DOI: 10.1016/j.neuropharm.2006.07.013. Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus

Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus

10.1016/j.neuropharm.2006.07.013

Crossref journal-article

Elsevier BV

Neuropharmacology (78)

Bibliography

Bartlett, T. E., Bannister, N. J., Collett, V. J., Dargan, S. L., Massey, P. V., Bortolotto, Z. A., Fitzjohn, S. M., Bashir, Z. I., Collingridge, G. L., & Lodge, D. (2007). Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus. Neuropharmacology, 52(1), 60â70.

Authors 10

Thomas E. Bartlett (first)
Neil J. Bannister (additional)
Valerie J. Collett (additional)
Sheila L. Dargan (additional)
Peter V. Massey (additional)
Zuner A. Bortolotto (additional)
Stephen M. Fitzjohn (additional)
Zafar I. Bashir (additional)
Graham L. Collingridge (additional)
David Lodge (additional)

References 45 Referenced 230

10.1016/S0165-0270(01)00374-0 / J. Neurosci. Methods / The LTP program: a data acquisition program for on-line analysis of long-term potentiation and other synaptic events by Anderson (2001)
10.1046/j.1471-4159.1995.64052004.x / J. Neurochem. / Transfection of N-methyl-d-aspartate receptors in a non-neuronal cell line leads to cell death by Anegawa (1995)
10.1016/S0960-894X(02)00074-4 / Bioorg. Med. Chem. Lett. / 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition by Auberson (2002)
10.1016/j.neuron.2005.08.034 / Neuron / NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII by Barria (2005)
10.1523/JNEUROSCI.1905-05.2005 / J. Neurosci. / Lack of NMDA receptor subtype selectivity for hippocampal long-term potentiation by Berberich (2005)
{'key': '10.1016/j.neuropharm.2006.07.013_bib6', 'first-page': '370', 'article-title': 'CP-101606 Pfizer Inc', 'volume': '1', 'author': 'Chazot', 'year': '2000', 'journal-title': 'Curr. Opin. Investig. Drugs'} / Curr. Opin. Investig. Drugs / CP-101606 Pfizer Inc by Chazot (2000)
10.1016/S0021-9258(19)51098-5 / J. Biol. Chem. / Molecular characterization of N-methyl-d-aspartate receptors expressed in mammalian cells yields evidence for the coexistence of three subunit types within a discrete receptor molecule by Chazot (1994)
10.1523/JNEUROSCI.22-09-03628.2002 / J. Neurosci. / A hippocampal NR2B deficit can mimic age-related changes in long-term potentiation and spatial learning in the Fischer 344 rat by Clayton (2002)
10.1038/sj.bjp.0705861 / Br. J. Pharmacol. / Interactions between NMDA receptors and mGlu5 receptors expressed in HEK293 cells by Collett (2004)
10.1113/jphysiol.1983.sp014478 / J. Physiol. / Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus by Collingridge (1983)
10.1016/S0959-4388(00)00215-4 / Curr. Opin. Neurobiol. / NMDA receptor subunits: diversity, development and disease by Cull-Candy (2001)
10.1073/pnas.89.10.4363 / Proc. Natl. Acad. Sci. U.S.A. / Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-d-aspartate receptor blockade by Dudek (1992)
10.1038/sj.bjp.0705644 / Br. J. Pharmacol. / Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl) piperazine-2,3-dicarboxylic acid by Feng (2004)
{'key': '10.1016/j.neuropharm.2006.07.013_bib14', 'first-page': '1285', 'article-title': 'Ro 25-6981, a highly potent and selective blocker of N-methyl-d-aspartate receptors containing the NR2B subunit. Characterization in vitro', 'volume': '283', 'author': 'Fischer', 'year': '1997', 'journal-title': 'J. Pharmacol. Exp. Ther.'} / J. Pharmacol. Exp. Ther. / Ro 25-6981, a highly potent and selective blocker of N-methyl-d-aspartate receptors containing the NR2B subunit. Characterization in vitro by Fischer (1997)
10.1016/0006-8993(91)90867-U / Brain Res. / Reversal of long-term potentiation (depotentiation) induced by tetanus stimulation of the input to CA1 neurons of guinea pig hippocampal slices by Fujii (1991)
10.1016/j.neuron.2005.03.005 / Neuron / Modulation of triheteromeric NMDA receptors by N-terminal domain ligands by Hatton (2005)
10.1124/jpet.301.3.938 / J. Pharmacol. Exp. Ther. / Ifenprodil and ethanol enhance NMDA receptor-dependent long-term depression by Hendricson (2002)
10.1016/S0304-3940(97)00252-8 / Neurosci. Lett. / Long-term potentiation and long-term depression are induced through pharmacologically distinct NMDA receptors by Hrabetova (1997)
