DOI: 10.1016/j.neuron.2008.04.015. Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating

Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating

10.1016/j.neuron.2008.04.015

Crossref journal-article

Elsevier BV

Neuron (78)

Bibliography

Cheung, K.-H., Shineman, D., MÃ¼ller, M., CÃ¡rdenas, C., Mei, L., Yang, J., Tomita, T., Iwatsubo, T., Lee, V. M.-Y., & Foskett, J. K. (2008). Mechanism of Ca2+ Disruption in Alzheimerâs Disease by Presenilin Regulation of InsP3 Receptor Channel Gating. Neuron, 58(6), 871â883.

Authors 10

King-Ho Cheung (first)
Diana Shineman (additional)
Marioly Müller (additional)
César Cárdenas (additional)
Lijuan Mei (additional)
Jun Yang (additional)
Taisuke Tomita (additional)
Takeshi Iwatsubo (additional)
Virginia M.-Y. Lee (additional)
J. Kevin Foskett (additional)

References 67 Referenced 366

10.1006/jmcc.2002.2082 / J. Mol. Cell. Cardiol. / Cardiac energy metabolism homeostasis: role of cytosolic calcium by Balaban (2002)
10.1006/nbdi.1999.0276 / Neurobiol. Dis. / Functional phenotype in transgenic mice expressing mutant human presenilin-1 by Barrow (2000)
10.1038/35036035 / Nat. Rev. Mol. Cell Biol. / The versatility and universality of calcium signalling by Berridge (2000)
10.1016/S0140-6736(06)69113-7 / Lancet / Alzheimer's disease by Blennow (2006)
10.1523/JNEUROSCI.2177-05.2005 / J. Neurosci. / Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory by Buckner (2005)
10.1073/pnas.91.10.4489 / Proc. Natl. Acad. Sci. USA / Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner by Buxbaum (1994)
10.1074/jbc.M313296200 / J. Biol. Chem. / Activity-dependent expression of inositol 1,4,5-trisphosphate receptor type 1 in hippocampal neurons by Cai (2004)
10.1074/jbc.M112117200 / J. Biol. Chem. / The presenilin 1 deltaE9 mutation gives enhanced basal phospholipase C activity and a resultant increase in intracellular calcium concentrations by Cedazo-Minguez (2002)
10.1074/jbc.M000040200 / J. Biol. Chem. / Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons by Chan (2000)
10.1016/j.neuron.2005.10.028 / Neuron / Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo by Cirrito (2005)
10.1038/nm0197-67 / Nat. Med. / Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice by Citron (1997)
10.1038/sj.embor.7400897 / EMBO Rep. / Loss-of-function presenilin mutations in Alzheimer disease. Talking point on the role of presenilin mutations in Alzheimer disease by De Strooper (2007)
10.1038/ncb960 / Nat. Cell Biol. / Reconstitution of gamma-secretase activity by Edbauer (2003)
10.1006/nbdi.1998.0176 / Neurobiol. Dis. / Calcium responses in fibroblasts from asymptomatic members of Alzheimer's disease families by Etcheberrigaray (1998)
10.1152/physrev.00035.2006 / Physiol. Rev. / Inositol trisphosphate receptor Ca2+ release channels by Foskett (2007)
10.1038/nm1006-1121 / Nat. Med. / Alzheimer disease: presenilin springs a leak by Gandy (2006)
10.1073/pnas.96.10.5797 / Proc. Natl. Acad. Sci. USA / Calcineurin controls inositol 1,4,5-trisphosphate type 1 receptor expression in neurons by Genazzani (1999)
10.1016/j.nbd.2004.10.016 / Neurobiol. Dis. / Reduction of Ca2+ stores and capacitative Ca2+ entry is associated with the familial Alzheimer's disease presenilin-2 T122R mutation and anticipates the onset of dementia by Giacomello (2005)
10.1097/00001756-199612200-00074 / Neuroreport / Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide by Guo (1996)
