Crossref journal-article
Elsevier BV
Neurobiology of Aging (78)
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Guo, C., Wang, T., Zheng, W., Shan, Z.-Y., Teng, W.-P., & Wang, Z.-Y. (2013). Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer’s disease. Neurobiology of Aging, 34(2), 562–575.

Authors 6
  1. Chuang Guo (first)
  2. Tao Wang (additional)
  3. Wei Zheng (additional)
  4. Zhong-Yan Shan (additional)
  5. Wei-Ping Teng (additional)
  6. Zhan-You Wang (additional)
References 72 Referenced 171
  1. 10.1016/S0165-0173(03)00174-7 / Brain Res. Brain Res. Rev / Amyloid-beta: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-beta by Atwood (2003)
  2. 10.1046/j.1471-4159.2000.0751219.x / J. Neurochem / Characterization of copper interactions with alzheimer amyloid beta peptides: identification of an attomolar-affinity copper binding site on amyloid beta1–42 by Atwood (2000)
  3. 10.2174/156720510791162403 / Curr. Alzheimer Res / Up-regulation of hypoxia-inducible factor (HIF)-1α and HIF-target genes in cortical neurons by the novel multifunctional iron chelator anti-Alzheimer drug, M30 by Avramovich-Tirosh (2010)
  4. 10.2174/156720507781788927 / Curr. Alzheimer Res / Neurorescue activity, APP regulation and amyloid-beta peptide reduction by novel multi-functional brain permeable iron- chelating- antioxidants, M-30 and green tea polyphenol, EGCG by Avramovich-Tirosh (2007)
  5. 10.1002/jnr.20864 / J. Neurosci. Res / Interleukin-1α stimulates non-amyloidogenic pathway by α-secretase (ADAM-10 and ADAM-17) cleavage of APP in human astrocytic cells involving p38 MAP kinase by Bandyopadhyay (2006)
  6. 10.1016/j.neurobiolaging.2004.02.022 / Neurobiol. Aging / Secreted beta-amyloid precursor protein activates microglia via JNK and p38-MAPK by Bodles (2005)
  7. 10.1016/S0166-2236(03)00067-5 / Trends Neurosci / The metallobiology of Alzheimer's disease by Bush (2003)
  8. 10.1016/j.nurt.2008.05.001 / Neurotherapeutics / Therapeutics for Alzheimer's disease based on the metal hypothesis by Bush (2008)
  9. 10.1016/j.arr.2004.01.002 / Ageing Res. Rev / Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease by Castellani (2004)
  10. 10.1002/ajh.10348 / Am. J. Hematol / Iron chelators for the treatment of iron overload disease: Relationship between structure, redox activity, and toxicity by Chaston (2003)
  11. 10.1016/S0896-6273(01)00317-8 / Neuron / Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice by Cherny (2001)
  12. 10.1074/jbc.274.33.23223 / J. Biol. Chem / Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion by Cherny (1999)
  13. 10.1074/jbc.M110.149161 / J. Biol. Chem / Selective translational control of the Alzheimer amyloid precursor protein transcript by iron regulatory protein-1 by Cho (2010)
  14. 10.1016/0140-6736(91)92978-B / Lancet / Intramuscular desferrioxamine in patients with Alzheimer's disease by Crapper McLachlan (1991)
  15. 10.1007/BF00966731 / Neurochem. Res / Effects of chelators on iron uptake and release by the brain in the rat by Crowe (1994)
  16. 10.1093/jn/126.1.183 / J. Nutr / Iron and copper interact during their uptake and deposition in the brain and other organs of developing rats exposed to dietary excess of the two metals by Crowe (1996)
  17. 10.1111/j.1749-6632.2000.tb06938.x / Ann. N. Y. Acad. Sci / Metal chelation as a potential therapy for Alzheimer's disease by Cuajungco (2000)
  18. 10.1016/j.neurobiolaging.2007.02.006 / Neurobiol. Aging / Reversion of age-related recognition memory impairment by iron chelation in rats by De Lima (2008)
  19. 10.1126/science.2111583 / Science / Cleavage of amyloid beta peptide during constitutive processing of its precursor by Esch (1990)
  20. 10.1023/A:1020799512190 / Biometals / The copper-iron chronicles: the story of an intimate relationship by Fox (2003)
  21. 10.1016/0300-483X(88)90010-8 / Toxicology / Neurotoxicity associated with deferoxamine therapy by Freedman (1988)
  22. 10.3109/10717549709051878 / Drug Deliv / Delivery of 125I-NGF to the brain via the olfactory route by Frey (1997)
  23. 10.1038/41343 / Nature / Cloning and characterization of a mammalian proton-coupled metal-ion transporter by Gunshin (1997)
  24. 10.1038/357500a0 / Nature / Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments by Haass (1992)
