DOI: 10.1016/j.tim.2015.12.004. The Interplay of Dengue Virus Morphological Diversity and Human Antibodies

The Interplay of Dengue Virus Morphological Diversity and Human Antibodies

10.1016/j.tim.2015.12.004

Crossref journal-article

Elsevier BV

Trends in Microbiology (78)

Bibliography

Lok, S.-M. (2016). The Interplay of Dengue Virus Morphological Diversity and Human Antibodies. Trends in Microbiology, 24(4), 284â293.

Authors 1

Shee-Mei Lok (first)

References 44 Referenced 49

10.1016/S0065-3527(03)60011-4 / Adv. Virus Res. / Neutralization and antibody-dependent enhancement of dengue viruses by Halstead (2003)
10.1016/S0140-6736(14)61060-6 / Lancet / Clinical efficacy and safety of a novel tetravalent dengue vaccine in healthy children in Asia: a phase 3, randomised, observer-masked, placebo-controlled trial by Capeding (2014)
10.1128/JVI.02641-13 / J. Virol. / Near-atomic resolution cryo-electron microscopic structure of dengue serotype 4 virus by Kostyuchenko (2014)
10.1016/S0092-8674(02)00660-8 / Cell / Structure of dengue virus: implications for flavivirus organization, maturation, and fusion by Kuhn (2002)
10.1038/nsmb.2463 / Nat. Struct. Mol. Biol. / Cryo-EM structure of the mature dengue virus at 3.5-A resolution by Zhang (2013)
10.1038/375291a0 / Nature / The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolution by Rey (1995)
10.1038/nature02165 / Nature / Structure of the dengue virus envelope protein after membrane fusion by Modis (2004)
10.1038/sj.emboj.7600064 / EMBO J. / Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformation by Bressanelli (2004)
10.1126/science.1153264 / Science / Structure of the immature dengue virus at low pH primes proteolytic maturation by Yu (2008)
10.1126/science.1153263 / Science / The flavivirus precursor membrane–envelope protein complex: structure and maturation by Li (2008)
10.1128/JVI.01637-09 / J. Virol. / Association of the pr peptides with dengue virus at acidic pH blocks membrane fusion by Yu (2009)
10.1128/JVI.00197-13 / J. Virol. / Immature and mature dengue serotype 1 virus structures provide insight into the maturation process by Kostyuchenko (2013)
10.1038/ncomms7341 / Nat. Commun. / A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins by Fibriansah (2015)
10.1016/j.cell.2005.11.042 / Cell / Cryo-EM reconstruction of dengue virus in complex with the carbohydrate recognition domain of DC-SIGN by Pokidysheva (2006)
10.1038/nm0897-866 / Nat. Med. / Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate by Chen (1997)
10.1099/vir.0.037317-0 / J. Gen. Virol. / Residues in domain III of the dengue virus envelope glycoprotein involved in cell-surface glycosaminoglycan binding by Watterson (2012)
10.1128/JVI.00757-13 / J. Virol. / Structural changes in dengue virus when exposed to a temperature of 37 degrees C by Fibriansah (2013)
10.1073/pnas.1304300110 / Proc. Natl. Acad. Sci. U.S.A. / Dengue structure differs at the temperatures of its human and mosquito hosts by Zhang (2013)
10.1126/science.aaa8651 / Science / DENGUE VIRUS. Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers by Fibriansah (2015)
10.1038/emboj.2009.245 / EMBO J. / Structural basis for the preferential recognition of immature flaviviruses by a fusion-loop antibody by Cherrier (2009)
10.1371/journal.ppat.1000718 / PLoS Pathog. / Immature dengue virus: a veiled pathogen? by Rodenhuis-Zybert (2010)
10.1371/journal.pone.0029957 / PLoS ONE / Antibodies against the envelope glycoprotein promote infectivity of immature dengue virus serotype 2 by da Silva Voorham (2012)
