DOI: 10.1016/j.tibs.2005.03.008. The yeast Mediator complex and its regulation

The yeast Mediator complex and its regulation

10.1016/j.tibs.2005.03.008

Crossref journal-article

Elsevier BV

Trends in Biochemical Sciences (78)

Bibliography

BjÃ¶rklund, S., & Gustafsson, C. M. (2005). The yeast Mediator complex and its regulation. Trends in Biochemical Sciences, 30(5), 240â244.

Authors 2

Stefan Björklund (first)
Claes M. Gustafsson (additional)

References 55 Referenced 152

10.1016/0092-8674(90)90685-8 / Cell / A novel Mediator between activator proteins and the RNA polymerase II transcription apparatus by Kelleher (1990)
10.1038/350436a0 / Nature / A Mediator required for activation of RNA polymerase II transcription in vitro by Flanagan (1991)
10.1016/0092-8674(94)90221-6 / Cell / A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II by Kim (1994)
10.1101/gad.12.1.45 / Genes Dev. / The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain by Myers (1998)
10.1016/j.molcel.2004.05.011 / Mol. Cell / A unified nomenclature for protein subunits of Mediator complexes linking transcriptional regulators to RNA polymerase II by Bourbon (2004)
10.1146/annurev.biochem.69.1.729 / Annu. Rev. Biochem. / Mediator of transcriptional regulation by Myers (2000)
10.1128/MCB.10.3.1010 / Mol. Cell. Biol. / RNA polymerase II mutants defective in transcription of a subset of genes by Scafe (1990)
10.1016/S0021-9258(18)45229-5 / J. Biol. Chem. / Messenger RNA synthesis in mammalian cells is catalyzed by the phosphorylated form of RNA polymerase II by Cadena (1987)
10.1016/S0021-9258(19)47159-7 / J. Biol. Chem. / The transition of RNA polymerase II from initiation to elongation is associated with phosphorylation of the carboxyl-terminal domain of subunit IIa by Payne (1989)
10.1038/370075a0 / Nature / Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongation by O'Brien (1994)
10.1016/0092-8674(94)90040-X / Cell / Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK by Feaver (1994)
10.1093/genetics/123.4.715 / Genetics / Intragenic and extragenic suppressors of mutations in the heptapeptide repeat domain of Saccharomyces cerevisiae RNA polymerase II by Nonet (1989)
10.1073/pnas.94.12.6075 / Proc. Natl. Acad. Sci. U. S. A. / Evidence for a mediator cycle at the initiation of transcription by Svejstrup (1997)
10.1074/jbc.M409046200 / J. Biol. Chem. / The Soh1/MED31 protein is an ancient component of Schizosaccharomyces pombe and Saccharomyces cerevisiae Mediator by Linder (2004)
10.1093/nar/gkh878 / Nucleic Acids Res. / A high resolution protein interaction map of the yeast Mediator complex by Guglielmi (2004)
10.1074/jbc.M207195200 / J. Biol. Chem. / A complex of the Srb8, -9, -10, and -11 transcriptional regulatory proteins from yeast by Borggrefe (2002)
10.1073/pnas.1030497100 / Proc. Natl. Acad. Sci. U. S. A. / TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution by Samuelsen (2003)
10.1016/S0092-8674(00)81641-4 / Cell / Dissecting the regulatory circuitry of a eukaryotic genome by Holstege (1998)
10.1074/jbc.M306750200 / J. Biol. Chem. / Mediator influences Schizosaccharomyces pombe RNA polymerase II-dependent transcription in vitro by Spahr (2003)
10.1128/MCB.21.14.4604-4613.2001 / Mol. Cell. Biol. / Characterization of Mediator complexes from HeLa cell nuclear extract by Wang (2001)
10.1101/gad.987602 / Genes Dev. / Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation by Naar (2002)
10.1016/S1097-2765(00)80112-4 / Mol. Cell / Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases by Hengartner (1998)
10.1038/nature01243 / Nature / Srb10/Cdk8 regulates yeast filamentous growth by phosphorylating the transcription factor Ste12 by Nelson (2003)
10.1038/386569a0 / Nature / Transcriptional activation by recruitment by Ptashne (1997)
10.1016/S1097-2765(00)80088-X / Mol. Cell / An activator target in the RNA polymerase II holoenzyme by Koh (1998)
10.1128/MCB.20.23.8709-8719.2000 / Mol. Cell. Biol. / In vivo requirement of activator-specific binding targets of mediator by Park (2000)
10.1073/pnas.2036346100 / Proc. Natl. Acad. Sci. U. S. A. / Association of the Mediator complex with enhancers of active genes by Kuras (2003)
10.1016/0092-8674(95)90389-5 / Cell / Contact with a component of the polymerase II holoenzyme suffices for gene activation by Barberis (1995)
