DOI: 10.1016/j.neurobiolaging.2004.12.004. Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains

Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains

10.1016/j.neurobiolaging.2004.12.004

Crossref journal-article

Elsevier BV

Neurobiology of Aging (78)

Bibliography

Mishto, M., Bellavista, E., Santoro, A., Stolzing, A., Ligorio, C., Nacmias, B., Spazzafumo, L., Chiappelli, M., Licastro, F., Sorbi, S., Pession, A., Ohm, T., Grune, T., & Franceschi, C. (2006). Immunoproteasome and LMP2 polymorphism in aged and Alzheimerâs disease brains. Neurobiology of Aging, 27(1), 54â66.

Authors 14

Michele Mishto (first)
Elena Bellavista (additional)
Aurelia Santoro (additional)
Alexandra Stolzing (additional)
Claudia Ligorio (additional)
Benedetta Nacmias (additional)
Liana Spazzafumo (additional)
Martina Chiappelli (additional)
Federico Licastro (additional)
Sandro Sorbi (additional)
Annalisa Pession (additional)
Thomas Ohm (additional)
Tilman Grune (additional)
Claudio Franceschi (additional)

References 50 Referenced 170

{'key': '10.1016/j.neurobiolaging.2004.12.004_bib1', 'series-title': 'Diagnostic and statistical manual of mental disorders', 'year': '1994'} / Diagnostic and statistical manual of mental disorders (1994)
10.1016/S0197-4580(00)00143-3 / Neurobiol Aging / Neuroinflammation and Alzheimer's disease: critical roles for cytokine/A beta-induced glial activation, NF-kappaB, and apolipoprotein E by Bales (2000)
10.1086/302196 / Am J Hum Genet / p53 variants predisposing to cancer are present in healthy centenarians by Bonafé (1999)
10.1038/sj.cdd.4401415 / Cell Death Differ / The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death by Bonafé (2004)
10.1016/S0003-9861(02)00493-9 / Arch Biochem Biophys / Proteasome-mediated degradation of tau proteins occurs independently of the chymotrypsin-like activity by a non-processive pathway by Cardozo (2002)
10.1056/NEJM200307103490219 / N Engl J Med / Genetics of neurodegenerative disorders by Caruso (2003)
10.1016/S0925-4439(00)00039-9 / Biochim Biophys Acta / Role of the proteasome in Alzheimer's disease by Checler (2000)
{'issue': '1', 'key': '10.1016/j.neurobiolaging.2004.12.004_bib8', 'first-page': '156', 'article-title': 'Single-step method of RNA isolation by acid guanidinium thiocyanate–phenol–chloroform extraction', 'volume': '162', 'author': 'Chomezynski', 'year': '1987', 'journal-title': 'Anal Biochem'} / Anal Biochem / Single-step method of RNA isolation by acid guanidinium thiocyanate–phenol–chloroform extraction by Chomezynski (1987)
{'key': '10.1016/j.neurobiolaging.2004.12.004_bib9', 'first-page': '532', 'article-title': 'A reagent for the single step simultaneous isolation of RNA, DNA and protein from cell and tissue samples', 'volume': '15', 'author': 'Chomezynski', 'year': '1993', 'journal-title': 'Biotechniques'} / Biotechniques / A reagent for the single step simultaneous isolation of RNA, DNA and protein from cell and tissue samples by Chomezynski (1993)
10.1523/JNEUROSCI.23-37-11653.2003 / J Neurosci / Neuronal induction of the immunoproteasome in huntington's disease by Diaz-Hernández (2003)
10.1046/j.1471-4159.2003.01885.x / J Neurochem / Characterization of chronic low-level proteasome inhibition on neural homeostasis by Ding (2003)
10.1016/S0014-5793(03)00582-9 / FEBS Lett / Role of the proteasome in protein oxidation and neural viability following low-level oxidative stress by Ding (2003)
10.1016/S0197-4580(02)00019-2 / Neurobiol Aging / Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases by Floyd (2002)
10.1016/S0165-5728(02)00258-8 / J Neuroimmunol / Induced neuronal expression of class I major histocompatibility complex mRNA in acute and chronic inflammation models by Foster (2002)
10.1016/S0264-410X(99)00513-7 / Vaccine / Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space by Franceschi (2000)
10.1002/j.1460-2075.1994.tb06625.x / EMBO J / Displacement of housekeeping proteasome subunits by MHC-encoded LMPs: a newly discovered mechanism for modulating the multicatalytic proteinase complex by Früh (1994)
10.1126/sageke.2003.34.re6 / Sci Aging Knowledge Environ / Ubiquitin, proteasomes, and the aging brain by Gray (2003)
10.1074/jbc.270.34.19702 / J Biol Chem / Amyloid beta-protein inhibits ubiquitin-dependent protein degradation in vitro by Gregori (1995)
10.1046/j.1365-2265.1999.00755.x / Clin Endocrinol / Association of the large multifunctional proteasome (LMP2) gene with Graves’ disease is a result of linkage disequilibrium with the HLA haplotype DRB1*0304-DQB1*02-DQA1*0501 by Heward (1999)
10.1016/j.abb.2003.10.010 / Arch Biochem Biophys / Altered proteasome function and subunit composition in aged muscle by Husom (2004)
