DOI: 10.1016/j.str.2007.04.008. Structure and Rearrangements in the Carboxy-Terminal Region of SpIH Channels

Structure and Rearrangements in the Carboxy-Terminal Region of SpIH Channels

10.1016/j.str.2007.04.008

Crossref journal-article

Elsevier BV

Structure (78)

Bibliography

Flynn, G. E., Black, K. D., Islas, L. D., Sankaran, B., & Zagotta, W. N. (2007). Structure and Rearrangements in the Carboxy-Terminal Region of SpIH Channels. Structure, 15(6), 671â682.

Authors 5

Galen E. Flynn (first)
Kevin D. Black (additional)
Leon D. Islas (additional)
Banumathi Sankaran (additional)
William N. Zagotta (additional)

References 41 Referenced 71

10.1107/S0909049503024130 / J. Synchrotron Radiat. / Recent developments in the PHENIX software for automated crystallographic structure determination by Adams (2004)
10.1073/pnas.88.21.9868 / Proc. Natl. Acad. Sci. USA / Control of ligand specificity in cyclic nucleotide-gated channels from rod photoreceptors and olfactory epithelium by Altenhofen (1991)
10.1085/jgp.117.6.519 / J. Gen. Physiol. / Integrated allosteric model of voltage gating of HCN channels by Altomare (2001)
10.1196/annals.1302.009 / Ann. N Y Acad. Sci. / Pacemaker channels by Baruscotti (2004)
10.1016/S1050-1738(02)00162-7 / Trends Cardiovasc. Med. / Cardiac HCN channels: structure, function, and modulation by Biel (2002)
10.1107/S0907444998003254 / Acta Crystallogr. D Biol. Crystallogr. / Crystallography & NMR System: a new software suite for macromolecular structure determination by Brunger (1998)
10.1107/S0907444994003112 / Acta Crystallogr. D Biol. Crystallogr. / The CCP4 suite: programs for X-ray crystallography (1994)
10.1016/j.cell.2004.10.030 / Cell / Structural basis of ligand activation in a cyclic nucleotide regulated potassium channel by Clayton (2004)
10.1038/sj.bjp.0702164 / Br. J. Pharmacol. / Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors by Colquhoun (1998)
10.1085/jgp.200409178 / J. Gen. Physiol. / Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels by Craven (2004)
10.1093/nar/gkh398 / Nucleic Acids Res. / MolProbity: structure validation and all-atom contact analysis for nucleic acids and their complexes by Davis (2004)
10.1098/rspb.1957.0018 / Proc. R. Soc. Lond. B Biol. Sci. / Interaction at end-plate receptors between different choline derivatives by Del Castillo (1957)
10.1113/jphysiol.1991.sp018457 / J. Physiol. / The contribution of the ‘pacemaker’ current (if) to generation of spontaneous activity in rabbit sino-atrial node myocytes by DiFrancesco (1991)
10.1126/science.2916119 / Science / Muscarinic modulation of cardiac rate at low acetylcholine concentrations by DiFrancesco (1989)
10.1107/S0907444904019158 / Acta Crystallogr. D Biol. Crystallogr. / Coot: model-building tools for molecular graphics by Emsley (2004)
10.1006/jmbi.1997.0892 / J. Mol. Biol. / Thermodynamics of the interaction of barnase and barstar: changes in free energy versus changes in enthalpy on mutation by Frisch (1997)
10.1038/31248 / Nature / Molecular identification of a hyperpolarization-activated channel in sea urchin sperm by Gauss (1998)
10.1016/0896-6273(95)90229-5 / Neuron / Localization of regions affecting an allosteric transition in cyclic nucleotide-activated channels by Gordon (1995)
10.1007/BF00656997 / Pflugers Arch. / Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches by Hamill (1981)
