DOI: 10.1016/j.neuron.2005.02.029. Mutations in Drosophila sec15 Reveal a Function in Neuronal Targeting for a Subset of Exocyst Components

Mutations in Drosophila sec15 Reveal a Function in Neuronal Targeting for a Subset of Exocyst Components

10.1016/j.neuron.2005.02.029

Crossref journal-article

Elsevier BV

Neuron (78)

Bibliography

Mehta, S. Q., Hiesinger, P. R., Beronja, S., Zhai, R. G., Schulze, K. L., Verstreken, P., Cao, Y., Zhou, Y., Tepass, U., Crair, M. C., & Bellen, H. J. (2005). Mutations in Drosophila sec15 Reveal a Function in Neuronal Targeting for a Subset of Exocyst Components. Neuron, 46(2), 219â232.

Authors 11

Sunil Q. Mehta (first)
P. Robin Hiesinger (additional)
Slobodan Beronja (additional)
R. Grace Zhai (additional)
Karen L. Schulze (additional)
Patrik Verstreken (additional)
Yu Cao (additional)
Yi Zhou (additional)
Ulrich Tepass (additional)
Michael C. Crair (additional)
Hugo J. Bellen (additional)

References 66 Referenced 123

10.1034/j.1600-0854.2002.31206.x / Traffic / Drosophila Sec10 is required for hormone secretion but not general exocytosis or neurotransmission by Andrews (2002)
10.1083/jcb.200408165 / J. Cell Biol. / Recycling endosomes can serve as intermediates during transport from the Golgi to the plasma membrane of MDCK cells by Ang (2004)
10.1093/emboj/cdg325 / EMBO J. / Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins by Barton (2003)
10.1073/pnas.90.7.2559 / Proc. Natl. Acad. Sci. USA / The molecular machinery for secretion is conserved from yeast to neurons by Bennett (1993)
10.1073/pnas.58.3.1112 / Proc. Natl. Acad. Sci. USA / Behavioral mutants of Drosophila isolated by countercurrent distribution by Benzer (1967)
10.1083/jcb.200408124 / J. Cell Biol. / Vesicles carry most exocyst subunits to exocytic sites marked by the remaining two subunits, Sec3p and Exo70p by Boyd (2004)
10.1002/j.1460-2075.1993.tb05732.x / EMBO J. / Genetic and molecular identification of a Drosophila histidine decarboxylase gene required in photoreceptor transmitter synthesis by Burg (1993)
10.1016/S0896-6273(00)00122-7 / Neuron / Afferent growth cone interactions control synaptic specificity in the Drosophila visual system by Clandinin (2000)
10.1016/S0896-6273(02)00876-0 / Neuron / Making connections in the fly visual system by Clandinin (2002)
10.1016/S0896-6273(01)00474-3 / Neuron / Drosophila LAR Regulates R1–R6 and R7 Target Specificity in the Visual System by Clandinin (2001)
10.1080/0968768031000122548 / Mol. Membr. Biol. / ER-to-Golgi transport: COP I and COP II function (Review) by Duden (2003)
10.1523/JNEUROSCI.23-16-06567.2003 / J. Neurosci. / N- and C-terminal domains of beta-catenin, respectively, are required to initiate and shape axon arbors of retinal ganglion cells in vivo by Elul (2003)
10.1083/jcb.142.3.609 / J. Cell Biol. / Spatial regulation of exocytosis: lessons from yeast by Finger (1998)
10.1007/BF00218858 / Cell Tissue Res. / The optic lobe of Drosophila melanogaster. I. A golgi analysis of wild-type structure by Fischbach (1989)
10.1006/dbio.1997.8727 / Dev. Biol. / The secretory protein Sec8 is required for paraxial mesoderm formation in the mouse by Friedrich (1997)
10.1523/JNEUROSCI.03-11-02336.1983 / J. Neurosci. / Quantitative features of synapse formation in the fly’s visual system. I. The presynaptic photoreceptor terminal by Frohlich (1983)
10.1073/pnas.79.24.7929 / Proc. Natl. Acad. Sci. USA / Monoclonal antibodies against the Drosophila nervous system by Fujita (1982)