10.1046/j.1471-4159.2003.01642.x / J Neurochem / Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease by Keck (2003)
10.1046/j.1471-4159.2000.0750436.x / J Neurochem / Impaired proteasome function in Alzheimer's disease by Keller (2000)
10.1016/S1568-1637(01)00006-X / Ageing Res Rev / The proteasome in brain aging by Keller (2002)
10.1093/protein/15.4.287 / Protein Eng / Prediction of proteasome cleavage motifs by neural networks by Kesmir (2002)
10.1001/archneur.1985.04060100083029 / Arch Neurol / Diagnosis of Alzheimer's disease by Khachaturian (1985)
10.1038/35056572 / Nat Rev / Antigen processing by the proteasome by Kloetzel (2001)
10.1073/pnas.170173897 / Proc Natl Acad Sci USA / Inhibition of the ubiquitin-proteasome system in Alzheimer's disease by Lam (2000)
10.1038/77046 / Nat Genet / Gene-expression profile of the ageing brain in mice by Lee (2000)
10.1016/S0197-4580(03)00013-7 / Neurobiol Aging / Interleukin-6 gene alleles affect the risk of Alzheimer's disease and levels of the cytokine in blood and brain by Licastro (2003)
{'issue': '1', 'key': '10.1016/j.neurobiolaging.2004.12.004_bib30', 'first-page': '183', 'article-title': 'LMP2 polymorphism is associated with extraspinal disease in HLA-B27 negative Caucasian and Mexican Mestizo patients with ankylosing spondylitis', 'volume': '27', 'author': 'Maksymowych', 'year': '2000', 'journal-title': 'J Rheumatol'} / J Rheumatol / LMP2 polymorphism is associated with extraspinal disease in HLA-B27 negative Caucasian and Mexican Mestizo patients with ankylosing spondylitis by Maksymowych (2000)
10.1080/13550280290100969 / J Neurovirol / Local neuroinflammation and the progression of Alzheimer's disease by McGeer (2002)
10.1074/jbc.M301032200 / J Biol Chem / Inhibition of proteasome activity induces concerted expression of proteasome genes and de novo formation of mammalian proteasomes by Meiners (2003)
10.1016/S0531-5565(01)00196-6 / Exp Gerontol / Age dependent impact of LMP polymorphisms on TNF alpha-induced apoptosis in human peripheral blood mononuclear cells by Mishto (2002)
{'key': '10.1016/j.neurobiolaging.2004.12.004_bib34', 'first-page': '419', 'article-title': 'Immunoproteasomes and immunosenescence', 'volume': '2', 'author': 'Mishto', 'year': '2003', 'journal-title': 'ARR'} / ARR / Immunoproteasomes and immunosenescence by Mishto (2003)
10.1126/science.7624779 / Science / Induction of MHC class I genes in neurons by Neumann (1995)
10.1006/bbrc.2000.3676 / Biochem Biophys Res Commun / Tissue distribution of constitutive proteasomes, immunoproteasomes, and PA28 in rats by Noda (2000)
10.1016/S0165-5728(02)00439-3 / J Neuroimmunol / Interferon-gamma-inducible subunits are incorporated in human brain 20S proteasome by Piccinini (2003)
10.1016/S0169-328X(03)00337-1 / Mol Brain Res / Quantifying mRNA in post-mortem human brain: influence of gender, age at death, post-mortem interval, brain pH, agonal state and inter-lobe mRNA variance by Preece (2003)
10.1016/S0092-8674(94)90462-6 / Cell / Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules by Rock (1994)
10.1146/annurev.immunol.17.1.739 / Annu Rev Immunol / Degradation of cell proteins and the generation of MHC class I-presented peptides by Rock (1999)
10.1016/0896-6273(91)90052-2 / Neuron / The molecular pathology of Alzheimer's disease by Selkoe (1991)
10.1016/0304-3940(94)90054-X / Neurosci Lett / ApoE allele frequencies in Italian sporadic and familial Alzheimer's disease by Sorbi (1994)
10.1074/jbc.M313579200 / J Biol Chem / Proteasome inhibition alters neural mitochondrial homeostasis and mitochondria turnover by Sullivan (2004)
The Dementia Study Group of the Italian Neurological Society, Guidelines for the diagnosis of dementia and Alzheimer's disease. Neurol Sci 2000;21(4):187–194. (10.1007/s100720070075)
10.1136/ard.57.1.33 / Ann Rheum Dis / Analysis of LMP and TAP polymorphisms by polymerase chain reaction-restriction fragment length polymorphism in rheumatoid arthritis by Vinasco (1998)
10.1146/annurev.biochem.68.1.1015 / Annu Rev Biochem / The 26S proteasome: a molecular machine designed for controlled proteolysis by Voges (1999)
10.1007/BF00184520 / Immunogenetics / Genomic organization and tissue expression of the mouse proteasome gene Lmp-7 by Zanelli (1993)
10.1023/A:1022337519035 / Neurochem Res / The induction of the TNFalpha death domain signaling pathway in Alzheimer's disease brain by Zhao (2003)
10.1073/pnas.90.7.2681 / Proc Nat Acad Sci USA / Molecular basis of genetic polymorphism in major histocompatibility complex-linked proteasome gene (LMP-2) by Zhou (1993)
10.1006/geno.1993.1245 / Genomics / Genomic organization and tissue expression of mouse proteasome gene Lmp-2 by Zhou (1993)