10.1016/0076-6879(92)07009-D / Methods Enzymol. / Nonstationary noise analysis and application to patch clamp recordings by Heinemann (1992)
10.1016/S0076-6879(97)77012-5 / Methods Enzymol. / Electron-density map interpretation by Jones (1997)
10.1146/annurev.physiol.63.1.235 / Annu. Rev. Physiol. / Molecular diversity of pacemaker ion channels by Kaupp (2001)
10.1021/bi00134a015 / Biochemistry / Molecular model of the cyclic GMP-binding domain of the cyclic GMP-gated ion channel by Kumar (1992)
10.1093/nar/22.15.2894 / Nucleic Acids Res. / Mutagenesis of the cyclic AMP receptor protein of Escherichia coli: targeting positions 83, 127 and 128 of the cyclic nucleotide binding pocket by Lee (1994)
10.1017/S0033583597003326 / Q. Rev. Biophys. / Cyclic nucleotide-gated channels: structural basis of ligand efficacy and allosteric modulation by Li (1997)
10.1146/annurev.physiol.66.050802.084104 / Annu. Rev. Physiol. / Structure and function of glutamate receptor ion channels by Mayer (2004)
10.1016/S0022-2836(65)80285-6 / J. Mol. Biol. / On the nature of allosteric transitions: a plausible model by Monod (1965)
10.1146/annurev.ph.58.030196.001503 / Annu. Rev. Physiol. / Queer current and pacemaker: the hyperpolarization-activated cation current in neurons by Pape (1996)
10.1038/nsb878 / Nat. Struct. Biol. / Structure and regulation of the cAMP-binding domains of Epac2 by Rehmann (2003)
10.1146/annurev.physiol.65.092101.142734 / Annu. Rev. Physiol. / Hyperpolarization-activated cation currents: from molecules to physiological function by Robinson (2003)
10.1093/protein/9.4.333 / Protein Eng. / Predicted ligand interactions of 3′5′-cyclic nucleotide-gated channel binding sites: comparison of retina and olfactory binding site models by Scott (1996)
10.1016/S0896-6273(04)00083-2 / Neuron / Inactivation in HCN channels results from reclosure of the activation gate: desensitization to voltage by Shin (2004)
10.1126/science.7638597 / Science / Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains by Su (1995)
10.1107/S0021889897006766 / J. Appl. Cryst. / MOLREP: an automated program for molecular replacement by Vagin (1997)
10.1016/0896-6273(95)90150-7 / Neuron / Molecular mechanism for ligand discrimination of cyclic nucleotide-gated channels by Varnum (1995)
10.1107/S0907444902001567 / Acta Crystallogr. D Biol. Crystallogr. / A structural double-mutant cycle: estimating the strength of a buried salt bridge in barnase by Vaughan (2002)
10.1110/ps.051723606 / Protein Sci. / A simple electrostatic switch important in the activation of type I protein kinase A by cyclic AMP by Vigil (2006)
10.1016/S0021-9258(18)45620-7 / J. Biol. Chem. / Crystal structure of a cyclic AMP-independent mutant of catabolite gene activator protein by Weber (1987)
10.1021/bi00440a059 / Biochemistry / Predicted structures of the cGMP binding domains of the cGMP-dependent protein kinase: a key alanine/threonine difference in evolutionary divergence of cAMP and cGMP binding sites by Weber (1989)
10.1073/pnas.86.18.7243 / Proc. Natl. Acad. Sci. USA / Gating of single Shaker potassium channels in Drosophila muscle and in Xenopus oocytes injected with Shaker mRNA by Zagotta (1989)
10.1038/nature01922 / Nature / Structural basis for modulation and agonist specificity of HCN pacemaker channels by Zagotta (2003)

