DOI: 10.1016/j.neuron.2007.05.029. Activity-Dependent Validation of Excitatory versus Inhibitory Synapses by Neuroligin-1 versus Neuroligin-2

Activity-Dependent Validation of Excitatory versus Inhibitory Synapses by Neuroligin-1 versus Neuroligin-2

10.1016/j.neuron.2007.05.029

Crossref journal-article

Elsevier BV

Neuron (78)

Bibliography

Chubykin, A. A., Atasoy, D., Etherton, M. R., Brose, N., Kavalali, E. T., Gibson, J. R., & SÃ¼dhof, T. C. (2007). Activity-Dependent Validation of Excitatory versus Inhibitory Synapses by Neuroligin-1 versus Neuroligin-2. Neuron, 54(6), 919â931.

Authors 7

Alexander A. Chubykin (first)
Deniz Atasoy (additional)
Mark R. Etherton (additional)
Nils Brose (additional)
Ege T. Kavalali (additional)
Jay R. Gibson (additional)
Thomas C. Südhof (additional)

References 50 Referenced 493

10.1016/0306-4522(91)90333-J / Neuroscience / Thalamocortical response of mouse somatosensory (barrel) cortex in vitro by Agmon (1991)
10.1523/JNEUROSCI.1957-06.2006 / J. Neurosci. / Retraction of synapses and dendritic spines induced by off-target effects of RNA interference by Alvarez (2006)
10.1126/science.1072356 / Science / SynCAM, a synaptic adhesion molecule that drives synapse assembly by Biederer (2002)
10.1016/j.neuron.2005.08.026 / Neuron / A splice code for trans-synaptic cell adhesion mediated by binding of NL1 to alpha- and beta-neurexins by Boucard (2005)
10.1016/S0960-9822(00)00663-1 / Curr. Biol. / Synapse formation: if it looks like a duck and quacks like a duck by Cantallops (2000)
10.1093/hmg/ddh158 / Hum. Mol. Genet. / Disorder-associated mutations lead to functional inactivation of NLs by Chih (2004)
10.1126/science.1107470 / Science / Control of excitatory and inhibitory synapse formation by NLs by Chih (2005)
10.1016/j.neuron.2006.06.005 / Neuron / Alternative splicing controls selective trans-synaptic interactions of the neuroligin-neurexin complex by Chih (2006)
10.1074/jbc.M410723200 / J. Biol. Chem. / Dissection of synapse induction by NLs: effect of a neuroligin mutation associated with autism by Chubykin (2005)
10.1523/JNEUROSCI.0468-04.2004 / J. Neurosci. / The Arg451Cys-neuroligin-3 mutation associated with autism reveals a defect in protein processing by Comoletti (2004)
10.1038/nn1074 / Nat. Neurosci. / Neurexin mediates the assembly of presynaptic terminals by Dean (2003)
10.1016/S0896-6273(00)81151-4 / Neuron / Synaptic strength as a function of post- versus presynaptic expression of the neural cell adhesion molecule NCAM by Dityatev (2000)
10.1002/(SICI)1097-4695(199910)41:1<92::AID-NEU12>3.0.CO;2-U / J. Neurobiol. / Synaptic plasticity at thalamocortical synapses in developing rat somatosensory cortex: LTP, LTD, and silent synapses by Feldman (1999)
10.1038/47035 / Nature / Two networks of electrically coupled inhibitory neurons in neocortex by Gibson (1999)
10.1016/S0896-6273(03)00608-1 / Neuron / Mechanisms of synapse assembly and disassembly by Goda (2003)
10.1523/JNEUROSCI.20-06-02229.2000 / J. Neurosci. / Distinct roles for ionotropic and metabotropic glutamate receptors in the maturation of excitatory synapses by Gomperts (2000)
10.1016/j.cell.2004.11.035 / Cell / Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via NLs by Graf (2004)
10.1126/science.1110011 / Science / Neuroscience. Making synapses: a balancing act by Hussain (2005)
10.1016/0092-8674(95)90396-8 / Cell / NL1: a splice site-specific ligand for beta-neurexins by Ichtchenko (1995)
10.1074/jbc.271.5.2676 / J. Biol. Chem. / Structures, alternative splicing, and neurexin binding of multiple neuroligins by Ichtchenko (1996)
10.1126/science.277.5331.1511 / Science / Binding of NLs to PSD-95 by Irie (1997)
10.1038/ng1136 / Nat. Genet. / Mutations of the X-linked genes encoding NLs NLGN3 and NLGN4 are associated with autism by Jamain (2003)
10.1073/pnas.96.22.12893 / Proc. Natl. Acad. Sci. USA / Activity-dependent regulation of synaptic clustering in a hippocampal culture system by Kavalali (1999)