10.1523/JNEUROSCI.20-12-j0002.2000 / J. Neurosci. / Distinct NMDA receptor subpopulations contribute to long-term potentiation and long-term depression induction by Hrabetova (2000)
10.1111/j.1469-7793.1999.00099.x / J. Physiol. / Early postnatal switch in magnesium sensitivity of NMDA receptors in rat CA1 pyramidal cells by Kirson (1999)
10.1523/JNEUROSCI.23-34-10791.2003 / J. Neurosci / Intracellular domains of NMDA receptor subtypes are determinants for long-term potentiation induction by Kohr (2003)
10.1016/S0896-6273(00)80051-3 / Neuron / Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor epsilon 2 subunit mutant mice by Kutsuwada (1996)
10.1073/pnas.86.23.9574 / Proc. Natl. Acad. Sci. U.S.A. / A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory by Lisman (1989)
10.1126/science.1096615 / Science / Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity by Liu (2004)
10.1113/jphysiol.2004.063792 / J. Physiol / Extrasynaptic NR2B and NR2D subunits of NMDA receptors shape ‘superslow’ afterburst EPSC in rat hippocampus by Lozovaya (2004)
10.1007/s00221-004-2193-6 / Exp. Brain Res. / Selective subunit antagonists suggest an inhibitory relationship between NR2B and NR2A-subunit containing N-methyl-d-aspartate receptors in hippocampal slices by Mallon (2005)
10.1016/j.brainres.2005.12.077 / Brain Res. / Early chronic blockade of NR2B subunits and transient activation of NMDA receptors modulate LTP in mouse auditory cortex by Mao (2006)
10.1523/JNEUROSCI.1697-04.2004 / J. Neurosci. / Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression by Massey (2004)
10.1016/0896-6273(94)90210-0 / Neuron / Developmental and regional expression in the rat brain and functional properties of four NMDA receptors by Monyer (1994)
10.1021/jm0492498 / J. Med. Chem. / Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists by Morley (2005)
10.1016/0896-6273(92)90248-C / Neuron / Mechanisms underlying induction of homosynaptic long-term depression in area CA1 of the hippocampus by Mulkey (1992)
10.1046/j.1471-4159.1998.70052147.x / J. Neurochem. / In vitro binding properties in rat brain of [3H]Ro 25-6981, a potent and selective antagonist of NMDA receptors containing NR2B subunits by Mutel (1998)
10.1523/JNEUROSCI.5242-05.2006 / J. Neurosci. / Relating NMDA receptor function to receptor subunit composition: limitations of the pharmacological approach by Neyton (2006)
10.1016/0304-3940(90)90070-P / Neurosci. Lett. / Whole-cell patch-clamp recordings of an NMDA receptor-mediated synaptic current in rat hippocampal slices by Randall (1990)
10.1038/373151a0 / Nature / Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit by Sakimura (1995)
10.1016/S0896-6273(03)00476-8 / Neuron / Neocortical LTD via coincident activation of presynaptic NMDA and cannabinoid receptors by Sjostrom (2003)
10.1016/S0092-8674(00)80921-6 / Cell / Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo by Sprengel (1998)
10.1038/43432 / Nature / Genetic enhancement of learning and memory in mice by Tang (1999)
10.1111/j.1460-9568.2005.04236.x / Eur. J. Neurosci. / Roles of NMDA receptor NR2A and NR2B subtypes for long-term depression in the anterior cingulate cortex by Toyoda (2005)
10.1152/jn.1998.79.2.555 / J. Neurophysiol. / Functional and pharmacological differences between recombinant N-methyl-d-aspartate receptors by Vicini (1998)
10.1523/JNEUROSCI.2388-05.2005 / J. Neurosci. / Activation of NR2A-containing NMDA receptors is not obligatory for NMDA receptor-dependent long-term potentiation by Weitlauf (2005)
10.1046/j.1471-4159.1997.68020469.x / J. Neurochem. / NMDA receptor heterogeneity during postnatal development of the rat brain: differential expression of the NR2A, NR2B, and NR2C subunit proteins by Wenzel (1997)
10.1523/JNEUROSCI.0406-05.2005 / J. Neurosci. / Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake by Yang (2005)
10.1523/JNEUROSCI.23-16-06557.2003 / J. Neurosci. / Two forms of synaptic plasticity with distinct dependence on age, experience, and NMDA receptor subtype in rat visual cortex by Yoshimura (2003)
10.1016/j.neuron.2005.08.014 / Neuron / Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory by Zhao (2005)

