DOI: 10.1016/j.neuron.2007.03.028. The Neuregulin-1 Receptor ErbB4 Controls Glutamatergic Synapse Maturation and Plasticity

The Neuregulin-1 Receptor ErbB4 Controls Glutamatergic Synapse Maturation and Plasticity

10.1016/j.neuron.2007.03.028

Crossref journal-article

Elsevier BV

Neuron (78)

Bibliography

Li, B., Woo, R.-S., Mei, L., & Malinow, R. (2007). The Neuregulin-1 Receptor ErbB4 Controls Glutamatergic Synapse Maturation and Plasticity. Neuron, 54(4), 583â597.

Authors 4

Bo Li (first)
Ran-Sook Woo (additional)
Lin Mei (additional)
Roberto Malinow (additional)

References 100 Referenced 287

10.1097/01.yco.0000214337.29378.cd / Curr. Opin. Psychiatry / What have we learned from proton magnetic resonance spectroscopy about schizophrenia? A critical update by Abbott (2006)
10.1038/sj.emboj.7600126 / EMBO J. / Tyrosine phosphorylation of GluR2 is required for insulin-stimulated AMPA receptor endocytosis and LTD by Ahmadian (2004)
10.1242/dev.124.18.3501 / Development / Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex by Anton (1997)
10.1073/pnas.91.21.9970 / Proc. Natl. Acad. Sci. USA / A strategy for the analysis of gene expression during neural development by Arnold (1994)
10.1083/jcb.200212085 / J. Cell Biol. / Back signaling by the Nrg-1 intracellular domain by Bao (2003)
10.1016/j.neuron.2005.08.034 / Neuron / NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII by Barria (2005)
10.1093/cercor/7.8.740 / Cereb. Cortex / Altered development of prefrontal neurons in rhesus monkeys with neonatal mesial temporo-limbic lesions: a proton magnetic resonance spectroscopic imaging study by Bertolino (1997)
10.1007/s002590000372 / Eur. J. Nucl. Med. / Imaging the glutamatergic system in vivo—relevance to schizophrenia by Bressan (2000)
10.1016/S0959-4388(00)00210-5 / Curr. Opin. Neurobiol. / Neuregulin and ErbB receptor signaling pathways in the nervous system by Buonanno (2001)
10.1523/JNEUROSCI.21-13-04740.2001 / J. Neurosci. / Neuregulin signaling regulates neural precursor growth and the generation of oligodendrocytes in vitro by Calaora (2001)
10.1016/S0896-6273(00)80155-5 / Neuron / GGF/neuregulin is a neuronal signal that promotes the proliferation and survival and inhibits the differentiation of oligodendrocyte progenitors by Canoll (1996)
10.1016/S0014-4827(02)00100-3 / Exp. Cell Res. / ErbB-4: mechanism of action and biology by Carpenter (2003)
10.1093/jnen/62.1.42 / J. Neuropathol. Exp. Neurol. / Neuregulin-1 and erbB4 immunoreactivity is associated with neuritic plaques in Alzheimer disease brain and in a transgenic model of Alzheimer disease by Chaudhury (2003)
10.1016/0896-6273(95)90289-9 / Neuron / Regulation of the acetylcholine receptor epsilon subunit gene by recombinant ARIA: an in vitro model for transynaptic gene regulation by Chu (1995)
10.1016/S0074-7742(04)59019-0 / Int. Rev. Neurobiol. / NMDA receptor function, neuroplasticity, and the pathophysiology of schizophrenia by Coyle (2004)
10.1016/S0924-977X(03)00007-5 / Eur. Neuropsychopharmacol. / Neonatal lesions in the amygdala or ventral hippocampus disrupt prepulse inhibition of the acoustic startle response; implications for an animal model of neurodevelopmental disorders like schizophrenia by Daenen (2003)
10.1073/pnas.0407976101 / Proc. Natl. Acad. Sci. USA / Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo by Dittgen (2004)
10.1016/S0074-7742(04)59003-7 / Int. Rev. Neurobiol. / The synaptic pathology of schizophrenia: is aberrant neurodevelopment and plasticity to blame? by Eastwood (2004)
10.1523/JNEUROSCI.4733-03.2004 / J. Neurosci. / Postsynaptic density 95 controls AMPA receptor incorporation during long-term potentiation and experience-driven synaptic plasticity by Ehrlich (2004)
10.1073/pnas.95.4.1888 / Proc. Natl. Acad. Sci. USA / Activity-dependent regulation of Neu differentiation factor/neuregulin expression in rat brain by Eilam (1998)
10.1126/science.290.5495.1364 / Science / PSD-95 involvement in maturation of excitatory synapses by El-Husseini (2000)
10.1126/science.1108258 / Science / Synapses form in skeletal muscles lacking neuregulin receptors by Escher (2005)
10.1016/S0014-4827(02)00102-7 / Exp. Cell Res. / Neuregulins: functions, forms, and signaling strategies by Falls (2003)
10.1016/0092-8674(93)90407-H / Cell / ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family by Falls (1993)
10.1016/S0896-6273(00)00087-8 / Neuron / Evidence that axon-derived neuregulin promotes oligodendrocyte survival in the developing rat optic nerve by Fernandez (2000)
10.1146/annurev.neuro.20.1.429 / Annu. Rev. Neurosci. / ARIA: a neuromuscular junction neuregulin by Fischbach (1997)
10.1016/j.yjmcc.2003.09.012 / J. Mol. Cell. Cardiol. / Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis via erbB4-dependent activation of PI3-kinase/Akt by Fukazawa (2003)
10.1073/pnas.97.7.3596 / Proc. Natl. Acad. Sci. USA / The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses by Garcia (2000)
10.1016/j.mcn.2004.08.001 / Mol. Cell. Neurosci. / Neuregulin-1beta induces neurite extension and arborization in cultured hippocampal neurons by Gerecke (2004)
10.1523/JNEUROSCI.1086-05.2005 / J. Neurosci. / Regulation of NMDA receptors by neuregulin signaling in prefrontal cortex by Gu (2005)
10.1038/nm1418 / Nat. Med. / Altered neuregulin 1-erbB4 signaling contributes to NMDA> receptor hypofunction in schizophrenia by Hahn (2006)
