DOI: 10.1016/j.tibs.2005.09.005. Mammalian cyclin-dependent kinases

10.1016/j.tibs.2005.09.005

Crossref journal-article

Elsevier BV

Trends in Biochemical Sciences (78)

Bibliography

Malumbres, M., & Barbacid, M. (2005). Mammalian cyclin-dependent kinases. Trends in Biochemical Sciences, 30(11), 630â641.

Authors 2

Marcos Malumbres (first)
Mariano Barbacid (additional)

References 91 Referenced 975

10.1016/0092-8674(86)90550-7 / Cell / Schizosaccharomyces pombe and Saccharomyces cerevisiae: a look at yeasts divided by Russell (1986)
10.1016/0092-8674(87)90227-3 / Cell / Identification of p34 and p13, human homologs of the cell cycle regulators of fission yeast encoded by cdc2+ and suc1+ by Draetta (1987)
10.1038/327031a0 / Nature / Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2 by Lee (1987)
10.1073/pnas.84.2.388 / Proc. Natl. Acad. Sci. U. S. A. / Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family by Hanks (1987)
10.1002/j.1460-2075.1991.tb07808.x / EMBO J. / A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1 by Elledge (1991)
10.1073/pnas.88.3.1039 / Proc. Natl. Acad. Sci. U. S. A. / Cloning by differential screening of a Xenopus cDNA coding for a protein highly homologous to cdc2 by Paris (1991)
10.1038/353174a0 / Nature / Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase by Tsai (1991)
10.1073/pnas.88.20.9006 / Proc. Natl. Acad. Sci. U. S. A. / Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation by Ninomiya-Tsuji (1991)
10.1002/j.1460-2075.1992.tb05360.x / EMBO J. / A family of cdc2-related protein kinases by Meyerson (1992)
10.1016/0092-8674(92)90360-O / Cell / Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins by Matsushime (1992)
10.1016/0092-8674(92)90518-H / Cell / D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA by Xiong (1992)
10.1073/pnas.89.22.10867 / Proc. Natl. Acad. Sci. U. S. A. / Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression by Hellmich (1992)
10.1016/0092-8674(94)90535-5 / Cell / A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase by Fisher (1994)
10.1073/pnas.92.19.8871 / Proc. Natl. Acad. Sci. U. S. A. / Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C by Tassan (1995)
10.1073/pnas.91.9.3834 / Proc. Natl. Acad. Sci. U. S. A. / PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro by Graña (1994)
{'key': '10.1016/j.tibs.2005.09.005_bib16', 'first-page': '2097', 'article-title': 'PISSLRE, a human novel CDC2-related protein kinase', 'volume': '9', 'author': 'Graña', 'year': '1994', 'journal-title': 'Oncogene'} / Oncogene / PISSLRE, a human novel CDC2-related protein kinase by Graña (1994)
10.1016/S0021-9258(17)40749-6 / J. Biol. Chem. / Molecular cloning and expression of alternatively spliced PITSLRE protein kinase isoforms by Xiang (1994)
10.1016/0092-8674(83)90420-8 / Cell / Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division by Evans (1983)
10.1016/0955-0674(89)90099-9 / Curr. Opin. Cell Biol. / Maturation promoting factor, cyclin and the control of M-phase by Hunt (1989)
10.1038/344503a0 / Nature / Universal control mechanism regulating onset of M-phase by Nurse (1990)
10.1016/0960-9822(91)90193-Z / Curr. Biol. / Population explosion in the cyclin family by Xiong (1991)
10.1101/gad.13.12.1501 / Genes Dev. / CDK inhibitors: positive and negative regulators of G1-phase progression by Sherr (1999)
10.1038/35106065 / Nat. Rev. Cancer / To cycle or not to cycle: a critical decision in cancer by Malumbres (2001)
10.1038/sj.onc.1208608 / Oncogene / Cell cycle in mouse development by Ciemerych (2005)
10.1038/sj.onc.1208619 / Oncogene / Pocket proteins and cell cycle control by Cobrinik (2005)
10.1101/gad.847700 / Genes Dev. / Ablation of the retinoblastoma gene family deregulates G1 control causing immortalization and increased cell turnover under growth-restricting conditions by Dannenberg (2000)
10.1101/gad.843200 / Genes Dev. / Targeted disruption of the three Rb-related genes leads to loss of G1 control and immortalization by Sage (2000)
10.1016/S0092-8674(04)00300-9 / Cell / Cyclin C/Cdk3 promotes Rb-dependent G0 exit by Ren (2004)
10.1101/gad.10.7.851 / Genes Dev. / Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit by Hofmann (1996)
