10.1016/j.pneurobio.2011.08.013
Crossref journal-article
Elsevier BV
Progress in Neurobiology (78)
Bibliography

Jimenez-Sanchez, M., Thomson, F., Zavodszky, E., & Rubinsztein, D. C. (2012). Autophagy and polyglutamine diseases. Progress in Neurobiology, 97(2), 67–82.

Authors 4
  1. Maria Jimenez-Sanchez (first)
  2. Frances Thomson (additional)
  3. Eszter Zavodszky (additional)
  4. David C. Rubinsztein (additional)
References 192 Referenced 79
  1. 10.1074/jbc.M109.013193 / J. Biol. Chem. / Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity by Aiken (2009)
  2. 10.1038/nature02998 / Nature / Inclusion body formation reduces levels of mutant Huntingtin and the risk of neuronal death by Arrasate (2004)
  3. 10.1093/hmg/ddm217 / Hum. Mol. Genet. / Huntingtin has a membrane association signal that can modulate Huntingtin aggregation, nuclear entry and toxicity by Atwal (2007)
  4. 10.1083/jcb.200803137 / J. Cell Biol. / Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum by Axe (2008)
  5. 10.1371/journal.pone.0007124 / PLoS ONE / Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling by Balgi (2009)
  6. 10.1074/jbc.273.34.21883 / J. Biol. Chem. / Isolation and characterization of rat liver amphisomes. Evidence for fusion of autophagosomes with both early and late endosomes by Berg (1998)
  7. 10.1093/hmg/ddi458 / Hum. Mol. Genet. / Rapamycin alleviates toxicity of different aggregate-prone proteins by Berger (2006)
  8. 10.1093/hmg/ddi331 / Hum. Mol. Genet. / Lithium rescues toxicity of aggregate-prone proteins in Drosophila by perturbing Wnt pathway by Berger (2005)
  9. 10.1111/j.1471-4159.2004.02369.x / J. Neurochem. / Caspase-mediated proteolysis of the polyglutamine disease protein ataxin-3 by Berke (2004)
  10. 10.1523/JNEUROSCI.4540-06.2007 / J. Neurosci. / Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence by Bichelmeier (2007)
  11. 10.1083/jcb.200507002 / J. Cell Biol. / p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on Huntingtin-induced cell death by Bjørkøy (2005)
  12. 10.1111/j.1432-1033.1997.0240a.x / Eur. J. Biochem. / The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes by Blommaart (1997)
  13. 10.1158/0008-5472.CAN-08-4344 / Cancer Res. / Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells by Bommareddy (2009)
  14. 10.1038/mt.2009.17 / Mol. Ther. / Nonallele-specific silencing of mutant and wild-type Huntingtin demonstrates therapeutic efficacy in Huntington's disease mice by Boudreau (2009)
  15. 10.1016/j.cell.2010.06.007 / Cell / Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria by Cárdenas (2010)
  16. 10.1074/jbc.M204861200 / J. Biol. Chem. / Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation by Carmichael (2002)
  17. 10.1016/j.devcel.2008.08.012 / Dev. Cell / The role of autophagy in mammalian development: cell makeover rather than cell death by Cecconi (2008)
  18. 10.1074/jbc.M703663200 / J. Biol. Chem. / siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy by Chan (2007)
  19. 10.1128/MCB.01082-08 / Mol. Cell. Biol. / Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism by Chan (2009)
  20. 10.1038/emboj.2009.369 / EMBO J. / Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1 by Chang (2010)
  21. 10.1242/jeb.01133 / J. Exp. Biol. / Role of trehalose phosphate synthase and trehalose during hypoxia: from flies to mammals by Chen (2004)
  22. 10.1016/S0896-6273(03)00195-8 / Neuron / Finding the intracellular signaling pathways affected by mood disorder treatments by Coyle (2003)
  23. 10.1038/sj.cdd.4402099 / Cell Death Differ. / Regulation of autophagy by the inositol trisphosphate receptor by Criollo (2007)
  24. 10.1093/hmg/ddi422 / Hum. Mol. Genet. / Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy by Davies (2006)
  25. 10.1083/jcb.200801099 / J. Cell Biol. / Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents by Degtyarev (2008)
  26. 10.1073/pnas.1530212100 / Proc. Natl. Acad. Sci. U.S.A. / Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates by Donaldson (2003)