10.1073/pnas.081071198 / Proc. Natl. Acad. Sci. USA / Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia by Hakak (2001)
10.1098/rstb.1999.0394 / Philos. Trans. R. Soc. Lond. B Biol. Sci. / Processing of ARIA and release from isolated nerve terminals by Han (1999)
10.1146/annurev.ne.17.030194.002013 / Annu. Rev. Neurosci. / Dendritic spines: cellular specializations imparting both stability and flexibility to synaptic function by Harris (1994)
10.1007/s00213-003-1761-y / Psychopharmacology (Berl.) / The hippocampus in schizophrenia: a review of the neuropathological evidence and its pathophysiological implications by Harrison (2004)
10.1038/sj.mp.4001558 / Mol. Psychiatry / Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence by Harrison (2005)
10.1016/j.biopsych.2005.11.002 / Biol. Psychiatry / Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology by Harrison (2006)
10.1196/annals.1300.006 / Ann. N Y Acad. Sci. / Glutamate receptors and transporters in the hippocampus in schizophrenia by Harrison (2003)
10.1038/sj.mp.4001434 / Mol. Psychiatry / Expression analysis of neuregulin-1 in the dorsolateral prefrontal cortex in schizophrenia by Hashimoto (2004)
10.1016/S0896-6273(02)01101-7 / Neuron / A role for neuregulin1 signaling in muscle spindle differentiation by Hippenmeyer (2002)
10.1016/j.neuron.2006.10.035 / Neuron / AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss by Hsieh (2006)
10.1016/S0896-6273(00)81176-9 / Neuron / Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses by Huang (2000)
10.1038/sj.mp.4001551 / Mol. Psychiatry / Glutamate as a therapeutic target in psychiatric disorders by Javitt (2004)
10.1038/373158a0 / Nature / Neuregulins are concentrated at nerve-muscle synapses and activate ACh-receptor gene expression by Jo (1995)
10.1016/S0896-6273(03)00722-0 / Neuron / Glutamatergic plasticity by synaptic delivery of GluR-B(long)-containing AMPA receptors by Kolleker (2003)
10.1523/JNEUROSCI.3918-05.2006 / J. Neurosci. / Glutamate receptor exocytosis and spine enlargement during chemically induced long-term potentiation by Kopec (2006)
10.1038/sj.mp.4001844 / Mol. Psychiatry / Changes in NMDA receptor subunits and interacting PSD proteins in dorsolateral prefrontal and anterior cingulate cortex indicate abnormal regional expression in schizophrenia by Kristiansen (2006)
10.1016/j.conb.2005.12.003 / Curr. Opin. Neurobiol. / Assembly of the postsynaptic membrane at the neuromuscular junction: paradigm lost by Kummer (2006)
10.1523/JNEUROSCI.2100-05.2005 / J. Neurosci. / Neuregulin-1 reverses long-term potentiation at CA1 hippocampal synapses by Kwon (2005)
10.1016/j.neuroscience.2004.04.026 / Neuroscience / Neuregulin-1 (NRG-1) mRNA and protein in the adult human brain by Law (2004)
10.1073/pnas.0602002103 / Proc. Natl. Acad. Sci. USA / Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5′ SNPs associated with the disease by Law (2006)
10.1093/hmg/ddl449 / Hum. Mol. Genet. / Disease-associated intronic variants in the ErbB4 gene are related to altered ErbB4 splice-variant expression in the brain in schizophrenia by Law (2007)
10.1196/annals.1300.007 / Ann. N Y Acad. Sci. / Altered cortical glutamate neurotransmission in schizophrenia: evidence from morphological studies of pyramidal neurons by Lewis (2003)
10.1073/pnas.97.3.1299 / Proc. Natl. Acad. Sci. USA / Aberrant development of motor axons and neuromuscular synapses in erbB2-deficient mice by Lin (2000)
{'key': '10.1016/j.neuron.2007.03.028_bib55', 'first-page': '282', 'article-title': 'Using animal models to test a neurodevelopmental hypothesis of schizophrenia', 'volume': '29', 'author': 'Lipska', 'year': '2004', 'journal-title': 'J. Psychiatry Neurosci.'} / J. Psychiatry Neurosci. / Using animal models to test a neurodevelopmental hypothesis of schizophrenia by Lipska (2004)
10.1523/JNEUROSCI.21-15-05660.2001 / J. Neurosci. / Neuregulins increase alpha7 nicotinic acetylcholine receptors and enhance excitatory synaptic transmission in GABAergic interneurons of the hippocampus by Liu (2001)
10.1016/j.cell.2006.01.042 / Cell / Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigation by Lopez-Bendito (2006)
10.1523/JNEUROSCI.23-08-03164.2003 / J. Neurosci. / Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts by Ma (2003)
10.1016/S0896-6273(00)80779-5 / Neuron / Rescue of the cardiac defect in ErbB2 mutant mice reveals essential roles of ErbB2 in peripheral nervous system development by Morris (1999)
10.1016/S0896-6273(02)00975-3 / Neuron / Transmission of olfactory information between three populations of neurons in the antennal lobe of the fly by Ng (2002)
10.1002/ajmg.b.30236 / Am. J. Med. Genet. B Neuropsychiatr. Genet. / Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia by Norton (2006)
10.1097/01.yco.0000214341.52249.59 / Curr. Opin. Psychiatry / An update on the genetics of schizophrenia by Norton (2006)
10.1002/hipo.10185 / Hippocampus / Neuregulin1 downregulates postsynaptic GABAA receptors at the hippocampal inhibitory synapse by Okada (2004)
10.1038/37795 / Nature / Neuregulin-beta induces expression of an NMDA-receptor subunit by Ozaki (1997)
10.1002/(SICI)1097-4547(20000301)59:5<612::AID-JNR4>3.0.CO;2-V / J. Neurosci. Res. / Roles of neuregulin in synaptogenesis between mossy fibers and cerebellar granule cells by Ozaki (2000)
10.1111/j.1471-4159.2004.02719.x / J. Neurochem. / Protein processing and releases of neuregulin-1 are regulated in an activity-dependent manner by Ozaki (2004)