Dates

Type	When
Created	18 years, 2 months ago (June 14, 2007, 1:04 a.m.)
Deposited	1 year, 6 months ago (Feb. 10, 2024, 11:58 a.m.)
Indexed	2 months, 4 weeks ago (June 5, 2025, 1:05 p.m.)
Issued	18 years, 3 months ago (June 1, 2007)
Published	18 years, 3 months ago (June 1, 2007)
Published Print	18 years, 3 months ago (June 1, 2007)

Funders 2

National Eye Institute 10.13039/100000053
Region: Americas
gov (National government)
Labels3
1. Instituto Nacional del Ojo
2. NIH/National Eye Institute
3. NEI
Awards1
1. EY10329
Howard Hughes Medical Institute 10.13039/100000011
Region: Americas
pri (Research institutes and centers)
Labels2
1. Howard Hughes Medical Institute Inc
2. HHMI

BibTeX

@article{Flynn_2007, title={Structure and Rearrangements in the Carboxy-Terminal Region of SpIH Channels}, volume={15}, ISSN={0969-2126}, url={http://dx.doi.org/10.1016/j.str.2007.04.008}, DOI={10.1016/j.str.2007.04.008}, number={6}, journal={Structure}, publisher={Elsevier BV}, author={Flynn, Galen E. and Black, Kevin D. and Islas, Leon D. and Sankaran, Banumathi and Zagotta, William N.}, year={2007}, month=jun, pages={671–682} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        6,
        5
      ]
    ],
    "date-time": "2025-06-05T17:05:51Z",
    "timestamp": 1749143151432,
    "version": "3.37.3"
  },
  "reference-count": 41,
  "publisher": "Elsevier BV",
  "issue": "6",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2007,
            6,
            1
          ]
        ],
        "date-time": "2007-06-01T00:00:00Z",
        "timestamp": 1180656000000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2013,
            8,
            22
          ]
        ],
        "date-time": "2013-08-22T00:00:00Z",
        "timestamp": 1377129600000
      },
      "content-version": "vor",
      "delay-in-days": 2274,
      "URL": "http://www.elsevier.com/open-access/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2007,
            6,
            1
          ]
        ],
        "date-time": "2007-06-01T00:00:00Z",
        "timestamp": 1180656000000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-017"
    },
    {
      "start": {
        "date-parts": [
          [
            2007,
            6,
            1
          ]
        ],
        "date-time": "2007-06-01T00:00:00Z",
        "timestamp": 1180656000000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-037"
    },
    {
      "start": {
        "date-parts": [
          [
            2007,
            6,
            1
          ]
        ],
        "date-time": "2007-06-01T00:00:00Z",
        "timestamp": 1180656000000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-012"
    },
    {
      "start": {
        "date-parts": [
          [
            2007,
            6,
            1
          ]
        ],
        "date-time": "2007-06-01T00:00:00Z",
        "timestamp": 1180656000000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-029"
    },
    {
      "start": {
        "date-parts": [
          [
            2007,
            6,
            1
          ]
        ],
        "date-time": "2007-06-01T00:00:00Z",
        "timestamp": 1180656000000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-004"
    }
  ],
  "funder": [
    {
      "DOI": "10.13039/100000053",
      "name": "National Eye Institute",
      "doi-asserted-by": "publisher",
      "award": [
        "EY10329"
      ],
      "id": [
        {
          "id": "10.13039/100000053",
          "id-type": "DOI",
          "asserted-by": "publisher"
        }
      ]
    },
    {
      "DOI": "10.13039/100000011",
      "name": "Howard Hughes Medical Institute",
      "doi-asserted-by": "publisher",
      "id": [
        {
          "id": "10.13039/100000011",
          "id-type": "DOI",
          "asserted-by": "publisher"
        }
      ]
    }
  ],
  "content-domain": {
    "domain": [
      "cell.com",
      "elsevier.com",
      "sciencedirect.com"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        2007,
        6
      ]
    ]
  },
  "DOI": "10.1016/j.str.2007.04.008",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2007,
        6,
        14
      ]
    ],
    "date-time": "2007-06-14T05:04:48Z",
    "timestamp": 1181797488000
  },
  "page": "671-682",
  "update-policy": "https://doi.org/10.1016/elsevier_cm_policy",
  "source": "Crossref",
  "is-referenced-by-count": 71,
  "title": "Structure and Rearrangements in the Carboxy-Terminal Region of SpIH Channels",
  "prefix": "10.1016",
  "volume": "15",
  "author": [
    {
      "given": "Galen E.",
      "family": "Flynn",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Kevin D.",
      "family": "Black",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Leon D.",
      "family": "Islas",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Banumathi",
      "family": "Sankaran",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "William N.",