Dates

Type	When
Created	19 years ago (Aug. 11, 2006, 7:08 a.m.)
Deposited	4 years, 1 month ago (July 31, 2021, 6:44 a.m.)
Indexed	4 hours, 5 minutes ago (Sept. 4, 2025, 10:22 a.m.)
Issued	18 years, 8 months ago (Jan. 1, 2007)
Published	18 years, 8 months ago (Jan. 1, 2007)
Published Print	18 years, 8 months ago (Jan. 1, 2007)

Funders 0

None

BibTeX

@article{Bartlett_2007, title={Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus}, volume={52}, ISSN={0028-3908}, url={http://dx.doi.org/10.1016/j.neuropharm.2006.07.013}, DOI={10.1016/j.neuropharm.2006.07.013}, number={1}, journal={Neuropharmacology}, publisher={Elsevier BV}, author={Bartlett, Thomas E. and Bannister, Neil J. and Collett, Valerie J. and Dargan, Sheila L. and Massey, Peter V. and Bortolotto, Zuner A. and Fitzjohn, Stephen M. and Bashir, Zafar I. and Collingridge, Graham L. and Lodge, David}, year={2007}, month=jan, pages={60–70} }

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      "author": "Auberson",
      "year": "2002",
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      "first-page": "289",
      "DOI": "10.1016/j.neuron.2005.08.034",
      "article-title": "NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII",
      "volume": "48",
      "author": "Barria",
      "year": "2005",
      "journal-title": "Neuron"
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      "doi-asserted-by": "crossref",
      "first-page": "6907",
      "DOI": "10.1523/JNEUROSCI.1905-05.2005",
      "article-title": "Lack of NMDA receptor subtype selectivity for hippocampal long-term potentiation",
      "volume": "25",
      "author": "Berberich",
      "year": "2005",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib6",
      "first-page": "370",
      "article-title": "CP-101606 Pfizer Inc",
      "volume": "1",
      "author": "Chazot",
      "year": "2000",
      "journal-title": "Curr. Opin. Investig. Drugs"
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "24403",
      "DOI": "10.1016/S0021-9258(19)51098-5",
      "article-title": "Molecular characterization of N-methyl-d-aspartate receptors expressed in mammalian cells yields evidence for the coexistence of three subunit types within a discrete receptor molecule",
      "volume": "269",
      "author": "Chazot",
      "year": "1994",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "3628",
      "DOI": "10.1523/JNEUROSCI.22-09-03628.2002",
      "article-title": "A hippocampal NR2B deficit can mimic age-related changes in long-term potentiation and spatial learning in the Fischer 344 rat",
      "volume": "22",
      "author": "Clayton",
      "year": "2002",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "991",
      "DOI": "10.1038/sj.bjp.0705861",
      "article-title": "Interactions between NMDA receptors and mGlu5 receptors expressed in HEK293 cells",
      "volume": "142",
      "author": "Collett",
      "year": "2004",
      "journal-title": "Br. J. Pharmacol."
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      "first-page": "33",
      "DOI": "10.1113/jphysiol.1983.sp014478",
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      "volume": "334",
      "author": "Collingridge",
      "year": "1983",
      "journal-title": "J. Physiol."
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib11",
      "doi-asserted-by": "crossref",
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      "DOI": "10.1016/S0959-4388(00)00215-4",
      "article-title": "NMDA receptor subunits: diversity, development and disease",
      "volume": "11",
      "author": "Cull-Candy",
      "year": "2001",
      "journal-title": "Curr. Opin. Neurobiol."
    },
    {
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      "volume": "89",
      "author": "Dudek",
      "year": "1992",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "508",
      "DOI": "10.1038/sj.bjp.0705644",
      "article-title": "Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl) piperazine-2,3-dicarboxylic acid",
      "volume": "141",
      "author": "Feng",
      "year": "2004",
      "journal-title": "Br. J. Pharmacol."
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib14",
      "first-page": "1285",
      "article-title": "Ro 25-6981, a highly potent and selective blocker of N-methyl-d-aspartate receptors containing the NR2B subunit. Characterization in vitro",
      "volume": "283",
      "author": "Fischer",
      "year": "1997",
      "journal-title": "J. Pharmacol. Exp. Ther."
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "112",
      "DOI": "10.1016/0006-8993(91)90867-U",
      "article-title": "Reversal of long-term potentiation (depotentiation) induced by tetanus stimulation of the input to CA1 neurons of guinea pig hippocampal slices",
      "volume": "555",
      "author": "Fujii",
      "year": "1991",
      "journal-title": "Brain Res."
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "261",