  25. 10.1016/j.neulet.2004.12.080 / Neurosci. Lett / A role for hypoxia-inducible factor-1alpha in desferoxamine neuroprotection by Hamrick (2005)
  26. 10.1007/s13346-011-0050-2 / Drug Deliv. Transl. Res / Intranasal delivery of deferoxamine reduces spatial memory loss in APP/PS1 mice by Hanson (2012)
  27. 10.1124/jpet.108.149807 / J. Pharmacol. Exp. Ther / Intranasal deferoxamine provides increased brain exposure and significant protection in rat ischemic stroke by Hanson (2009)
  28. 10.1126/science.1072994 / Science / The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics by Hardy (2002)
  29. 10.1126/science.1566067 / Science / Alzheimer's disease: the amyloid cascade hypothesis by Hardy (1992)
  30. 10.3233/JAD-2004-6310 / J. Alzheimers Dis / Aluminium, iron, zinc and copper influence the in vitro formation of amyloid fibrils of Abeta42 in a manner which may have consequences for metal chelation therapy in Alzheimer's disease by House (2004)
  31. 10.1021/bi900907a / Biochemistry / Ternary complexes of iron, amyloid-beta, and nitrilotriacetic acid: binding affinities, redox properties, and relevance to iron-induced oxidative stress in Alzheimer's disease by Jiang (2009)
  32. 10.1083/jcb.200301115 / J. Cell Biol / APP processing is regulated by cytoplasmic phosphorylation by Lee (2003)
  33. 10.1016/j.neuroimage.2010.11.073 / NeuroImage / Increased brain iron coincides with early plaque formation in a mouse model of Alzheimer's disease by Leskovjan (2011)
  34. 10.1002/ijc.2910630421 / Int. J. Cancer / Influence of hepatic artery occlusion and desferrioxamine on liver-tumour growth by Lindnér (1995)
  35. 10.1016/S0022-510X(98)00092-6 / J. Neurol. Sci / Copper, iron and zinc in Alzheimer's disease senile plaques by Lovell (1998)
  36. 10.3233/JAD-2004-6610 / J. Alzheimers Dis / Induction of hyperphosphorylated tau in primary rat cortical neuron cultures mediated by oxidative stress and glycogen synthase kinase-3 by Lovell (2004)
  37. 10.1016/S0079-6468(08)70220-0 / Prog. J. Med. Chem / The present status of chelating agents in medicine by May (1983)
  38. 10.1007/s10571-009-9401-7 / Cell. Mol. Neurobiol / Chronic exposure to high levels of zinc or copper has little effect on brain metal homeostasis or Abeta accumulation in transgenic APP-C100 mice by Maynard (2009)
  39. 10.4155/fmc.09.140 / Future. J. Med. Chem / Mechanisms of brain iron transport: insight into neurodegeneration and CNS disorders by Mills (2010)
  40. 10.1016/j.tox.2011.11.003 / Toxicology / Deferoxamine pretreatment prevents Cr(VI)-induced nephrotoxicity and oxidant stress: Role of Cr(VI) chelation by Molina-Jijón (2012)
  41. 10.1007/978-1-60327-029-8_25 / Methods Mol. Biol / Detection and localization of markers of oxidative stress by in situ methods: application in the study of Alzheimer disease by Moreira (2010)
  42. 10.1385/JMN:24:1:129 / J. Mol. Neurosci / FDA-preapproved drugs targeted to the translational regulation and processing of the amyloid precursor protein by Morse (2004)
  43. 10.1249/00005768-199305000-00006 / Med. Sci. Sports Exer / Effects of iron supplementation and discontinuation on serum copper, zinc, calcium and magnesium levels in women by Newhouse (1993)
  44. 10.2174/156720210790820172 / Curr. Neurovasc Res / Iron leads to memory impairment that is associated with a decrease in acetylcholinesterase pathways by Perez (2010)
  45. 10.1016/S0002-9343(00)00547-7 / Am. J. Med / Oxidative injury in diseases of the central nervous system: focus on Alzheimer's disease by Praticò (2000)
  46. 10.1136/jmg.2003.015552 / J. Med. Genet / Synergy between the C2 allele of transferrin and the C282Y allele of the haemochromatosis gene (HFE) as risk factors for developing Alzheimer's disease by Robson (2004)
  47. 10.1042/BST0361282 / Biochem. Soc. Trans / Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease by Rogers (2008)
  48. 10.2174/1389450043345272 / Curr. Drug Targets / Metal and inflammatory targets for Alzheimer's disease by Rogers (2004)
  49. 10.1074/jbc.M207435200 / J. Biol. Chem / An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript by Rogers (2002)