10.1038/nrm2101 / Nat. Rev. Mol. Cell Biol. / Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide by Haass (2007)
10.1016/j.neuron.2006.09.016 / Neuron / A hundred years of Alzheimer's disease research by Hardy (2006)
10.1126/science.1072994 / Science / The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics by Hardy (2002)
10.1016/j.nbd.2004.08.002 / Neurobiol. Dis. / Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity by Hebert (2004)
10.1016/0197-4580(96)00074-7 / Neurobiol. Aging / Calcium responses in human fibroblasts: a diagnostic molecular profile for Alzheimer's disease by Hirashima (1996)
10.1093/hmg/6.10.1639 / Hum. Mol. Genet. / The presenilins and Alzheimer's disease by Hutton (1997)
10.1113/jphysiol.2006.109504 / J. Physiol. / Graded recruitment and inactivation of single InsP3 receptor Ca2+-release channels: implications for quantal Ca2+ release by Ionescu (2006)
10.1073/pnas.91.2.534 / Proc. Natl. Acad. Sci. USA / Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease by Ito (1994)
10.1016/j.neulet.2005.10.088 / Neurosci. Lett. / Calcium oscillations in type-1 astrocytes, the effect of a presenilin 1 (PS1) mutation by Johnston (2006)
10.1074/jbc.273.22.14015 / J. Biol. Chem. / Regulation of amyloid precursor protein secretion by glutamate receptors in human Ntera 2 neurons by Jolly-Tornetta (1998)
10.1016/S0896-6273(03)00124-7 / Neuron / APP processing and synaptic function by Kamenetz (2003)
10.1016/j.ceca.2006.03.005 / Cell Calcium / Up-regulation of inositol 1,4,5-trisphosphate receptor type 1 is responsible for a decreased endoplasmic-reticulum Ca2+ content in presenilin double knock-out cells by Kasri (2006)
10.1038/nrn960 / Nat. Rev. Neurosci. / Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease by LaFerla (2002)
10.1016/j.ceca.2005.04.001 / Cell Calcium / Rapid functional assays of recombinant IP3 receptors by Laude (2005)
10.1074/jbc.274.46.32535 / J. Biol. Chem. / Presenilin-2 mutations modulate amplitude and kinetics of inositol 1, 4,5-trisphosphate-mediated calcium signals by Leissring (1999)
10.1046/j.1471-4159.1999.0721061.x / J. Neurochem. / Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes by Leissring (1999)
10.1083/jcb.149.4.793 / J. Cell Biol. / Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice by Leissring (2000)
10.1006/nbdi.2001.0382 / Neurobiol. Dis. / Subcellular mechanisms of presenilin-mediated enhancement of calcium signaling by Leissring (2001)
10.1016/j.cellsig.2004.09.005 / Cell. Signal. / The overexpression of presenilin2 and Alzheimer's-disease-linked presenilin2 variants influences TRPC6-enhanced Ca2+ entry into HEK293 cells by Lessard (2005)
10.1073/pnas.95.26.15821 / Proc. Natl. Acad. Sci. USA / Inositol 1,4,5-trisphosphate activation of inositol trisphosphate receptor Ca2+ channel by ligand tuning of Ca2+ inhibition by Mak (1998)
10.1038/nature02621 / Nature / Pathways towards and away from Alzheimer's disease by Mattson (2004)
10.1002/(SICI)1097-4547(19971115)50:4<505::AID-JNR1>3.0.CO;2-I / J. Neurosci. Res. / Cell and molecular neurobiology of presenilins: a role for the endoplasmic reticulum in the pathogenesis of Alzheimer's disease? by Mattson (1997)
10.1016/S0143-4160(03)00128-3 / Cell Calcium / Neuronal and glial calcium signaling in Alzheimer's disease by Mattson (2003)
10.1523/JNEUROSCI.20-04-01358.2000 / J. Neurosci. / Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis by Mattson (2000)