10.1016/S1097-2765(03)00144-8 / Mol. Cell / Independent recruitment in vivo by Gal4 of two complexes required for transcription by Bryant (2003)
10.1016/S1097-2765(01)00266-0 / Mol. Cell / Cdk1 triggers association of RNA polymerase to cell cycle promoters only after recruitment of the mediator by SBF by Cosma (2001)
10.1101/gad.921601 / Genes Dev. / The Swi5 activator recruits the Mediator complex to the HO promoter without RNA polymerase II by Bhoite (2001)
10.1016/S1097-2765(01)00296-9 / Mol. Cell / Mediator, not holoenzyme, is directly recruited to the heat shock promoter by HSF upon heat shock by Park (2001)
10.1038/35041603 / Nature / A transcription reinitiation intermediate that is stabilized by activator by Yudkovsky (2000)
10.1073/pnas.041611198 / Proc. Natl. Acad. Sci. U. S. A. / Interaction of a transcriptional repressor with the RNA polymerase II holoenzyme plays a crucial role in repression by Zaman (2001)
10.1128/MCB.18.3.1163 / Mol. Cell. Biol. / Functional relationships of Srb10-Srb11 kinase, carboxy-terminal domain kinase CTDK-I, and transcriptional corepressor Ssn6-Tup1 by Kuchin (1998)
10.1093/genetics/155.4.1535 / Genetics / Genetic analysis of the role of Pol II holoenzyme components in repression by the Cyc8-Tup1 corepressor in yeast by Lee (2000)
10.1016/S1097-2765(03)00521-5 / Mol. Cell / Ras induces mediator complex exchange on C/EBPβ by Mo (2004)
10.1128/MCB.12.10.4503 / Mol. Cell. Biol. / Involvement of the SIN4 global transcriptional regulator in the chromatin structure of Saccharomyces cerevisiae by Jiang (1992)
10.1074/jbc.M206946200 / J. Biol. Chem. / Functional interactions within yeast mediator and evidence of differential subunit modifications by Balciunas (2003)
10.1128/MCB.24.4.1721-1735.2004 / Mol. Cell. Biol. / Two cyclin-dependent kinases promote RNA polymerase II transcription and formation of the scaffold complex by Liu (2004)
10.1074/jbc.M404426200 / J. Biol. Chem. / Mutual targeting of mediator and the TFIIH kinase Kin28 by Guidi (2004)
10.1073/pnas.0400221101 / Proc. Natl. Acad. Sci. U. S. A. / Site-specific Srb10-dependent phosphorylation of the yeast Mediator subunit Med2 regulates gene expression from the 2-microm plasmid by Hallberg (2004)
10.1016/0168-9525(91)90018-L / Trends Genet. / RAS genes in Saccharomyces cerevisiae: signal transduction in search of a pathway by Broach (1991)
10.1016/0092-8674(85)90305-8 / Cell / In yeast, RAS proteins are controlling elements of adenylate cyclase by Toda (1985)
10.1093/genetics/157.1.17 / Genetics / The rye mutants identify a role for Ssn/Srb proteins of the RNA polymerase II holoenzyme during stationary phase entry in Saccharomyces cerevisiae by Chang (2001)
10.1093/genetics/159.1.77 / Genetics / The Ras/PKA signaling pathway of Saccharomyces cerevisiae exhibits a functional interaction with the Sin4p complex of the RNA polymerase II holoenzyme by Howard (2001)
10.1016/j.molcel.2004.05.021 / Mol. Cell / The Ras/PKA signaling pathway directly targets the Srb9 protein, a component of the general RNA polymerase II transcription apparatus by Chang (2004)
10.1016/0092-8674(91)90042-W / Cell / Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast by Lew (1991)
10.1016/S0092-8674(04)00300-9 / Cell / Cyclin C/cdk3 promotes Rb-dependent G0 exit by Ren (2004)
10.1126/science.283.5404.985 / Science / Conserved structures of mediator and RNA polymerase II holoenzyme by Asturias (1999)
10.1073/pnas.260489497 / Proc. Natl. Acad. Sci. U. S. A. / Structural organization of yeast and mammalian mediator complexes by Dotson (2000)
10.1128/MCB.24.15.6871-6886.2004 / Mol. Cell. Biol. / A triad of subunits from the Gal11/tail domain of Srb mediator is an in vivo target of transcriptional activator Gcn4p by Zhang (2004)
10.1074/jbc.M004364200 / J. Biol. Chem. / Functional connections between mediator components and general transcription factors of Saccharomyces cerevisiae by Sakurai (2000)
10.1074/jbc.273.23.14059 / J. Biol. Chem. / Activation and repression of transcription by differential contact: two sides of a coin by Roy (1998)
10.1016/j.sbi.2004.01.012 / Curr. Opin. Struct. Biol. / Catabolite activator protein: DNA binding and transcription activation by Lawson (2004)

