Crossref journal-article
Elsevier BV
Trends in Neurosciences (78)
Bibliography

Bear, M. F., Huber, K. M., & Warren, S. T. (2004). The mGluR theory of fragile X mental retardation. Trends in Neurosciences, 27(7), 370–377.

Authors 3
  1. Mark F Bear (first)
  2. Kimberly M Huber (additional)
  3. Stephen T Warren (additional)
References 95 Referenced 1,324
  1. 10.1146/annurev.neuro.25.112701.142909 / Annu. Rev. Neurosci. / A decade of molecular studies of fragile X syndrome by O'Donnell (2002)
  2. {'key': '10.1016/j.tins.2004.04.009_BIB2', 'series-title': 'Fragile X Syndrome: Diagnosis, Treatment, and Research', 'first-page': '3', 'article-title': 'The physical and behavioral phenotype', 'author': 'Hagerman', 'year': '2002'} / Fragile X Syndrome: Diagnosis, Treatment, and Research / The physical and behavioral phenotype by Hagerman (2002)
  3. 10.1159/000072845 / Cytogenet. Genome Res. / Understanding fragile X syndrome: insights from animal models by Bakker (2003)
  4. 10.1007/BF00687814 / Acta Neuropathol. (Berl.) / Adult fragile X syndrome. Clinico-neuropathologic findings by Rudelli (1985)
  5. 10.1002/ajmg.1320410306 / Am. J. Med. Genet. / Analysis of neocortex in three males with the fragile X syndrome by Hinton (1991)
  6. 10.1002/1096-8628(20010115)98:2<161::AID-AJMG1025>3.0.CO;2-B / Am. J. Med. Genet. / Abnormal dendritic spine characteristics in the temporal and visual cortices of patients with fragile-X syndrome: a quantitative examination by Irwin (2001)
  7. 10.1126/science.186.4169.1126 / Science / Dendritic spine ‘dysgenesis’ and mental retardation by Purpura (1974)
  8. 10.1093/cercor/10.10.981 / Cereb. Cortex / Dendritic anomalies in disorders associated with mental retardation by Kaufmann (2000)
  9. {'key': '10.1016/j.tins.2004.04.009_BIB9', 'first-page': '23', 'article-title': 'Fmr1 knockout mice: a model to study fragile X mental retardation. The Dutch–Belgian fragile X consortium', 'volume': '78', 'author': 'Bakker', 'year': '1994', 'journal-title': 'Cell'} / Cell / Fmr1 knockout mice: a model to study fragile X mental retardation. The Dutch–Belgian fragile X consortium by Bakker (1994)
  10. 10.1016/S0168-9525(03)00017-9 / Trends Genet. / Of mice and the fragile X syndrome by Kooy (2003)
  11. 10.1523/JNEUROSCI.21-14-05139.2001 / J. Neurosci. / Abnormal development of dendritic spines in FMR1 knock-out mice by Nimchinsky (2001)
  12. 10.1002/ajmg.10500 / Am. J. Med. Genet. / Dendritic spine and dendritic field characteristics of layer V pyramidal neurons in the visual cortex of fragile-X knockout mice by Irwin (2002)
  13. 10.1073/pnas.122205699 / Proc. Natl. Acad. Sci. U. S. A. / Altered synaptic plasticity in a mouse model of fragile X mental retardation by Huber (2002)
  14. {'key': '10.1016/j.tins.2004.04.009_BIB14', 'series-title': 'Mechanistic Relationships between Development and Learning', 'first-page': '205', 'article-title': 'The role of LTD and LTP in development and learning', 'author': 'Bear', 'year': '1998'} / Mechanistic Relationships between Development and Learning / The role of LTD and LTP in development and learning by Bear (1998)
  15. 10.1113/jphysiol.1982.sp014103 / J. Physiol. / Climbing fibre induced depression of both mossy fibre responsiveness and glutamate sensitivity of cerebellar Purkinje cells by Ito (1982)
  16. {'key': '10.1016/j.tins.2004.04.009_BIB16', 'first-page': '85', 'article-title': 'Long term depression', 'volume': 'Vol. 12', 'author': 'Ito', 'year': '1989'} / Long term depression by Ito (1989)
  17. 10.1073/pnas.89.10.4363 / Proc. Natl. Acad. Sci. U. S. A. / Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-d-aspartate receptor blockade by Dudek (1992)
  18. 10.1016/0092-8674(94)90205-4 / Cell / Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice by Aiba (1994)
  19. 10.1016/0896-6273(94)90441-3 / Neuron / Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cells by Shigemoto (1994)
  20. 10.1016/S0896-6273(00)80336-0 / Neuron / Two distinct forms of long-term depression coexist in CA1 hippocampal pyramidal cells by Oliet (1997)
  21. 10.1016/S0092-8674(03)00122-3 / Cell / Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory by Lee (2003)