10.1101/gad.981002 / Genes Dev. / Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells by Paddison (2002)
10.1093/schbul/sbi034 / Schizophr. Bull. / Structural brain imaging evidence for multiple pathological processes at different stages of brain development in schizophrenia by Pantelis (2005)
10.1038/sj.mp.4001608 / Mol. Psychiatry / Support for involvement of neuregulin 1 in schizophrenia pathophysiology by Petryshen (2005)
{'key': '10.1016/j.neuron.2007.03.028_bib69', 'first-page': '133', 'article-title': 'Significance of dysfunctional glutamatergic transmission for the development of psychotic symptoms', 'volume': '55', 'author': 'Pietraszek', 'year': '2003', 'journal-title': 'Pol. J. Pharmacol.'} / Pol. J. Pharmacol. / Significance of dysfunctional glutamatergic transmission for the development of psychotic symptoms by Pietraszek (2003)
10.1038/sj.mp.4001751 / Mol. Psychiatry / First in vivo evidence of an NMDA receptor deficit in medication-free schizophrenic patients by Pilowsky (2006)
10.1111/j.1440-1681.2005.04257.x / Clin. Exp. Pharmacol. Physiol. / Investigating the neurodevelopmental hypothesis of schizophrenia by Rehn (2005)
10.1111/j.1460-9568.2006.04727.x / Eur. J. Neurosci. / ErbB receptor signalling regulates dendrite formation in mouse cerebellar granule cells in vivo by Rieff (2006)
10.1523/JNEUROSCI.19-24-10757.1999 / J. Neurosci. / Neuregulin induces GABA(A) receptor subunit expression and neurite outgrowth in cerebellar granule cells by Rieff (1999)
10.1016/S0896-6273(00)80346-3 / Neuron / Neuregulin and erbB receptors play a critical role in neuronal migration by Rio (1997)
10.1016/S0306-4522(03)00503-7 / Neuroscience / Neuregulin-1beta modulates in vivo entorhinal-hippocampal synaptic transmission in adult rats by Roysommuti (2003)
10.1016/S0896-6273(01)00353-1 / Neuron / Targeting transcription to the neuromuscular synapse by Schaeffer (2001)
10.1002/glia.10275 / Glia / erbB3 is dispensable for oligodendrocyte development in vitro and in vivo by Schmucker (2003)
10.1080/10673220600642960 / Harv. Rev. Psychiatry / Schizophrenia: do the genetics and neurobiology of neuregulin provide a pathogenesis model? by Scolnick (2006)
10.1002/ajmg.b.30275 / Am. J. Med. Genet. B Neuropsychiatr. Genet. / The involvement of ErbB4 with schizophrenia: association and expression studies by Silberberg (2006)
10.1086/342734 / Am. J. Hum. Genet. / Neuregulin 1 and susceptibility to schizophrenia by Stefansson (2002)
10.1016/0165-0270(91)90128-M / J. Neurosci. Methods / A simple method for organotypic cultures of nervous tissue by Stoppini (1991)
10.1196/annals.1316.011 / Ann. N Y Acad. Sci. / Prefrontal abnormality of schizophrenia revealed by DNA microarray: impact on glial and neurotrophic gene expression by Sugai (2004)
10.1016/j.neuron.2005.08.017 / Neuron / Neuregulin-1 type III determines the ensheathment fate of axons by Taveggia (2005)
10.1083/jcb.103.2.493 / J. Cell Biol. / Purification and characterization of a polypeptide from chick brain that promotes the accumulation of acetylcholine receptors in chick myotubes by Usdin (1986)
10.2174/1566524033479627 / Curr. Mol. Med. / Neurodevelopmental animal models of schizophrenia: effects on prepulse inhibition by Van den Buuse (2003)
10.1073/pnas.91.24.11626 / Proc. Natl. Acad. Sci. USA / A role for the acetylcholine receptor-inducing protein ARIA in oligodendrocyte development by Vartanian (1994)
10.1073/pnas.96.2.731 / Proc. Natl. Acad. Sci. USA / Failure of spinal cord oligodendrocyte development in mice lacking neuregulin by Vartanian (1999)
10.1016/j.biopsych.2006.03.017 / Biol. Psychiatry / A novel missense mutation in the transmembrane domain of neuregulin 1 is associated with schizophrenia by Walss-Bass (2006)
10.1074/jbc.M005700200 / J. Biol. Chem. / The N-terminal region of neuregulin isoforms determines the accumulation of cell surface and released neuregulin ectodomain by Wang (2001)
10.1101/gad.13.19.2538 / Genes Dev. / Peripheral nervous system defects in erbB2 mutants following genetic rescue of heart development by Woldeyesus (1999)
10.1016/S0896-6273(00)80873-9 / Neuron / Cysteine-rich domain isoforms of the neuregulin-1 gene are required for maintenance of peripheral synapses by Wolpowitz (2000)
10.1016/j.neuron.2007.04.009 / Neuron / Neuregulin-1 enhances depolarization-induced GABA release by Woo (2007)
10.1111/j.1471-4159.2004.02685.x / J. Neurochem. / Neuregulin induces GABAA receptor beta2 subunit expression in cultured rat cerebellar granule neurons by activating multiple signaling pathways by Xie (2004)
10.1111/j.1471-4159.2006.04182.x / J. Neurochem. / Association of PSD-95 with ErbB4 facilitates neuregulin signaling in cerebellar granule neurons in culture by Xie (2007)
10.1016/S0896-6273(00)80454-7 / Neuron / A cysteine-rich isoform of neuregulin controls the level of expression of neuronal nicotinic receptor channels during synaptogenesis by Yang (1998)
10.1016/j.mcn.2004.10.001 / Mol. Cell. Neurosci. / Neuregulin-induced expression of the acetylcholine receptor requires endocytosis of ErbB receptors by Yang (2005)
10.1038/35052073 / Nat. Rev. Mol. Cell Biol. / Untangling the ErbB signalling network by Yarden (2001)
10.1038/80614 / Nat. Neurosci. / Postnatal synaptic potentiation: delivery of GluR4-containing AMPA receptors by spontaneous activity by Zhu (2000)
10.1016/S0092-8674(02)00897-8 / Cell / Ras and Rap control AMPA receptor trafficking during synaptic plasticity by Zhu (2002)