10.1073/pnas.041596198 / Proc. Natl. Acad. Sci. U. S. A. / A premature-termination mutation in the Mus musculus cyclin-dependent kinase 3 gene by Ye (2001)
10.1038/sj.onc.1208613 / Oncogene / Cyclin E in normal and neoplastic cell cycles by Hwang (2005)
10.1074/jbc.M203951200 / J. Biol. Chem. / Characterization and expression of mammalian cyclin B3, a prepachytene meiotic cyclin by Nguyen (2002)
10.1038/35048096 / Nat. Rev. Mol. Cell Biol. / Mitotic kinases as regulators of cell division and its checkpoints by Nigg (2001)
10.1038/nature02062 / Nature / Targets of the cyclin-dependent kinase Cdk1 by Ubersax (2003)
10.1101/gad.1013102 / Genes Dev. / The anaphase-promoting complex: it's not just for mitosis any more by Harper (2002)
10.1016/j.bbapap.2003.11.020 / Biochim. Biophys. Acta / Neuronal cyclin-dependent kinase 5: role in nervous system function and its specific inhibition by the Cdk5 inhibitory peptide by Kesavapany (2004)
10.1016/j.conb.2004.05.002 / Curr. Opin. Neurobiol. / A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease by Cruz (2004)
10.4161/cc.4.4.1607 / Cell Cycle / CAK – cyclin-dependent activating kinase: a key kinase in cell cycle control and a target for drugs? by Lolli (2005)
10.1038/35024111 / Nature / TFIIH is negatively regulated by cdk8-containing mediator complexes by Akoulitchev (2000)
10.1016/j.gene.2004.05.007 / Gene / Cellular control of gene expression by T-type cyclin/CDK9 complexes by Garriga (2004)
10.1038/sj.onc.1204295 / Oncogene / Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity by Kasten (2001)
10.1016/j.cellsig.2005.02.005 / Cell. Signal. / Role of CDK/cyclin complexes in transcription and RNA splicing by Loyer (2005)
10.1038/8751 / Nat. Genet. / Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-cell hyperplasia by Rane (1999)
10.1128/MCB.19.10.7011 / Mol. Cell. Biol. / Targeted disruption of Cdk4 delays cell cycle entry with enhanced p27Kip1 activity by Tsutsui (1999)
10.1016/j.cell.2004.08.002 / Cell / Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6 by Malumbres (2004)
10.1038/sj.onc.1206506 / Oncogene / Genetic rescue of Cdk4 null mice restores pancreatic β-cell proliferation but not homeostatic cell number by Martin (2003)
10.1210/en.143.8.3001 / Endocrinology / Pituitary hypoplasia and lactotroph dysfunction in mice deficient for cyclin-dependent kinase-4 by Moons (2002)
10.1016/j.cell.2004.07.025 / Cell / Mouse development and cell proliferation in the absence of D-cyclins by Kozar (2004)
10.1038/ng1232 / Nat. Genet. / Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice by Ortega (2003)
10.1016/j.cub.2003.09.024 / Curr. Biol. / Cdk2 knockout mice are viable by Berthet (2003)
10.1016/j.ccr.2005.05.006 / Cancer Cell / Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27Kip1 and p21Cip1 by Martin (2005)
10.1038/ncb1284 / Nat. Cell Biol. / Cdc2–cyclin E complexes regulate the G1/S phase transition by Aleem (2005)
10.1093/emboj/cdg482 / EMBO J. / Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells by Parisi (2003)
10.1016/S0092-8674(03)00645-7 / Cell / Cyclin E ablation in the mouse by Geng (2003)
Murphy, M. et al. (1997) Delayed early embryonic lethality following disruption of the murine cyclin A2 gene. Nat. Genet. 15, 83–86; erratum ibid (1999) Nat. Genet. 23, 481 (10.1038/70612)
10.1073/pnas.95.8.4344 / Proc. Natl. Acad. Sci. U. S. A. / Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero by Brandeis (1998)
10.1038/3855 / Nat. Genet. / Cyclin A1 is required for meiosis in the male mouse by Liu (1998)
10.1073/pnas.93.20.11173 / Proc. Natl. Acad. Sci. U. S. A. / Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death by Ohshima (1996)
10.1101/gad.10.7.816 / Genes Dev. / The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation by Nikolic (1996)
10.1523/JNEUROSCI.21-02-00550.2001 / J. Neurosci. / Neuronal cyclin-dependent kinase 5 activity is critical for survival by Tanaka (2001)
10.1523/JNEUROSCI.21-17-06758.2001 / J. Neurosci. / p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment by Ko (2001)
10.1093/emboj/20.11.2844 / EMBO J. / Inability to enter S phase and defective RNA polymerase II CTD phosphorylation in mice lacking Mat1 by Rossi (2001)