  22. 10.1016/S0028-3908(98)00222-6 / Neuropharmacology / Induction of LTD in the adult hippocampus by the synaptic activation of AMPA/kainate and metabotropic glutamate receptors by Kemp (1999)
  23. 10.1038/8123 / Nat. Neurosci. / Rapid redistribution of glutamate receptors contributes to long-term depression in hippocampal cultures by Carroll (1999)
  24. 10.1038/nn746 / Nat. Neurosci. / Internalization of ionotropic glutamate receptors in response to mGluR activation by Snyder (2001)
  25. 10.1126/science.288.5469.1254 / Science / Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression by Huber (2000)
  26. 10.1523/JNEUROSCI.20-22-08572.2000 / J. Neurosci. / Requirement of translation but not transcription for the maintenance of long-term depression in the CA1 region of freely moving rats by Manahan-Vaughan (2000)
  27. 10.1016/S0304-3940(02)01400-3 / Neurosci. Lett. / Anisomycin inhibits the late maintenance of long-term depression in rat hippocampal slices in vitro by Sajikumar (2003)
  28. 10.1152/jn.2001.86.1.321 / J. Neurophysiol. / Chemical induction of mGluR5- and protein synthesis-dependent long-term depression in hippocampal area CA1 by Huber (2001)
  29. 10.1523/JNEUROSCI.21-14-04943.2001 / J. Neurosci. / G(alpha)q-deficient mice lack metabotropic glutamate receptor-dependent long-term depression but show normal long-term potentiation in the hippocampal CA1 region by Kleppisch (2001)
  30. Huber, K.M. et al. (2001) Evidence for a novel signal transduction pathway in hippocampal mGluR-dependent LTD. Program number 388.7. In Abstract Viewer/Itinerary Planner, Society for Neuroscience Online.
  31. 10.1523/JNEUROSCI.0099-04.2004 / J. Neurosci. / Metabotropic glutamate receptor activation regulates fragile X mental retardation protein and FMR1 mRNA localization differentially in dendrites and at synapses by Antar (2004)
  32. 10.1073/pnas.94.10.5395 / Proc. Natl. Acad. Sci. U. S. A. / Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation by Weiler (1997)
  33. 10.1002/(SICI)1096-8628(19960809)64:2<246::AID-AJMG2>3.0.CO;2-S / Am. J. Med. Genet. / Long-term potentiation in the hippocampus of fragile X knockout mice by Godfraind (1996)
  34. 10.1016/S0306-4522(99)00285-7 / Neuroscience / Fragile X mouse: strain effects of knockout phenotype and evidence suggesting deficient amygdala function by Paradee (1999)
  35. 10.1097/00008480-200312000-00003 / Curr. Opin. Pediatr. / Understanding the biological underpinnings of fragile X syndrome by Chiurazzi (2003)
  36. 10.1016/S0968-0004(03)00033-1 / Trends Biochem. Sci. / New insights into fragile X syndrome: from molecules to neurobehaviors by Jin (2003)
  37. 10.1016/S0896-6273(03)00090-4 / Neuron / Sunrise at the synapse: the FMRP mRNP shaping the synaptic interface by Antar (2003)
  38. 10.1523/JNEUROSCI.17-05-01539.1997 / J. Neurosci. / Fragile X mental retardation protein: nucleocytoplasmic shuttling and association with somatodendritic ribosomes by Feng (1997)
  39. 10.1016/S1097-2765(00)80012-X / Mol. Cell / FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association by Feng (1997)
  40. 10.1016/S0092-8674(01)00568-2 / Cell / Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome by Brown (2001)
  41. 10.1016/S0092-8674(01)00566-9 / Cell / Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function by Darnell (2001)
  42. 10.1016/S0896-6273(03)00034-5 / Neuron / RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice by Miyashiro (2003)
  43. 10.1016/S0306-4522(03)00406-8 / Neuroscience / The fragile X mental retardation protein binds and regulates a novel class of mRNAs containing U rich target sequences by Chen (2003)
  44. 10.1016/S0092-8674(03)00079-5 / Cell / The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses by Zalfa (2003)
  45. 10.1523/JNEUROSCI.22-23-10232.2002 / J. Neurosci. / Dendritic BC1 RNA: functional role in regulation of translation initiation by Wang (2002)
  46. 10.1038/nn1174 / Nat. Neurosci. / Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway by Jin (2004)
  47. 10.1101/gad.1025202 / Genes Dev. / Fragile X-related protein and VIG associate with the RNA interference machinery by Caudy (2002)
  48. 10.1101/gad.1022002 / Genes Dev. / A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins by Ishizuka (2002)