  27. 10.1126/science.7618107 / Science / Inactivation of the mouse Huntington's disease gene homolog Hdh by Duyao (1995)
  28. 10.1126/science.1196371 / Science / Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy by Egan (2011)
  29. 10.1046/j.1471-4159.1999.0720185.x / J. Neurochem. / Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity by Ellerby (1999)
  30. 10.1016/j.molcel.2010.04.007 / Mol. Cell / The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy by Filimonenko (2010)
  31. 10.1038/nature05925 / Nature / Ambra1 regulates autophagy and development of the nervous system by Fimia (2007)
  32. 10.1091/mbc.E07-12-1257 / Mol. Biol. Cell / The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy by Fujita (2008)
  33. 10.1091/mbc.E09-08-0693 / Mol. Biol. Cell / Combinational soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins VAMP8 and Vti1b mediate fusion of antimicrobial and canonical autophagosomes with lysosomes by Furuta (2010)
  34. 10.1074/jbc.M900573200 / J. Biol. Chem. / ULK1·ATG13·FIP200 complex mediates mTOR signaling and is essential for autophagy by Ganley (2009)
  35. 10.1523/JNEUROSCI.22-12-04897.2002 / J. Neurosci. / Polyglutamine-expanded ataxin-7 promotes non-cell-autonomous purkinje cell degeneration and displays proteolytic cleavage in ataxic transgenic mice by Garden (2002)
  36. 10.1038/nrg1691 / Nat. Rev. Genet. / Diseases of unstable repeat expansion: mechanisms and common principles by Gatchel (2005)
  37. 10.1091/mbc.E09-11-0969 / Mol. Biol. Cell / Post-Golgi Sec proteins are required for autophagy in Saccharomyces cerevisiae by Geng (2010)
  38. 10.1016/S0021-9258(19)74287-2 / J. Biol. Chem. / Dependence of hepatocytic autophagy on intracellularly sequestered calcium by Gordon (1993)
  39. 10.1016/0006-291X(88)90556-6 / Biochem. Biophys. Res. Commun. / Prelysosomal convergence of autophagic and endocytic pathways by Gordon (1988)
  40. 10.1016/S1566-2772(02)00044-0 / Clin. Neurosci. Res. / Mood stabilizer psychopharmacology by Gould (2002)
  41. 10.1016/j.cell.2006.04.026 / Cell / Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant Huntingtin by Graham (2006)
  42. 10.4161/auto.5.8.10122 / Autophagy / Autophagy as the main means of cytotoxicity by glucocorticoids in hematological malignancies by Grandér (2009)
  43. 10.1016/j.cell.2004.11.038 / Cell / Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages by Gutierrez (2004)
  44. 10.1083/jcb.141.5.1097 / J. Cell Biol. / The influence of Huntingtin protein size on nuclear localization and cellular toxicity by Hackam (1998)
  45. 10.1016/j.cell.2010.04.009 / Cell / Mitochondria supply membranes for autophagosome biogenesis during starvation by Hailey (2010)
  46. 10.1007/s00401-010-0703-0 / Acta Neuropathol. / Neurotoxic protein oligomerisation associated with polyglutamine diseases by Hands (2010)
  47. 10.1038/nature04724 / Nature / Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice by Hara (2006)
  48. 10.1001/archneurol.2009.180 / Arch. Neurol. / Progress and challenges in RNA interference therapy for Huntington disease by Harper (2009)
  49. 10.1073/pnas.0501507102 / Proc. Natl. Acad. Sci. U.S.A. / RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model by Harper (2005)
  50. 10.1038/ncb1991 / Nat. Cell Biol. / A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation by Hayashi-Nishino (2009)
  51. 10.1074/jbc.M308762200 / J. Biol. Chem. / A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L by Hemelaar (2003)
  52. 10.1093/hmg/ddq285 / Hum. Mol. Genet. / Early autophagic response in a novel knock-in model of Huntington disease by Heng (2010)
  53. 10.1016/S0896-6273(00)80764-3 / Neuron / A YAC mouse model for Huntington's disease with full-length mutant Huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration by Hodgson (1999)
  54. 10.1038/sj.emboj.7600426 / EMBO J. / Inefficient degradation of truncated polyglutamine proteins by the proteasome by Holmberg (2004)