Dates

Type	When
Created	18 years, 3 months ago (May 25, 2007, 1:44 a.m.)
Deposited	1 year, 4 months ago (April 22, 2024, 1:56 p.m.)
Indexed	2 months, 2 weeks ago (June 17, 2025, 4:09 a.m.)
Issued	18 years, 4 months ago (May 1, 2007)
Published	18 years, 4 months ago (May 1, 2007)
Published Print	18 years, 4 months ago (May 1, 2007)

Funders 0

None

BibTeX

@article{Li_2007, title={The Neuregulin-1 Receptor ErbB4 Controls Glutamatergic Synapse Maturation and Plasticity}, volume={54}, ISSN={0896-6273}, url={http://dx.doi.org/10.1016/j.neuron.2007.03.028}, DOI={10.1016/j.neuron.2007.03.028}, number={4}, journal={Neuron}, publisher={Elsevier BV}, author={Li, Bo and Woo, Ran-Sook and Mei, Lin and Malinow, Roberto}, year={2007}, month=may, pages={583–597} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        6,
        17
      ]
    ],
    "date-time": "2025-06-17T08:09:12Z",
    "timestamp": 1750147752054
  },
  "reference-count": 100,
  "publisher": "Elsevier BV",
  "issue": "4",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2007,
            5,
            1
          ]
        ],
        "date-time": "2007-05-01T00:00:00Z",
        "timestamp": 1177977600000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2007,
            5,
            1
          ]
        ],
        "date-time": "2007-05-01T00:00:00Z",
        "timestamp": 1177977600000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/legal/tdmrep-license"
    },
    {
      "start": {
        "date-parts": [
          [
            2013,
            8,
            22
          ]
        ],
        "date-time": "2013-08-22T00:00:00Z",
        "timestamp": 1377129600000
      },
      "content-version": "vor",
      "delay-in-days": 2305,
      "URL": "http://www.elsevier.com/open-access/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2007,
            5,
            1
          ]
        ],
        "date-time": "2007-05-01T00:00:00Z",
        "timestamp": 1177977600000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-017"
    },
    {
      "start": {
        "date-parts": [
          [
            2007,
            5,
            1
          ]
        ],
        "date-time": "2007-05-01T00:00:00Z",
        "timestamp": 1177977600000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-037"
    },
    {
      "start": {
        "date-parts": [
          [
            2007,
            5,
            1
          ]
        ],
        "date-time": "2007-05-01T00:00:00Z",
        "timestamp": 1177977600000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-012"
    },
    {
      "start": {
        "date-parts": [
          [
            2007,
            5,
            1
          ]
        ],
        "date-time": "2007-05-01T00:00:00Z",
        "timestamp": 1177977600000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-029"
    },
    {
      "start": {
        "date-parts": [
          [
            2007,
            5,
            1
          ]
        ],
        "date-time": "2007-05-01T00:00:00Z",
        "timestamp": 1177977600000
      },
      "content-version": "stm-asf",
      "delay-in-days": 0,
      "URL": "https://doi.org/10.15223/policy-004"
    }
  ],
  "content-domain": {
    "domain": [
      "cell.com",
      "elsevier.com",
      "sciencedirect.com"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        2007,
        5
      ]
    ]
  },
  "DOI": "10.1016/j.neuron.2007.03.028",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2007,
        5,
        25
      ]
    ],
    "date-time": "2007-05-25T05:44:05Z",
    "timestamp": 1180071845000
  },
  "page": "583-597",
  "update-policy": "http://dx.doi.org/10.1016/elsevier_cm_policy",
  "source": "Crossref",
  "is-referenced-by-count": 287,
  "title": "The Neuregulin-1 Receptor ErbB4 Controls Glutamatergic Synapse Maturation and Plasticity",
  "prefix": "10.1016",
  "volume": "54",
  "author": [
    {
      "given": "Bo",
      "family": "Li",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Ran-Sook",
      "family": "Woo",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Lin",
      "family": "Mei",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Roberto",
      "family": "Malinow",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/j.neuron.2007.03.028_bib1",
      "doi-asserted-by": "crossref",
      "first-page": "135",
      "DOI": "10.1097/01.yco.0000214337.29378.cd",
      "article-title": "What have we learned from proton magnetic resonance spectroscopy about schizophrenia? A critical update",
      "volume": "19",
      "author": "Abbott",
      "year": "2006",
      "journal-title": "Curr. Opin. Psychiatry"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib2",
      "doi-asserted-by": "crossref",
      "first-page": "1040",
      "DOI": "10.1038/sj.emboj.7600126",
      "article-title": "Tyrosine phosphorylation of GluR2 is required for insulin-stimulated AMPA receptor endocytosis and LTD",
      "volume": "23",
      "author": "Ahmadian",
      "year": "2004",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib3",
      "doi-asserted-by": "crossref",
      "first-page": "3501",
      "DOI": "10.1242/dev.124.18.3501",
      "article-title": "Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex",
      "volume": "124",
      "author": "Anton",
      "year": "1997",
      "journal-title": "Development"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib4",
      "doi-asserted-by": "crossref",
      "first-page": "9970",
      "DOI": "10.1073/pnas.91.21.9970",
      "article-title": "A strategy for the analysis of gene expression during neural development",
      "volume": "91",
      "author": "Arnold",
      "year": "1994",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "1133",
      "DOI": "10.1083/jcb.200212085",
      "article-title": "Back signaling by the Nrg-1 intracellular domain",
      "volume": "161",
      "author": "Bao",
      "year": "2003",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib6",
      "doi-asserted-by": "crossref",
      "first-page": "289",
      "DOI": "10.1016/j.neuron.2005.08.034",
      "article-title": "NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII",
      "volume": "48",
      "author": "Barria",
      "year": "2005",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "740",
      "DOI": "10.1093/cercor/7.8.740",
      "article-title": "Altered development of prefrontal neurons in rhesus monkeys with neonatal mesial temporo-limbic lesions: a proton magnetic resonance spectroscopic imaging study",
      "volume": "7",
      "author": "Bertolino",
      "year": "1997",
      "journal-title": "Cereb. Cortex"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "1723",
      "DOI": "10.1007/s002590000372",
      "article-title": "Imaging the glutamatergic system in vivo\u2014relevance to schizophrenia",
      "volume": "27",
      "author": "Bressan",
      "year": "2000",
      "journal-title": "Eur. J. Nucl. Med."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "287",
      "DOI": "10.1016/S0959-4388(00)00210-5",
      "article-title": "Neuregulin and ErbB receptor signaling pathways in the nervous system",
      "volume": "11",
      "author": "Buonanno",
      "year": "2001",
      "journal-title": "Curr. Opin. Neurobiol."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib10",
      "doi-asserted-by": "crossref",
      "first-page": "4740",
      "DOI": "10.1523/JNEUROSCI.21-13-04740.2001",
      "article-title": "Neuregulin signaling regulates neural precursor growth and the generation of oligodendrocytes in vitro",
      "volume": "21",
      "author": "Calaora",
      "year": "2001",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib11",
      "doi-asserted-by": "crossref",
      "first-page": "229",
      "DOI": "10.1016/S0896-6273(00)80155-5",
      "article-title": "GGF/neuregulin is a neuronal signal that promotes the proliferation and survival and inhibits the differentiation of oligodendrocyte progenitors",
      "volume": "17",
      "author": "Canoll",
      "year": "1996",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "66",
      "DOI": "10.1016/S0014-4827(02)00100-3",