10.1152/physrev.1990.70.2.391 / Physiol. Rev. / Role of calcium ions in regulation of mammalian intramitochondrial metabolism by McCormack (1990)
10.1016/S0091-679X(03)01007-0 / Methods Cell Biol. / Culturing hippocampal and cortical neurons by Meberg (2003)
10.1172/JCI30447 / J. Clin. Invest. / Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1 by Nelson (2007)
10.1152/ajpcell.00508.2005 / Am. J. Physiol. Cell Physiol. / Effect of gamma-secretase inhibitors on muscarinic receptor-mediated calcium signaling in human salivary epithelial cells by Oh (2006)
10.1021/bi00181a016 / Biochemistry / Calcium ionophore increases amyloid beta peptide production by cultured cells by Querfurth (1994)
10.1038/nm0896-864 / Nat. Med. / Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease by Scheuner (1996)
10.1074/jbc.M010977200 / J. Biol. Chem. / Mutant presenilins disturb neuronal calcium homeostasis in the brain of transgenic mice, decreasing the threshold for excitotoxicity and facilitating long-term potentiation by Schneider (2001)
10.1073/pnas.0608332104 / Proc. Natl. Acad. Sci. USA / The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism by Shen (2007)
10.1016/S0006-8993(02)02970-0 / Brain Res. / Ca2+ stores and capacitative Ca2+ entry in human neuroblastoma (SH-SY5Y) cells expressing a familial Alzheimer's disease presenilin-1 mutation by Smith (2002)
10.1016/j.ceca.2005.06.021 / Cell Calcium / Calcium dysregulation in Alzheimer's disease: recent advances gained from genetically modified animals by Smith (2005)
10.1111/j.1471-4159.2005.03332.x / J. Neurochem. / Enhanced caffeine-induced Ca2+ release in the 3xTg-AD mouse model of Alzheimer's disease by Smith (2005)
10.1177/1073858404270899 / Neuroscientist / Calcium dysregulation, IP3 signaling, and Alzheimer's disease by Stutzmann (2005)
10.1523/JNEUROSCI.4386-03.2004 / J. Neurosci. / Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability by Stutzmann (2004)
10.1523/JNEUROSCI.0739-06.2006 / J. Neurosci. / Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice by Stutzmann (2006)
10.1093/emboj/16.11.3078 / EMBO J. / Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptor by Sugawara (1997)
10.1074/jbc.M606736200 / J. Biol. Chem. / Amyloid-beta-(1–42) increases ryanodine receptor-3 expression and function in neurons of TgCRND8 mice by Supnet (2006)
10.1126/science.8191290 / Science / An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants by Suzuki (1994)
10.1096/fj.05-3744fje / FASEB J. / Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling by Takeda (2005)
10.1016/j.cell.2006.06.059 / Cell / Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations by Tu (2006)
10.1152/physrev.00004.2004 / Physiol. Rev. / Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons by Verkhratsky (2005)
10.1038/ncb1302 / Nat. Cell Biol. / The endoplasmic reticulum gateway to apoptosis by Bcl-XL modulation of the InsP3R by White (2005)
10.1016/S0896-6273(00)00066-0 / Neuron / Presenilin-mediated modulation of capacitative calcium entry by Yoo (2000)
10.1016/j.nbd.2003.11.002 / Neurobiol. Dis. / The presenilin 2 M239I mutation associated with familial Alzheimer's disease reduces Ca2+ release from intracellular stores by Zatti (2004)
10.1016/j.ceca.2006.03.002 / Cell Calcium / Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels by Zatti (2006)