10.1371/journal.pone.0098785 / PLoS ONE / Immature dengue virus is infectious in human immature dendritic cells via interaction with the receptor molecule DC-SIGN by Richter (2014)
10.1038/ncomms4877 / Nat. Commun. / A toggle switch controls the low pH-triggered rearrangement and maturation of the dengue virus envelope proteins by Zheng (2014)
10.1038/embor.2011.75 / EMBO Rep. / Maturation of flaviviruses starts from one or more icosahedrally independent nucleation centres by Plevka (2011)
10.1128/JVI.00432-07 / J. Virol. / Type- and subcomplex-specific neutralizing antibodies against domain III of dengue virus type 2 envelope protein recognize adjacent epitopes by Sukupolvi-Petty (2007)
10.1073/pnas.1200566109 / Proc. Natl. Acad. Sci. U.S.A. / Identification of human neutralizing antibodies that bind to complex epitopes on dengue virions by de Alwis (2012)
10.1016/j.chom.2010.08.007 / Cell Host Microbe / The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity by Beltramello (2010)
10.1038/nature03956 / Nature / Structural basis of West Nile virus neutralization by a therapeutic antibody by Nybakken (2005)
10.1038/nsmb.1382 / Nat. Struct. Mol. Biol. / Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins by Lok (2008)
10.1016/j.str.2012.01.001 / Structure / Mechanism of dengue virus broad cross-neutralization by a monoclonal antibody by Cockburn (2012)
10.1371/journal.ppat.1002930 / PLoS Pathog. / Structural basis of differential neutralization of DENV-1 genotypes by an antibody that recognizes a cryptic epitope by Austin (2012)
10.4049/jimmunol.1200227 / J. Immunol. / Structural analysis of a dengue cross-reactive antibody complexed with envelope domain III reveals the molecular basis of cross-reactivity by Midgley (2012)
10.1073/pnas.0603488103 / Proc. Natl. Acad. Sci. U.S.A. / West Nile virus in complex with the Fab fragment of a neutralizing monoclonal antibody by Kaufmann (2006)
10.1371/journal.ppat.1000672 / PLoS Pathog. / Capturing a flavivirus pre-fusion intermediate by Kaufmann (2009)
10.1128/JVI.02411-14 / J. Virol. / Structure of acidic pH dengue virus showing the fusogenic glycoprotein trimers by Zhang (2015)
10.1371/journal.ppat.1002111 / PLoS Pathog. / A dynamic landscape for antibody binding modulates antibody-mediated neutralization of West Nile virus by Dowd (2011)
10.1128/JVI.01140-14 / J. Virol. / Combined effects of the structural heterogeneity and dynamics of flaviviruses on antibody recognition by Dowd (2014)
10.1038/emboj.2011.439 / EMBO J. / Structural insights into the neutralization mechanism of a higher primate antibody against dengue virus by Cockburn (2012)
10.1126/scitranslmed.3003888 / Sci. Transl. Med. / The structural basis for serotype-specific neutralization of dengue virus by a human antibody by Teoh (2012)
10.1002/emmm.201303404 / EMBO Mol. Med. / A potent anti-dengue human antibody preferentially recognizes the conformation of E protein monomers assembled on the virus surface by Fibriansah (2014)
10.1073/pnas.1011036107 / Proc. Natl. Acad. Sci. U.S.A. / Neutralization of West Nile virus by cross-linking of its surface proteins with Fab fragments of the human monoclonal antibody CR4354 by Kaufmann (2010)
10.1038/ni.3058 / Nat. Immunol. / A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus by Dejnirattisai (2015)
10.1038/nature14130 / Nature / Recognition determinants of broadly neutralizing human antibodies against dengue viruses by Rouvinski (2015)