      "family": "Zagotta",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/j.str.2007.04.008_bib1",
      "doi-asserted-by": "crossref",
      "first-page": "53",
      "DOI": "10.1107/S0909049503024130",
      "article-title": "Recent developments in the PHENIX software for automated crystallographic structure determination",
      "volume": "11",
      "author": "Adams",
      "year": "2004",
      "journal-title": "J. Synchrotron Radiat."
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib2",
      "doi-asserted-by": "crossref",
      "first-page": "9868",
      "DOI": "10.1073/pnas.88.21.9868",
      "article-title": "Control of ligand specificity in cyclic nucleotide-gated channels from rod photoreceptors and olfactory epithelium",
      "volume": "88",
      "author": "Altenhofen",
      "year": "1991",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib3",
      "doi-asserted-by": "crossref",
      "first-page": "519",
      "DOI": "10.1085/jgp.117.6.519",
      "article-title": "Integrated allosteric model of voltage gating of HCN channels",
      "volume": "117",
      "author": "Altomare",
      "year": "2001",
      "journal-title": "J. Gen. Physiol."
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib4",
      "doi-asserted-by": "crossref",
      "first-page": "111",
      "DOI": "10.1196/annals.1302.009",
      "article-title": "Pacemaker channels",
      "volume": "1015",
      "author": "Baruscotti",
      "year": "2004",
      "journal-title": "Ann. N Y Acad. Sci."
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "206",
      "DOI": "10.1016/S1050-1738(02)00162-7",
      "article-title": "Cardiac HCN channels: structure, function, and modulation",
      "volume": "12",
      "author": "Biel",
      "year": "2002",
      "journal-title": "Trends Cardiovasc. Med."
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib6",
      "doi-asserted-by": "crossref",
      "first-page": "905",
      "DOI": "10.1107/S0907444998003254",
      "article-title": "Crystallography & NMR System: a new software suite for macromolecular structure determination",
      "volume": "54",
      "author": "Brunger",
      "year": "1998",
      "journal-title": "Acta Crystallogr. D\u00a0Biol. Crystallogr."
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "760",
      "DOI": "10.1107/S0907444994003112",
      "article-title": "The CCP4 suite: programs for X-ray crystallography",
      "volume": "50",
      "year": "1994",
      "journal-title": "Acta Crystallogr. D Biol. Crystallogr."
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "615",
      "DOI": "10.1016/j.cell.2004.10.030",
      "article-title": "Structural basis of ligand activation in a cyclic nucleotide regulated potassium channel",
      "volume": "119",
      "author": "Clayton",
      "year": "2004",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "924",
      "DOI": "10.1038/sj.bjp.0702164",
      "article-title": "Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors",
      "volume": "125",
      "author": "Colquhoun",
      "year": "1998",
      "journal-title": "Br. J. Pharmacol."
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib10",
      "doi-asserted-by": "crossref",
      "first-page": "663",
      "DOI": "10.1085/jgp.200409178",
      "article-title": "Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels",
      "volume": "124",
      "author": "Craven",
      "year": "2004",
      "journal-title": "J. Gen. Physiol."
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib11",
      "doi-asserted-by": "crossref",
      "first-page": "W615",
      "DOI": "10.1093/nar/gkh398",
      "article-title": "MolProbity: structure validation and all-atom contact analysis for nucleic acids and their complexes",
      "volume": "32",
      "author": "Davis",
      "year": "2004",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "369",
      "DOI": "10.1098/rspb.1957.0018",
      "article-title": "Interaction at end-plate receptors between different choline derivatives",
      "volume": "146",
      "author": "Del Castillo",
      "year": "1957",
      "journal-title": "Proc. R. Soc. Lond. B Biol. Sci."
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "23",
      "DOI": "10.1113/jphysiol.1991.sp018457",
      "article-title": "The contribution of the \u2018pacemaker\u2019 current (if) to generation of spontaneous activity in rabbit sino-atrial node myocytes",
      "volume": "434",
      "author": "DiFrancesco",
      "year": "1991",
      "journal-title": "J. Physiol."
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "669",
      "DOI": "10.1126/science.2916119",
      "article-title": "Muscarinic modulation of cardiac rate at low acetylcholine concentrations",
      "volume": "243",
      "author": "DiFrancesco",
      "year": "1989",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "2126",
      "DOI": "10.1107/S0907444904019158",
      "article-title": "Coot: model-building tools for molecular graphics",
      "volume": "60",