10.1242/jcs.00121 / J. Cell Sci. / Conditional ablation of the Mat1 subunit of TFIIH in Schwann cells provides evidence that Mat1 is not required for general transcription by Korsisaari (2002)
10.1128/MCB.24.8.3188-3197.2004 / Mol. Cell. Biol. / Failure to proliferate and mitotic arrest of CDK11p110/p58-null mutant mice at the blastocyst stage of embryonic cell development by Li (2004)
{'key': '10.1016/j.tibs.2005.09.005_bib65', 'first-page': '73', 'article-title': 'Cyclin D-dependent kinases, INK4 inhibitors and cancer', 'volume': '1602', 'author': 'Ortega', 'year': '2002', 'journal-title': 'Biochim. Biophys. Acta'} / Biochim. Biophys. Acta / Cyclin D-dependent kinases, INK4 inhibitors and cancer by Ortega (2002)
10.1126/science.7652577 / Science / A p16Ink4a-insensitive Cdk4 mutant targeted by cytolytic T lymphocytes in a human melanoma by Wolfel (1995)
10.1038/sj.onc.1203033 / Oncogene / Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations by Corcoran (1999)
10.1182/blood-2003-04-1220 / Blood / In B-cell chronic lymphocytic leukemias, 7q21 translocations lead to overexpression of the CDK6 gene by Hayette (2003)
10.1093/emboj/20.23.6637 / EMBO J. / Wide spectrum of tumors in knock in mice carrying a Cdk4 protein insensitive to INK4 inhibitors by Sotillo (2001)
10.1073/pnas.241338598 / Proc. Natl. Acad. Sci. U. S. A. / Invasive melanoma in Cdk4 targeted mice by Sotillo (2001)
10.1016/S0165-6147(02)02071-0 / Trends Pharmacol. Sci. / Pharmacological inhibitors of cyclin-dependent kinases by Knockaert (2002)
10.1038/35082500 / Nature / Specific protection against breast cancers by cyclin D1 ablation by Yu (2001)
10.1101/gad.1033002 / Genes Dev. / Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence by Zou (2002)
10.1128/MCB.24.17.7538-7547.2004 / Mol. Cell. Biol. / Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues by Miliani de Marval (2004)
10.1016/S1535-6108(03)00053-9 / Cancer Cell / Proliferation of cancer cells despite CDK2 inhibition by Tetsu (2003)
10.1002/j.1460-2075.1994.tb06955.x / EMBO J. / Human cyclin F by Bai (1994)
10.1093/emboj/19.6.1378 / EMBO J. / Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin–cyclin interaction by Kong (2000)
10.1128/MCB.24.6.2487-2498.2004 / Mol. Cell. Biol. / Cyclin F disruption compromises placental development and affects normal cell cycle execution by Tetzlaff (2004)
10.1016/S1534-5807(02)00182-X / Dev. Cell / Cyclin G: a regulator of the p53–Mdm2 network by Chen (2002)
10.1038/sj.onc.1204270 / Oncogene / Cyclin G1 is involved in G2/M arrest in response to DNA damage and in growth control after damage recovery by Kimura (2001)
10.1073/pnas.0403175101 / Proc. Natl. Acad. Sci. U. S. A. / Serine/threonine kinase cyclin G-associated kinase regulates epidermal growth factor receptor signaling by Zhang (2004)
10.1006/excr.1995.1406 / Exp. Cell Res. / Cyclin I: a new cyclin encoded by a gene isolated from human brain by Nakamura (1995)
10.1006/dbio.2000.9916 / Dev. Biol. / A role for cyclin J in the rapid nuclear division cycles of early Drosophila embryogenesis by Kolonin (2000)
10.1016/S0378-1119(02)01210-6 / Gene / Molecular cloning and characterization of a novel gene family of four ancient conserved domain proteins (ACDP) by Wang (2003)
10.1038/sj.onc.1205996 / Oncogene / Uracil in DNA – occurrence, consequences and repair by Krokan (2002)
10.1111/j.0953-816X.2003.03128.x / Eur. J. Neurosci. / Cyclin S: a new member of the cyclin family plays a role in long-term memory by Edelheit (2004)
10.4161/cc.4.2.1410 / Cell Cycle / Revisiting the ‘Cdk-centric’ view of the mammalian cell cycle by Malumbres (2005)
10.1006/jmbi.1999.2640 / J. Mol. Biol. / Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors by Pavletich (1999)
10.1038/sj.onc.1206019 / Oncogene / Activation of cyclin D1-kinase in murine fibroblasts lacking both p21Cip1 and p27Kip1 by Sugimoto (2002)
10.1128/MCB.23.20.7285-7290.2003 / Mol. Cell. Biol. / P27Kip1 and p21Cip1 are not required for the formation of active D cyclin–cdk4 complexes by Bagui (2003)
10.1093/nar/25.24.4876 / Nucleic Acids Res. / The ClustalX windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools by Thompson (1997)