10.1016/S0092-8674(00)81435-X / Cell / Sec6/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells by Grindstaff (1998)
10.1093/emboj/18.4.1071 / EMBO J. / The exocyst is an effector for Sec4p, targeting secretory vesicles to sites of exocytosis by Guo (1999)
10.1016/S0962-8924(00)01754-2 / Trends Cell Biol. / Protein complexes in transport vesicle targeting by Guo (2000)
10.1523/JNEUROSCI.19-04-01324.1999 / J. Neurosci. / The sec6/8 complex is located at neurite outgrowth and axonal synapse-assembly domains by Hazuka (1999)
10.1523/JNEUROSCI.19-17-07548.1999 / J. Neurosci. / Neuropil pattern formation and regulation of cell adhesion molecules in Drosophila optic lobe development depend on synaptobrevin by Hiesinger (1999)
10.1002/1096-9861(20000108)429:2<277::AID-CNE8>3.0.CO;2-8 / J. Comp. Neurol. / Visualization of synaptic markers in the optic neuropils of Drosophila using a new constrained deconvolution method by Hiesinger (2001)
10.1016/S0896-6273(00)80251-2 / Neuron / The mammalian brain rsec6/8 complex by Hsu (1996)
10.1016/S0962-8924(99)01516-0 / Trends Cell Biol. / Targeting vesicles to specific sites on the plasma membrane: the role of the sec6/8 complex by Hsu (1999)
10.1016/S0074-7696(04)33006-8 / Int. Rev. Cytol. / The exocyst complex in polarized exocytosis by Hsu (2004)
10.1038/nature01533 / Nature / The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin by Inoue (2003)
10.1038/nature720 / Nature / Drosophila Crumbs is a positional cue in photoreceptor adherens junctions and rhabdomeres by Izaddoost (2002)
10.1016/S0896-6273(02)00643-8 / Neuron / Drosophila liprin-alpha and the receptor phosphatase Dlar control synapse morphogenesis by Kaufmann (2002)
10.1073/pnas.94.26.14438 / Proc. Natl. Acad. Sci. USA / Subunit structure of the mammalian exocyst complex by Kee (1997)
10.1007/BF00235588 / Exp. Brain Res. by Kirschfeld (1967)
10.1016/S0896-6273(00)80701-1 / Neuron / Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis by Lee (1999)
10.1016/S0166-2236(00)01791-4 / Trends Neurosci. / Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development by Lee (2001)
10.1016/S0896-6273(01)00291-4 / Neuron / N-cadherin regulates target specificity in the Drosophila visual system by Lee (2001)
10.1038/nn1063 / Nat. Neurosci. / The protocadherin Flamingo is required for axon target selection in the Drosophila visual system by Lee (2003)
10.1016/S0896-6273(01)00471-8 / Neuron / Cell-autonomous and -nonautonomous functions of LAR in R7 photoreceptor axon targeting by Maurel-Zaffran (2001)
{'key': '10.1016/j.neuron.2005.02.029_bib37', 'series-title': 'The Development of Drosophila Melanogaster', 'first-page': '1363', 'article-title': 'The development of the optic lobe', 'author': 'Meinertzhagen', 'year': '1993'} / The Development of Drosophila Melanogaster / The development of the optic lobe by Meinertzhagen (1993)
10.1242/dev.00931 / Development / The exocyst component Sec5 is required for membrane traffic and polarity in the Drosophila ovary by Murthy (2004)
10.1016/S0896-6273(03)00031-X / Neuron / Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists by Murthy (2003)
10.1038/nature01602 / Nature / Adaptation of core mechanisms to generate cell polarity by Nelson (2003)
10.1242/dev.127.4.851 / Development / Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics by Newsome (2000)
10.1016/0092-8674(80)90128-2 / Cell / Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway by Novick (1980)