      "author": "Emsley",
      "year": "2004",
      "journal-title": "Acta Crystallogr. D Biol. Crystallogr."
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "696",
      "DOI": "10.1006/jmbi.1997.0892",
      "article-title": "Thermodynamics of the interaction of barnase and barstar: changes in free energy versus changes in enthalpy on mutation",
      "volume": "267",
      "author": "Frisch",
      "year": "1997",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "583",
      "DOI": "10.1038/31248",
      "article-title": "Molecular identification of a hyperpolarization-activated channel in sea urchin sperm",
      "volume": "393",
      "author": "Gauss",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "857",
      "DOI": "10.1016/0896-6273(95)90229-5",
      "article-title": "Localization of regions affecting an allosteric transition in cyclic nucleotide-activated channels",
      "volume": "14",
      "author": "Gordon",
      "year": "1995",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "85",
      "DOI": "10.1007/BF00656997",
      "article-title": "Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches",
      "volume": "391",
      "author": "Hamill",
      "year": "1981",
      "journal-title": "Pflugers Arch."
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "131",
      "DOI": "10.1016/0076-6879(92)07009-D",
      "article-title": "Nonstationary noise analysis and application to patch clamp recordings",
      "volume": "207",
      "author": "Heinemann",
      "year": "1992",
      "journal-title": "Methods Enzymol."
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "173",
      "DOI": "10.1016/S0076-6879(97)77012-5",
      "article-title": "Electron-density map interpretation",
      "volume": "277",
      "author": "Jones",
      "year": "1997",
      "journal-title": "Methods Enzymol."
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "235",
      "DOI": "10.1146/annurev.physiol.63.1.235",
      "article-title": "Molecular diversity of pacemaker ion channels",
      "volume": "63",
      "author": "Kaupp",
      "year": "2001",
      "journal-title": "Annu. Rev. Physiol."
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "4643",
      "DOI": "10.1021/bi00134a015",
      "article-title": "Molecular model of the cyclic GMP-binding domain of the cyclic GMP-gated ion channel",
      "volume": "31",
      "author": "Kumar",
      "year": "1992",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "2894",
      "DOI": "10.1093/nar/22.15.2894",
      "article-title": "Mutagenesis of the cyclic AMP receptor protein of Escherichia coli: targeting positions 83, 127 and 128 of the cyclic nucleotide binding pocket",
      "volume": "22",
      "author": "Lee",
      "year": "1994",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "177",
      "DOI": "10.1017/S0033583597003326",
      "article-title": "Cyclic nucleotide-gated channels: structural basis of ligand efficacy and allosteric modulation",
      "volume": "30",
      "author": "Li",
      "year": "1997",
      "journal-title": "Q. Rev. Biophys."
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "161",
      "DOI": "10.1146/annurev.physiol.66.050802.084104",
      "article-title": "Structure and function of glutamate receptor ion channels",
      "volume": "66",
      "author": "Mayer",
      "year": "2004",
      "journal-title": "Annu. Rev. Physiol."
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "88",
      "DOI": "10.1016/S0022-2836(65)80285-6",
      "article-title": "On the nature of allosteric transitions: a plausible model",
      "volume": "12",
      "author": "Monod",
      "year": "1965",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "299",
      "DOI": "10.1146/annurev.ph.58.030196.001503",
      "article-title": "Queer current and pacemaker: the hyperpolarization-activated cation current in neurons",
      "volume": "58",
      "author": "Pape",
      "year": "1996",
      "journal-title": "Annu. Rev. Physiol."
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "26",
      "DOI": "10.1038/nsb878",
      "article-title": "Structure and regulation of the cAMP-binding domains of Epac2",
      "volume": "10",
      "author": "Rehmann",
      "year": "2003",
      "journal-title": "Nat. Struct. Biol."
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "453",
      "DOI": "10.1146/annurev.physiol.65.092101.142734",
      "article-title": "Hyperpolarization-activated cation currents: from molecules to physiological function",
      "volume": "65",
      "author": "Robinson",
      "year": "2003",
      "journal-title": "Annu. Rev. Physiol."
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "333",
      "DOI": "10.1093/protein/9.4.333",
      "article-title": "Predicted ligand interactions of 3\u20325\u2032-cyclic nucleotide-gated channel binding sites: comparison of retina and olfactory binding site models",
      "volume": "9",
      "author": "Scott",
      "year": "1996",