Dates

Type	When
Created	9 years, 7 months ago (Dec. 30, 2015, 10 a.m.)
Deposited	3 years, 1 month ago (July 6, 2022, 3:30 a.m.)
Indexed	4 weeks, 2 days ago (July 30, 2025, 11:25 a.m.)
Issued	9 years, 4 months ago (April 1, 2016)
Published	9 years, 4 months ago (April 1, 2016)
Published Print	9 years, 4 months ago (April 1, 2016)

Funders 1

Ministry of Education - Singapore 10.13039/501100001459
Region: Asia
gov (National government)
Labels5
1. Ministry of Education
2. Ministry of Education (Singapore)
3. MOE Singapore
4. Ministry of Education, Singapore
5. MOE
Awards1
1. MOE2012-T3-1-008

BibTeX

@article{Lok_2016, title={The Interplay of Dengue Virus Morphological Diversity and Human Antibodies}, volume={24}, ISSN={0966-842X}, url={http://dx.doi.org/10.1016/j.tim.2015.12.004}, DOI={10.1016/j.tim.2015.12.004}, number={4}, journal={Trends in Microbiology}, publisher={Elsevier BV}, author={Lok, Shee-Mei}, year={2016}, month=apr, pages={284–293} }

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      "volume": "384",
      "author": "Capeding",
      "year": "2014",
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      "author": "Kostyuchenko",
      "year": "2014",
      "journal-title": "J. Virol."
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      "doi-asserted-by": "crossref",
      "first-page": "717",
      "DOI": "10.1016/S0092-8674(02)00660-8",
      "article-title": "Structure of dengue virus: implications for flavivirus organization, maturation, and fusion",
      "volume": "108",
      "author": "Kuhn",
      "year": "2002",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.tim.2015.12.004_bib0245",
      "doi-asserted-by": "crossref",
      "first-page": "105",
      "DOI": "10.1038/nsmb.2463",
      "article-title": "Cryo-EM structure of the mature dengue virus at 3.5-A resolution",
      "volume": "20",
      "author": "Zhang",
      "year": "2013",
      "journal-title": "Nat. Struct. Mol. Biol."
    },
    {
      "key": "10.1016/j.tim.2015.12.004_bib0250",
      "doi-asserted-by": "crossref",
      "first-page": "291",
      "DOI": "10.1038/375291a0",
      "article-title": "The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolution",
      "volume": "375",
      "author": "Rey",
      "year": "1995",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.tim.2015.12.004_bib0255",
      "doi-asserted-by": "crossref",
      "first-page": "313",
      "DOI": "10.1038/nature02165",
      "article-title": "Structure of the dengue virus envelope protein after membrane fusion",
      "volume": "427",
      "author": "Modis",
      "year": "2004",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.tim.2015.12.004_bib0260",
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      "article-title": "Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformation",
      "volume": "23",
      "author": "Bressanelli",
      "year": "2004",
      "journal-title": "EMBO J."
    },
    {
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      "doi-asserted-by": "crossref",
      "first-page": "1834",
      "DOI": "10.1126/science.1153264",
      "article-title": "Structure of the immature dengue virus at low pH primes proteolytic maturation",
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      "author": "Yu",
      "year": "2008",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.tim.2015.12.004_bib0440",
      "doi-asserted-by": "crossref",
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      "author": "Li",
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      "author": "Kostyuchenko",
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      "journal-title": "J. Virol."
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      "author": "Fibriansah",
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      "volume": "3",
      "author": "Chen",
      "year": "1997",
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      "doi-asserted-by": "crossref",
      "first-page": "72",
      "DOI": "10.1099/vir.0.037317-0",
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      "volume": "93",
      "author": "Watterson",
      "year": "2012",
      "journal-title": "J. Gen. Virol."
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      "volume": "87",
      "author": "Fibriansah",
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      "author": "Fibriansah",
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      "volume": "28",
      "author": "Cherrier",
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      "author": "Rodenhuis-Zybert",
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      "volume": "7",
      "author": "da Silva Voorham",
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      "first-page": "3877",
      "DOI": "10.1038/ncomms4877",
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      "volume": "5",
      "author": "Zheng",
      "year": "2014",
      "journal-title": "Nat. Commun."
    },
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      "first-page": "602",
      "DOI": "10.1038/embor.2011.75",
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      "volume": "12",
      "author": "Plevka",
      "year": "2011",
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      "first-page": "12816",
      "DOI": "10.1128/JVI.00432-07",
      "article-title": "Type- and subcomplex-specific neutralizing antibodies against domain III of dengue virus type 2 envelope protein recognize adjacent epitopes",
      "volume": "81",
      "author": "Sukupolvi-Petty",
      "year": "2007",
      "journal-title": "J. Virol."
    },
    {
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      "first-page": "7439",
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      "article-title": "Identification of human neutralizing antibodies that bind to complex epitopes on dengue virions",
      "volume": "109",
      "author": "de Alwis",
      "year": "2012",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
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      "first-page": "271",
      "DOI": "10.1016/j.chom.2010.08.007",
      "article-title": "The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity",
      "volume": "8",