  50. {'key': '10.1016/j.neurobiolaging.2012.05.009_bib51', 'first-page': '209', 'article-title': "Reversal by desferrioxamine of tau protein aggregates following two days of treatment in aluminum-induced neurofibrillary degeneration in rabbit: implications for clinical trials in Alzheimer's disease", 'volume': '19', 'author': 'Savory', 'year': '1998', 'journal-title': 'Neurotoxicology'} / Neurotoxicology / Reversal by desferrioxamine of tau protein aggregates following two days of treatment in aluminum-induced neurofibrillary degeneration in rabbit: implications for clinical trials in Alzheimer's disease by Savory (1998)
  51. 10.2174/0929867013372922 / Curr. Med. Chem / Chemistry and biochemistry of oxidative stress in neurodegenerative disease by Sayre (2001)
  52. 10.1007/s00109-006-0140-7 / J. Mol. Med / Copper and clioquinol treatment in young APP transgenic and wild-type mice: effects on life expectancy, body weight, and metal-ion levels by Schäfer (2007)
  53. 10.1016/0896-6273(91)90052-2 / Neuron / The molecular pathology of Alzheimer's disease by Selkoe (1991)
  54. 10.1016/j.neuropharm.2003.09.005 / Neuropharmacology / Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lesion in rats by Shachar (2004)
  55. 10.1126/science.1439760 / Science / Production of the Alzheimer amyloid beta protein by normal proteolytic processing by Shoji (1992)
  56. 10.1046/j.1471-4159.1998.70052212.x / J. Neurochem / Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress by Smith (1998)
  57. 10.1016/0031-9384(95)02030-6 / Physiol. Behav / Neurobehavioral dysfunctions associated with dietary iron overload by Sobotka (1996)
  58. 10.1016/j.neurobiolaging.2007.10.012 / Neurobiol. Aging / Zinc and copper modulate Alzheimer Abeta levels in human cerebrospinal fluid by Strozyk (2009)
  59. 10.1016/j.nbd.2005.10.013 / Neurobiol. Dis / Age-related evolution of amyloid burden, iron load, and MR relaxation times in a transgenic mouse model of Alzheimer's disease by El Tannir El Tayara (2006)
  60. 10.1074/jbc.M407410200 / J. Biol. Chem / Clioquinol mediates copper uptake and counteracts copper efflux activities of the amyloid precursor protein of Alzheimer's disease by Treiber (2004)
  61. 10.1080/10284150701350653 / Nutr. Neurosci / Iron regulation in C57BLI6 and DBA/2 mice subjected to iron overload by Unger (2007)
  62. 10.1196/annals.1332.003 / Ann. N. Y. Acad. Sci / The integrated role of desferrioxamine and phenserine targeted to an iron-responsive element in the APP-mRNA 5'-untranslated region by Venti (2004)
  63. 10.1006/nbdi.1999.0250 / Neurobiol. Dis / The role of copper in neurodegenerative disease by Waggoner (1999)
  64. 10.1038/416535a / Nature / Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo by Walsh (2002)
  65. 10.1186/1750-1326-5-46 / Mol. Neurodegener / Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model by Wang (2010)
  66. 10.1016/j.spen.2006.08.008 / Semin. Pediatr. Neurol / Iron: a new target for pharmacological intervention in neurodegenerative diseases by Whitnall (2006)
  67. 10.1016/0378-4274(95)03532-X / Toxicol. Lett / Toxicity of iron and hydrogen peroxide: the Fenton reaction by Winterbourn (1995)
  68. 10.1079/BJN19940194 / Br. J. Nutr / Increasing intakes of iron reduce status, absorption and biliary excretion of copper in rats by Yu (1994)
  69. 10.1038/nrn1537 / Nat. Rev. Neurosci / Iron, brain ageing and neurodegenerative disorders by Zecca (2004)
  70. 10.1016/j.neurobiolaging.2008.02.018 / Neurobiol. Aging / Altered expression and distribution of zinc transporters in APP/PS1 transgenic mouse brain by Zhang (2010)
  71. 10.1096/fj.09-135749 / FASEB J / Divalent metal transporter 1 is involved in amyloid precursor protein processing and Abeta generation by Zheng (2009)
  72. 10.1148/radiol.2532082324 / Radiology / Quantitative MR phase-corrected imaging to investigate increased brain iron deposition of patients with Alzheimer disease by Zhu (2009)
Dates
Type When
Created 13 years, 2 months ago (June 19, 2012, 2:20 a.m.)
Deposited 1 year, 6 months ago (Jan. 25, 2024, 3:28 a.m.)
Indexed 4 weeks ago (July 26, 2025, 5:32 a.m.)
Issued 12 years, 6 months ago (Feb. 1, 2013)
Published 12 years, 6 months ago (Feb. 1, 2013)
Published Print 12 years, 6 months ago (Feb. 1, 2013)
Funders 3
  1. National Natural Science Foundation of China 10.13039/501100001809