10.1016/S0896-6273(01)00183-0 / Neuron / Glial cells mediate target layer selection of retinal axons in the developing visual system of Drosophila by Poeck (2001)
10.1016/0092-8674(88)90249-8 / Cell / slit: an EGF-homologous locus of D. melanogaster involved in the development of the embryonic central nervous system by Rothberg (1988)
10.1038/ncb990 / Nat. Cell Biol. / NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex by Sans (2003)
10.1016/S0092-8674(03)00972-3 / Cell / 23 genes, 23 years later by Schekman (2004)
10.1016/0896-6273(95)90032-2 / Neuron / Restricted expression of the irreC-rst protein is required for normal axonal projections of columnar visual neurons by Schneider (1995)
10.1016/j.cub.2003.12.021 / Curr. Biol. / Vesicle transport: a close collaboration of Rabs and effectors by Spang (2004)
10.3109/01677068909066203 / J. Neurogenet. / Ultrastructure of the ocellar visual system in normal and mutant Drosophila melanogaster by Stark (1989)
10.1093/genetics/152.4.1631 / Genetics / A genetic method for generating Drosophila eyes composed exclusively of mitotic clones of a single genotype by Stowers (1999)
10.1042/bj20020381 / Biochem. J. / Expression of the leucocyte common antigen-related (LAR) tyrosine phosphatase is regulated by cell density through functional E-cadherin complexes by Symons (2002)
10.1002/j.1460-2075.1996.tb01039.x / EMBO J. / The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae by TerBush (1996)
10.1016/S0896-6273(00)80961-7 / Neuron / Synaptic clustering of the cell adhesion molecule fasciclin II by discs-large and its role in the regulation of presynaptic structure by Thomas (1997)
10.1523/JNEUROSCI.21-11-03839.2001 / J. Neurosci. / The exocyst complex associates with microtubules to mediate vesicle targeting and neurite outgrowth by Vega (2001)
10.1016/S0896-6273(03)00644-5 / Neuron / Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating by Verstreken (2003)
10.1016/S0306-4522(03)00065-4 / Neuroscience / Sec6 is localized to the plasma membrane of mature synaptic terminals and is transported with Secretogranin II-containing vesicles by Vik-Mo (2003)
10.1074/jbc.M313778200 / J. Biol. Chem. / The mammalian exocyst, a complex required for exocytosis, inhibits tubulin polymerization by Wang (2004)
10.1016/S1534-5807(01)00063-6 / Dev. Cell / The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic by Whyte (2001)
10.1242/jcs.115.13.2627 / J. Cell Sci. / Vesicle tethering complexes in membrane traffic by Whyte (2002)
10.1016/S0896-6273(01)80021-0 / Neuron / Neuronal polarity: controlling the sorting and diffusion of membrane components by Winckler (1999)
10.1083/jcb.150.6.1361 / J. Cell Biol. / Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts by Wodarz (2000)
10.1242/jcs.00893 / J. Cell Sci. / Mechanism of recruiting Sec6/8 (exocyst) complex to the apical junctional complex during polarization of epithelial cells by Yeaman (2004)
10.1038/nn1132 / Nat. Neurosci. / Beta-catenin is critical for dendritic morphogenesis by Yu (2003)
10.1016/S0896-6273(01)00185-4 / Neuron / Assembling the presynaptic active zone: a characterization of an active one precursor vesicle by Zhai (2001)
10.1073/pnas.1832753100 / Proc. Natl. Acad. Sci. USA / Mapping Drosophila mutations with molecularly defined P element insertions by Zhai (2003)
10.1074/jbc.M402264200 / J. Biol. Chem. / Sec15 Is an Effector for the Rab11 GTPase in Mammalian Cells by Zhang (2004)