Dates

Type	When
Created	20 years, 4 months ago (April 9, 2005, 7:57 a.m.)
Deposited	4 years, 1 month ago (July 8, 2021, 1:23 a.m.)
Indexed	2 months ago (June 24, 2025, 2:22 p.m.)
Issued	20 years, 3 months ago (May 1, 2005)
Published	20 years, 3 months ago (May 1, 2005)
Published Print	20 years, 3 months ago (May 1, 2005)

Funders 0

None

BibTeX

@article{Bj_rklund_2005, title={The yeast Mediator complex and its regulation}, volume={30}, ISSN={0968-0004}, url={http://dx.doi.org/10.1016/j.tibs.2005.03.008}, DOI={10.1016/j.tibs.2005.03.008}, number={5}, journal={Trends in Biochemical Sciences}, publisher={Elsevier BV}, author={Björklund, Stefan and Gustafsson, Claes M.}, year={2005}, month=may, pages={240–244} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        6,
        24
      ]
    ],
    "date-time": "2025-06-24T18:22:24Z",
    "timestamp": 1750789344318
  },
  "reference-count": 55,
  "publisher": "Elsevier BV",
  "issue": "5",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2005,
            5,
            1
          ]
        ],
        "date-time": "2005-05-01T00:00:00Z",
        "timestamp": 1114905600000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2005,
        5
      ]
    ]
  },
  "DOI": "10.1016/j.tibs.2005.03.008",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2005,
        4,
        9
      ]
    ],
    "date-time": "2005-04-09T11:57:04Z",
    "timestamp": 1113047824000
  },
  "page": "240-244",
  "source": "Crossref",
  "is-referenced-by-count": 152,
  "title": "The yeast Mediator complex and its regulation",
  "prefix": "10.1016",
  "volume": "30",
  "author": [
    {
      "given": "Stefan",
      "family": "Bj\u00f6rklund",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Claes M.",
      "family": "Gustafsson",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/j.tibs.2005.03.008_bib1",
      "doi-asserted-by": "crossref",
      "first-page": "1209",
      "DOI": "10.1016/0092-8674(90)90685-8",
      "article-title": "A novel Mediator between activator proteins and the RNA polymerase II transcription apparatus",
      "volume": "61",
      "author": "Kelleher",
      "year": "1990",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib2",
      "doi-asserted-by": "crossref",
      "first-page": "436",
      "DOI": "10.1038/350436a0",
      "article-title": "A Mediator required for activation of RNA polymerase II transcription in vitro",
      "volume": "350",
      "author": "Flanagan",
      "year": "1991",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib3",
      "doi-asserted-by": "crossref",
      "first-page": "599",
      "DOI": "10.1016/0092-8674(94)90221-6",
      "article-title": "A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II",
      "volume": "77",
      "author": "Kim",
      "year": "1994",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib4",
      "doi-asserted-by": "crossref",
      "first-page": "45",
      "DOI": "10.1101/gad.12.1.45",
      "article-title": "The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain",
      "volume": "12",
      "author": "Myers",
      "year": "1998",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "553",
      "DOI": "10.1016/j.molcel.2004.05.011",
      "article-title": "A unified nomenclature for protein subunits of Mediator complexes linking transcriptional regulators to RNA polymerase II",
      "volume": "14",
      "author": "Bourbon",
      "year": "2004",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib6",
      "doi-asserted-by": "crossref",
      "first-page": "729",
      "DOI": "10.1146/annurev.biochem.69.1.729",
      "article-title": "Mediator of transcriptional regulation",
      "volume": "69",
      "author": "Myers",
      "year": "2000",
      "journal-title": "Annu. Rev. Biochem."
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "1010",
      "DOI": "10.1128/MCB.10.3.1010",
      "article-title": "RNA polymerase II mutants defective in transcription of a subset of genes",