Dates

Type	When
Created	20 years, 7 months ago (Feb. 3, 2005, 7:16 a.m.)
Deposited	6 years, 7 months ago (Jan. 29, 2019, 6:50 p.m.)
Indexed	1 month ago (July 30, 2025, 11:26 a.m.)
Issued	19 years, 8 months ago (Jan. 1, 2006)
Published	19 years, 8 months ago (Jan. 1, 2006)
Published Print	19 years, 8 months ago (Jan. 1, 2006)

Funders 0

None

BibTeX

@article{Mishto_2006, title={Immunoproteasome and LMP2 polymorphism in aged and Alzheimer’s disease brains}, volume={27}, ISSN={0197-4580}, url={http://dx.doi.org/10.1016/j.neurobiolaging.2004.12.004}, DOI={10.1016/j.neurobiolaging.2004.12.004}, number={1}, journal={Neurobiology of Aging}, publisher={Elsevier BV}, author={Mishto, Michele and Bellavista, Elena and Santoro, Aurelia and Stolzing, Alexandra and Ligorio, Claudia and Nacmias, Benedetta and Spazzafumo, Liana and Chiappelli, Martina and Licastro, Federico and Sorbi, Sandro and Pession, Annalisa and Ohm, Thomas and Grune, Tilman and Franceschi, Claudio}, year={2006}, month=jan, pages={54–66} }