      "author": "Beltramello",
      "year": "2010",
      "journal-title": "Cell Host Microbe"
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      "first-page": "764",
      "DOI": "10.1038/nature03956",
      "article-title": "Structural basis of West Nile virus neutralization by a therapeutic antibody",
      "volume": "43",
      "author": "Nybakken",
      "year": "2005",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.tim.2015.12.004_bib0365",
      "doi-asserted-by": "crossref",
      "first-page": "312",
      "DOI": "10.1038/nsmb.1382",
      "article-title": "Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins",
      "volume": "15",
      "author": "Lok",
      "year": "2008",
      "journal-title": "Nat. Struct. Mol. Biol."
    },
    {
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      "doi-asserted-by": "crossref",
      "first-page": "303",
      "DOI": "10.1016/j.str.2012.01.001",
      "article-title": "Mechanism of dengue virus broad cross-neutralization by a monoclonal antibody",
      "volume": "20",
      "author": "Cockburn",
      "year": "2012",
      "journal-title": "Structure"
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    {
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      "first-page": "e1002930",
      "DOI": "10.1371/journal.ppat.1002930",
      "article-title": "Structural basis of differential neutralization of DENV-1 genotypes by an antibody that recognizes a cryptic epitope",
      "volume": "8",
      "author": "Austin",
      "year": "2012",
      "journal-title": "PLoS Pathog."
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      "DOI": "10.4049/jimmunol.1200227",
      "article-title": "Structural analysis of a dengue cross-reactive antibody complexed with envelope domain III reveals the molecular basis of cross-reactivity",
      "volume": "188",
      "author": "Midgley",
      "year": "2012",
      "journal-title": "J. Immunol."
    },
    {
      "key": "10.1016/j.tim.2015.12.004_bib0385",
      "doi-asserted-by": "crossref",
      "first-page": "12400",
      "DOI": "10.1073/pnas.0603488103",
      "article-title": "West Nile virus in complex with the Fab fragment of a neutralizing monoclonal antibody",
      "volume": "103",
      "author": "Kaufmann",
      "year": "2006",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "10.1016/j.tim.2015.12.004_bib0390",
      "doi-asserted-by": "crossref",
      "first-page": "e1000672",
      "DOI": "10.1371/journal.ppat.1000672",
      "article-title": "Capturing a flavivirus pre-fusion intermediate",
      "volume": "5",
      "author": "Kaufmann",
      "year": "2009",
      "journal-title": "PLoS Pathog."
    },
    {
      "key": "10.1016/j.tim.2015.12.004_bib0395",
      "doi-asserted-by": "crossref",
      "first-page": "743",
      "DOI": "10.1128/JVI.02411-14",
      "article-title": "Structure of acidic pH dengue virus showing the fusogenic glycoprotein trimers",
      "volume": "89",
      "author": "Zhang",
      "year": "2015",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/j.tim.2015.12.004_bib0400",
      "doi-asserted-by": "crossref",
      "first-page": "e1002111",
      "DOI": "10.1371/journal.ppat.1002111",
      "article-title": "A dynamic landscape for antibody binding modulates antibody-mediated neutralization of West Nile virus",
      "volume": "7",
      "author": "Dowd",
      "year": "2011",
      "journal-title": "PLoS Pathog."
    },
    {
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      "doi-asserted-by": "crossref",
      "first-page": "11726",
      "DOI": "10.1128/JVI.01140-14",
      "article-title": "Combined effects of the structural heterogeneity and dynamics of flaviviruses on antibody recognition",
      "volume": "88",
      "author": "Dowd",
      "year": "2014",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/j.tim.2015.12.004_bib0410",
      "doi-asserted-by": "crossref",
      "first-page": "767",
      "DOI": "10.1038/emboj.2011.439",
      "article-title": "Structural insights into the neutralization mechanism of a higher primate antibody against dengue virus",
      "volume": "31",
      "author": "Cockburn",
      "year": "2012",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.tim.2015.12.004_bib0415",
      "doi-asserted-by": "crossref",
      "first-page": "139ra183",
      "DOI": "10.1126/scitranslmed.3003888",
      "article-title": "The structural basis for serotype-specific neutralization of dengue virus by a human antibody",
      "volume": "4",
      "author": "Teoh",
      "year": "2012",
      "journal-title": "Sci. Transl. Med."
    },
    {
      "key": "10.1016/j.tim.2015.12.004_bib0420",
      "doi-asserted-by": "crossref",
      "first-page": "358",
      "DOI": "10.1002/emmm.201303404",
      "article-title": "A potent anti-dengue human antibody preferentially recognizes the conformation of E protein monomers assembled on the virus surface",
      "volume": "6",
      "author": "Fibriansah",
      "year": "2014",
      "journal-title": "EMBO Mol. Med."
    },
    {
      "key": "10.1016/j.tim.2015.12.004_bib0425",
      "doi-asserted-by": "crossref",
      "first-page": "18950",
      "DOI": "10.1073/pnas.1011036107",
      "article-title": "Neutralization of West Nile virus by cross-linking of its surface proteins with Fab fragments of the human monoclonal antibody CR4354",
      "volume": "107",
      "author": "Kaufmann",
      "year": "2010",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "10.1016/j.tim.2015.12.004_bib0430",
      "doi-asserted-by": "crossref",
      "first-page": "170",
      "DOI": "10.1038/ni.3058",
      "article-title": "A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus",
      "volume": "16",
      "author": "Dejnirattisai",
      "year": "2015",
      "journal-title": "Nat. Immunol."
    },
    {
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      "first-page": "109",
      "DOI": "10.1038/nature14130",
      "article-title": "Recognition determinants of broadly neutralizing human antibodies against dengue viruses",
      "volume": "520",
      "author": "Rouvinski",
      "year": "2015",
      "journal-title": "Nature"
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