Dates

Type	When
Created	19 years, 10 months ago (Oct. 20, 2005, 10:20 a.m.)
Deposited	4 years, 1 month ago (July 18, 2021, 2:33 p.m.)
Indexed	1 day, 1 hour ago (Aug. 27, 2025, 11:37 a.m.)
Issued	19 years, 9 months ago (Nov. 1, 2005)
Published	19 years, 9 months ago (Nov. 1, 2005)
Published Print	19 years, 9 months ago (Nov. 1, 2005)

Funders 0

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BibTeX

@article{Malumbres_2005, title={Mammalian cyclin-dependent kinases}, volume={30}, ISSN={0968-0004}, url={http://dx.doi.org/10.1016/j.tibs.2005.09.005}, DOI={10.1016/j.tibs.2005.09.005}, number={11}, journal={Trends in Biochemical Sciences}, publisher={Elsevier BV}, author={Malumbres, Marcos and Barbacid, Mariano}, year={2005}, month=nov, pages={630–641} }

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      "volume": "269",
      "author": "Xiang",
      "year": "1994",
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    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "389",
      "DOI": "10.1016/0092-8674(83)90420-8",
      "article-title": "Cyclin: a protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division",
      "volume": "33",
      "author": "Evans",
      "year": "1983",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "268",
      "DOI": "10.1016/0955-0674(89)90099-9",
      "article-title": "Maturation promoting factor, cyclin and the control of M-phase",
      "volume": "1",
      "author": "Hunt",
      "year": "1989",
      "journal-title": "Curr. Opin. Cell Biol."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "503",
      "DOI": "10.1038/344503a0",
      "article-title": "Universal control mechanism regulating onset of M-phase",
      "volume": "344",
      "author": "Nurse",
      "year": "1990",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "362",
      "DOI": "10.1016/0960-9822(91)90193-Z",
      "article-title": "Population explosion in the cyclin family",
      "volume": "1",
      "author": "Xiong",
      "year": "1991",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "1501",
      "DOI": "10.1101/gad.13.12.1501",
      "article-title": "CDK inhibitors: positive and negative regulators of G1-phase progression",
      "volume": "13",
      "author": "Sherr",
      "year": "1999",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "222",
      "DOI": "10.1038/35106065",
      "article-title": "To cycle or not to cycle: a critical decision in cancer",
      "volume": "1",
      "author": "Malumbres",
      "year": "2001",
      "journal-title": "Nat. Rev. Cancer"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "2877",
      "DOI": "10.1038/sj.onc.1208608",
      "article-title": "Cell cycle in mouse development",
      "volume": "24",
      "author": "Ciemerych",
      "year": "2005",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "2796",
      "DOI": "10.1038/sj.onc.1208619",
      "article-title": "Pocket proteins and cell cycle control",
      "volume": "24",
      "author": "Cobrinik",
      "year": "2005",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "3051",
      "DOI": "10.1101/gad.847700",
      "article-title": "Ablation of the retinoblastoma gene family deregulates G1 control causing immortalization and increased cell turnover under growth-restricting conditions",
      "volume": "14",
      "author": "Dannenberg",
      "year": "2000",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "3037",
      "DOI": "10.1101/gad.843200",
      "article-title": "Targeted disruption of the three Rb-related genes leads to loss of G1 control and immortalization",
      "volume": "14",
      "author": "Sage",
      "year": "2000",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "239",
      "DOI": "10.1016/S0092-8674(04)00300-9",
      "article-title": "Cyclin C/Cdk3 promotes Rb-dependent G0 exit",
      "volume": "117",
      "author": "Ren",
      "year": "2004",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "851",
      "DOI": "10.1101/gad.10.7.851",
      "article-title": "Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit",
      "volume": "10",
      "author": "Hofmann",
      "year": "1996",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "1682",
      "DOI": "10.1073/pnas.041596198",
      "article-title": "A premature-termination mutation in the Mus musculus cyclin-dependent kinase 3 gene",
      "volume": "98",
      "author": "Ye",
      "year": "2001",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "2776",
      "DOI": "10.1038/sj.onc.1208613",
      "article-title": "Cyclin E in normal and neoplastic cell cycles",
      "volume": "24",
      "author": "Hwang",
      "year": "2005",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "41960",
      "DOI": "10.1074/jbc.M203951200",
      "article-title": "Characterization and expression of mammalian cyclin B3, a prepachytene meiotic cyclin",
      "volume": "277",