Dates

Type	When
Created	17 years, 2 months ago (June 26, 2008, 5:01 a.m.)
Deposited	6 years, 3 months ago (May 12, 2019, 6:11 a.m.)
Indexed	2 months ago (July 4, 2025, 12:31 a.m.)
Issued	17 years, 3 months ago (June 1, 2008)
Published	17 years, 3 months ago (June 1, 2008)
Published Print	17 years, 3 months ago (June 1, 2008)

Funders 0

None

BibTeX

@article{Cheung_2008, title={Mechanism of Ca2+ Disruption in Alzheimer’s Disease by Presenilin Regulation of InsP3 Receptor Channel Gating}, volume={58}, ISSN={0896-6273}, url={http://dx.doi.org/10.1016/j.neuron.2008.04.015}, DOI={10.1016/j.neuron.2008.04.015}, number={6}, journal={Neuron}, publisher={Elsevier BV}, author={Cheung, King-Ho and Shineman, Diana and Müller, Marioly and Cárdenas, César and Mei, Lijuan and Yang, Jun and Tomita, Taisuke and Iwatsubo, Takeshi and Lee, Virginia M.-Y. and Foskett, J. Kevin}, year={2008}, month=jun, pages={871–883} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        4
      ]
    ],
    "date-time": "2025-07-04T04:31:40Z",
    "timestamp": 1751603500319
  },
  "reference-count": 67,
  "publisher": "Elsevier BV",
  "issue": "6",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2008,
            6,
            1
          ]
        ],
        "date-time": "2008-06-01T00:00:00Z",
        "timestamp": 1212278400000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2013,
            7,
            17
          ]
        ],
        "date-time": "2013-07-17T00:00:00Z",
        "timestamp": 1374019200000
      },
      "content-version": "vor",
      "delay-in-days": 1872,
      "URL": "https://www.elsevier.com/open-access/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2008,
        6
      ]
    ]
  },
  "DOI": "10.1016/j.neuron.2008.04.015",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2008,
        6,
        26
      ]
    ],
    "date-time": "2008-06-26T09:01:23Z",
    "timestamp": 1214470883000
  },
  "page": "871-883",
  "source": "Crossref",
  "is-referenced-by-count": 366,
  "title": "Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating",
  "prefix": "10.1016",
  "volume": "58",
  "author": [
    {
      "given": "King-Ho",
      "family": "Cheung",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Diana",
      "family": "Shineman",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Marioly",
      "family": "M\u00fcller",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "C\u00e9sar",
      "family": "C\u00e1rdenas",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Lijuan",
      "family": "Mei",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Jun",
      "family": "Yang",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Taisuke",
      "family": "Tomita",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Takeshi",
      "family": "Iwatsubo",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Virginia M.-Y.",
      "family": "Lee",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "J. Kevin",
      "family": "Foskett",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/j.neuron.2008.04.015_bib1",
      "doi-asserted-by": "crossref",
      "first-page": "1259",
      "DOI": "10.1006/jmcc.2002.2082",
      "article-title": "Cardiac energy metabolism homeostasis: role of cytosolic calcium",
      "volume": "34",
      "author": "Balaban",
      "year": "2002",
      "journal-title": "J. Mol. Cell. Cardiol."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib2",
      "doi-asserted-by": "crossref",
      "first-page": "119",
      "DOI": "10.1006/nbdi.1999.0276",
      "article-title": "Functional phenotype in transgenic mice expressing mutant human presenilin-1",
      "volume": "7",
      "author": "Barrow",
      "year": "2000",
      "journal-title": "Neurobiol. Dis."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib3",
      "doi-asserted-by": "crossref",
      "first-page": "11",
      "DOI": "10.1038/35036035",
      "article-title": "The versatility and universality of calcium signalling",
      "volume": "1",
      "author": "Berridge",
      "year": "2000",
      "journal-title": "Nat. Rev. Mol. Cell Biol."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib4",
      "doi-asserted-by": "crossref",
      "first-page": "387",
      "DOI": "10.1016/S0140-6736(06)69113-7",
      "article-title": "Alzheimer's disease",
      "volume": "368",
      "author": "Blennow",
      "year": "2006",
      "journal-title": "Lancet"
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "7709",
      "DOI": "10.1523/JNEUROSCI.2177-05.2005",
      "article-title": "Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory",
      "volume": "25",
      "author": "Buckner",
      "year": "2005",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib6",
      "doi-asserted-by": "crossref",
      "first-page": "4489",
      "DOI": "10.1073/pnas.91.10.4489",
      "article-title": "Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner",
      "volume": "91",
      "author": "Buxbaum",
      "year": "1994",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "23691",
      "DOI": "10.1074/jbc.M313296200",
      "article-title": "Activity-dependent expression of inositol 1,4,5-trisphosphate receptor type 1 in hippocampal neurons",