Dates

Type	When
Created	20 years, 4 months ago (April 21, 2005, 7:41 a.m.)
Deposited	1 year, 4 months ago (April 22, 2024, 1:19 p.m.)
Indexed	3 months, 1 week ago (May 22, 2025, 1:45 p.m.)
Issued	20 years, 5 months ago (April 1, 2005)
Published	20 years, 5 months ago (April 1, 2005)
Published Print	20 years, 5 months ago (April 1, 2005)

Funders 0

None

BibTeX

@article{Mehta_2005, title={Mutations in Drosophila sec15 Reveal a Function in Neuronal Targeting for a Subset of Exocyst Components}, volume={46}, ISSN={0896-6273}, url={http://dx.doi.org/10.1016/j.neuron.2005.02.029}, DOI={10.1016/j.neuron.2005.02.029}, number={2}, journal={Neuron}, publisher={Elsevier BV}, author={Mehta, Sunil Q. and Hiesinger, P. Robin and Beronja, Slobodan and Zhai, R. Grace and Schulze, Karen L. and Verstreken, Patrik and Cao, Yu and Zhou, Yi and Tepass, Ulrich and Crair, Michael C. and Bellen, Hugo J.}, year={2005}, month=apr, pages={219–232} }

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    },
    {
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      "volume": "167",
      "author": "Ang",
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      "journal-title": "Proc. Natl. Acad. Sci. USA"
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      "volume": "167",
      "author": "Boyd",
      "year": "2004",
      "journal-title": "J. Cell Biol."
    },
    {
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      "first-page": "911",
      "DOI": "10.1002/j.1460-2075.1993.tb05732.x",
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      "volume": "258",
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      "first-page": "364",
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      "volume": "192",
      "author": "Friedrich",
      "year": "1997",
      "journal-title": "Dev. Biol."
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "2336",
      "DOI": "10.1523/JNEUROSCI.03-11-02336.1983",
      "article-title": "Quantitative features of synapse formation in the fly\u2019s visual system. I. The presynaptic photoreceptor terminal",
      "volume": "3",
      "author": "Frohlich",
      "year": "1983",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "7929",
      "DOI": "10.1073/pnas.79.24.7929",
      "article-title": "Monoclonal antibodies against the Drosophila nervous system",
      "volume": "79",
      "author": "Fujita",
      "year": "1982",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "731",
      "DOI": "10.1016/S0092-8674(00)81435-X",
      "article-title": "Sec6/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells",
      "volume": "93",
      "author": "Grindstaff",
      "year": "1998",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "1071",
      "DOI": "10.1093/emboj/18.4.1071",
      "article-title": "The exocyst is an effector for Sec4p, targeting secretory vesicles to sites of exocytosis",
      "volume": "18",
      "author": "Guo",
      "year": "1999",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "251",
      "DOI": "10.1016/S0962-8924(00)01754-2",
      "article-title": "Protein complexes in transport vesicle targeting",
      "volume": "10",
      "author": "Guo",
      "year": "2000",
      "journal-title": "Trends Cell Biol."
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "1324",
      "DOI": "10.1523/JNEUROSCI.19-04-01324.1999",
      "article-title": "The sec6/8 complex is located at neurite outgrowth and axonal synapse-assembly domains",
      "volume": "19",
      "author": "Hazuka",
      "year": "1999",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "7548",
      "DOI": "10.1523/JNEUROSCI.19-17-07548.1999",
      "article-title": "Neuropil pattern formation and regulation of cell adhesion molecules in Drosophila optic lobe development depend on synaptobrevin",
      "volume": "19",
      "author": "Hiesinger",
      "year": "1999",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "277",
      "DOI": "10.1002/1096-9861(20000108)429:2<277::AID-CNE8>3.0.CO;2-8",
      "article-title": "Visualization of synaptic markers in the optic neuropils of Drosophila using a new constrained deconvolution method",
      "volume": "429",
      "author": "Hiesinger",
      "year": "2001",
      "journal-title": "J. Comp. Neurol."
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "1209",
      "DOI": "10.1016/S0896-6273(00)80251-2",
      "article-title": "The mammalian brain rsec6/8 complex",
      "volume": "17",
      "author": "Hsu",
      "year": "1996",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "150",