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      "volume": "75",
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    },
    {
      "issue": "4",
      "key": "10.1016/j.neurobiolaging.2004.12.004_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "287",
      "DOI": "10.1093/protein/15.4.287",
      "article-title": "Prediction of proteasome cleavage motifs by neural networks",
      "volume": "15",
      "author": "Kesmir",
      "year": "2002",
      "journal-title": "Protein Eng"
    },
    {
      "issue": "11",
      "key": "10.1016/j.neurobiolaging.2004.12.004_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "1097",
      "DOI": "10.1001/archneur.1985.04060100083029",
      "article-title": "Diagnosis of Alzheimer's disease",
      "volume": "42",
      "author": "Khachaturian",
      "year": "1985",
      "journal-title": "Arch Neurol"
    },
    {
      "key": "10.1016/j.neurobiolaging.2004.12.004_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "179",
      "DOI": "10.1038/35056572",
      "article-title": "Antigen processing by the proteasome",
      "volume": "2",
      "author": "Kloetzel",
      "year": "2001",
      "journal-title": "Nat Rev"
    },
    {
      "issue": "18",
      "key": "10.1016/j.neurobiolaging.2004.12.004_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "9902",
      "DOI": "10.1073/pnas.170173897",
      "article-title": "Inhibition of the ubiquitin-proteasome system in Alzheimer's disease",
      "volume": "97",
      "author": "Lam",
      "year": "2000",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "issue": "3",
      "key": "10.1016/j.neurobiolaging.2004.12.004_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "294",
      "DOI": "10.1038/77046",
      "article-title": "Gene-expression profile of the ageing brain in mice",
      "volume": "25",
      "author": "Lee",
      "year": "2000",
      "journal-title": "Nat Genet"
    },
    {
      "issue": "7",
      "key": "10.1016/j.neurobiolaging.2004.12.004_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "921",
      "DOI": "10.1016/S0197-4580(03)00013-7",
      "article-title": "Interleukin-6 gene alleles affect the risk of Alzheimer's disease and levels of the cytokine in blood and brain",
      "volume": "24",
      "author": "Licastro",
      "year": "2003",
      "journal-title": "Neurobiol Aging"
    },
    {
      "issue": "1",
      "key": "10.1016/j.neurobiolaging.2004.12.004_bib30",
      "first-page": "183",
      "article-title": "LMP2 polymorphism is associated with extraspinal disease in HLA-B27 negative Caucasian and Mexican Mestizo patients with ankylosing spondylitis",
      "volume": "27",
      "author": "Maksymowych",
      "year": "2000",
      "journal-title": "J Rheumatol"
    },
    {
      "issue": "6",
      "key": "10.1016/j.neurobiolaging.2004.12.004_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "529",
      "DOI": "10.1080/13550280290100969",
      "article-title": "Local neuroinflammation and the progression of Alzheimer's disease",
      "volume": "8",
      "author": "McGeer",
      "year": "2002",
      "journal-title": "J Neurovirol"
    },
    {
      "issue": "24",
      "key": "10.1016/j.neurobiolaging.2004.12.004_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "21517",
      "DOI": "10.1074/jbc.M301032200",
      "article-title": "Inhibition of proteasome activity induces concerted expression of proteasome genes and de novo formation of mammalian proteasomes",
      "volume": "278",
      "author": "Meiners",
      "year": "2003",
      "journal-title": "J Biol Chem"
    },
    {
      "issue": "2\u20133",
      "key": "10.1016/j.neurobiolaging.2004.12.004_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "301",
      "DOI": "10.1016/S0531-5565(01)00196-6",
      "article-title": "Age dependent impact of LMP polymorphisms on TNF alpha-induced apoptosis in human peripheral blood mononuclear cells",
      "volume": "37",
      "author": "Mishto",
      "year": "2002",
      "journal-title": "Exp Gerontol"
    },
    {
      "key": "10.1016/j.neurobiolaging.2004.12.004_bib34",
      "first-page": "419",
      "article-title": "Immunoproteasomes and immunosenescence",
      "volume": "2",
      "author": "Mishto",
      "year": "2003",
      "journal-title": "ARR"
    },
    {
      "issue": "5223",
      "key": "10.1016/j.neurobiolaging.2004.12.004_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "549",
      "DOI": "10.1126/science.7624779",
      "article-title": "Induction of MHC class I genes in neurons",
      "volume": "269",
      "author": "Neumann",
      "year": "1995",
      "journal-title": "Science"
    },
    {
      "issue": "2",
      "key": "10.1016/j.neurobiolaging.2004.12.004_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "348",
      "DOI": "10.1006/bbrc.2000.3676",
      "article-title": "Tissue distribution of constitutive proteasomes, immunoproteasomes, and PA28 in rats",
      "volume": "277",
      "author": "Noda",
      "year": "2000",
      "journal-title": "Biochem Biophys Res Commun"
    },
    {
      "issue": "1-2",
      "key": "10.1016/j.neurobiolaging.2004.12.004_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "135",
      "DOI": "10.1016/S0165-5728(02)00439-3",
      "article-title": "Interferon-gamma-inducible subunits are incorporated in human brain 20S proteasome",