      "volume": "279",
      "author": "Cai",
      "year": "2004",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "36646",
      "DOI": "10.1074/jbc.M112117200",
      "article-title": "The presenilin 1 deltaE9 mutation gives enhanced basal phospholipase C activity and a resultant increase in intracellular calcium concentrations",
      "volume": "277",
      "author": "Cedazo-Minguez",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "18195",
      "DOI": "10.1074/jbc.M000040200",
      "article-title": "Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons",
      "volume": "275",
      "author": "Chan",
      "year": "2000",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib10",
      "doi-asserted-by": "crossref",
      "first-page": "913",
      "DOI": "10.1016/j.neuron.2005.10.028",
      "article-title": "Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo",
      "volume": "48",
      "author": "Cirrito",
      "year": "2005",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib11",
      "doi-asserted-by": "crossref",
      "first-page": "67",
      "DOI": "10.1038/nm0197-67",
      "article-title": "Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice",
      "volume": "3",
      "author": "Citron",
      "year": "1997",
      "journal-title": "Nat. Med."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "141",
      "DOI": "10.1038/sj.embor.7400897",
      "article-title": "Loss-of-function presenilin mutations in Alzheimer disease. Talking point on the role of presenilin mutations in Alzheimer disease",
      "volume": "8",
      "author": "De Strooper",
      "year": "2007",
      "journal-title": "EMBO Rep."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "486",
      "DOI": "10.1038/ncb960",
      "article-title": "Reconstitution of gamma-secretase activity",
      "volume": "5",
      "author": "Edbauer",
      "year": "2003",
      "journal-title": "Nat. Cell Biol."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "37",
      "DOI": "10.1006/nbdi.1998.0176",
      "article-title": "Calcium responses in fibroblasts from asymptomatic members of Alzheimer's disease families",
      "volume": "5",
      "author": "Etcheberrigaray",
      "year": "1998",
      "journal-title": "Neurobiol. Dis."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "593",
      "DOI": "10.1152/physrev.00035.2006",
      "article-title": "Inositol trisphosphate receptor Ca2+ release channels",
      "volume": "87",
      "author": "Foskett",
      "year": "2007",
      "journal-title": "Physiol. Rev."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "1121",
      "DOI": "10.1038/nm1006-1121",
      "article-title": "Alzheimer disease: presenilin springs a leak",
      "volume": "12",
      "author": "Gandy",
      "year": "2006",
      "journal-title": "Nat. Med."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "5797",
      "DOI": "10.1073/pnas.96.10.5797",
      "article-title": "Calcineurin controls inositol 1,4,5-trisphosphate type 1 receptor expression in neurons",
      "volume": "96",
      "author": "Genazzani",
      "year": "1999",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "638",
      "DOI": "10.1016/j.nbd.2004.10.016",
      "article-title": "Reduction of Ca2+ stores and capacitative Ca2+ entry is associated with the familial Alzheimer's disease presenilin-2 T122R mutation and anticipates the onset of dementia",
      "volume": "18",
      "author": "Giacomello",
      "year": "2005",
      "journal-title": "Neurobiol. Dis."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "379",
      "DOI": "10.1097/00001756-199612200-00074",
      "article-title": "Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide",
      "volume": "8",
      "author": "Guo",
      "year": "1996",
      "journal-title": "Neuroreport"
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "101",
      "DOI": "10.1038/nrm2101",
      "article-title": "Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide",
      "volume": "8",
      "author": "Haass",
      "year": "2007",
      "journal-title": "Nat. Rev. Mol. Cell Biol."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "3",
      "DOI": "10.1016/j.neuron.2006.09.016",
      "article-title": "A hundred years of Alzheimer's disease research",
      "volume": "52",
      "author": "Hardy",
      "year": "2006",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "353",
      "DOI": "10.1126/science.1072994",
      "article-title": "The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics",
      "volume": "297",
      "author": "Hardy",
      "year": "2002",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "260",
      "DOI": "10.1016/j.nbd.2004.08.002",
      "article-title": "Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity",
      "volume": "17",
      "author": "Hebert",
      "year": "2004",
      "journal-title": "Neurobiol. Dis."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "549",
      "DOI": "10.1016/0197-4580(96)00074-7",
      "article-title": "Calcium responses in human fibroblasts: a diagnostic molecular profile for Alzheimer's disease",
      "volume": "17",
      "author": "Hirashima",