  49. 10.1016/S0092-8674(01)00589-X / Cell / Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function by Zhang (2001)
  50. 10.1093/hmg/10.4.329 / Hum. Mol. Genet. / Evidence that fragile X mental retardation protein is a negative regulator of translation by Laggerbauer (2001)
  51. 10.1093/nar/29.11.2276 / Nucleic Acids Res. / The fragile X mental retardation protein inhibits translation via interacting with mRNA by Li (2001)
  52. 10.1073/pnas.2336265100 / Proc. Natl. Acad. Sci. U. S. A. / The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95 by Todd (2003)
  53. 10.1146/annurev.neuro.24.1.299 / Annu. Rev. Neurosci. / Protein synthesis at synaptic sites on dendrites by Steward (2001)
  54. 10.1016/S0896-6273(03)00635-4 / Neuron / Compartmentalized synthesis and degradation of proteins in neurons by Steward (2003)
  55. 10.1073/pnas.90.15.7168 / Proc. Natl. Acad. Sci. U. S. A. / Metabotropic glutamate receptors trigger postsynaptic protein synthesis by Weiler (1993)
  56. 10.1073/pnas.231485698 / Proc. Natl. Acad. Sci. U. S. A. / Identification of sites for exponential translation in living dendrites by Job (2001)
  57. 10.1152/jn.1998.80.2.989 / J. Neurophysiol. / Requirement of protein synthesis for group 1 mGluR-mediated induction of eplileptiform discharges by Merlin (1998)
  58. 10.1152/jn.2002.88.4.1625 / J. Neurophysiol. / Role of synaptic metabotropic glutamate receptors in epileptiform discharges in hippocampal slices by Lee (2002)
  59. 10.1523/JNEUROSCI.23-13-05634.2003 / J. Neurosci. / Activation of metabotropic glutamate 5 and NMDA receptors underlies the induction of persistent bursting and associated long-lasting changes in CA3 recurrent connections by Stoop (2003)
  60. 10.1152/jn.1996.76.2.953 / J. Neurophysiol. / Facilitation of long-term potentiation by prior activation of metabotropic glutamate receptors by Cohen (1996)
  61. 10.1007/BF02738403 / Exp. Brain Res. / An investigation of depotentiation of long-term potentiation in the CA1 region of the hippocampus by Bashir (1994)
  62. 10.1016/S0028-3908(97)00181-0 / Neuropharmacology / The group I mGlu receptor agonist DHPG induces a novel form of LTD in the CA1 region of the hippocampus by Palmer (1997)
  63. 10.1523/JNEUROSCI.20-03-00969.2000 / J. Neurosci. / Metabotropic glutamate receptors trigger homosynaptic protein synthesis to prolong LTP by Raymond (2000)
  64. 10.1523/JNEUROSCI.22-20-08838.2002 / J. Neurosci. / The group I metabotropic glutamate receptor agonist (S)-3,5-dihydroxyphenylglycine induces a novel form of depotentiation in the CA1 region of the hippocampus by Zho (2002)
  65. 10.1016/S0028-3908(01)00134-4 / Neuropharmacology / Metabotropic glutamate receptor activation causes a rapid redistribution of AMPA receptors by Xiao (2001)
  66. 10.1016/S0896-6273(02)00898-X / Neuron / Altered presynaptic vesicle release and cycling during mGluR-dependent LTD by Zakharenko (2002)
  67. 10.1073/pnas.032681099 / Proc. Natl. Acad. Sci. U. S. A. / Dendritic spines elongate after stimulation of group 1 metabotropic glutamate receptors in cultured hippocampal neurons by Vanderklish (2002)
  68. 10.1523/JNEUROSCI.09-08-02982.1989 / J. Neurosci. / Dendritic spines of CA 1 pyramidal cells in the rat hippocampus: serial electron microscopy with reference to their biophysical characteristics by Harris (1989)
  69. 10.1016/S0896-6273(00)80565-6 / Neuron / Cell type and pathway dependence of synaptic AMPA receptor number and variability in the hippocampus by Nusser (1998)
  70. 10.1523/JNEUROSCI.17-15-05858.1997 / J. Neurosci. / Quantitative ultrastructural analysis of hippocampal excitatory synapses by Schikorski (1997)
  71. 10.1152/jn.2001.86.1.280 / J. Neurophysiol. / Induction of long-term depression in cerebellar Purkinje cells requires a rapidly turned over protein by Karachot (2001)
  72. 10.1523/JNEUROSCI.22-12-05219.2002 / J. Neurosci. / The group I metabotropic glutamate receptor mGluR5 is required for fear memory formation and long-term potentiation in the lateral amygdala by Rodrigues (2002)
  73. 10.1038/sj.bjp.0703923 / Br. J. Pharmacol. / Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist by Tatarczynska (2001)