      "author": "Nguyen",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "21",
      "DOI": "10.1038/35048096",
      "article-title": "Mitotic kinases as regulators of cell division and its checkpoints",
      "volume": "2",
      "author": "Nigg",
      "year": "2001",
      "journal-title": "Nat. Rev. Mol. Cell Biol."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "859",
      "DOI": "10.1038/nature02062",
      "article-title": "Targets of the cyclin-dependent kinase Cdk1",
      "volume": "425",
      "author": "Ubersax",
      "year": "2003",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "2179",
      "DOI": "10.1101/gad.1013102",
      "article-title": "The anaphase-promoting complex: it's not just for mitosis any more",
      "volume": "16",
      "author": "Harper",
      "year": "2002",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "143",
      "DOI": "10.1016/j.bbapap.2003.11.020",
      "article-title": "Neuronal cyclin-dependent kinase 5: role in nervous system function and its specific inhibition by the Cdk5 inhibitory peptide",
      "volume": "1697",
      "author": "Kesavapany",
      "year": "2004",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "390",
      "DOI": "10.1016/j.conb.2004.05.002",
      "article-title": "A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease",
      "volume": "14",
      "author": "Cruz",
      "year": "2004",
      "journal-title": "Curr. Opin. Neurobiol."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "572",
      "DOI": "10.4161/cc.4.4.1607",
      "article-title": "CAK \u2013 cyclin-dependent activating kinase: a key kinase in cell cycle control and a target for drugs?",
      "volume": "4",
      "author": "Lolli",
      "year": "2005",
      "journal-title": "Cell Cycle"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "102",
      "DOI": "10.1038/35024111",
      "article-title": "TFIIH is negatively regulated by cdk8-containing mediator complexes",
      "volume": "407",
      "author": "Akoulitchev",
      "year": "2000",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "15",
      "DOI": "10.1016/j.gene.2004.05.007",
      "article-title": "Cellular control of gene expression by T-type cyclin/CDK9 complexes",
      "volume": "337",
      "author": "Garriga",
      "year": "2004",
      "journal-title": "Gene"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "1832",
      "DOI": "10.1038/sj.onc.1204295",
      "article-title": "Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity",
      "volume": "20",
      "author": "Kasten",
      "year": "2001",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "1033",
      "DOI": "10.1016/j.cellsig.2005.02.005",
      "article-title": "Role of CDK/cyclin complexes in transcription and RNA splicing",
      "volume": "17",
      "author": "Loyer",
      "year": "2005",
      "journal-title": "Cell. Signal."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "44",
      "DOI": "10.1038/8751",
      "article-title": "Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in \u03b2-cell hyperplasia",
      "volume": "22",
      "author": "Rane",
      "year": "1999",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib44",
      "doi-asserted-by": "crossref",
      "first-page": "7011",
      "DOI": "10.1128/MCB.19.10.7011",
      "article-title": "Targeted disruption of Cdk4 delays cell cycle entry with enhanced p27Kip1 activity",
      "volume": "19",
      "author": "Tsutsui",
      "year": "1999",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib45",
      "doi-asserted-by": "crossref",
      "first-page": "493",
      "DOI": "10.1016/j.cell.2004.08.002",
      "article-title": "Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6",
      "volume": "118",
      "author": "Malumbres",
      "year": "2004",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib46",
      "doi-asserted-by": "crossref",
      "first-page": "5261",
      "DOI": "10.1038/sj.onc.1206506",
      "article-title": "Genetic rescue of Cdk4 null mice restores pancreatic \u03b2-cell proliferation but not homeostatic cell number",
      "volume": "22",
      "author": "Martin",
      "year": "2003",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib47",
      "doi-asserted-by": "crossref",
      "first-page": "3001",
      "DOI": "10.1210/en.143.8.3001",
      "article-title": "Pituitary hypoplasia and lactotroph dysfunction in mice deficient for cyclin-dependent kinase-4",
      "volume": "143",
      "author": "Moons",
      "year": "2002",
      "journal-title": "Endocrinology"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib48",
      "doi-asserted-by": "crossref",
      "first-page": "477",
      "DOI": "10.1016/j.cell.2004.07.025",
      "article-title": "Mouse development and cell proliferation in the absence of D-cyclins",
      "volume": "118",
      "author": "Kozar",
      "year": "2004",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib49",