      "DOI": "10.1016/S0962-8924(99)01516-0",
      "article-title": "Targeting vesicles to specific sites on the plasma membrane: the role of the sec6/8 complex",
      "volume": "9",
      "author": "Hsu",
      "year": "1999",
      "journal-title": "Trends Cell Biol."
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "243",
      "DOI": "10.1016/S0074-7696(04)33006-8",
      "article-title": "The exocyst complex in polarized exocytosis",
      "volume": "233",
      "author": "Hsu",
      "year": "2004",
      "journal-title": "Int. Rev. Cytol."
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "629",
      "DOI": "10.1038/nature01533",
      "article-title": "The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin",
      "volume": "422",
      "author": "Inoue",
      "year": "2003",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "178",
      "DOI": "10.1038/nature720",
      "article-title": "Drosophila Crumbs is a positional cue in photoreceptor adherens junctions and rhabdomeres",
      "volume": "416",
      "author": "Izaddoost",
      "year": "2002",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "27",
      "DOI": "10.1016/S0896-6273(02)00643-8",
      "article-title": "Drosophila liprin-alpha and the receptor phosphatase Dlar control synapse morphogenesis",
      "volume": "34",
      "author": "Kaufmann",
      "year": "2002",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "14438",
      "DOI": "10.1073/pnas.94.26.14438",
      "article-title": "Subunit structure of the mammalian exocyst complex",
      "volume": "94",
      "author": "Kee",
      "year": "1997",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "248",
      "DOI": "10.1007/BF00235588",
      "volume": "3",
      "author": "Kirschfeld",
      "year": "1967",
      "journal-title": "Exp. Brain Res."
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "451",
      "DOI": "10.1016/S0896-6273(00)80701-1",
      "article-title": "Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis",
      "volume": "22",
      "author": "Lee",
      "year": "1999",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "251",
      "DOI": "10.1016/S0166-2236(00)01791-4",
      "article-title": "Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development",
      "volume": "24",
      "author": "Lee",
      "year": "2001",
      "journal-title": "Trends Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "437",
      "DOI": "10.1016/S0896-6273(01)00291-4",
      "article-title": "N-cadherin regulates target specificity in the Drosophila visual system",
      "volume": "30",
      "author": "Lee",
      "year": "2001",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "557",
      "DOI": "10.1038/nn1063",
      "article-title": "The protocadherin Flamingo is required for axon target selection in the Drosophila visual system",
      "volume": "6",
      "author": "Lee",
      "year": "2003",
      "journal-title": "Nat. Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "225",
      "DOI": "10.1016/S0896-6273(01)00471-8",
      "article-title": "Cell-autonomous and -nonautonomous functions of LAR in R7 photoreceptor axon targeting",
      "volume": "32",
      "author": "Maurel-Zaffran",
      "year": "2001",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib37",
      "series-title": "The Development of Drosophila Melanogaster",
      "first-page": "1363",
      "article-title": "The development of the optic lobe",
      "author": "Meinertzhagen",
      "year": "1993"
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "377",
      "DOI": "10.1242/dev.00931",
      "article-title": "The exocyst component Sec5 is required for membrane traffic and polarity in the Drosophila ovary",
      "volume": "131",
      "author": "Murthy",
      "year": "2004",
      "journal-title": "Development"
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "433",
      "DOI": "10.1016/S0896-6273(03)00031-X",
      "article-title": "Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists",
      "volume": "37",
      "author": "Murthy",
      "year": "2003",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "766",
      "DOI": "10.1038/nature01602",
      "article-title": "Adaptation of core mechanisms to generate cell polarity",
      "volume": "422",
      "author": "Nelson",
      "year": "2003",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "851",
      "DOI": "10.1242/dev.127.4.851",
      "article-title": "Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics",