10.1126/science.7569905 / Science / Domain interaction between NMDA-receptor subunits and the postsynaptic density protein PSD-95 by Kornau (1995)
10.1086/382137 / Am. J. Hum. Genet. / X-linked mental retardation and autism are associated with a mutation in the NLGN4 gene, a member of the neuroligin family by Laumonnier (2004)
10.1186/1744-8069-1-12 / Mol. Pain / New players tip the scales in the balance between excitatory and inhibitory synapses by Levinson (2005)
10.1074/jbc.M413812200 / J. Biol. Chem. / Neuroligins mediate excitatory and inhibitory synapse formation: involvement of PSD-95 and neurexin-1beta in neuroligin-induced synaptic specificity by Levinson (2005)
10.1016/j.neuron.2005.09.006 / Neuron / Autonomous function of synaptotagmin 1 in triggering synchronous release independent of asynchronous release by Maximov (2005)
10.1016/j.jneumeth.2006.10.009 / J. Neurosci. Methods / Monitoring synaptic transmission in primary neuronal cultures using local extracellular stimulation by Maximov (2007)
10.1038/nature01755 / Nature / α-neurexins couple Ca2+-channels to synaptic vesicle exocytosis by Missler (2003)
10.1038/39908 / Nature / Identification and characterization of the vesicular GABA transporter by McIntire (1997)
10.1073/pnas.0502038102 / Proc. Natl. Acad. Sci. USA / Postsynaptic assembly induced by neurexin-neuroligin interaction and neurotransmitter by Nam (2005)
10.1523/JNEUROSCI.16-07-02157.1996 / J. Neurosci. / Interaction between the C terminus of NMDA-receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases by Niethammer (1996)
10.1038/sj.emboj.7601103 / EMBO J. / Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+-triggered neurotransmitter release by Pang (2006)
10.1016/j.tins.2005.03.004 / Trends Neurosci. / Homeostatic plasticity and NMDA-receptor trafficking by Perez-Otano (2005)
10.1038/nn719 / Nat. Neurosci. / Postsynaptic conversion of silent synapses during LTP affects synaptic gain and transmission dynamics by Poncer (2001)
10.1523/JNEUROSCI.22-11-04406.2002 / J. Neurosci. / Multiple mechanisms for the potentiation of AMPA receptor-mediated transmission by alpha-Ca2+/calmodulin-dependent protein kinase II by Poncer (2002)
10.1073/pnas.0405939101 / Proc. Natl. Acad. Sci. USA / A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin by Prange (2004)
10.1523/JNEUROSCI.3165-04.2005 / J. Neurosci. / Selective capability of SynCAM and neuroligin for functional synapse assembly by Sara (2005)
10.1016/S0092-8674(00)80877-6 / Cell / Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons by Scheiffele (2000)
10.1038/42706 / Nature / Evidence from Turner's syndrome of an imprinted X-linked locus affecting cognitive function by Skuse (1997)
10.1073/pnas.96.3.1100 / Proc. Natl. Acad. Sci. USA / NL1 is a postsynaptic cell-adhesion molecule of excitatory synapses by Song (1999)
10.1038/nature05028 / Nature / NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus by Tashiro (2006)
10.1126/science.1621094 / Science / Neurexins: Synaptic cell surface proteins related to the α-latrotoxin receptor and laminin by Ushkaryov (1992)
10.1078/0171-9335-00410 / Eur. J. Cell Biol. / Neuroligin 2 is exclusively localized to inhibitory synapses by Varoqueaux (2004)
10.1016/j.neuron.2006.09.003 / Neuron / Neuroligins are essential for synapse function but not for initial synapse formation by Varoqueaux (2006)
10.1523/JNEUROSCI.16-17-05425.1996 / J. Neurosci. / Calcium influx via the NMDA-receptor induces immediate early gene transcription by a MAP kinase/ERK-dependent mechanism by Xia (1996)
10.1016/S0955-0674(03)00107-8 / Curr. Opin. Cell Biol. / Synaptic adhesion molecules by Yamagata (2003)
10.1038/sj.mp.4001629 / Mol. Psychiatry / Analysis of the neuroligin 3 and 4 genes in autism and other neuropsychiatric patients by Yan (2005)
10.1126/science.1089071 / Science / Postnatal neurodevelopmental disorders: meeting at the synapse? by Zoghbi (2003)