      "doi-asserted-by": "crossref",
      "first-page": "25",
      "DOI": "10.1038/ng1232",
      "article-title": "Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice",
      "volume": "35",
      "author": "Ortega",
      "year": "2003",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib50",
      "doi-asserted-by": "crossref",
      "first-page": "1775",
      "DOI": "10.1016/j.cub.2003.09.024",
      "article-title": "Cdk2 knockout mice are viable",
      "volume": "13",
      "author": "Berthet",
      "year": "2003",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib51",
      "doi-asserted-by": "crossref",
      "first-page": "591",
      "DOI": "10.1016/j.ccr.2005.05.006",
      "article-title": "Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27Kip1 and p21Cip1",
      "volume": "7",
      "author": "Martin",
      "year": "2005",
      "journal-title": "Cancer Cell"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib52",
      "doi-asserted-by": "crossref",
      "first-page": "831",
      "DOI": "10.1038/ncb1284",
      "article-title": "Cdc2\u2013cyclin E complexes regulate the G1/S phase transition",
      "volume": "7",
      "author": "Aleem",
      "year": "2005",
      "journal-title": "Nat. Cell Biol."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib53",
      "doi-asserted-by": "crossref",
      "first-page": "4794",
      "DOI": "10.1093/emboj/cdg482",
      "article-title": "Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells",
      "volume": "22",
      "author": "Parisi",
      "year": "2003",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib54",
      "doi-asserted-by": "crossref",
      "first-page": "431",
      "DOI": "10.1016/S0092-8674(03)00645-7",
      "article-title": "Cyclin E ablation in the mouse",
      "volume": "114",
      "author": "Geng",
      "year": "2003",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib55",
      "doi-asserted-by": "crossref",
      "unstructured": "Murphy, M. et al. (1997) Delayed early embryonic lethality following disruption of the murine cyclin A2 gene. Nat. Genet. 15, 83\u201386; erratum ibid (1999) Nat. Genet. 23, 481",
      "DOI": "10.1038/70612"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib56",
      "doi-asserted-by": "crossref",
      "first-page": "4344",
      "DOI": "10.1073/pnas.95.8.4344",
      "article-title": "Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero",
      "volume": "95",
      "author": "Brandeis",
      "year": "1998",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib57",
      "doi-asserted-by": "crossref",
      "first-page": "377",
      "DOI": "10.1038/3855",
      "article-title": "Cyclin A1 is required for meiosis in the male mouse",
      "volume": "20",
      "author": "Liu",
      "year": "1998",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib58",
      "doi-asserted-by": "crossref",
      "first-page": "11173",
      "DOI": "10.1073/pnas.93.20.11173",
      "article-title": "Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death",
      "volume": "93",
      "author": "Ohshima",
      "year": "1996",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib59",
      "doi-asserted-by": "crossref",
      "first-page": "816",
      "DOI": "10.1101/gad.10.7.816",
      "article-title": "The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation",
      "volume": "10",
      "author": "Nikolic",
      "year": "1996",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib60",
      "doi-asserted-by": "crossref",
      "first-page": "550",
      "DOI": "10.1523/JNEUROSCI.21-02-00550.2001",
      "article-title": "Neuronal cyclin-dependent kinase 5 activity is critical for survival",
      "volume": "21",
      "author": "Tanaka",
      "year": "2001",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib61",
      "doi-asserted-by": "crossref",
      "first-page": "6758",
      "DOI": "10.1523/JNEUROSCI.21-17-06758.2001",
      "article-title": "p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment",
      "volume": "21",
      "author": "Ko",
      "year": "2001",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib62",
      "doi-asserted-by": "crossref",
      "first-page": "2844",
      "DOI": "10.1093/emboj/20.11.2844",
      "article-title": "Inability to enter S phase and defective RNA polymerase II CTD phosphorylation in mice lacking Mat1",
      "volume": "20",
      "author": "Rossi",
      "year": "2001",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib63",
      "doi-asserted-by": "crossref",
      "first-page": "4275",
      "DOI": "10.1242/jcs.00121",
      "article-title": "Conditional ablation of the Mat1 subunit of TFIIH in Schwann cells provides evidence that Mat1 is not required for general transcription",
      "volume": "115",
      "author": "Korsisaari",
      "year": "2002",