      "volume": "127",
      "author": "Newsome",
      "year": "2000",
      "journal-title": "Development"
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "205",
      "DOI": "10.1016/0092-8674(80)90128-2",
      "article-title": "Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway",
      "volume": "21",
      "author": "Novick",
      "year": "1980",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "99",
      "DOI": "10.1016/S0896-6273(01)00183-0",
      "article-title": "Glial cells mediate target layer selection of retinal axons in the developing visual system of Drosophila",
      "volume": "29",
      "author": "Poeck",
      "year": "2001",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib44",
      "doi-asserted-by": "crossref",
      "first-page": "1047",
      "DOI": "10.1016/0092-8674(88)90249-8",
      "article-title": "slit: an EGF-homologous locus of D. melanogaster involved in the development of the embryonic central nervous system",
      "volume": "55",
      "author": "Rothberg",
      "year": "1988",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib45",
      "doi-asserted-by": "crossref",
      "first-page": "520",
      "DOI": "10.1038/ncb990",
      "article-title": "NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex",
      "volume": "5",
      "author": "Sans",
      "year": "2003",
      "journal-title": "Nat. Cell Biol."
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib46",
      "doi-asserted-by": "crossref",
      "first-page": "S13",
      "DOI": "10.1016/S0092-8674(03)00972-3",
      "article-title": "23 genes, 23 years later",
      "volume": "116",
      "author": "Schekman",
      "year": "2004",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib47",
      "doi-asserted-by": "crossref",
      "first-page": "259",
      "DOI": "10.1016/0896-6273(95)90032-2",
      "article-title": "Restricted expression of the irreC-rst protein is required for normal axonal projections of columnar visual neurons",
      "volume": "15",
      "author": "Schneider",
      "year": "1995",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib48",
      "doi-asserted-by": "crossref",
      "first-page": "R33",
      "DOI": "10.1016/j.cub.2003.12.021",
      "article-title": "Vesicle transport: a close collaboration of Rabs and effectors",
      "volume": "14",
      "author": "Spang",
      "year": "2004",
      "journal-title": "Curr. Biol."
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib49",
      "doi-asserted-by": "crossref",
      "first-page": "127",
      "DOI": "10.3109/01677068909066203",
      "article-title": "Ultrastructure of the ocellar visual system in normal and mutant Drosophila melanogaster",
      "volume": "5",
      "author": "Stark",
      "year": "1989",
      "journal-title": "J. Neurogenet."
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib50",
      "doi-asserted-by": "crossref",
      "first-page": "1631",
      "DOI": "10.1093/genetics/152.4.1631",
      "article-title": "A genetic method for generating Drosophila eyes composed exclusively of mitotic clones of a single genotype",
      "volume": "152",
      "author": "Stowers",
      "year": "1999",
      "journal-title": "Genetics"
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib51",
      "doi-asserted-by": "crossref",
      "first-page": "513",
      "DOI": "10.1042/bj20020381",
      "article-title": "Expression of the leucocyte common antigen-related (LAR) tyrosine phosphatase is regulated by cell density through functional E-cadherin complexes",
      "volume": "365",
      "author": "Symons",
      "year": "2002",
      "journal-title": "Biochem. J."
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib52",
      "doi-asserted-by": "crossref",
      "first-page": "6483",
      "DOI": "10.1002/j.1460-2075.1996.tb01039.x",
      "article-title": "The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae",
      "volume": "15",
      "author": "TerBush",
      "year": "1996",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib53",
      "doi-asserted-by": "crossref",
      "first-page": "787",
      "DOI": "10.1016/S0896-6273(00)80961-7",
      "article-title": "Synaptic clustering of the cell adhesion molecule fasciclin II by discs-large and its role in the regulation of presynaptic structure",
      "volume": "19",
      "author": "Thomas",
      "year": "1997",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib54",
      "doi-asserted-by": "crossref",
      "first-page": "3839",
      "DOI": "10.1523/JNEUROSCI.21-11-03839.2001",