      "article-title": "ErbB-4: mechanism of action and biology",
      "volume": "284",
      "author": "Carpenter",
      "year": "2003",
      "journal-title": "Exp. Cell Res."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "42",
      "DOI": "10.1093/jnen/62.1.42",
      "article-title": "Neuregulin-1 and erbB4 immunoreactivity is associated with neuritic plaques in Alzheimer disease brain and in\u00a0a transgenic model of Alzheimer disease",
      "volume": "62",
      "author": "Chaudhury",
      "year": "2003",
      "journal-title": "J. Neuropathol. Exp. Neurol."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "329",
      "DOI": "10.1016/0896-6273(95)90289-9",
      "article-title": "Regulation of the acetylcholine receptor epsilon subunit gene by recombinant ARIA: an in vitro model for transynaptic gene regulation",
      "volume": "14",
      "author": "Chu",
      "year": "1995",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "491",
      "DOI": "10.1016/S0074-7742(04)59019-0",
      "article-title": "NMDA receptor function, neuroplasticity, and the pathophysiology of schizophrenia",
      "volume": "59",
      "author": "Coyle",
      "year": "2004",
      "journal-title": "Int. Rev. Neurobiol."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "187",
      "DOI": "10.1016/S0924-977X(03)00007-5",
      "article-title": "Neonatal lesions in the amygdala or ventral hippocampus disrupt prepulse inhibition of the acoustic startle response; implications for an animal model of neurodevelopmental disorders like schizophrenia",
      "volume": "13",
      "author": "Daenen",
      "year": "2003",
      "journal-title": "Eur. Neuropsychopharmacol."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "18206",
      "DOI": "10.1073/pnas.0407976101",
      "article-title": "Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo",
      "volume": "101",
      "author": "Dittgen",
      "year": "2004",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "47",
      "DOI": "10.1016/S0074-7742(04)59003-7",
      "article-title": "The synaptic pathology of schizophrenia: is aberrant neurodevelopment and plasticity to blame?",
      "volume": "59",
      "author": "Eastwood",
      "year": "2004",
      "journal-title": "Int. Rev. Neurobiol."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "916",
      "DOI": "10.1523/JNEUROSCI.4733-03.2004",
      "article-title": "Postsynaptic density 95 controls AMPA receptor incorporation during long-term potentiation and experience-driven synaptic plasticity",
      "volume": "24",
      "author": "Ehrlich",
      "year": "2004",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "1888",
      "DOI": "10.1073/pnas.95.4.1888",
      "article-title": "Activity-dependent regulation of Neu differentiation factor/neuregulin expression in rat brain",
      "volume": "95",
      "author": "Eilam",
      "year": "1998",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "1364",
      "DOI": "10.1126/science.290.5495.1364",
      "article-title": "PSD-95 involvement in maturation of excitatory synapses",
      "volume": "290",
      "author": "El-Husseini",
      "year": "2000",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "1920",
      "DOI": "10.1126/science.1108258",
      "article-title": "Synapses form in skeletal muscles lacking neuregulin receptors",
      "volume": "308",
      "author": "Escher",
      "year": "2005",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "14",
      "DOI": "10.1016/S0014-4827(02)00102-7",
      "article-title": "Neuregulins: functions, forms, and signaling strategies",
      "volume": "284",
      "author": "Falls",
      "year": "2003",
      "journal-title": "Exp. Cell Res."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "801",
      "DOI": "10.1016/0092-8674(93)90407-H",
      "article-title": "ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family",
      "volume": "72",
      "author": "Falls",
      "year": "1993",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "81",
      "DOI": "10.1016/S0896-6273(00)00087-8",
      "article-title": "Evidence that axon-derived neuregulin promotes oligodendrocyte survival in the developing rat optic nerve",
      "volume": "28",
      "author": "Fernandez",
      "year": "2000",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "429",
      "DOI": "10.1146/annurev.neuro.20.1.429",
      "article-title": "ARIA: a neuromuscular junction neuregulin",
      "volume": "20",
      "author": "Fischbach",
      "year": "1997",
      "journal-title": "Annu. Rev. Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "1473",
      "DOI": "10.1016/j.yjmcc.2003.09.012",
      "article-title": "Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis via erbB4-dependent activation of PI3-kinase/Akt",
      "volume": "35",
      "author": "Fukazawa",
      "year": "2003",
      "journal-title": "J. Mol. Cell. Cardiol."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "3596",
      "DOI": "10.1073/pnas.97.7.3596",
      "article-title": "The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses",
      "volume": "97",
      "author": "Garcia",
      "year": "2000",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "379",
      "DOI": "10.1016/j.mcn.2004.08.001",
      "article-title": "Neuregulin-1beta induces neurite extension and arborization in cultured hippocampal neurons",
      "volume": "27",
      "author": "Gerecke",
      "year": "2004",
      "journal-title": "Mol. Cell. Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "4974",
      "DOI": "10.1523/JNEUROSCI.1086-05.2005",
      "article-title": "Regulation of NMDA receptors by neuregulin signaling in prefrontal cortex",
      "volume": "25",
      "author": "Gu",
      "year": "2005",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "734",
      "DOI": "10.1038/nm1418",
      "article-title": "Altered neuregulin 1-erbB4 signaling contributes to NMDA> receptor hypofunction in schizophrenia",
      "volume": "12",
      "author": "Hahn",
      "year": "2006",
      "journal-title": "Nat. Med."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "4746",
      "DOI": "10.1073/pnas.081071198",
      "article-title": "Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia",
      "volume": "98",
      "author": "Hakak",
      "year": "2001",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "411",
      "DOI": "10.1098/rstb.1999.0394",
      "article-title": "Processing of ARIA and release from isolated nerve terminals",
      "volume": "354",
      "author": "Han",
      "year": "1999",
      "journal-title": "Philos. Trans. R. Soc. Lond. B Biol. Sci."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "341",
      "DOI": "10.1146/annurev.ne.17.030194.002013",
      "article-title": "Dendritic spines: cellular specializations imparting both stability and flexibility to synaptic function",
      "volume": "17",
      "author": "Harris",
      "year": "1994",
      "journal-title": "Annu. Rev. Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "151",
      "DOI": "10.1007/s00213-003-1761-y",
      "article-title": "The hippocampus in schizophrenia: a review of the neuropathological evidence and its pathophysiological implications",
      "volume": "174",
      "author": "Harrison",
      "year": "2004",
      "journal-title": "Psychopharmacology (Berl.)"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "40",
      "DOI": "10.1038/sj.mp.4001558",
      "article-title": "Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence",
      "volume": "10",
      "author": "Harrison",
      "year": "2005",
      "journal-title": "Mol. Psychiatry"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "132",
      "DOI": "10.1016/j.biopsych.2005.11.002",
      "article-title": "Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology",
      "volume": "60",
      "author": "Harrison",
      "year": "2006",
      "journal-title": "Biol. Psychiatry"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "94",
      "DOI": "10.1196/annals.1300.006",
      "article-title": "Glutamate receptors and transporters in the hippocampus in schizophrenia",