      "year": "1996",
      "journal-title": "Neurobiol. Aging"
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "1639",
      "DOI": "10.1093/hmg/6.10.1639",
      "article-title": "The presenilins and Alzheimer's disease",
      "volume": "6",
      "author": "Hutton",
      "year": "1997",
      "journal-title": "Hum. Mol. Genet."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "645",
      "DOI": "10.1113/jphysiol.2006.109504",
      "article-title": "Graded recruitment and inactivation of single InsP3 receptor Ca2+-release channels: implications for quantal Ca2+ release",
      "volume": "573",
      "author": "Ionescu",
      "year": "2006",
      "journal-title": "J. Physiol."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "534",
      "DOI": "10.1073/pnas.91.2.534",
      "article-title": "Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease",
      "volume": "91",
      "author": "Ito",
      "year": "1994",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "159",
      "DOI": "10.1016/j.neulet.2005.10.088",
      "article-title": "Calcium oscillations in type-1 astrocytes, the effect of a presenilin 1 (PS1) mutation",
      "volume": "395",
      "author": "Johnston",
      "year": "2006",
      "journal-title": "Neurosci. Lett."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "14015",
      "DOI": "10.1074/jbc.273.22.14015",
      "article-title": "Regulation of amyloid precursor protein secretion by glutamate receptors in human Ntera 2 neurons",
      "volume": "273",
      "author": "Jolly-Tornetta",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "925",
      "DOI": "10.1016/S0896-6273(03)00124-7",
      "article-title": "APP processing and synaptic function",
      "volume": "37",
      "author": "Kamenetz",
      "year": "2003",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "41",
      "DOI": "10.1016/j.ceca.2006.03.005",
      "article-title": "Up-regulation of inositol 1,4,5-trisphosphate receptor type 1 is responsible for a decreased endoplasmic-reticulum Ca2+ content in presenilin double knock-out cells",
      "volume": "40",
      "author": "Kasri",
      "year": "2006",
      "journal-title": "Cell Calcium"
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "862",
      "DOI": "10.1038/nrn960",
      "article-title": "Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease",
      "volume": "3",
      "author": "LaFerla",
      "year": "2002",
      "journal-title": "Nat. Rev. Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "45",
      "DOI": "10.1016/j.ceca.2005.04.001",
      "article-title": "Rapid functional assays of recombinant IP3 receptors",
      "volume": "38",
      "author": "Laude",
      "year": "2005",
      "journal-title": "Cell Calcium"
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "32535",
      "DOI": "10.1074/jbc.274.46.32535",
      "article-title": "Presenilin-2 mutations modulate amplitude and kinetics of inositol 1, 4,5-trisphosphate-mediated calcium signals",
      "volume": "274",
      "author": "Leissring",
      "year": "1999",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "1061",
      "DOI": "10.1046/j.1471-4159.1999.0721061.x",
      "article-title": "Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes",
      "volume": "72",
      "author": "Leissring",
      "year": "1999",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "793",
      "DOI": "10.1083/jcb.149.4.793",
      "article-title": "Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice",
      "volume": "149",
      "author": "Leissring",
      "year": "2000",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "469",
      "DOI": "10.1006/nbdi.2001.0382",
      "article-title": "Subcellular mechanisms of presenilin-mediated enhancement of calcium signaling",
      "volume": "8",
      "author": "Leissring",
      "year": "2001",
      "journal-title": "Neurobiol. Dis."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "437",
      "DOI": "10.1016/j.cellsig.2004.09.005",
      "article-title": "The overexpression of presenilin2 and Alzheimer's-disease-linked presenilin2 variants influences TRPC6-enhanced Ca2+ entry into HEK293 cells",
      "volume": "17",
      "author": "Lessard",
      "year": "2005",
      "journal-title": "Cell. Signal."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "15821",
      "DOI": "10.1073/pnas.95.26.15821",
      "article-title": "Inositol 1,4,5-trisphosphate activation of inositol trisphosphate receptor Ca2+ channel by ligand tuning of Ca2+ inhibition",
      "volume": "95",
      "author": "Mak",
      "year": "1998",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "631",
      "DOI": "10.1038/nature02621",
      "article-title": "Pathways towards and away from Alzheimer's disease",
      "volume": "430",
      "author": "Mattson",
      "year": "2004",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "505",
      "DOI": "10.1002/(SICI)1097-4547(19971115)50:4<505::AID-JNR1>3.0.CO;2-I",
      "article-title": "Cell and molecular neurobiology of presenilins: a role for the endoplasmic reticulum in the pathogenesis of Alzheimer's disease?",
      "volume": "50",
      "author": "Mattson",