      "DOI": "10.1016/j.neuron.2005.03.005",
      "article-title": "Modulation of triheteromeric NMDA receptors by N-terminal domain ligands",
      "volume": "46",
      "author": "Hatton",
      "year": "2005",
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      "first-page": "938",
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      "article-title": "Ifenprodil and ethanol enhance NMDA receptor-dependent long-term depression",
      "volume": "301",
      "author": "Hendricson",
      "year": "2002",
      "journal-title": "J. Pharmacol. Exp. Ther."
    },
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      "key": "10.1016/j.neuropharm.2006.07.013_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "107",
      "DOI": "10.1016/S0304-3940(97)00252-8",
      "article-title": "Long-term potentiation and long-term depression are induced through pharmacologically distinct NMDA receptors",
      "volume": "226",
      "author": "Hrabetova",
      "year": "1997",
      "journal-title": "Neurosci. Lett."
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib19",
      "doi-asserted-by": "crossref",
      "DOI": "10.1523/JNEUROSCI.20-12-j0002.2000",
      "article-title": "Distinct NMDA receptor subpopulations contribute to long-term potentiation and long-term depression induction",
      "volume": "20",
      "author": "Hrabetova",
      "year": "2000",
      "journal-title": "J. Neurosci."
    },
    {
      "issue": "Pt 1",
      "key": "10.1016/j.neuropharm.2006.07.013_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "99",
      "DOI": "10.1111/j.1469-7793.1999.00099.x",
      "article-title": "Early postnatal switch in magnesium sensitivity of NMDA receptors in rat CA1 pyramidal cells",
      "volume": "521",
      "author": "Kirson",
      "year": "1999",
      "journal-title": "J. Physiol."
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "10791",
      "DOI": "10.1523/JNEUROSCI.23-34-10791.2003",
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      "volume": "23",
      "author": "Kohr",
      "year": "2003",
      "journal-title": "J. Neurosci"
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "333",
      "DOI": "10.1016/S0896-6273(00)80051-3",
      "article-title": "Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor epsilon 2 subunit mutant mice",
      "volume": "16",
      "author": "Kutsuwada",
      "year": "1996",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "9574",
      "DOI": "10.1073/pnas.86.23.9574",
      "article-title": "A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory",
      "volume": "86",
      "author": "Lisman",
      "year": "1989",
      "journal-title": "Proc. Natl. Acad. Sci. U.S.A."
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "1021",
      "DOI": "10.1126/science.1096615",
      "article-title": "Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity",
      "volume": "304",
      "author": "Liu",
      "year": "2004",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "451",
      "DOI": "10.1113/jphysiol.2004.063792",
      "article-title": "Extrasynaptic NR2B and NR2D subunits of NMDA receptors shape \u2018superslow\u2019 afterburst EPSC in rat hippocampus",
      "volume": "558",
      "author": "Lozovaya",
      "year": "2004",
      "journal-title": "J. Physiol"
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "374",
      "DOI": "10.1007/s00221-004-2193-6",
      "article-title": "Selective subunit antagonists suggest an inhibitory relationship between NR2B and NR2A-subunit containing N-methyl-d-aspartate receptors in hippocampal slices",
      "volume": "162",
      "author": "Mallon",
      "year": "2005",
      "journal-title": "Exp. Brain Res."
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "131",
      "DOI": "10.1016/j.brainres.2005.12.077",
      "article-title": "Early chronic blockade of NR2B subunits and transient activation of NMDA receptors modulate LTP in mouse auditory cortex",
      "volume": "1073\u20131074",
      "author": "Mao",
      "year": "2006",
      "journal-title": "Brain Res."
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "7821",
      "DOI": "10.1523/JNEUROSCI.1697-04.2004",
      "article-title": "Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression",
      "volume": "24",
      "author": "Massey",
      "year": "2004",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "529",
      "DOI": "10.1016/0896-6273(94)90210-0",
      "article-title": "Developmental and regional expression in the rat brain and functional properties of four NMDA receptors",
      "volume": "12",
      "author": "Monyer",
      "year": "1994",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "2627",
      "DOI": "10.1021/jm0492498",
      "article-title": "Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists",
      "volume": "48",
      "author": "Morley",
      "year": "2005",