      "journal-title": "J. Cell Sci."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib64",
      "doi-asserted-by": "crossref",
      "first-page": "3188",
      "DOI": "10.1128/MCB.24.8.3188-3197.2004",
      "article-title": "Failure to proliferate and mitotic arrest of CDK11p110/p58-null mutant mice at the blastocyst stage of embryonic cell development",
      "volume": "24",
      "author": "Li",
      "year": "2004",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib65",
      "first-page": "73",
      "article-title": "Cyclin D-dependent kinases, INK4 inhibitors and cancer",
      "volume": "1602",
      "author": "Ortega",
      "year": "2002",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib66",
      "doi-asserted-by": "crossref",
      "first-page": "1281",
      "DOI": "10.1126/science.7652577",
      "article-title": "A p16Ink4a-insensitive Cdk4 mutant targeted by cytolytic T lymphocytes in a human melanoma",
      "volume": "269",
      "author": "Wolfel",
      "year": "1995",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib67",
      "doi-asserted-by": "crossref",
      "first-page": "6271",
      "DOI": "10.1038/sj.onc.1203033",
      "article-title": "Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations",
      "volume": "18",
      "author": "Corcoran",
      "year": "1999",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib68",
      "doi-asserted-by": "crossref",
      "first-page": "1549",
      "DOI": "10.1182/blood-2003-04-1220",
      "article-title": "In B-cell chronic lymphocytic leukemias, 7q21 translocations lead to overexpression of the CDK6 gene",
      "volume": "102",
      "author": "Hayette",
      "year": "2003",
      "journal-title": "Blood"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib69",
      "doi-asserted-by": "crossref",
      "first-page": "6637",
      "DOI": "10.1093/emboj/20.23.6637",
      "article-title": "Wide spectrum of tumors in knock in mice carrying a Cdk4 protein insensitive to INK4 inhibitors",
      "volume": "20",
      "author": "Sotillo",
      "year": "2001",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib70",
      "doi-asserted-by": "crossref",
      "first-page": "13312",
      "DOI": "10.1073/pnas.241338598",
      "article-title": "Invasive melanoma in Cdk4 targeted mice",
      "volume": "98",
      "author": "Sotillo",
      "year": "2001",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib71",
      "doi-asserted-by": "crossref",
      "first-page": "417",
      "DOI": "10.1016/S0165-6147(02)02071-0",
      "article-title": "Pharmacological inhibitors of cyclin-dependent kinases",
      "volume": "23",
      "author": "Knockaert",
      "year": "2002",
      "journal-title": "Trends Pharmacol. Sci."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib72",
      "doi-asserted-by": "crossref",
      "first-page": "1017",
      "DOI": "10.1038/35082500",
      "article-title": "Specific protection against breast cancers by cyclin D1 ablation",
      "volume": "411",
      "author": "Yu",
      "year": "2001",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib73",
      "doi-asserted-by": "crossref",
      "first-page": "2923",
      "DOI": "10.1101/gad.1033002",
      "article-title": "Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence",
      "volume": "16",
      "author": "Zou",
      "year": "2002",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib74",
      "doi-asserted-by": "crossref",
      "first-page": "7538",
      "DOI": "10.1128/MCB.24.17.7538-7547.2004",
      "article-title": "Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues",
      "volume": "24",
      "author": "Miliani de Marval",
      "year": "2004",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib75",
      "doi-asserted-by": "crossref",
      "first-page": "233",
      "DOI": "10.1016/S1535-6108(03)00053-9",
      "article-title": "Proliferation of cancer cells despite CDK2 inhibition",
      "volume": "3",
      "author": "Tetsu",
      "year": "2003",
      "journal-title": "Cancer Cell"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib76",
      "doi-asserted-by": "crossref",
      "first-page": "6087",
      "DOI": "10.1002/j.1460-2075.1994.tb06955.x",
      "article-title": "Human cyclin F",
      "volume": "13",
      "author": "Bai",
      "year": "1994",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib77",
      "doi-asserted-by": "crossref",
      "first-page": "1378",
      "DOI": "10.1093/emboj/19.6.1378",
      "article-title": "Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin\u2013cyclin interaction",
      "volume": "19",
      "author": "Kong",
      "year": "2000",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib78",
      "doi-asserted-by": "crossref",
      "first-page": "2487",
      "DOI": "10.1128/MCB.24.6.2487-2498.2004",
      "article-title": "Cyclin F disruption compromises placental development and affects normal cell cycle execution",