  55. 10.1091/mbc.E08-12-1248 / Mol. Biol. Cell / Nutrient-dependent mTORC1 association with the ULK1–Atg13–FIP200 complex required for autophagy by Hosokawa (2009)
  56. 10.1074/jbc.M802182200 / J. Biol. Chem. / Structural basis for sorting mechanism of p62 in selective autophagy by Ichimura (2008)
  57. 10.1016/j.cell.2006.06.055 / Cell / TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth by Inoki (2006)
  58. 10.1016/S0092-8674(03)00929-2 / Cell / TSC2 mediates cellular energy response to control cell growth and survival by Inoki (2003)
  59. 10.1091/mbc.E08-01-0080 / Mol. Biol. Cell / Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG by Itakura (2008)
  60. 10.1073/pnas.0505801102 / Proc. Natl. Acad. Sci. U.S.A. / Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation by Iwata (2005)
  61. 10.1038/ncb1183 / Nat. Cell Biol. / Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive by Jacinto (2004)
  62. 10.1093/hmg/ddr195 / Hum. Mol. Genet. / HD CAG-correlated gene expression changes support a simple dominant gain of function by Jacobsen (2011)
  63. 10.1111/j.1600-0854.2008.00701.x / Traffic / The itinerary of autophagosomes: from peripheral formation to kiss-and-run fusion with lysosomes by Jahreiss (2008)
  64. 10.1016/j.cell.2009.03.018 / Cell / Acetylation targets mutant Huntingtin to autophagosomes for degradation by Jeong (2009)
  65. 10.1093/emboj/19.21.5720 / EMBO J. / LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing by Kabeya (2000)
  66. 10.3233/JAD-2008-15314 / J. Alzheimers Dis. / Antioxidants in central nervous system diseases: preclinical promise and translational challenges by Kamat (2008)
  67. 10.1016/j.devcel.2009.06.014 / Dev. Cell / Atg32 is a mitochondrial protein that confers selectivity during mitophagy by Kanki (2009)
  68. 10.1242/jcs.073874 / J. Cell Sci. / Chaperone-mediated autophagy at a glance by Kaushik (2011)
  69. 10.1523/JNEUROSCI.20-19-07268.2000 / J. Neurosci. / Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy by Kegel (2000)
  70. 10.1093/embo-reports/kve061 / EMBO Rep. / Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network by Kihara (2001)
  71. 10.1016/S0092-8674(02)00808-5 / Cell / mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery by Kim (2002)
  72. 10.1016/j.abb.2007.03.034 / Archives of Biochemistry and Biophysics / Selective degradation of mitochondria by mitophagy by Kim (2007)
  73. 10.1038/ncb2152 / Nat. Cell Biol. / AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 by Kim (2011)
  74. 10.1247/csf.08005 / Cell Struct. Funct. / Dynein-dependent movement of autophagosomes mediates efficient encounters with lysosomes by Kimura (2008)
  75. 10.4161/auto.5338 / Autophagy / Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes by Klionsky (2008)
  76. 10.1038/nature04723 / Nature / Loss of autophagy in the central nervous system causes neurodegeneration in mice by Komatsu (2006)
  77. 10.1016/j.cell.2007.10.035 / Cell / Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice by Komatsu (2007)
  78. 10.1016/j.molcel.2009.01.021 / Mol. Cell / Autophagy inhibition compromises degradation of ubiquitin–proteasome pathway substrates by Korolchuk (2009)
  79. 10.1038/ncb2204 / Nat. Cell Biol. / Lysosomal positioning coordinates cellular nutrient responses by Korolchuk (2011)
  80. 10.1038/nature03029 / Nature / The role of autophagy during the early neonatal starvation period by Kuma (2004)
  81. 10.4161/auto.4012 / Autophagy / LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: caution in the interpretation of LC3 localization by Kuma (2007)
  82. 10.1097/00001756-200107200-00009 / Neuroreport / Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies by Kuusisto (2001)
  83. 10.1002/ana.410360604 / Ann. Neurol. / Trinucleotide repeat expansion in neurological disease by La Spada (1994)
  84. 10.1038/cdd.2009.46 / Cell Death Differ. / Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy by Laane (2009)