    Region: Asia

    gov (National government)

    Labels11
    1. Chinese National Science Foundation
    2. Natural Science Foundation of China
    3. National Science Foundation of China
    4. NNSF of China
    5. NSF of China
    6. 国家自然科学基金委员会
    7. National Nature Science Foundation of China
    8. Guójiā Zìrán Kēxué Jījīn Wěiyuánhuì
    9. NSFC
    10. NNSF
    11. NNSFC
    Awards3
    1. 81000468
    2. 81071004
    3. 81100808
  2. Program for New Century Excellent Talents in University 10.13039/501100004602

    Region: Asia

    gov (Local government)

    Labels3
    1. New Century Excellent Talents Program
    2. Program for New Century Excellent Talents
    3. NCET
    Awards1
    1. NCET-04-0288
  3. Department of Education of Liaoning Province 10.13039/501100007620

    Region: Asia

    gov (Local government)

    Labels4
    1. 辽宁省教育厅
    2. The Educational Department of Liaoning Province
    3. Liaoning Provincial Education Department
    4. Educational Department of Liaoning Province
    Awards1
    1. L2010567

@article{Guo_2013, title={Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer’s disease}, volume={34}, ISSN={0197-4580}, url={http://dx.doi.org/10.1016/j.neurobiolaging.2012.05.009}, DOI={10.1016/j.neurobiolaging.2012.05.009}, number={2}, journal={Neurobiology of Aging}, publisher={Elsevier BV}, author={Guo, Chuang and Wang, Tao and Zheng, Wei and Shan, Zhong-Yan and Teng, Wei-Ping and Wang, Zhan-You}, year={2013}, month=feb, pages={562–575} }