      "volume": "10",
      "author": "Scafe",
      "year": "1990",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "12468",
      "DOI": "10.1016/S0021-9258(18)45229-5",
      "article-title": "Messenger RNA synthesis in mammalian cells is catalyzed by the phosphorylated form of RNA polymerase II",
      "volume": "262",
      "author": "Cadena",
      "year": "1987",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "19621",
      "DOI": "10.1016/S0021-9258(19)47159-7",
      "article-title": "The transition of RNA polymerase II from initiation to elongation is associated with phosphorylation of the carboxyl-terminal domain of subunit IIa",
      "volume": "264",
      "author": "Payne",
      "year": "1989",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib10",
      "doi-asserted-by": "crossref",
      "first-page": "75",
      "DOI": "10.1038/370075a0",
      "article-title": "Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongation",
      "volume": "370",
      "author": "O'Brien",
      "year": "1994",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib11",
      "doi-asserted-by": "crossref",
      "first-page": "1103",
      "DOI": "10.1016/0092-8674(94)90040-X",
      "article-title": "Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK",
      "volume": "79",
      "author": "Feaver",
      "year": "1994",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "715",
      "DOI": "10.1093/genetics/123.4.715",
      "article-title": "Intragenic and extragenic suppressors of mutations in the heptapeptide repeat domain of Saccharomyces cerevisiae RNA polymerase II",
      "volume": "123",
      "author": "Nonet",
      "year": "1989",
      "journal-title": "Genetics"
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "6075",
      "DOI": "10.1073/pnas.94.12.6075",
      "article-title": "Evidence for a mediator cycle at the initiation of transcription",
      "volume": "94",
      "author": "Svejstrup",
      "year": "1997",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "49455",
      "DOI": "10.1074/jbc.M409046200",
      "article-title": "The Soh1/MED31 protein is an ancient component of Schizosaccharomyces pombe and Saccharomyces cerevisiae Mediator",
      "volume": "279",
      "author": "Linder",
      "year": "2004",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "5379",
      "DOI": "10.1093/nar/gkh878",
      "article-title": "A high resolution protein interaction map of the yeast Mediator complex",
      "volume": "32",
      "author": "Guglielmi",
      "year": "2004",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "44202",
      "DOI": "10.1074/jbc.M207195200",
      "article-title": "A complex of the Srb8, -9, -10, and -11 transcriptional regulatory proteins from yeast",
      "volume": "277",
      "author": "Borggrefe",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "6422",
      "DOI": "10.1073/pnas.1030497100",
      "article-title": "TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution",
      "volume": "100",
      "author": "Samuelsen",
      "year": "2003",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "717",
      "DOI": "10.1016/S0092-8674(00)81641-4",
      "article-title": "Dissecting the regulatory circuitry of a eukaryotic genome",
      "volume": "95",
      "author": "Holstege",
      "year": "1998",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "51301",
      "DOI": "10.1074/jbc.M306750200",
      "article-title": "Mediator influences Schizosaccharomyces pombe RNA polymerase II-dependent transcription in vitro",
      "volume": "278",
      "author": "Spahr",
      "year": "2003",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "4604",
      "DOI": "10.1128/MCB.21.14.4604-4613.2001",
      "article-title": "Characterization of Mediator complexes from HeLa cell nuclear extract",
      "volume": "21",
      "author": "Wang",
      "year": "2001",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "1339",