  85. 10.1002/ajmg.b.30992 / Am. J. Med. Genet. B: Neuropsychiatr. Genet. / CAG-repeat length and the age of onset in Huntington disease (HD): a review and validation study of statistical approaches by Langbehn (2010)
  86. 10.1242/jcs.114.16.2903 / J. Cell Sci. / PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? by Lawlor (2001)
  87. 10.1038/nature09299 / Nature / Enhancement of proteasome activity by a small-molecule inhibitor of USP14 by Lee (2010)
  88. 10.1016/j.immuni.2009.12.006 / Immunity / In vivo requirement for Atg5 in antigen presentation by dendritic cells by Lee (2010)
  89. 10.1089/rej.2005.8.3 / Rejuvenation Res. / Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging by Lemasters (2005)
  90. 10.1038/ncb1740 / Nat. Cell Biol. / Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking by Liang (2008)
  91. 10.1038/nrd2926 / Nat. Rev. Drug Discov. / Targeting the phosphoinositide 3-kinase pathway in cancer by Liu (2009)
  92. 10.1016/j.ddstr.2009.12.001 / Drug Discov. Today Ther. Strateg. / mTOR mediated anti-cancer drug discovery by Liu (2009)
  93. 10.1016/S1097-2765(02)00636-6 / Mol. Cell / Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control by Loewith (2002)
  94. 10.1093/hmg/7.9.1355 / Hum. Mol. Genet. / A cellular model that recapitulates major pathogenic steps of Huntington's disease by Lunkes (1998)
  95. 10.1016/S0092-8674(00)81369-0 / Cell / Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice by Mangiarini (1996)
  96. 10.1038/nn.2528 / Nat. Neurosci. / Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease by Martinez-Vicente (2010)
  97. 10.1523/JNEUROSCI.18-14-05508.1998 / J. Neurosci. / Mice lacking ataxin-1 display learning deficits and decreased hippocampal paired-pulse facilitation by Matilla (1998)
  98. 10.4161/auto.3595 / Autophagy / ATG genes involved in non-selective autophagy are conserved from yeast to man, but the selective Cvt and pexophagy pathways also require organism-specific genes by Meijer (2007)
  99. 10.1093/brain/awp292 / Brain / Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3 by Menzies (2010)
  100. 10.1016/j.neuron.2010.06.021 / Neuron / Matrix metalloproteinases are modifiers of Huntingtin proteolysis and toxicity in Huntington's disease by Miller (2010)
  101. 10.1093/emboj/18.14.3888 / EMBO J. / Apg16p is required for the function of the Apg12p–Apg5p conjugate in the yeast autophagy pathway by Mizushima (1999)
  102. 10.1242/jcs.00381 / J. Cell Sci. / Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12–Apg5 conjugate by Mizushima (2003)
  103. 10.1038/26506 / Nature / A protein conjugation system essential for autophagy by Mizushima (1998)
  104. 10.1016/S0014-5793(02)03739-0 / FEBS Lett. / Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid method by Mizushima (2002)
  105. 10.1093/hmg/ddp115 / Hum. Mol. Genet. / Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy by Montie (2009)
  106. 10.1523/JNEUROSCI.4720-09.2009 / J. Neurosci. / Posttranslational modification of ataxin-7 at lysine 257 prevents autophagy-mediated turnover of an N-terminal caspase-7 cleavage fragment by Mookerjee (2009)
  107. 10.1126/science.1103966 / Science / Autophagy defends cells against invading Group A Streptococcus by Nakagawa (2004)
  108. 10.1016/j.cell.2007.05.021 / Cell / Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion by Nakatogawa (2007)
  109. 10.1371/journal.pbio.1000298 / PLoS Biol. / PINK1 is selectively stabilized on impaired mitochondria to activate Parkin by Narendra (2010)
  110. 10.1083/jcb.200809125 / J. Cell Biol. / Parkin is recruited selectively to impaired mitochondria and promotes their autophagy by Narendra (2008)
  111. 10.1074/jbc.M300550200 / J. Biol. Chem. / The mouse APG10 homologue, an E2-like enzyme for Apg12p conjugation, facilitates MAP-LC3 modification by Nemoto (2003)