      "year": "1997",
      "journal-title": "J. Neurosci. Res."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "385",
      "DOI": "10.1016/S0143-4160(03)00128-3",
      "article-title": "Neuronal and glial calcium signaling in Alzheimer's disease",
      "volume": "34",
      "author": "Mattson",
      "year": "2003",
      "journal-title": "Cell Calcium"
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "1358",
      "DOI": "10.1523/JNEUROSCI.20-04-01358.2000",
      "article-title": "Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis",
      "volume": "20",
      "author": "Mattson",
      "year": "2000",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib44",
      "doi-asserted-by": "crossref",
      "first-page": "391",
      "DOI": "10.1152/physrev.1990.70.2.391",
      "article-title": "Role of calcium ions in regulation of mammalian intramitochondrial metabolism",
      "volume": "70",
      "author": "McCormack",
      "year": "1990",
      "journal-title": "Physiol. Rev."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib45",
      "doi-asserted-by": "crossref",
      "first-page": "111",
      "DOI": "10.1016/S0091-679X(03)01007-0",
      "article-title": "Culturing hippocampal and cortical neurons",
      "volume": "71",
      "author": "Meberg",
      "year": "2003",
      "journal-title": "Methods Cell Biol."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib46",
      "doi-asserted-by": "crossref",
      "first-page": "1230",
      "DOI": "10.1172/JCI30447",
      "article-title": "Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1",
      "volume": "117",
      "author": "Nelson",
      "year": "2007",
      "journal-title": "J. Clin. Invest."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib47",
      "doi-asserted-by": "crossref",
      "first-page": "C76",
      "DOI": "10.1152/ajpcell.00508.2005",
      "article-title": "Effect of gamma-secretase inhibitors on muscarinic receptor-mediated calcium signaling in human salivary epithelial cells",
      "volume": "291",
      "author": "Oh",
      "year": "2006",
      "journal-title": "Am. J. Physiol. Cell Physiol."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib48",
      "doi-asserted-by": "crossref",
      "first-page": "4550",
      "DOI": "10.1021/bi00181a016",
      "article-title": "Calcium ionophore increases amyloid beta peptide production by cultured cells",
      "volume": "33",
      "author": "Querfurth",
      "year": "1994",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib49",
      "doi-asserted-by": "crossref",
      "first-page": "864",
      "DOI": "10.1038/nm0896-864",
      "article-title": "Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease",
      "volume": "2",
      "author": "Scheuner",
      "year": "1996",
      "journal-title": "Nat. Med."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib50",
      "doi-asserted-by": "crossref",
      "first-page": "11539",
      "DOI": "10.1074/jbc.M010977200",
      "article-title": "Mutant presenilins disturb neuronal calcium homeostasis in the brain of transgenic mice, decreasing the threshold for excitotoxicity and facilitating long-term potentiation",
      "volume": "276",
      "author": "Schneider",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib51",
      "doi-asserted-by": "crossref",
      "first-page": "403",
      "DOI": "10.1073/pnas.0608332104",
      "article-title": "The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism",
      "volume": "104",
      "author": "Shen",
      "year": "2007",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib52",
      "doi-asserted-by": "crossref",
      "first-page": "105",
      "DOI": "10.1016/S0006-8993(02)02970-0",
      "article-title": "Ca2+ stores and capacitative Ca2+ entry in human neuroblastoma (SH-SY5Y) cells expressing a familial Alzheimer's disease presenilin-1 mutation",
      "volume": "949",
      "author": "Smith",
      "year": "2002",
      "journal-title": "Brain Res."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib53",
      "doi-asserted-by": "crossref",
      "first-page": "427",
      "DOI": "10.1016/j.ceca.2005.06.021",
      "article-title": "Calcium dysregulation in Alzheimer's disease: recent advances gained from genetically modified animals",
      "volume": "38",
      "author": "Smith",
      "year": "2005",
      "journal-title": "Cell Calcium"
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib54",
      "doi-asserted-by": "crossref",
      "first-page": "1711",
      "DOI": "10.1111/j.1471-4159.2005.03332.x",
      "article-title": "Enhanced caffeine-induced Ca2+ release in the 3xTg-AD mouse model of Alzheimer's disease",
      "volume": "94",
      "author": "Smith",
      "year": "2005",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib55",
      "doi-asserted-by": "crossref",
      "first-page": "110",
      "DOI": "10.1177/1073858404270899",
      "article-title": "Calcium dysregulation, IP3 signaling, and Alzheimer's disease",
      "volume": "11",
      "author": "Stutzmann",
      "year": "2005",
      "journal-title": "Neuroscientist"
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib56",
      "doi-asserted-by": "crossref",