      "DOI": "10.1101/gad.987602",
      "article-title": "Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation",
      "volume": "16",
      "author": "Naar",
      "year": "2002",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "43",
      "DOI": "10.1016/S1097-2765(00)80112-4",
      "article-title": "Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases",
      "volume": "2",
      "author": "Hengartner",
      "year": "1998",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "187",
      "DOI": "10.1038/nature01243",
      "article-title": "Srb10/Cdk8 regulates yeast filamentous growth by phosphorylating the transcription factor Ste12",
      "volume": "421",
      "author": "Nelson",
      "year": "2003",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "569",
      "DOI": "10.1038/386569a0",
      "article-title": "Transcriptional activation by recruitment",
      "volume": "386",
      "author": "Ptashne",
      "year": "1997",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "895",
      "DOI": "10.1016/S1097-2765(00)80088-X",
      "article-title": "An activator target in the RNA polymerase II holoenzyme",
      "volume": "1",
      "author": "Koh",
      "year": "1998",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "8709",
      "DOI": "10.1128/MCB.20.23.8709-8719.2000",
      "article-title": "In vivo requirement of activator-specific binding targets of mediator",
      "volume": "20",
      "author": "Park",
      "year": "2000",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "13887",
      "DOI": "10.1073/pnas.2036346100",
      "article-title": "Association of the Mediator complex with enhancers of active genes",
      "volume": "100",
      "author": "Kuras",
      "year": "2003",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "359",
      "DOI": "10.1016/0092-8674(95)90389-5",
      "article-title": "Contact with a component of the polymerase II holoenzyme suffices for gene activation",
      "volume": "81",
      "author": "Barberis",
      "year": "1995",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "1301",
      "DOI": "10.1016/S1097-2765(03)00144-8",
      "article-title": "Independent recruitment in vivo by Gal4 of two complexes required for transcription",
      "volume": "11",
      "author": "Bryant",
      "year": "2003",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "1213",
      "DOI": "10.1016/S1097-2765(01)00266-0",
      "article-title": "Cdk1 triggers association of RNA polymerase to cell cycle promoters only after recruitment of the mediator by SBF",
      "volume": "7",
      "author": "Cosma",
      "year": "2001",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "2457",
      "DOI": "10.1101/gad.921601",
      "article-title": "The Swi5 activator recruits the Mediator complex to the HO promoter without RNA polymerase II",
      "volume": "15",
      "author": "Bhoite",
      "year": "2001",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "9",
      "DOI": "10.1016/S1097-2765(01)00296-9",
      "article-title": "Mediator, not holoenzyme, is directly recruited to the heat shock promoter by HSF upon heat shock",
      "volume": "8",
      "author": "Park",
      "year": "2001",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "225",
      "DOI": "10.1038/35041603",
      "article-title": "A transcription reinitiation intermediate that is stabilized by activator",
      "volume": "408",
      "author": "Yudkovsky",
      "year": "2000",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "2550",
      "DOI": "10.1073/pnas.041611198",
      "article-title": "Interaction of a transcriptional repressor with the RNA polymerase II holoenzyme plays a crucial role in repression",
      "volume": "98",
      "author": "Zaman",
      "year": "2001",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "1163",
      "DOI": "10.1128/MCB.18.3.1163",