  112. 10.1038/cdd.2010.31 / Cell Death Differ. / Neurodegeneration by polyglutamine Atrophin is not rescued by induction of autophagy by Nisoli (2010)
  113. 10.1038/embor.2009.256 / EMBO Rep. / Nix is a selective autophagy receptor for mitochondrial clearance by Novak (2010)
  114. 10.1016/j.devcel.2009.06.013 / Dev. Cell / Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy by Okamoto (2009)
  115. 10.1016/S0092-8674(00)80464-X / Cell / Ectopically expressed CAG repeats cause intranuclear inclusions and a progressive late onset neurological phenotype in the mouse by Ordway (1997)
  116. 10.1101/gad.888401 / Genes Dev. / Beyond the Qs in the polyglutamine diseases by Orr (2001)
  117. 10.1146/annurev.neuro.29.051605.113042 / Annu. Rev. Neurosci. / Trinucleotide repeat disorders by Orr (2007)
  118. 10.1038/nature05853 / Nature / HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS by Pandey (2007)
  119. 10.1146/annurev.biochem.73.071403.161303 / Annu. Rev. Biochem. / Inositol 1,4,5-trisphosphate receptors as signal integrators by Patterson (2004)
  120. 10.1016/j.cell.2005.07.002 / Cell / Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy by Pattingre (2005)
  121. 10.1038/35084141 / Nature / Cause of neural death in neurodegenerative diseases attributable to expansion of glutamine repeats by Perutz (2001)
  122. 10.1074/jbc.275.2.992 / J. Biol. Chem. / Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells by Petiot (2000)
  123. 10.1176/ajp.152.12.1771 / Am. J. Psychiatry / Trial of d-alpha-tocopherol in Huntington's disease by Peyser (1995)
  124. 10.1016/S1097-2765(01)00347-1 / Mol. Cell / Ubiquitin enters the new millennium by Pickart (2001)
  125. 10.1093/hmg/ddg346 / Hum. Mol. Genet. / Autophagy regulates the processing of amino terminal Huntingtin fragments by Qin (2003)
  126. 10.1093/hmg/ddl036 / Hum. Mol. Genet. / Rapamycin pre-treatment protects against apoptosis by Ravikumar (2006)
  127. 10.1038/ng1591 / Nat. Genet. / Dynein mutations impair autophagic clearance of aggregate-prone proteins by Ravikumar (2005)
  128. 10.1093/hmg/11.9.1107 / Hum. Mol. Genet. / Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy by Ravikumar (2002)
  129. 10.1242/jcs.025726 / J. Cell Sci. / Rab5 modulates aggregation and toxicity of mutant Huntingtin through macroautophagy in cell and fly models of Huntington disease by Ravikumar (2008)
  130. 10.1038/ncb2078 / Nat. Cell Biol. / Plasma membrane contributes to the formation of pre-autophagosomal structures by Ravikumar (2010)
  131. 10.1152/physrev.00030.2009 / Physiol. Rev. / Regulation of mammalian autophagy in physiology and pathophysiology by Ravikumar (2010)
  132. 10.1093/hmg/ddg109 / Hum. Mol. Genet. / Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant Huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy by Ravikumar (2003)
  133. 10.1038/ng1362 / Nat. Genet. / Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease by Ravikumar (2004)
  134. 10.1158/0008-5472.CAN-06-4615 / Cancer Res. / Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases by Raynaud (2007)
  135. 10.1242/jcs.076489 / J. Cell Sci. / Autophagic substrate clearance requires activity of the syntaxin-5 SNARE complex by Renna (2011)
  136. 10.1093/hmg/6.8.1289 / Hum. Mol. Genet. / SCA6 is caused by moderate CAG expansion in the alpha1A-voltage-dependent calcium channel gene by Riess (1997)
  137. 10.2174/092986710791959800 / Curr. Med. Chem. / Towards the treatment of polyglutamine diseases: the modulatory role of protein context by Robertson (2010)
  138. 10.4161/auto.2229 / Autophagy / Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes by Rodriguez-Enriquez (2006)
  139. 10.1016/j.ymthe.2005.05.006 / Mol. Ther. / Intrastriatal rAAV-mediated delivery of anti-Huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice by Rodriguez-Lebron (2005)
  140. 10.1093/hmg/ddq093 / Hum. Mol. Genet. / Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease by Rose (2010)