      "volume": "1003",
      "author": "Harrison",
      "year": "2003",
      "journal-title": "Ann. N Y Acad. Sci."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "299",
      "DOI": "10.1038/sj.mp.4001434",
      "article-title": "Expression analysis of neuregulin-1 in the dorsolateral prefrontal cortex in schizophrenia",
      "volume": "9",
      "author": "Hashimoto",
      "year": "2004",
      "journal-title": "Mol. Psychiatry"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "1035",
      "DOI": "10.1016/S0896-6273(02)01101-7",
      "article-title": "A role for neuregulin1 signaling in muscle spindle differentiation",
      "volume": "36",
      "author": "Hippenmeyer",
      "year": "2002",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "831",
      "DOI": "10.1016/j.neuron.2006.10.035",
      "article-title": "AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss",
      "volume": "52",
      "author": "Hsieh",
      "year": "2006",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "443",
      "DOI": "10.1016/S0896-6273(00)81176-9",
      "article-title": "Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses",
      "volume": "26",
      "author": "Huang",
      "year": "2000",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "984",
      "DOI": "10.1038/sj.mp.4001551",
      "article-title": "Glutamate as a therapeutic target in psychiatric disorders",
      "volume": "9",
      "author": "Javitt",
      "year": "2004",
      "journal-title": "Mol. Psychiatry"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib44",
      "doi-asserted-by": "crossref",
      "first-page": "158",
      "DOI": "10.1038/373158a0",
      "article-title": "Neuregulins are concentrated at nerve-muscle synapses and activate ACh-receptor gene expression",
      "volume": "373",
      "author": "Jo",
      "year": "1995",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib45",
      "doi-asserted-by": "crossref",
      "first-page": "1199",
      "DOI": "10.1016/S0896-6273(03)00722-0",
      "article-title": "Glutamatergic plasticity by synaptic delivery of GluR-B(long)-containing AMPA receptors",
      "volume": "40",
      "author": "Kolleker",
      "year": "2003",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib46",
      "doi-asserted-by": "crossref",
      "first-page": "2000",
      "DOI": "10.1523/JNEUROSCI.3918-05.2006",
      "article-title": "Glutamate receptor exocytosis and spine enlargement during chemically induced long-term potentiation",
      "volume": "26",
      "author": "Kopec",
      "year": "2006",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib47",
      "doi-asserted-by": "crossref",
      "first-page": "737",
      "DOI": "10.1038/sj.mp.4001844",
      "article-title": "Changes in NMDA receptor subunits and interacting PSD proteins in dorsolateral prefrontal and anterior cingulate cortex indicate abnormal regional expression in schizophrenia",
      "volume": "11",
      "author": "Kristiansen",
      "year": "2006",
      "journal-title": "Mol. Psychiatry"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib48",
      "doi-asserted-by": "crossref",
      "first-page": "74",
      "DOI": "10.1016/j.conb.2005.12.003",
      "article-title": "Assembly of the postsynaptic membrane at the neuromuscular junction: paradigm lost",
      "volume": "16",
      "author": "Kummer",
      "year": "2006",
      "journal-title": "Curr. Opin. Neurobiol."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib49",
      "doi-asserted-by": "crossref",
      "first-page": "9378",
      "DOI": "10.1523/JNEUROSCI.2100-05.2005",
      "article-title": "Neuregulin-1 reverses long-term potentiation at CA1 hippocampal synapses",
      "volume": "25",
      "author": "Kwon",
      "year": "2005",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib50",
      "doi-asserted-by": "crossref",
      "first-page": "125",
      "DOI": "10.1016/j.neuroscience.2004.04.026",
      "article-title": "Neuregulin-1 (NRG-1) mRNA and protein in the adult human brain",
      "volume": "127",
      "author": "Law",
      "year": "2004",
      "journal-title": "Neuroscience"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib51",
      "doi-asserted-by": "crossref",
      "first-page": "6747",
      "DOI": "10.1073/pnas.0602002103",
      "article-title": "Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5\u2032 SNPs associated with the disease",
      "volume": "103",
      "author": "Law",
      "year": "2006",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib52",
      "doi-asserted-by": "crossref",
      "first-page": "129",
      "DOI": "10.1093/hmg/ddl449",
      "article-title": "Disease-associated intronic variants in the ErbB4 gene are related to altered ErbB4 splice-variant expression in the brain in schizophrenia",
      "volume": "16",
      "author": "Law",
      "year": "2007",
      "journal-title": "Hum. Mol. Genet."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib53",
      "doi-asserted-by": "crossref",
      "first-page": "102",
      "DOI": "10.1196/annals.1300.007",
      "article-title": "Altered cortical glutamate neurotransmission in schizophrenia: evidence from morphological studies of pyramidal neurons",
      "volume": "1003",
      "author": "Lewis",
      "year": "2003",
      "journal-title": "Ann. N Y Acad. Sci."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib54",
      "doi-asserted-by": "crossref",
      "first-page": "1299",
      "DOI": "10.1073/pnas.97.3.1299",
      "article-title": "Aberrant development of motor axons and neuromuscular synapses in erbB2-deficient mice",
      "volume": "97",
      "author": "Lin",
      "year": "2000",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib55",
      "first-page": "282",
      "article-title": "Using animal models to test a neurodevelopmental hypothesis of schizophrenia",
      "volume": "29",
      "author": "Lipska",
      "year": "2004",
      "journal-title": "J. Psychiatry Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib56",
      "doi-asserted-by": "crossref",
      "first-page": "5660",
      "DOI": "10.1523/JNEUROSCI.21-15-05660.2001",
      "article-title": "Neuregulins increase alpha7 nicotinic acetylcholine receptors and enhance excitatory synaptic transmission in GABAergic interneurons of the hippocampus",
      "volume": "21",
      "author": "Liu",
      "year": "2001",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib57",
      "doi-asserted-by": "crossref",
      "first-page": "127",
      "DOI": "10.1016/j.cell.2006.01.042",
      "article-title": "Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigation",
      "volume": "125",
      "author": "Lopez-Bendito",
      "year": "2006",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib58",
      "doi-asserted-by": "crossref",
      "first-page": "3164",
      "DOI": "10.1523/JNEUROSCI.23-08-03164.2003",
      "article-title": "Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts",
      "volume": "23",
      "author": "Ma",
      "year": "2003",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib59",
      "doi-asserted-by": "crossref",
      "first-page": "273",
      "DOI": "10.1016/S0896-6273(00)80779-5",
      "article-title": "Rescue of the cardiac defect in ErbB2 mutant mice reveals essential roles of ErbB2 in peripheral nervous system development",
      "volume": "23",
      "author": "Morris",
      "year": "1999",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib99",
      "doi-asserted-by": "crossref",
      "first-page": "463",
      "DOI": "10.1016/S0896-6273(02)00975-3",
      "article-title": "Transmission of olfactory information between three populations of neurons in the antennal lobe of the fly",
      "volume": "36",
      "author": "Ng",
      "year": "2002",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib60",
      "doi-asserted-by": "crossref",
      "first-page": "96",
      "DOI": "10.1002/ajmg.b.30236",
      "article-title": "Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia",
      "volume": "141",
      "author": "Norton",
      "year": "2006",