      "article-title": "Functional relationships of Srb10-Srb11 kinase, carboxy-terminal domain kinase CTDK-I, and transcriptional corepressor Ssn6-Tup1",
      "volume": "18",
      "author": "Kuchin",
      "year": "1998",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "1535",
      "DOI": "10.1093/genetics/155.4.1535",
      "article-title": "Genetic analysis of the role of Pol II holoenzyme components in repression by the Cyc8-Tup1 corepressor in yeast",
      "volume": "155",
      "author": "Lee",
      "year": "2000",
      "journal-title": "Genetics"
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "241",
      "DOI": "10.1016/S1097-2765(03)00521-5",
      "article-title": "Ras induces mediator complex exchange on C/EBP\u03b2",
      "volume": "13",
      "author": "Mo",
      "year": "2004",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "4503",
      "DOI": "10.1128/MCB.12.10.4503",
      "article-title": "Involvement of the SIN4 global transcriptional regulator in the chromatin structure of Saccharomyces cerevisiae",
      "volume": "12",
      "author": "Jiang",
      "year": "1992",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "3831",
      "DOI": "10.1074/jbc.M206946200",
      "article-title": "Functional interactions within yeast mediator and evidence of differential subunit modifications",
      "volume": "278",
      "author": "Balciunas",
      "year": "2003",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "1721",
      "DOI": "10.1128/MCB.24.4.1721-1735.2004",
      "article-title": "Two cyclin-dependent kinases promote RNA polymerase II transcription and formation of the scaffold complex",
      "volume": "24",
      "author": "Liu",
      "year": "2004",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "29114",
      "DOI": "10.1074/jbc.M404426200",
      "article-title": "Mutual targeting of mediator and the TFIIH kinase Kin28",
      "volume": "279",
      "author": "Guidi",
      "year": "2004",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "3370",
      "DOI": "10.1073/pnas.0400221101",
      "article-title": "Site-specific Srb10-dependent phosphorylation of the yeast Mediator subunit Med2 regulates gene expression from the 2-microm plasmid",
      "volume": "101",
      "author": "Hallberg",
      "year": "2004",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "28",
      "DOI": "10.1016/0168-9525(91)90018-L",
      "article-title": "RAS genes in Saccharomyces cerevisiae: signal transduction in search of a pathway",
      "volume": "7",
      "author": "Broach",
      "year": "1991",
      "journal-title": "Trends Genet."
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib44",
      "doi-asserted-by": "crossref",
      "first-page": "27",
      "DOI": "10.1016/0092-8674(85)90305-8",
      "article-title": "In yeast, RAS proteins are controlling elements of adenylate cyclase",
      "volume": "40",
      "author": "Toda",
      "year": "1985",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib45",
      "doi-asserted-by": "crossref",
      "first-page": "17",
      "DOI": "10.1093/genetics/157.1.17",
      "article-title": "The rye mutants identify a role for Ssn/Srb proteins of the RNA polymerase II holoenzyme during stationary phase entry in Saccharomyces cerevisiae",
      "volume": "157",
      "author": "Chang",
      "year": "2001",
      "journal-title": "Genetics"
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib46",
      "doi-asserted-by": "crossref",
      "first-page": "77",
      "DOI": "10.1093/genetics/159.1.77",
      "article-title": "The Ras/PKA signaling pathway of Saccharomyces cerevisiae exhibits a functional interaction with the Sin4p complex of the RNA polymerase II holoenzyme",
      "volume": "159",
      "author": "Howard",
      "year": "2001",
      "journal-title": "Genetics"
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib47",
      "doi-asserted-by": "crossref",
      "first-page": "107",
      "DOI": "10.1016/j.molcel.2004.05.021",