  141. 10.1038/nature05291 / Nature / The roles of intracellular protein-degradation pathways in neurodegeneration by Rubinsztein (2006)
  142. 10.4161/auto.5.5.8823 / Autophagy / In search of an “autophagomometer” by Rubinsztein (2009)
  143. 10.1074/jbc.270.2.815 / J. Biol. Chem. / Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells by Sabers (1995)
  144. 10.1016/j.devcel.2010.12.003 / Dev. Cell / Microautophagy of cytosolic proteins by late endosomes by Sahu (2011)
  145. 10.1038/nature07006 / Nature / Essential role for Nix in autophagic maturation of erythroid cells by Sandoval (2008)
  146. 10.1016/j.ceb.2005.09.009 / Curr. Opin. Cell Biol. / Growing roles for the mTOR pathway by Sarbassov (2005)
  147. 10.1074/jbc.M609532200 / J. Biol. Chem. / Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant Huntingtin and alpha-synuclein by Sarkar (2007)
  148. 10.1083/jcb.200504035 / J. Cell Biol. / Lithium induces autophagy by inhibiting inositol monophosphatase by Sarkar (2005)
  149. 10.1093/hmg/ddm294 / Hum. Mol. Genet. / A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin by Sarkar (2008)
  150. 10.1038/nchembio883 / Nat. Chem. Biol. / Small molecules enhance autophagy and reduce toxicity in Huntington's disease models by Sarkar (2007)
  151. 10.1038/sj.emboj.7601623 / EMBO J. / Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4 by Scherz-Shouval (2007)
  152. 10.1073/pnas.0708818104 / Proc. Natl. Acad. Sci. U.S.A. / NIX is required for programmed mitochondrial clearance during reticulocyte maturation by Schweers (2007)
  153. 10.1111/j.1399-0004.2006.00668.x / Clin. Genet. / Predictive testing for Huntington disease: interpretation and significance of intermediate alleles by Semaka (2006)
  154. 10.1074/jbc.M600364200 / J. Biol. Chem. / Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1 by Shibata (2006)
  155. 10.1002/ana.410440724 / Ann. Neurol. / DATATOP: a decade of neuroprotective inquiry. Parkinson Study Group. Deprenyl and tocopherol antioxidative therapy of parkinsonism by Shoulson (1998)
  156. 10.1242/jcs.01287 / J. Cell Sci. / Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes by Simonsen (2004)
  157. 10.1001/archneurol.2007.56 / Arch. Neurol. / Protein misfolding and neurodegeneration by Soto (2008)
  158. 10.1073/pnas.0810452105 / Proc. Natl. Acad. Sci. U.S.A. / Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase by Sun (2008)
  159. 10.1093/jmcb/mjq005 / J. Mol. Cell. Biol. / Polyglutamine diseases: where does toxicity come from? What is toxicity? Where are we going? by Takahashi (2010)
  160. 10.1093/hmg/ddm311 / Hum. Mol. Genet. / Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic by Takahashi (2008)
  161. 10.4161/auto.7.1.14015 / Autophagy / Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy by Takahashi (2011)
  162. 10.1038/nm985 / Nat. Med. / Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease by Tanaka (2004)
  163. 10.1074/jbc.C000752200 / J. Biol. Chem. / The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3 by Tanida (2001)
  164. 10.1074/jbc.M200385200 / J. Biol. Chem. / Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p by Tanida (2002)
  165. 10.1074/jbc.M407016200 / J. Biol. Chem. / Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes by Tanida (2004)
  166. 10.1073/pnas.202476899 / Proc. Natl. Acad. Sci. U.S.A. / Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling by Tee (2002)
  167. 10.1074/jbc.M900301200 / J. Biol. Chem. / An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1 by Thoreen (2009)
  168. 10.1096/fj.10-175158 / FASEB J. / A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway by Tian (2011)
  169. 10.1093/hmg/ddq253 / Hum. Mol. Genet. / Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease by Underwood (2010)
  170. 10.1091/mbc.E09-04-0345 / Mol. Biol. Cell / Exit from the Golgi is required for the expansion of the autophagosomal phagophore in yeast Saccharomyces cerevisiae by van der Vaart (2010)