      "first-page": "508",
      "DOI": "10.1523/JNEUROSCI.4386-03.2004",
      "article-title": "Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability",
      "volume": "24",
      "author": "Stutzmann",
      "year": "2004",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib57",
      "doi-asserted-by": "crossref",
      "first-page": "5180",
      "DOI": "10.1523/JNEUROSCI.0739-06.2006",
      "article-title": "Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice",
      "volume": "26",
      "author": "Stutzmann",
      "year": "2006",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib58",
      "doi-asserted-by": "crossref",
      "first-page": "3078",
      "DOI": "10.1093/emboj/16.11.3078",
      "article-title": "Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptor",
      "volume": "16",
      "author": "Sugawara",
      "year": "1997",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib59",
      "doi-asserted-by": "crossref",
      "first-page": "38440",
      "DOI": "10.1074/jbc.M606736200",
      "article-title": "Amyloid-beta-(1\u201342) increases ryanodine receptor-3 expression and function in neurons of TgCRND8 mice",
      "volume": "281",
      "author": "Supnet",
      "year": "2006",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib60",
      "doi-asserted-by": "crossref",
      "first-page": "1336",
      "DOI": "10.1126/science.8191290",
      "article-title": "An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants",
      "volume": "264",
      "author": "Suzuki",
      "year": "1994",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib61",
      "doi-asserted-by": "crossref",
      "first-page": "2069",
      "DOI": "10.1096/fj.05-3744fje",
      "article-title": "Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling",
      "volume": "19",
      "author": "Takeda",
      "year": "2005",
      "journal-title": "FASEB J."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib62",
      "doi-asserted-by": "crossref",
      "first-page": "981",
      "DOI": "10.1016/j.cell.2006.06.059",
      "article-title": "Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations",
      "volume": "126",
      "author": "Tu",
      "year": "2006",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib63",
      "doi-asserted-by": "crossref",
      "first-page": "201",
      "DOI": "10.1152/physrev.00004.2004",
      "article-title": "Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons",
      "volume": "85",
      "author": "Verkhratsky",
      "year": "2005",
      "journal-title": "Physiol. Rev."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib64",
      "doi-asserted-by": "crossref",
      "first-page": "1021",
      "DOI": "10.1038/ncb1302",
      "article-title": "The endoplasmic reticulum gateway to apoptosis by Bcl-XL modulation of the InsP3R",
      "volume": "7",
      "author": "White",
      "year": "2005",
      "journal-title": "Nat. Cell Biol."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib65",
      "doi-asserted-by": "crossref",
      "first-page": "561",
      "DOI": "10.1016/S0896-6273(00)00066-0",
      "article-title": "Presenilin-mediated modulation of capacitative calcium entry",
      "volume": "27",
      "author": "Yoo",
      "year": "2000",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib66",
      "doi-asserted-by": "crossref",
      "first-page": "269",
      "DOI": "10.1016/j.nbd.2003.11.002",
      "article-title": "The presenilin 2 M239I mutation associated with familial Alzheimer's disease reduces Ca2+ release from intracellular stores",
      "volume": "15",
      "author": "Zatti",
      "year": "2004",
      "journal-title": "Neurobiol. Dis."
    },
    {
      "key": "10.1016/j.neuron.2008.04.015_bib67",
      "doi-asserted-by": "crossref",
      "first-page": "539",
      "DOI": "10.1016/j.ceca.2006.03.002",
      "article-title": "Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels",
      "volume": "39",
      "author": "Zatti",
      "year": "2006",
      "journal-title": "Cell Calcium"
    }
  ],
  "container-title": "Neuron",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S089662730800367X?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S089662730800367X?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2019,
        5,
        12
      ]
    ],
    "date-time": "2019-05-12T10:11:34Z",
    "timestamp": 1557655894000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S089662730800367X"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2008,
        6
      ]
    ]
  },
  "references-count": 67,
  "journal-issue": {
    "issue": "6",
    "published-print": {
      "date-parts": [
        [
          2008,
          6
        ]
      ]
    }
  },
  "alternative-id": [
    "S089662730800367X"
  ],
  "URL": "http://dx.doi.org/10.1016/j.neuron.2008.04.015",
  "relation": {
    "has-review": [
      {
        "id-type": "doi",
        "id": "10.3410/f.1117920.574025",
        "asserted-by": "object"
      }
    ]
  },
  "ISSN": [
    "0896-6273"
  ],
  "subject": [],
  "container-title-short": "Neuron",
  "published": {
    "date-parts": [
      [
        2008,
        6
      ]
    ]
  }
}