Dates

Type	When
Created	18 years, 2 months ago (June 21, 2007, 7:08 a.m.)
Deposited	1 year, 4 months ago (April 22, 2024, 1:57 p.m.)
Indexed	23 hours, 52 minutes ago (Aug. 30, 2025, 12:29 p.m.)
Issued	18 years, 2 months ago (June 1, 2007)
Published	18 years, 2 months ago (June 1, 2007)
Published Print	18 years, 2 months ago (June 1, 2007)

Funders 1

National Institute of Mental Health 10.13039/100000025
Region: Americas
gov (National government)
Labels3
1. Instituto Nacional de la Salud Mental
2. Mental Health NIMH
3. NIMH
Awards1
1. R37 MH52804-08

BibTeX

@article{Chubykin_2007, title={Activity-Dependent Validation of Excitatory versus Inhibitory Synapses by Neuroligin-1 versus Neuroligin-2}, volume={54}, ISSN={0896-6273}, url={http://dx.doi.org/10.1016/j.neuron.2007.05.029}, DOI={10.1016/j.neuron.2007.05.029}, number={6}, journal={Neuron}, publisher={Elsevier BV}, author={Chubykin, Alexander A. and Atasoy, Deniz and Etherton, Mark R. and Brose, Nils and Kavalali, Ege T. and Gibson, Jay R. and Südhof, Thomas C.}, year={2007}, month=jun, pages={919–931} }