      "journal-title": "Am. J. Med. Genet. B Neuropsychiatr. Genet."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib61",
      "doi-asserted-by": "crossref",
      "first-page": "158",
      "DOI": "10.1097/01.yco.0000214341.52249.59",
      "article-title": "An update on the genetics of schizophrenia",
      "volume": "19",
      "author": "Norton",
      "year": "2006",
      "journal-title": "Curr. Opin. Psychiatry"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib62",
      "doi-asserted-by": "crossref",
      "first-page": "337",
      "DOI": "10.1002/hipo.10185",
      "article-title": "Neuregulin1 downregulates postsynaptic GABAA receptors at the hippocampal inhibitory synapse",
      "volume": "14",
      "author": "Okada",
      "year": "2004",
      "journal-title": "Hippocampus"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib63",
      "doi-asserted-by": "crossref",
      "first-page": "691",
      "DOI": "10.1038/37795",
      "article-title": "Neuregulin-beta induces expression of an NMDA-receptor subunit",
      "volume": "390",
      "author": "Ozaki",
      "year": "1997",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib64",
      "doi-asserted-by": "crossref",
      "first-page": "612",
      "DOI": "10.1002/(SICI)1097-4547(20000301)59:5<612::AID-JNR4>3.0.CO;2-V",
      "article-title": "Roles of neuregulin in synaptogenesis between mossy fibers and cerebellar granule cells",
      "volume": "59",
      "author": "Ozaki",
      "year": "2000",
      "journal-title": "J. Neurosci. Res."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib65",
      "doi-asserted-by": "crossref",
      "first-page": "176",
      "DOI": "10.1111/j.1471-4159.2004.02719.x",
      "article-title": "Protein processing and releases of neuregulin-1 are regulated in an activity-dependent manner",
      "volume": "91",
      "author": "Ozaki",
      "year": "2004",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib66",
      "doi-asserted-by": "crossref",
      "first-page": "948",
      "DOI": "10.1101/gad.981002",
      "article-title": "Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells",
      "volume": "16",
      "author": "Paddison",
      "year": "2002",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib67",
      "doi-asserted-by": "crossref",
      "first-page": "672",
      "DOI": "10.1093/schbul/sbi034",
      "article-title": "Structural brain imaging evidence for multiple pathological processes at different stages of brain development in schizophrenia",
      "volume": "31",
      "author": "Pantelis",
      "year": "2005",
      "journal-title": "Schizophr. Bull."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib68",
      "doi-asserted-by": "crossref",
      "first-page": "366",
      "DOI": "10.1038/sj.mp.4001608",
      "article-title": "Support for involvement of neuregulin 1 in schizophrenia pathophysiology",
      "volume": "10",
      "author": "Petryshen",
      "year": "2005",
      "journal-title": "Mol. Psychiatry"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib69",
      "first-page": "133",
      "article-title": "Significance of dysfunctional glutamatergic transmission for the development of psychotic symptoms",
      "volume": "55",
      "author": "Pietraszek",
      "year": "2003",
      "journal-title": "Pol. J. Pharmacol."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib70",
      "doi-asserted-by": "crossref",
      "first-page": "118",
      "DOI": "10.1038/sj.mp.4001751",
      "article-title": "First in vivo evidence of an NMDA receptor deficit in medication-free schizophrenic patients",
      "volume": "11",
      "author": "Pilowsky",
      "year": "2006",
      "journal-title": "Mol. Psychiatry"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib71",
      "doi-asserted-by": "crossref",
      "first-page": "687",
      "DOI": "10.1111/j.1440-1681.2005.04257.x",
      "article-title": "Investigating the neurodevelopmental hypothesis of schizophrenia",
      "volume": "32",
      "author": "Rehn",
      "year": "2005",
      "journal-title": "Clin. Exp. Pharmacol. Physiol."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib72",
      "doi-asserted-by": "crossref",
      "first-page": "2225",
      "DOI": "10.1111/j.1460-9568.2006.04727.x",
      "article-title": "ErbB receptor signalling regulates dendrite formation in mouse cerebellar granule cells in vivo",
      "volume": "23",
      "author": "Rieff",
      "year": "2006",
      "journal-title": "Eur. J. Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib73",
      "doi-asserted-by": "crossref",
      "first-page": "10757",
      "DOI": "10.1523/JNEUROSCI.19-24-10757.1999",
      "article-title": "Neuregulin induces GABA(A) receptor subunit expression and neurite outgrowth in cerebellar granule cells",
      "volume": "19",
      "author": "Rieff",
      "year": "1999",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib74",
      "doi-asserted-by": "crossref",
      "first-page": "39",
      "DOI": "10.1016/S0896-6273(00)80346-3",
      "article-title": "Neuregulin and erbB receptors play a critical role in neuronal migration",
      "volume": "19",
      "author": "Rio",
      "year": "1997",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib75",
      "doi-asserted-by": "crossref",
      "first-page": "779",
      "DOI": "10.1016/S0306-4522(03)00503-7",
      "article-title": "Neuregulin-1beta modulates in vivo entorhinal-hippocampal synaptic transmission in adult rats",
      "volume": "121",
      "author": "Roysommuti",
      "year": "2003",
      "journal-title": "Neuroscience"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib76",
      "doi-asserted-by": "crossref",
      "first-page": "15",
      "DOI": "10.1016/S0896-6273(01)00353-1",
      "article-title": "Targeting transcription to the neuromuscular synapse",
      "volume": "31",
      "author": "Schaeffer",
      "year": "2001",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib77",
      "doi-asserted-by": "crossref",
      "first-page": "67",
      "DOI": "10.1002/glia.10275",
      "article-title": "erbB3 is dispensable for oligodendrocyte development in vitro and in vivo",
      "volume": "44",
      "author": "Schmucker",
      "year": "2003",
      "journal-title": "Glia"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib78",
      "doi-asserted-by": "crossref",
      "first-page": "64",
      "DOI": "10.1080/10673220600642960",
      "article-title": "Schizophrenia: do the genetics and neurobiology of neuregulin provide a pathogenesis model?",
      "volume": "14",
      "author": "Scolnick",
      "year": "2006",
      "journal-title": "Harv. Rev. Psychiatry"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib79",
      "doi-asserted-by": "crossref",
      "first-page": "142",
      "DOI": "10.1002/ajmg.b.30275",
      "article-title": "The involvement of ErbB4 with schizophrenia: association and expression studies",
      "volume": "141",
      "author": "Silberberg",
      "year": "2006",
      "journal-title": "Am. J. Med. Genet. B Neuropsychiatr. Genet."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib80",
      "doi-asserted-by": "crossref",
      "first-page": "877",
      "DOI": "10.1086/342734",
      "article-title": "Neuregulin 1 and susceptibility to schizophrenia",
      "volume": "71",
      "author": "Stefansson",
      "year": "2002",
      "journal-title": "Am. J. Hum. Genet."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib81",
      "doi-asserted-by": "crossref",
      "first-page": "173",
      "DOI": "10.1016/0165-0270(91)90128-M",
      "article-title": "A simple method for organotypic cultures of nervous tissue",
      "volume": "37",
      "author": "Stoppini",
      "year": "1991",
      "journal-title": "J. Neurosci. Methods"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib82",
      "doi-asserted-by": "crossref",
      "first-page": "84",
      "DOI": "10.1196/annals.1316.011",
      "article-title": "Prefrontal abnormality of schizophrenia revealed by DNA microarray: impact on glial and neurotrophic gene expression",
      "volume": "1025",
      "author": "Sugai",