      "article-title": "The Ras/PKA signaling pathway directly targets the Srb9 protein, a component of the general RNA polymerase II transcription apparatus",
      "volume": "15",
      "author": "Chang",
      "year": "2004",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib48",
      "doi-asserted-by": "crossref",
      "first-page": "1197",
      "DOI": "10.1016/0092-8674(91)90042-W",
      "article-title": "Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast",
      "volume": "66",
      "author": "Lew",
      "year": "1991",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib49",
      "doi-asserted-by": "crossref",
      "first-page": "239",
      "DOI": "10.1016/S0092-8674(04)00300-9",
      "article-title": "Cyclin C/cdk3 promotes Rb-dependent G0 exit",
      "volume": "117",
      "author": "Ren",
      "year": "2004",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib50",
      "doi-asserted-by": "crossref",
      "first-page": "985",
      "DOI": "10.1126/science.283.5404.985",
      "article-title": "Conserved structures of mediator and RNA polymerase II holoenzyme",
      "volume": "283",
      "author": "Asturias",
      "year": "1999",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib51",
      "doi-asserted-by": "crossref",
      "first-page": "14307",
      "DOI": "10.1073/pnas.260489497",
      "article-title": "Structural organization of yeast and mammalian mediator complexes",
      "volume": "97",
      "author": "Dotson",
      "year": "2000",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib52",
      "doi-asserted-by": "crossref",
      "first-page": "6871",
      "DOI": "10.1128/MCB.24.15.6871-6886.2004",
      "article-title": "A triad of subunits from the Gal11/tail domain of Srb mediator is an in vivo target of transcriptional activator Gcn4p",
      "volume": "24",
      "author": "Zhang",
      "year": "2004",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib53",
      "doi-asserted-by": "crossref",
      "first-page": "37251",
      "DOI": "10.1074/jbc.M004364200",
      "article-title": "Functional connections between mediator components and general transcription factors of Saccharomyces cerevisiae",
      "volume": "275",
      "author": "Sakurai",
      "year": "2000",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib54",
      "doi-asserted-by": "crossref",
      "first-page": "14059",
      "DOI": "10.1074/jbc.273.23.14059",
      "article-title": "Activation and repression of transcription by differential contact: two sides of a coin",
      "volume": "273",
      "author": "Roy",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.tibs.2005.03.008_bib55",
      "doi-asserted-by": "crossref",
      "first-page": "10",
      "DOI": "10.1016/j.sbi.2004.01.012",
      "article-title": "Catabolite activator protein: DNA binding and transcription activation",
      "volume": "14",
      "author": "Lawson",
      "year": "2004",
      "journal-title": "Curr. Opin. Struct. Biol."
    }
  ],
  "container-title": "Trends in Biochemical Sciences",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0968000405000800?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0968000405000800?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        7,
        8
      ]
    ],
    "date-time": "2021-07-08T05:23:17Z",
    "timestamp": 1625721797000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0968000405000800"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2005,
        5
      ]
    ]
  },
  "references-count": 55,
  "journal-issue": {
    "issue": "5",
    "published-print": {
      "date-parts": [
        [
          2005,
          5
        ]
      ]
    }
  },
  "alternative-id": [
    "S0968000405000800"
  ],
  "URL": "http://dx.doi.org/10.1016/j.tibs.2005.03.008",
  "relation": {},
  "ISSN": [
    "0968-0004"
  ],
  "subject": [],
  "container-title-short": "Trends in Biochemical Sciences",
  "published": {
    "date-parts": [
      [
        2005,
        5
      ]
    ]
  }
}