      "journal-title": "J. Med. Chem."
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "967",
      "DOI": "10.1016/0896-6273(92)90248-C",
      "article-title": "Mechanisms underlying induction of homosynaptic long-term depression in area CA1 of the hippocampus",
      "volume": "9",
      "author": "Mulkey",
      "year": "1992",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "2147",
      "DOI": "10.1046/j.1471-4159.1998.70052147.x",
      "article-title": "In vitro binding properties in rat brain of [3H]Ro 25-6981, a potent and selective antagonist of NMDA receptors containing NR2B subunits",
      "volume": "70",
      "author": "Mutel",
      "year": "1998",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "1331",
      "DOI": "10.1523/JNEUROSCI.5242-05.2006",
      "article-title": "Relating NMDA receptor function to receptor subunit composition: limitations of the pharmacological approach",
      "volume": "26",
      "author": "Neyton",
      "year": "2006",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "191",
      "DOI": "10.1016/0304-3940(90)90070-P",
      "article-title": "Whole-cell patch-clamp recordings of an NMDA receptor-mediated synaptic current in rat hippocampal slices",
      "volume": "114",
      "author": "Randall",
      "year": "1990",
      "journal-title": "Neurosci. Lett."
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "151",
      "DOI": "10.1038/373151a0",
      "article-title": "Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit",
      "volume": "373",
      "author": "Sakimura",
      "year": "1995",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "641",
      "DOI": "10.1016/S0896-6273(03)00476-8",
      "article-title": "Neocortical LTD via coincident activation of presynaptic NMDA and cannabinoid receptors",
      "volume": "39",
      "author": "Sjostrom",
      "year": "2003",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "279",
      "DOI": "10.1016/S0092-8674(00)80921-6",
      "article-title": "Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo",
      "volume": "92",
      "author": "Sprengel",
      "year": "1998",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "63",
      "DOI": "10.1038/43432",
      "article-title": "Genetic enhancement of learning and memory in mice",
      "volume": "401",
      "author": "Tang",
      "year": "1999",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "485",
      "DOI": "10.1111/j.1460-9568.2005.04236.x",
      "article-title": "Roles of NMDA receptor NR2A and NR2B subtypes for long-term depression in the anterior cingulate cortex",
      "volume": "22",
      "author": "Toyoda",
      "year": "2005",
      "journal-title": "Eur. J. Neurosci."
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "555",
      "DOI": "10.1152/jn.1998.79.2.555",
      "article-title": "Functional and pharmacological differences between recombinant N-methyl-d-aspartate receptors",
      "volume": "79",
      "author": "Vicini",
      "year": "1998",
      "journal-title": "J. Neurophysiol."
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "8386",
      "DOI": "10.1523/JNEUROSCI.2388-05.2005",
      "article-title": "Activation of NR2A-containing NMDA receptors is not obligatory for NMDA receptor-dependent long-term potentiation",
      "volume": "25",
      "author": "Weitlauf",
      "year": "2005",
      "journal-title": "J.\u00a0Neurosci."
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "469",
      "DOI": "10.1046/j.1471-4159.1997.68020469.x",
      "article-title": "NMDA receptor heterogeneity during postnatal development of the rat brain: differential expression of the NR2A, NR2B, and NR2C subunit proteins",
      "volume": "68",
      "author": "Wenzel",
      "year": "1997",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib44",
      "doi-asserted-by": "crossref",
      "first-page": "4288",
      "DOI": "10.1523/JNEUROSCI.0406-05.2005",
      "article-title": "Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake",
      "volume": "25",
      "author": "Yang",
      "year": "2005",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib45",
      "doi-asserted-by": "crossref",
      "first-page": "6557",
      "DOI": "10.1523/JNEUROSCI.23-16-06557.2003",
      "article-title": "Two forms of synaptic plasticity with distinct dependence on age, experience, and NMDA receptor subtype in rat visual cortex",
      "volume": "23",
      "author": "Yoshimura",
      "year": "2003",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.neuropharm.2006.07.013_bib46",
      "doi-asserted-by": "crossref",
      "first-page": "859",
      "DOI": "10.1016/j.neuron.2005.08.014",
      "article-title": "Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory",
      "volume": "47",
      "author": "Zhao",
      "year": "2005",
      "journal-title": "Neuron"
    }
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