  171. 10.1016/S1097-2765(04)00151-0 / Mol. Cell / Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins by Venkatraman (2004)
  172. 10.1016/S0896-6273(02)00733-X / Neuron / A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration by Watase (2002)
  173. 10.1074/jbc.M300227200 / J. Biol. Chem. / Alpha-Synuclein is degraded by both autophagy and the proteasome by Webb (2003)
  174. 10.4161/auto.6788 / Autophagy / Dual role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation by Wei (2008)
  175. 10.1016/j.devcel.2011.02.006 / Dev. Cell / LC3 and GATE-16 N termini mediate membrane fusion processes required for autophagosome biogenesis by Weidberg (2011)
  176. 10.1074/jbc.273.15.9158 / J. Biol. Chem. / Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract by Wellington (1998)
  177. 10.1523/JNEUROSCI.22-18-07862.2002 / J. Neurosci. / Caspase cleavage of mutant Huntingtin precedes neurodegeneration in Huntington's disease by Wellington (2002)
  178. 10.1016/j.neuron.2011.03.021 / Neuron / An antisense CAG repeat transcript at jph3 locus mediates expanded polyglutamine protein toxicity in Huntington's disease-like 2 mice by Wilburn (2011)
  179. 10.1038/417292a / Nature / A common mechanism of action for three mood-stabilizing drugs by Williams (2002)
  180. 10.1038/nchembio.79 / Nat. Chem. Biol. / Novel targets for Huntington's disease in an mTOR-independent autophagy pathway by Williams (2008)
  181. 10.1038/ncb1007-1102 / Nat. Cell Biol. / Autophagosome formation: core machinery and adaptations by Xie (2007)
  182. 10.1016/S0092-8674(00)80623-6 / Cell / Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease by Yamamoto (2000)
  183. 10.1247/csf.23.33 / Cell Struct. Funct. / Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells by Yamamoto (1998)
  184. 10.1093/hmg/11.23.2905 / Hum. Mol. Genet. / Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells by Yang (2002)
  185. 10.4161/auto.5.8.10274 / Autophagy / 3D tomography reveals connections between the phagophore and endoplasmic reticulum by Ylä-Anttila (2009)
  186. 10.1016/S0896-6273(02)01190-X / Neuron / SCA7 knockin mice model human SCA7 and reveal gradual accumulation of mutant ataxin-7 in neurons and abnormalities in short-term plasticity by Yoo (2003)
  187. 10.1242/jcs.03172 / J. Cell Sci. / Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes by Young (2006)
  188. 10.1002/j.1552-4604.1996.tb04174.x / J. Clin. Pharmacol. / Imidazoline receptor agonist drugs: a new approach to the treatment of systemic hypertension by Yu (1996)
  189. 10.1038/ng1095-155 / Nat. Genet. / Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue by Zeitlin (1995)
  190. 10.1073/pnas.0709695104 / Proc. Natl. Acad. Sci. U.S.A. / Small molecule regulators of autophagy identified by an image-based high-throughput screen by Zhang (2007)
  191. 10.1038/ncb999 / Nat. Cell Biol. / Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins by Zhang (2003)
  192. 10.1371/journal.pgen.1000838 / PLoS Genet. / Deletion of the Huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice by Zheng (2010)
Dates
Type When
Created 13 years, 11 months ago (Sept. 11, 2011, 2:32 p.m.)
Deposited 3 years, 8 months ago (Dec. 4, 2021, 4:19 a.m.)
Indexed 1 month, 3 weeks ago (July 12, 2025, 6:54 p.m.)
Issued 13 years, 4 months ago (May 1, 2012)
Published 13 years, 4 months ago (May 1, 2012)
Published Print 13 years, 4 months ago (May 1, 2012)
Funders 5
  1. MRC
  2. Wellcome Trust
  3. Wellcome Trust/MRC Strategic grant on Alzheimer's disease
  4. BBSRC/Lilly
  5. NIHR Biomedical Research Centre at Addenbrooke's Hospital

@article{Jimenez_Sanchez_2012, title={Autophagy and polyglutamine diseases}, volume={97}, ISSN={0301-0082}, url={http://dx.doi.org/10.1016/j.pneurobio.2011.08.013}, DOI={10.1016/j.pneurobio.2011.08.013}, number={2}, journal={Progress in Neurobiology}, publisher={Elsevier BV}, author={Jimenez-Sanchez, Maria and Thomson, Frances and Zavodszky, Eszter and Rubinsztein, David C.}, year={2012}, month=may, pages={67–82} }