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      "author": "Alvarez",
      "year": "2006",
      "journal-title": "J. Neurosci."
    },
    {
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      "year": "2002",
      "journal-title": "Science"
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    {
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      "volume": "48",
      "author": "Boucard",
      "year": "2005",
      "journal-title": "Neuron"
    },
    {
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      "article-title": "Synapse formation: if it looks like a duck and quacks like a duck",
      "volume": "10",
      "author": "Cantallops",
      "year": "2000",
      "journal-title": "Curr. Biol."
    },
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      "author": "Chih",
      "year": "2004",
      "journal-title": "Hum. Mol. Genet."
    },
    {
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      "doi-asserted-by": "crossref",
      "first-page": "1324",
      "DOI": "10.1126/science.1107470",
      "article-title": "Control of excitatory and inhibitory synapse formation by NLs",
      "volume": "307",
      "author": "Chih",
      "year": "2005",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib8",
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      "volume": "51",
      "author": "Chih",
      "year": "2006",
      "journal-title": "Neuron"
    },
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      "doi-asserted-by": "crossref",
      "first-page": "22365",
      "DOI": "10.1074/jbc.M410723200",
      "article-title": "Dissection of synapse induction by NLs: effect of a neuroligin mutation associated with autism",
      "volume": "280",
      "author": "Chubykin",
      "year": "2005",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib10",
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      "volume": "24",
      "author": "Comoletti",
      "year": "2004",
      "journal-title": "J. Neurosci."
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      "volume": "6",
      "author": "Dean",
      "year": "2003",
      "journal-title": "Nat. Neurosci."
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      "first-page": "207",
      "DOI": "10.1016/S0896-6273(00)81151-4",
      "article-title": "Synaptic strength as a function of post- versus presynaptic expression of the neural cell adhesion molecule NCAM",
      "volume": "26",
      "author": "Dityatev",
      "year": "2000",
      "journal-title": "Neuron"
    },
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      "first-page": "92",
      "DOI": "10.1002/(SICI)1097-4695(199910)41:1<92::AID-NEU12>3.0.CO;2-U",
      "article-title": "Synaptic plasticity at thalamocortical synapses in developing rat somatosensory cortex: LTP, LTD, and silent synapses",
      "volume": "41",
      "author": "Feldman",
      "year": "1999",
      "journal-title": "J. Neurobiol."
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "75",
      "DOI": "10.1038/47035",
      "article-title": "Two networks of electrically coupled inhibitory neurons in neocortex",
      "volume": "402",
      "author": "Gibson",
      "year": "1999",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib15",
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      "first-page": "243",
      "DOI": "10.1016/S0896-6273(03)00608-1",
      "article-title": "Mechanisms of synapse assembly and disassembly",
      "volume": "40",
      "author": "Goda",
      "year": "2003",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "2229",
      "DOI": "10.1523/JNEUROSCI.20-06-02229.2000",
      "article-title": "Distinct roles for ionotropic and metabotropic glutamate receptors in the maturation of excitatory synapses",
      "volume": "20",
      "author": "Gomperts",
      "year": "2000",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "1013",
      "DOI": "10.1016/j.cell.2004.11.035",
      "article-title": "Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via NLs",
      "volume": "119",
      "author": "Graf",
      "year": "2004",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "1207",
      "DOI": "10.1126/science.1110011",
      "article-title": "Neuroscience. Making synapses: a balancing act",
      "volume": "307",
      "author": "Hussain",
      "year": "2005",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "435",
      "DOI": "10.1016/0092-8674(95)90396-8",
      "article-title": "NL1: a splice site-specific ligand for beta-neurexins",
      "volume": "81",
      "author": "Ichtchenko",
      "year": "1995",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "2676",
      "DOI": "10.1074/jbc.271.5.2676",
      "article-title": "Structures, alternative splicing, and neurexin binding of multiple neuroligins",
      "volume": "271",
      "author": "Ichtchenko",
      "year": "1996",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "1511",
      "DOI": "10.1126/science.277.5331.1511",
      "article-title": "Binding of NLs to PSD-95",
      "volume": "277",
      "author": "Irie",
      "year": "1997",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "27",
      "DOI": "10.1038/ng1136",
      "article-title": "Mutations of the X-linked genes encoding NLs NLGN3 and NLGN4 are associated with autism",
      "volume": "34",
      "author": "Jamain",
      "year": "2003",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "12893",
      "DOI": "10.1073/pnas.96.22.12893",
      "article-title": "Activity-dependent regulation of synaptic clustering in a hippocampal culture system",
      "volume": "96",
      "author": "Kavalali",
      "year": "1999",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "1737",
      "DOI": "10.1126/science.7569905",
      "article-title": "Domain interaction between NMDA-receptor subunits and the postsynaptic density protein PSD-95",
      "volume": "269",
      "author": "Kornau",
      "year": "1995",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "552",
      "DOI": "10.1086/382137",
      "article-title": "X-linked mental retardation and autism are associated with a mutation in the NLGN4 gene, a member of the neuroligin family",
      "volume": "74",
      "author": "Laumonnier",
      "year": "2004",
      "journal-title": "Am. J. Hum. Genet."
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "12",
      "DOI": "10.1186/1744-8069-1-12",
      "article-title": "New players tip the scales in the balance between excitatory and inhibitory synapses",
      "volume": "1",
      "author": "Levinson",
      "year": "2005",
      "journal-title": "Mol. Pain"
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "17312",
      "DOI": "10.1074/jbc.M413812200",
      "article-title": "Neuroligins mediate excitatory and inhibitory synapse formation: involvement of PSD-95 and neurexin-1beta in neuroligin-induced synaptic specificity",
      "volume": "280",
      "author": "Levinson",
      "year": "2005",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "547",
      "DOI": "10.1016/j.neuron.2005.09.006",
