DOI: 10.1016/j.str.2004.01.015. Experimental Verification of Conformational Variation of Human Fatty Acid Synthase as Predicted by Normal Mode Analysis

Experimental Verification of Conformational Variation of Human Fatty Acid Synthase as Predicted by Normal Mode Analysis

10.1016/j.str.2004.01.015

Crossref journal-article

Elsevier BV

Structure (78)

Authors 6

Jacob Brink (first)
Steven J. Ludtke (additional)
Yifei Kong (additional)
Salih J. Wakil (additional)
Jianpeng Ma (additional)
Wah Chiu (additional)

References 22 Referenced 70

10.1073/pnas.012589499 / Proc. Natl. Acad. Sci. USA / Quaternary structure of human fatty acid synthase by electron cryomicroscopy by Brink (2002)
10.1073/pnas.94.11.5588 / Proc. Natl. Acad. Sci. USA / Animal fatty acid synthase: functional mapping and cloning and expression of the domain I constituent activities by Chirala (1997)
10.1073/pnas.051635998 / Proc. Natl. Acad. Sci. USA / Human fatty acid synthase: role of interdomain in the formation of catalytically active synthase dimer by Chirala (2001)
10.1146/annurev.nutr.17.1.325 / Annu. Rev. Nutr. / Mechanisms by which carbohydrates regulate expression of genes for glycolytic and lipogenic enzymes by Girard (1997)
10.1152/physrev.1995.75.1.47 / Physiol. Rev. / Physiological and molecular mechanisms involved in nutritional regulation of fatty acid synthesis by Hillgartner (1995)
10.1073/pnas.91.14.6379 / Proc. Natl. Acad. Sci. USA / Fatty acid synthesis: a potential selective target for antineoplastic therapy by Kuhajda (1994)
10.1126/science.288.5475.2379 / Science / Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors by Loftus (2000)
10.1006/jsbi.1999.4174 / J. Struct. Biol. / Eman: semiautomated software for high resolution single-particle reconstructions by Ludtke (1999)
10.1006/jmbi.2001.5133 / J. Mol. Biol. / A 11.5 Å single particle reconstruction of GroEL using EMAN by Ludtke (2001)
10.1016/S0021-9258(17)43805-1 / J. Biol. Chem. / The architecture of the animal fatty acid synthetase. I. Proteolytic dissection and peptide mapping by Mattick (1983)
10.1073/pnas.082148899 / Proc. Natl. Acad. Sci. USA / How to describe protein motion without amino acid sequence and atomic coordinates by Ming (2002)
10.1073/pnas.112222299 / Proc. Natl. Acad. Sci. USA / Domain movements in human fatty acid synthase by quantized elastic deformational model by Ming (2002)
10.1002/(SICI)1097-0142(19980801)83:3<528::AID-CNCR22>3.0.CO;2-X / Cancer / Fatty acid synthase expression in endometrial carcinoma: correlation with cell proliferation and hormone receptors by Pizer (1998)
10.1096/fasebj.8.15.8001737 / FASEB J. / The animal fatty acid synthase: one gene, one polypeptide, seven enzymes by Smith (1994)
10.1111/j.1432-1033.1985.tb09230.x / Eur. J. Biochem. / Mammalian fatty acid synthetase is a structurally and functionally symmetrical dimer by Smith (1985)
10.1016/S0021-9258(19)69376-2 / J. Biol. Chem. / Animal fatty acid synthetase. A novel arrangement of the beta-ketoacyl synthetase sites comprising domains of the two subunits by Stoops (1981)
10.1016/S0021-9258(18)61104-4 / J. Biol. Chem. / Small-angle neutron-scattering and electron microscope studies of the chicken liver fatty acid synthase by Stoops (1987)
10.1016/S0022-2836(02)00627-7 / J. Mol. Biol. / Exploring global distortions of biological macromolecules and assemblies from low-resolution structural information and elastic network theory by Tama (2002)
10.1016/S0021-9258(17)43808-7 / J. Biol. Chem. / The architecture of the animal fatty acid synthetase complex. IV. Mapping of active centers and model for the mechanism of action by Tsukamoto (1983)
10.1021/bi00437a001 / Biochemistry / Fatty acid synthase, a proficient multifunctional enzyme by Wakil (1989)
10.1146/annurev.bi.52.070183.002541 / Annu. Rev. Biochem. / Fatty acid synthesis and its regulation by Wakil (1983)
10.1111/j.1432-1033.1991.tb16052.x / Eur. J. Biochem. / Structural organization of the multifunctional animal fatty-acid synthase by Witkowski (1991)

Dates

Type	When
Created	17 years, 7 months ago (Jan. 24, 2008, 8:52 p.m.)
Deposited	3 years, 11 months ago (Sept. 2, 2021, 1:25 p.m.)
Indexed	4 weeks ago (July 30, 2025, 10:24 a.m.)
Issued	21 years, 6 months ago (Feb. 1, 2004)
Published	21 years, 6 months ago (Feb. 1, 2004)
Published Print	21 years, 6 months ago (Feb. 1, 2004)

Funders 0

None

BibTeX

@article{Brink_2004, title={Experimental Verification of Conformational Variation of Human Fatty Acid Synthase as Predicted by Normal Mode Analysis}, volume={12}, ISSN={0969-2126}, url={http://dx.doi.org/10.1016/j.str.2004.01.015}, DOI={10.1016/j.str.2004.01.015}, number={2}, journal={Structure}, publisher={Elsevier BV}, author={Brink, Jacob and Ludtke, Steven J. and Kong, Yifei and Wakil, Salih J. and Ma, Jianpeng and Chiu, Wah}, year={2004}, month=feb, pages={185–191} }

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