      "article-title": "The exocyst complex associates with microtubules to mediate vesicle targeting and neurite outgrowth",
      "volume": "21",
      "author": "Vega",
      "year": "2001",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib55",
      "doi-asserted-by": "crossref",
      "first-page": "733",
      "DOI": "10.1016/S0896-6273(03)00644-5",
      "article-title": "Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating",
      "volume": "40",
      "author": "Verstreken",
      "year": "2003",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib56",
      "doi-asserted-by": "crossref",
      "first-page": "73",
      "DOI": "10.1016/S0306-4522(03)00065-4",
      "article-title": "Sec6 is localized to the plasma membrane of mature synaptic terminals and is transported with Secretogranin II-containing vesicles",
      "volume": "119",
      "author": "Vik-Mo",
      "year": "2003",
      "journal-title": "Neuroscience"
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib57",
      "doi-asserted-by": "crossref",
      "first-page": "35958",
      "DOI": "10.1074/jbc.M313778200",
      "article-title": "The mammalian exocyst, a complex required for exocytosis, inhibits tubulin polymerization",
      "volume": "279",
      "author": "Wang",
      "year": "2004",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib58",
      "doi-asserted-by": "crossref",
      "first-page": "527",
      "DOI": "10.1016/S1534-5807(01)00063-6",
      "article-title": "The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic",
      "volume": "1",
      "author": "Whyte",
      "year": "2001",
      "journal-title": "Dev. Cell"
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib59",
      "doi-asserted-by": "crossref",
      "first-page": "2627",
      "DOI": "10.1242/jcs.115.13.2627",
      "article-title": "Vesicle tethering complexes in membrane traffic",
      "volume": "115",
      "author": "Whyte",
      "year": "2002",
      "journal-title": "J. Cell Sci."
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib60",
      "doi-asserted-by": "crossref",
      "first-page": "637",
      "DOI": "10.1016/S0896-6273(01)80021-0",
      "article-title": "Neuronal polarity: controlling the sorting and diffusion of membrane components",
      "volume": "23",
      "author": "Winckler",
      "year": "1999",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib61",
      "doi-asserted-by": "crossref",
      "first-page": "1361",
      "DOI": "10.1083/jcb.150.6.1361",
      "article-title": "Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts",
      "volume": "150",
      "author": "Wodarz",
      "year": "2000",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib62",
      "doi-asserted-by": "crossref",
      "first-page": "559",
      "DOI": "10.1242/jcs.00893",
      "article-title": "Mechanism of recruiting Sec6/8 (exocyst) complex to the apical junctional complex during polarization of epithelial cells",
      "volume": "117",
      "author": "Yeaman",
      "year": "2004",
      "journal-title": "J. Cell Sci."
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib63",
      "doi-asserted-by": "crossref",
      "first-page": "1169",
      "DOI": "10.1038/nn1132",
      "article-title": "Beta-catenin is critical for dendritic morphogenesis",
      "volume": "6",
      "author": "Yu",
      "year": "2003",
      "journal-title": "Nat. Neurosci."
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib64",
      "doi-asserted-by": "crossref",
      "first-page": "131",
      "DOI": "10.1016/S0896-6273(01)00185-4",
      "article-title": "Assembling the presynaptic active zone: a characterization of an active one precursor vesicle",
      "volume": "29",
      "author": "Zhai",
      "year": "2001",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib65",
      "doi-asserted-by": "crossref",
      "first-page": "10860",
      "DOI": "10.1073/pnas.1832753100",
      "article-title": "Mapping Drosophila mutations with molecularly defined P element insertions",
      "volume": "100",
      "author": "Zhai",
      "year": "2003",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.neuron.2005.02.029_bib66",
      "doi-asserted-by": "crossref",
      "first-page": "43027",
      "DOI": "10.1074/jbc.M402264200",
      "article-title": "Sec15 Is an Effector for the Rab11 GTPase in Mammalian Cells",
      "volume": "279",
      "author": "Zhang",
      "year": "2004",
      "journal-title": "J. Biol. Chem."
    }
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