      "volume": "135",
      "author": "Piccinini",
      "year": "2003",
      "journal-title": "J Neuroimmunol"
    },
    {
      "issue": "1\u20132",
      "key": "10.1016/j.neurobiolaging.2004.12.004_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "60",
      "DOI": "10.1016/S0169-328X(03)00337-1",
      "article-title": "Quantifying mRNA in post-mortem human brain: influence of gender, age at death, post-mortem interval, brain pH, agonal state and inter-lobe mRNA variance",
      "volume": "118",
      "author": "Preece",
      "year": "2003",
      "journal-title": "Mol Brain Res"
    },
    {
      "key": "10.1016/j.neurobiolaging.2004.12.004_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "761",
      "DOI": "10.1016/S0092-8674(94)90462-6",
      "article-title": "Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules",
      "volume": "78",
      "author": "Rock",
      "year": "1994",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.neurobiolaging.2004.12.004_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "739",
      "DOI": "10.1146/annurev.immunol.17.1.739",
      "article-title": "Degradation of cell proteins and the generation of MHC class I-presented peptides",
      "volume": "17",
      "author": "Rock",
      "year": "1999",
      "journal-title": "Annu Rev Immunol"
    },
    {
      "issue": "4",
      "key": "10.1016/j.neurobiolaging.2004.12.004_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "487",
      "DOI": "10.1016/0896-6273(91)90052-2",
      "article-title": "The molecular pathology of Alzheimer's disease",
      "volume": "6",
      "author": "Selkoe",
      "year": "1991",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.neurobiolaging.2004.12.004_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "100",
      "DOI": "10.1016/0304-3940(94)90054-X",
      "article-title": "ApoE allele frequencies in Italian sporadic and familial Alzheimer's disease",
      "volume": "177",
      "author": "Sorbi",
      "year": "1994",
      "journal-title": "Neurosci Lett"
    },
    {
      "key": "10.1016/j.neurobiolaging.2004.12.004_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "20699",
      "DOI": "10.1074/jbc.M313579200",
      "article-title": "Proteasome inhibition alters neural mitochondrial homeostasis and mitochondria turnover",
      "volume": "279",
      "author": "Sullivan",
      "year": "2004",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1016/j.neurobiolaging.2004.12.004_bib44",
      "doi-asserted-by": "crossref",
      "unstructured": "The Dementia Study Group of the Italian Neurological Society, Guidelines for the diagnosis of dementia and Alzheimer's disease. Neurol Sci 2000;21(4):187\u2013194.",
      "DOI": "10.1007/s100720070075"
    },
    {
      "issue": "1",
      "key": "10.1016/j.neurobiolaging.2004.12.004_bib45",
      "doi-asserted-by": "crossref",
      "first-page": "33",
      "DOI": "10.1136/ard.57.1.33",
      "article-title": "Analysis of LMP and TAP polymorphisms by polymerase chain reaction-restriction fragment length polymorphism in rheumatoid arthritis",
      "volume": "57",
      "author": "Vinasco",
      "year": "1998",
      "journal-title": "Ann Rheum Dis"
    },
    {
      "key": "10.1016/j.neurobiolaging.2004.12.004_bib46",
      "doi-asserted-by": "crossref",
      "first-page": "1015",
      "DOI": "10.1146/annurev.biochem.68.1.1015",
      "article-title": "The 26S proteasome: a molecular machine designed for controlled proteolysis",
      "volume": "68",
      "author": "Voges",
      "year": "1999",
      "journal-title": "Annu Rev Biochem"
    },
    {
      "issue": "6",
      "key": "10.1016/j.neurobiolaging.2004.12.004_bib47",
      "doi-asserted-by": "crossref",
      "first-page": "400",
      "DOI": "10.1007/BF00184520",
      "article-title": "Genomic organization and tissue expression of the mouse proteasome gene Lmp-7",
      "volume": "38",
      "author": "Zanelli",
      "year": "1993",
      "journal-title": "Immunogenetics"
    },
    {
      "issue": "2",
      "key": "10.1016/j.neurobiolaging.2004.12.004_bib48",
      "doi-asserted-by": "crossref",
      "first-page": "307",
      "DOI": "10.1023/A:1022337519035",
      "article-title": "The induction of the TNFalpha death domain signaling pathway in Alzheimer's disease brain",
      "volume": "28",
      "author": "Zhao",
      "year": "2003",
      "journal-title": "Neurochem Res"
    },
    {
      "key": "10.1016/j.neurobiolaging.2004.12.004_bib49",
      "doi-asserted-by": "crossref",
      "first-page": "2681",
      "DOI": "10.1073/pnas.90.7.2681",
      "article-title": "Molecular basis of genetic polymorphism in major histocompatibility complex-linked proteasome gene (LMP-2)",
      "volume": "90",
      "author": "Zhou",
      "year": "1993",
      "journal-title": "Proc Nat Acad Sci USA"
    },
    {
      "issue": "3",
      "key": "10.1016/j.neurobiolaging.2004.12.004_bib50",
      "doi-asserted-by": "crossref",
      "first-page": "664",
      "DOI": "10.1006/geno.1993.1245",
      "article-title": "Genomic organization and tissue expression of mouse proteasome gene Lmp-2",
      "volume": "16",
      "author": "Zhou",
      "year": "1993",
      "journal-title": "Genomics"
    }
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