      "volume": "24",
      "author": "Tetzlaff",
      "year": "2004",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib79",
      "doi-asserted-by": "crossref",
      "first-page": "518",
      "DOI": "10.1016/S1534-5807(02)00182-X",
      "article-title": "Cyclin G: a regulator of the p53\u2013Mdm2 network",
      "volume": "2",
      "author": "Chen",
      "year": "2002",
      "journal-title": "Dev. Cell"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib80",
      "doi-asserted-by": "crossref",
      "first-page": "3290",
      "DOI": "10.1038/sj.onc.1204270",
      "article-title": "Cyclin G1 is involved in G2/M arrest in response to DNA damage and in growth control after damage recovery",
      "volume": "20",
      "author": "Kimura",
      "year": "2001",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib81",
      "doi-asserted-by": "crossref",
      "first-page": "10296",
      "DOI": "10.1073/pnas.0403175101",
      "article-title": "Serine/threonine kinase cyclin G-associated kinase regulates epidermal growth factor receptor signaling",
      "volume": "101",
      "author": "Zhang",
      "year": "2004",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib82",
      "doi-asserted-by": "crossref",
      "first-page": "534",
      "DOI": "10.1006/excr.1995.1406",
      "article-title": "Cyclin I: a new cyclin encoded by a gene isolated from human brain",
      "volume": "221",
      "author": "Nakamura",
      "year": "1995",
      "journal-title": "Exp. Cell Res."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib83",
      "doi-asserted-by": "crossref",
      "first-page": "661",
      "DOI": "10.1006/dbio.2000.9916",
      "article-title": "A role for cyclin J in the rapid nuclear division cycles of early Drosophila embryogenesis",
      "volume": "227",
      "author": "Kolonin",
      "year": "2000",
      "journal-title": "Dev. Biol."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib84",
      "doi-asserted-by": "crossref",
      "first-page": "37",
      "DOI": "10.1016/S0378-1119(02)01210-6",
      "article-title": "Molecular cloning and characterization of a novel gene family of four ancient conserved domain proteins (ACDP)",
      "volume": "306",
      "author": "Wang",
      "year": "2003",
      "journal-title": "Gene"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib85",
      "doi-asserted-by": "crossref",
      "first-page": "8935",
      "DOI": "10.1038/sj.onc.1205996",
      "article-title": "Uracil in DNA \u2013 occurrence, consequences and repair",
      "volume": "21",
      "author": "Krokan",
      "year": "2002",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib86",
      "doi-asserted-by": "crossref",
      "first-page": "365",
      "DOI": "10.1111/j.0953-816X.2003.03128.x",
      "article-title": "Cyclin S: a new member of the cyclin family plays a role in long-term memory",
      "volume": "19",
      "author": "Edelheit",
      "year": "2004",
      "journal-title": "Eur. J. Neurosci."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib87",
      "doi-asserted-by": "crossref",
      "first-page": "206",
      "DOI": "10.4161/cc.4.2.1410",
      "article-title": "Revisiting the \u2018Cdk-centric\u2019 view of the mammalian cell cycle",
      "volume": "4",
      "author": "Malumbres",
      "year": "2005",
      "journal-title": "Cell Cycle"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib88",
      "doi-asserted-by": "crossref",
      "first-page": "821",
      "DOI": "10.1006/jmbi.1999.2640",
      "article-title": "Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors",
      "volume": "287",
      "author": "Pavletich",
      "year": "1999",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib89",
      "doi-asserted-by": "crossref",
      "first-page": "8067",
      "DOI": "10.1038/sj.onc.1206019",
      "article-title": "Activation of cyclin D1-kinase in murine fibroblasts lacking both p21Cip1 and p27Kip1",
      "volume": "21",
      "author": "Sugimoto",
      "year": "2002",
      "journal-title": "Oncogene"
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib90",
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      "first-page": "7285",
      "DOI": "10.1128/MCB.23.20.7285-7290.2003",
      "article-title": "P27Kip1 and p21Cip1 are not required for the formation of active D cyclin\u2013cdk4 complexes",
      "volume": "23",
      "author": "Bagui",
      "year": "2003",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.tibs.2005.09.005_bib91",
      "doi-asserted-by": "crossref",
      "first-page": "4876",
      "DOI": "10.1093/nar/25.24.4876",
      "article-title": "The ClustalX windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools",
      "volume": "24",
      "author": "Thompson",
      "year": "1997",
      "journal-title": "Nucleic Acids Res."
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