      "article-title": "Autonomous function of synaptotagmin 1 in triggering synchronous release independent of asynchronous release",
      "volume": "48",
      "author": "Maximov",
      "year": "2005",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "75",
      "DOI": "10.1016/j.jneumeth.2006.10.009",
      "article-title": "Monitoring synaptic transmission in primary neuronal cultures using local extracellular stimulation",
      "volume": "161",
      "author": "Maximov",
      "year": "2007",
      "journal-title": "J. Neurosci. Methods"
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "939",
      "DOI": "10.1038/nature01755",
      "article-title": "\u03b1-neurexins couple Ca2+-channels to synaptic vesicle exocytosis",
      "volume": "423",
      "author": "Missler",
      "year": "2003",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "870",
      "DOI": "10.1038/39908",
      "article-title": "Identification and characterization of the vesicular GABA transporter",
      "volume": "389",
      "author": "McIntire",
      "year": "1997",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "6137",
      "DOI": "10.1073/pnas.0502038102",
      "article-title": "Postsynaptic assembly induced by neurexin-neuroligin interaction and neurotransmitter",
      "volume": "102",
      "author": "Nam",
      "year": "2005",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "2157",
      "DOI": "10.1523/JNEUROSCI.16-07-02157.1996",
      "article-title": "Interaction between the C terminus of NMDA-receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases",
      "volume": "16",
      "author": "Niethammer",
      "year": "1996",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "2039",
      "DOI": "10.1038/sj.emboj.7601103",
      "article-title": "Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+-triggered neurotransmitter release",
      "volume": "25",
      "author": "Pang",
      "year": "2006",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "229",
      "DOI": "10.1016/j.tins.2005.03.004",
      "article-title": "Homeostatic plasticity and NMDA-receptor trafficking",
      "volume": "28",
      "author": "Perez-Otano",
      "year": "2005",
      "journal-title": "Trends Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "989",
      "DOI": "10.1038/nn719",
      "article-title": "Postsynaptic conversion of silent synapses during LTP affects synaptic gain and transmission dynamics",
      "volume": "4",
      "author": "Poncer",
      "year": "2001",
      "journal-title": "Nat. Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "4406",
      "DOI": "10.1523/JNEUROSCI.22-11-04406.2002",
      "article-title": "Multiple mechanisms for the potentiation of AMPA receptor-mediated transmission by alpha-Ca2+/calmodulin-dependent protein kinase II",
      "volume": "22",
      "author": "Poncer",
      "year": "2002",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "13915",
      "DOI": "10.1073/pnas.0405939101",
      "article-title": "A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin",
      "volume": "101",
      "author": "Prange",
      "year": "2004",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "260",
      "DOI": "10.1523/JNEUROSCI.3165-04.2005",
      "article-title": "Selective capability of SynCAM and neuroligin for functional synapse assembly",
      "volume": "25",
      "author": "Sara",
      "year": "2005",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "657",
      "DOI": "10.1016/S0092-8674(00)80877-6",
      "article-title": "Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons",
      "volume": "101",
      "author": "Scheiffele",
      "year": "2000",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "705",
      "DOI": "10.1038/42706",
      "article-title": "Evidence from Turner's syndrome of an imprinted X-linked locus affecting cognitive function",
      "volume": "387",
      "author": "Skuse",
      "year": "1997",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "1100",
      "DOI": "10.1073/pnas.96.3.1100",
      "article-title": "NL1 is a postsynaptic cell-adhesion molecule of excitatory synapses",
      "volume": "96",
      "author": "Song",
      "year": "1999",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "929",
      "DOI": "10.1038/nature05028",
      "article-title": "NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus",
      "volume": "442",
      "author": "Tashiro",
      "year": "2006",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib44",
      "doi-asserted-by": "crossref",
      "first-page": "50",
      "DOI": "10.1126/science.1621094",
      "article-title": "Neurexins: Synaptic cell surface proteins related to the \u03b1-latrotoxin receptor and laminin",
      "volume": "257",
      "author": "Ushkaryov",
      "year": "1992",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib45",
      "doi-asserted-by": "crossref",
      "first-page": "449",
      "DOI": "10.1078/0171-9335-00410",
      "article-title": "Neuroligin 2 is exclusively localized to inhibitory synapses",
      "volume": "83",
      "author": "Varoqueaux",
      "year": "2004",
      "journal-title": "Eur. J. Cell Biol."
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib46",
      "doi-asserted-by": "crossref",
      "first-page": "741",
      "DOI": "10.1016/j.neuron.2006.09.003",
      "article-title": "Neuroligins are essential for synapse function but not for initial synapse formation",
      "volume": "51",
      "author": "Varoqueaux",
      "year": "2006",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib47",
      "doi-asserted-by": "crossref",
      "first-page": "5425",
      "DOI": "10.1523/JNEUROSCI.16-17-05425.1996",
      "article-title": "Calcium influx via the NMDA-receptor induces immediate early gene transcription by a MAP kinase/ERK-dependent mechanism",
      "volume": "16",
      "author": "Xia",
      "year": "1996",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib48",
      "doi-asserted-by": "crossref",
      "first-page": "621",
      "DOI": "10.1016/S0955-0674(03)00107-8",
      "article-title": "Synaptic adhesion molecules",
      "volume": "15",
      "author": "Yamagata",
      "year": "2003",
      "journal-title": "Curr. Opin. Cell Biol."
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib49",
      "doi-asserted-by": "crossref",
      "first-page": "329",
      "DOI": "10.1038/sj.mp.4001629",
      "article-title": "Analysis of the neuroligin 3 and 4 genes in autism and other neuropsychiatric patients",
      "volume": "10",
      "author": "Yan",
      "year": "2005",
      "journal-title": "Mol. Psychiatry"
    },
    {
      "key": "10.1016/j.neuron.2007.05.029_bib50",
      "doi-asserted-by": "crossref",
      "first-page": "826",
      "DOI": "10.1126/science.1089071",
      "article-title": "Postnatal neurodevelopmental disorders: meeting at the synapse?",
      "volume": "302",
      "author": "Zoghbi",
      "year": "2003",
      "journal-title": "Science"
    }
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