      "year": "2004",
      "journal-title": "Ann. N Y Acad. Sci."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib83",
      "doi-asserted-by": "crossref",
      "first-page": "681",
      "DOI": "10.1016/j.neuron.2005.08.017",
      "article-title": "Neuregulin-1 type III determines the ensheathment fate of axons",
      "volume": "47",
      "author": "Taveggia",
      "year": "2005",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib84",
      "doi-asserted-by": "crossref",
      "first-page": "493",
      "DOI": "10.1083/jcb.103.2.493",
      "article-title": "Purification and characterization of a polypeptide from chick brain that promotes the accumulation of acetylcholine receptors in chick myotubes",
      "volume": "103",
      "author": "Usdin",
      "year": "1986",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib85",
      "doi-asserted-by": "crossref",
      "first-page": "459",
      "DOI": "10.2174/1566524033479627",
      "article-title": "Neurodevelopmental animal models of schizophrenia: effects on prepulse inhibition",
      "volume": "3",
      "author": "Van den Buuse",
      "year": "2003",
      "journal-title": "Curr. Mol. Med."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib86",
      "doi-asserted-by": "crossref",
      "first-page": "11626",
      "DOI": "10.1073/pnas.91.24.11626",
      "article-title": "A role for the acetylcholine receptor-inducing protein ARIA in\u00a0oligodendrocyte development",
      "volume": "91",
      "author": "Vartanian",
      "year": "1994",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib87",
      "doi-asserted-by": "crossref",
      "first-page": "731",
      "DOI": "10.1073/pnas.96.2.731",
      "article-title": "Failure of spinal cord oligodendrocyte development in mice lacking neuregulin",
      "volume": "96",
      "author": "Vartanian",
      "year": "1999",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib88",
      "doi-asserted-by": "crossref",
      "first-page": "548",
      "DOI": "10.1016/j.biopsych.2006.03.017",
      "article-title": "A novel missense mutation in the transmembrane domain of neuregulin\u00a01 is associated with schizophrenia",
      "volume": "60",
      "author": "Walss-Bass",
      "year": "2006",
      "journal-title": "Biol. Psychiatry"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib89",
      "doi-asserted-by": "crossref",
      "first-page": "2841",
      "DOI": "10.1074/jbc.M005700200",
      "article-title": "The N-terminal region of neuregulin isoforms determines the accumulation of cell surface and released neuregulin ectodomain",
      "volume": "276",
      "author": "Wang",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib90",
      "doi-asserted-by": "crossref",
      "first-page": "2538",
      "DOI": "10.1101/gad.13.19.2538",
      "article-title": "Peripheral nervous system defects in erbB2 mutants following genetic rescue of heart development",
      "volume": "13",
      "author": "Woldeyesus",
      "year": "1999",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib91",
      "doi-asserted-by": "crossref",
      "first-page": "79",
      "DOI": "10.1016/S0896-6273(00)80873-9",
      "article-title": "Cysteine-rich domain isoforms of the neuregulin-1 gene are required for maintenance of peripheral synapses",
      "volume": "25",
      "author": "Wolpowitz",
      "year": "2000",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib100",
      "doi-asserted-by": "crossref",
      "first-page": "599",
      "DOI": "10.1016/j.neuron.2007.04.009",
      "article-title": "Neuregulin-1 enhances depolarization-induced GABA release",
      "volume": "54",
      "author": "Woo",
      "year": "2007",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib92",
      "doi-asserted-by": "crossref",
      "first-page": "1521",
      "DOI": "10.1111/j.1471-4159.2004.02685.x",
      "article-title": "Neuregulin induces GABAA receptor beta2 subunit expression in cultured rat cerebellar granule neurons by activating multiple signaling pathways",
      "volume": "90",
      "author": "Xie",
      "year": "2004",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib93",
      "doi-asserted-by": "crossref",
      "first-page": "62",
      "DOI": "10.1111/j.1471-4159.2006.04182.x",
      "article-title": "Association of PSD-95 with ErbB4 facilitates neuregulin signaling in cerebellar granule neurons in culture",
      "volume": "100",
      "author": "Xie",
      "year": "2007",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib94",
      "doi-asserted-by": "crossref",
      "first-page": "255",
      "DOI": "10.1016/S0896-6273(00)80454-7",
      "article-title": "A cysteine-rich isoform of neuregulin controls the level of expression of neuronal nicotinic receptor channels during synaptogenesis",
      "volume": "20",
      "author": "Yang",
      "year": "1998",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib95",
      "doi-asserted-by": "crossref",
      "first-page": "335",
      "DOI": "10.1016/j.mcn.2004.10.001",
      "article-title": "Neuregulin-induced expression of the acetylcholine receptor requires endocytosis of ErbB receptors",
      "volume": "28",
      "author": "Yang",
      "year": "2005",
      "journal-title": "Mol. Cell. Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib96",
      "doi-asserted-by": "crossref",
      "first-page": "127",
      "DOI": "10.1038/35052073",
      "article-title": "Untangling the ErbB signalling network",
      "volume": "2",
      "author": "Yarden",
      "year": "2001",
      "journal-title": "Nat. Rev. Mol. Cell Biol."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib97",
      "doi-asserted-by": "crossref",
      "first-page": "1098",
      "DOI": "10.1038/80614",
      "article-title": "Postnatal synaptic potentiation: delivery of GluR4-containing AMPA receptors by spontaneous activity",
      "volume": "3",
      "author": "Zhu",
      "year": "2000",
      "journal-title": "Nat. Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2007.03.028_bib98",
      "doi-asserted-by": "crossref",
      "first-page": "443",
      "DOI": "10.1016/S0092-8674(02)00897-8",
      "article-title": "Ras and Rap control AMPA receptor trafficking during synaptic plasticity",
      "volume": "110",
      "author": "Zhu",
      "year": "2002",
      "journal-title": "Cell"
    }
  ],
  "container-title": "Neuron",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0896627307002607?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0896627307002607?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2024,
        4,
        22
      ]
    ],
    "date-time": "2024-04-22T17:56:30Z",
    "timestamp": 1713808590000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0896627307002607"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2007,
        5
      ]
    ]
  },
  "references-count": 100,
  "journal-issue": {
    "issue": "4",
    "published-print": {
      "date-parts": [
        [
          2007,
          5
        ]
      ]
    }
  },
  "alternative-id": [
    "S0896627307002607"
  ],
  "URL": "http://dx.doi.org/10.1016/j.neuron.2007.03.028",
  "relation": {},
  "ISSN": [
    "0896-6273"
  ],
  "subject": [],
  "container-title-short": "Neuron",
  "published": {
    "date-parts": [
      [
        2007,
        5
      ]
    ]
  },
  "assertion": [
    {
      "value": "Elsevier",
      "name": "publisher",
      "label": "This article is maintained by"
    },
    {
      "value": "The Neuregulin-1 Receptor ErbB4 Controls Glutamatergic Synapse Maturation and Plasticity",
      "name": "articletitle",
      "label": "Article Title"
    },
    {
      "value": "Neuron",
      "name": "journaltitle",
      "label": "Journal Title"
    },
    {
      "value": "https://doi.org/10.1016/j.neuron.2007.03.028",
      "name": "articlelink",
      "label": "CrossRef DOI link to publisher maintained version"
    },
    {
      "value": "article",
      "name": "content_type",
      "label": "Content Type"
    },
    {
      "value": "Copyright \u00a9 2007 Elsevier Inc. All rights reserved.",
      "name": "copyright",
      "label": "Copyright"
    }
  ]
}