      "journal-title": "Protein Eng."
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "737",
      "DOI": "10.1016/S0896-6273(04)00083-2",
      "article-title": "Inactivation in HCN channels results from reclosure of the activation gate: desensitization to voltage",
      "volume": "41",
      "author": "Shin",
      "year": "2004",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "807",
      "DOI": "10.1126/science.7638597",
      "article-title": "Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains",
      "volume": "269",
      "author": "Su",
      "year": "1995",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "1022",
      "DOI": "10.1107/S0021889897006766",
      "article-title": "MOLREP: an automated program for molecular replacement",
      "volume": "30",
      "author": "Vagin",
      "year": "1997",
      "journal-title": "J. Appl. Cryst."
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "619",
      "DOI": "10.1016/0896-6273(95)90150-7",
      "article-title": "Molecular mechanism for ligand discrimination of cyclic nucleotide-gated channels",
      "volume": "15",
      "author": "Varnum",
      "year": "1995",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "591",
      "DOI": "10.1107/S0907444902001567",
      "article-title": "A structural double-mutant cycle: estimating the strength of a buried salt bridge in barnase",
      "volume": "58",
      "author": "Vaughan",
      "year": "2002",
      "journal-title": "Acta Crystallogr. D Biol. Crystallogr."
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "113",
      "DOI": "10.1110/ps.051723606",
      "article-title": "A simple electrostatic switch important in the activation of type I protein kinase A by cyclic AMP",
      "volume": "15",
      "author": "Vigil",
      "year": "2006",
      "journal-title": "Protein Sci."
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "5630",
      "DOI": "10.1016/S0021-9258(18)45620-7",
      "article-title": "Crystal structure of a cyclic AMP-independent mutant of catabolite gene activator protein",
      "volume": "262",
      "author": "Weber",
      "year": "1987",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "6122",
      "DOI": "10.1021/bi00440a059",
      "article-title": "Predicted structures of the cGMP binding domains of the cGMP-dependent protein kinase: a key alanine/threonine difference in evolutionary divergence of cAMP and cGMP binding sites",
      "volume": "28",
      "author": "Weber",
      "year": "1989",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "7243",
      "DOI": "10.1073/pnas.86.18.7243",
      "article-title": "Gating of single Shaker potassium channels in Drosophila muscle and in Xenopus oocytes injected with Shaker mRNA",
      "volume": "86",
      "author": "Zagotta",
      "year": "1989",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.str.2007.04.008_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "200",
      "DOI": "10.1038/nature01922",
      "article-title": "Structural basis for modulation and agonist specificity of HCN pacemaker channels",
      "volume": "425",
      "author": "Zagotta",
      "year": "2003",
      "journal-title": "Nature"
    }
  ],
  "container-title": "Structure",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S096921260700175X?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S096921260700175X?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        2,
        10
      ]
    ],
    "date-time": "2024-02-10T16:58:54Z",
    "timestamp": 1707584334000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S096921260700175X"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2007,
        6
      ]
    ]
  },
  "references-count": 41,
  "journal-issue": {
    "issue": "6",
    "published-print": {
      "date-parts": [
        [
          2007,
          6
        ]
      ]
    }
  },
  "alternative-id": [
    "S096921260700175X"
  ],
  "URL": "http://dx.doi.org/10.1016/j.str.2007.04.008",
  "relation": {},
  "ISSN": [
    "0969-2126"
  ],
  "subject": [],
  "container-title-short": "Structure",
  "published": {
    "date-parts": [
      [
        2007,
        6
      ]
    ]
  },
  "assertion": [
    {
      "value": "Elsevier",
      "name": "publisher",
      "label": "This article is maintained by"
    },
    {
      "value": "Structure and Rearrangements in the Carboxy-Terminal Region of SpIH Channels",
      "name": "articletitle",
      "label": "Article Title"
    },
    {
      "value": "Structure",
      "name": "journaltitle",
      "label": "Journal Title"
    },
    {
      "value": "https://doi.org/10.1016/j.str.2007.04.008",
      "name": "articlelink",
      "label": "CrossRef DOI link to publisher maintained version"
    },
    {
      "value": "article",
      "name": "content_type",
      "label": "Content Type"
    },
    {
      "value": "Copyright \u00a9 2007 Elsevier Ltd. All rights reserved.",
      "name": "copyright",
      "label": "Copyright"
    }
  ]
}