  74. 10.1006/nlme.1998.3843 / Neurobiol. Learn. Mem. / The basal ganglia and chunking of action repertoires by Graybiel (1998)
  75. 10.1016/S0028-3908(02)00214-9 / Neuropharmacology / Corticostriatal LTP requires combined mGluR1 and mGluR5 activation by Gubellini (2003)
  76. 10.1016/S0028-3908(99)00242-7 / Neuropharmacology / Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893) by Chapman (2000)
  77. 10.1016/S0306-4522(01)00036-7 / Neuroscience / Fragile X mice develop sensory hyperreactivity to auditory stimuli by Chen (2001)
  78. 10.1523/JNEUROSCI.23-32-10238.2003 / J. Neurosci. / Long-term enhancement of neuronal excitability and temporal fidelity mediated by metabotropic glutamate receptor subtype 5 by Sourdet (2003)
  79. 10.1023/A:1022606200636 / Brain Topogr. / Augmentation of auditory N1 in children with fragile X syndrome by Castren (2003)
  80. 10.1111/j.1460-9568.2003.03073.x / Eur. J. Neurosci. / Disruption of prepulse inhibition in mice lacking mGluR1 by Brody (2003)
  81. 10.1016/S0006-8993(01)03309-1 / Brain Res. / Alterations in the auditory startle response in Fmr1 targeted mutant mouse models of fragile X syndrome by Nielsen (2002)
  82. 10.1007/s00418-003-0540-5 / Histochem. Cell Biol. / Immunohistochemical expressions of mGluR5, P2Y2 receptor, PLC-beta1, and IP3R-I and -II in Merkel cells in rat sinus hair follicles by Tachibana (2003)
  83. 10.1016/S0028-3908(00)00114-3 / Neuropharmacology / mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia by Walker (2001)
  84. 10.1152/jn.1999.82.1.272 / J. Neurophysiol. / Role of metabotropic glutamate receptor subtype mGluR1 in brief nociception and central sensitization of primate STT cells by Neugebauer (1999)
  85. 10.1038/sj.bjp.0702980 / Br. J. Pharmacol. / Functional group I metabotropic glutamate receptors in submucous plexus of guinea-pig ileum by Hu (1999)
  86. 10.1523/JNEUROSCI.20-09-03200.2000 / J. Neurosci. / Agonist- and reflex-evoked internalization of metabotropic glutamate receptor 5 in enteric neurons by Liu (2000)
  87. 10.1038/nn1033 / Nat. Neurosci. / Translation of clock rhythmicity into neural firing in suprachiasmatic nucleus requires mGluR-PLCbeta4 signaling by Park (2003)
  88. 10.1016/S0896-6273(02)00731-6 / Neuron / Drosophila fragile X protein, DFXR, regulates neuronal morphology and function in the brain by Morales (2002)
  89. 10.1016/S0896-6273(02)00724-9 / Neuron / Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest by Dockendorff (2002)
  90. 10.1016/S0960-9822(02)01036-9 / Curr. Biol. / A role for the Drosophila fragile X-related gene in circadian output by Inoue (2002)
  91. {'key': '10.1016/j.tins.2004.04.009_BIB91', 'first-page': '131', 'article-title': 'From molecules to mental states', 'volume': '127', 'author': 'Bear', 'year': '1998', 'journal-title': 'Daedalus'} / Daedalus / From molecules to mental states by Bear (1998)
  92. Yan, Q. et al. (2003) Audiogenic seizures and effects of mGluR5 antagonist MPEP in the fMR1-tm1cgr Fragile X mouse. Program number 634.5. In Abstract Viewer/Itinerary Planner, Society for Neuroscience Online.
  93. 10.1523/JNEUROSCI.17-13-05196.1997 / J. Neurosci. / Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP by Lu (1997)
  94. 10.1016/S0165-6147(00)01694-1 / Trends Pharmacol. Sci. / Novel allosteric antagonists shed light on mglu(5) receptors and CNS disorders by Spooren (2001)
  95. 10.1038/24790 / Nature / Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein by Migaud (1998)
Dates
Type When
Created 21 years, 3 months ago (May 8, 2004, 7:37 a.m.)
Deposited 6 years, 6 months ago (Feb. 9, 2019, 10:57 a.m.)
Indexed 12 minutes ago (Aug. 30, 2025, 11:34 p.m.)
Issued 21 years, 1 month ago (July 1, 2004)
Published 21 years, 1 month ago (July 1, 2004)
Published Print 21 years, 1 month ago (July 1, 2004)
Funders 0

None

@article{Bear_2004, title={The mGluR theory of fragile X mental retardation}, volume={27}, ISSN={0166-2236}, url={http://dx.doi.org/10.1016/j.tins.2004.04.009}, DOI={10.1016/j.tins.2004.04.009}, number={7}, journal={Trends in Neurosciences}, publisher={Elsevier BV}, author={Bear, Mark F and Huber, Kimberly M and Warren, Stephen T}, year={2004}, month=jul, pages={370–377} }