
      "year": "2002",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib56",
      "doi-asserted-by": "crossref",
      "first-page": "1059",
      "DOI": "10.1016/0092-8674(93)90636-5",
      "article-title": "Mammalian G1 cyclins",
      "volume": "73",
      "author": "Sherr",
      "year": "1993",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib57",
      "doi-asserted-by": "crossref",
      "first-page": "1003",
      "DOI": "10.1097/00001756-199703030-00037",
      "article-title": "c-Jun and cyclin D1 proteins as mediators of neuronal death after a focal ischaemic insult",
      "volume": "8",
      "author": "Guegan",
      "year": "1997",
      "journal-title": "NeuroReport"
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib58",
      "doi-asserted-by": "crossref",
      "first-page": "5045",
      "DOI": "10.1523/JNEUROSCI.21-14-05045.2001",
      "article-title": "Mild cerebral ischemia induces loss of cyclin-dependent kinase inhibitors and activation of cell cycle machinery before delayed neuronal cell death",
      "volume": "21",
      "author": "Katchanov",
      "year": "2001",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib59",
      "doi-asserted-by": "crossref",
      "first-page": "263",
      "DOI": "10.1046/j.1460-9568.1999.00434.x",
      "article-title": "Increased cyclin D1 in vulnerable neurons in the hippocampus after ischemia and epilepsy: a modulator of in vivo programmed cell death?",
      "volume": "11",
      "author": "Timsit",
      "year": "1999",
      "journal-title": "Eur. J. Neurosci."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib60",
      "doi-asserted-by": "crossref",
      "first-page": "10763",
      "DOI": "10.1523/JNEUROSCI.3883-04.2004",
      "article-title": "Hypoxia\u2013ischemia induced DNA synthesis without cell proliferation in dying neurons in adult rodent brain",
      "volume": "24",
      "author": "Kuan",
      "year": "2004",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib61",
      "doi-asserted-by": "crossref",
      "first-page": "2131",
      "DOI": "10.1523/JNEUROSCI.23-06-02131.2003",
      "article-title": "Cell cycle regulators in the neuronal death pathway of amyotrophic lateral sclerosis caused by mutant superoxide dismutase 1",
      "volume": "23",
      "author": "Nguyen",
      "year": "2003",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib62",
      "doi-asserted-by": "crossref",
      "first-page": "830",
      "DOI": "10.1523/JNEUROSCI.18-03-00830.1998",
      "article-title": "Multiple pathways of neuronal death induced by DNA damaging agents, NGF deprivation and oxidative stress",
      "volume": "18",
      "author": "Park",
      "year": "1998",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib63",
      "doi-asserted-by": "crossref",
      "first-page": "279",
      "DOI": "10.1002/syn.10307",
      "article-title": "Gene expression profiling in the midbrain of striatal 6-hydroxydopamine-injected mice",
      "volume": "51",
      "author": "Iwata",
      "year": "2004",
      "journal-title": "Synapse"
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib64",
      "doi-asserted-by": "crossref",
      "first-page": "67",
      "DOI": "10.1007/978-3-7091-6842-4_8",
      "article-title": "Induction of mitosis-related genes during dopamine-triggered apoptosis in sympathetic neurons",
      "volume": "50",
      "author": "Shirvan",
      "year": "1997",
      "journal-title": "J. Neural Transm. Suppl."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib65",
      "doi-asserted-by": "crossref",
      "first-page": "75",
      "DOI": "10.1006/excr.1999.4504",
      "article-title": "MPP+ inhibits proliferation of PC12 cells by a p21 (WAF1/CIP1)-dependent pathway and induces cell death in cells lacking p21 (WAF1/CIP1)",
      "volume": "250",
      "author": "Soldner",
      "year": "1999",
      "journal-title": "Exp. Cell Res."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib66",
      "doi-asserted-by": "crossref",
      "first-page": "2225",
      "DOI": "10.1096/fasebj.13.15.2225",
      "article-title": "Mitotic signaling by \u03b2-amyloid causes neuronal death",
      "volume": "13",
      "author": "Copani",
      "year": "1999",
      "journal-title": "FASEB J."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib67",
      "doi-asserted-by": "crossref",
      "first-page": "2557",
      "DOI": "10.1523/JNEUROSCI.23-07-02557.2003",
      "article-title": "Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease",
      "volume": "23",
      "author": "Yang",
      "year": "2003",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib68",
      "doi-asserted-by": "crossref",
      "first-page": "949",
      "DOI": "10.1007/s007020050104",
      "article-title": "Neuronal expression of cyclin dependent kinase inhibitors of the INK4 family in Alzheimer's disease",
      "volume": "105",
      "author": "Arendt",
      "year": "1998",
      "journal-title": "J. Neural Transm."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib69",
      "first-page": "273",
      "article-title": "Copper/zinc superoxide dismutase expression in the human central nervous system. Correlation with selective neuronal vulnerability",
      "volume": "148",
      "author": "Bergeron",
      "year": "1996",
      "journal-title": "Am. J. Pathol."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib70",
      "doi-asserted-by": "crossref",
      "first-page": "621",
      "DOI": "10.1002/jnr.20210",
      "article-title": "Oxidative-stress-induced death in the nervous system: cell cycle dependent or independent?",
      "volume": "77",
      "author": "Langley",
      "year": "2004",
      "journal-title": "J. Neurosci. Res."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib71",
      "doi-asserted-by": "crossref",
      "first-page": "549",
      "DOI": "10.1016/S0896-6273(04)00017-0",
      "article-title": "Cell cycle activation linked to neuronal cell death by DNA damage",
      "volume": "41",
      "author": "Kruman",
      "year": "2004",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib72",
      "doi-asserted-by": "crossref",
      "first-page": "1562",
      "DOI": "10.1128/MCB.20.5.1562-1570.2000",
      "article-title": "Terminally differentiated human neurons repair transcribed genes but display attenuated global DNA repair and modulation of repair gene expression",
      "volume": "20",
      "author": "Nouspikel",
      "year": "2000",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib73",
      "doi-asserted-by": "crossref",
      "first-page": "2797",
      "DOI": "10.1038/sj.onc.1207532",
      "article-title": "DNA damage-induced apoptosis",
      "volume": "23",
      "author": "Norbury",
      "year": "2004",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/j.tins.2005.09.011_bib74",
      "doi-asserted-by": "crossref",
      "first-page": "1066",
      "DOI": "10.1038/sj.cdd.4401465",
      "article-title": "Paraptosis: mediation by MAP kinases and inhibition by AIP-1/Alix",
      "volume": "11",
      "author": "Sperandio",
      "year": "2004",
      "journal-title": "Cell Death Differ."
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