DOI: 10.1016/j.neuro.2007.08.008. Pharmacological inhibition of neuronal NADPH oxidase protects against 1-methyl-4-phenylpyridinium (MPP+)-induced oxidative stress and apoptosis in mesencephalic dopaminergic neuronal cells

Pharmacological inhibition of neuronal NADPH oxidase protects against 1-methyl-4-phenylpyridinium (MPP+)-induced oxidative stress and apoptosis in mesencephalic dopaminergic neuronal cells

10.1016/j.neuro.2007.08.008

Crossref journal-article

Elsevier BV

NeuroToxicology (78)

Bibliography

Anantharam, V., Kaul, S., Song, C., Kanthasamy, A., & Kanthasamy, A. G. (2007). Pharmacological inhibition of neuronal NADPH oxidase protects against 1-methyl-4-phenylpyridinium (MPP+)-induced oxidative stress and apoptosis in mesencephalic dopaminergic neuronal cells. NeuroToxicology, 28(5), 988â997.

Authors 5

Vellareddy Anantharam (first)
Siddharth Kaul (additional)
Chunjuan Song (additional)
Arthi Kanthasamy (additional)
Anumantha G. Kanthasamy (additional)

References 76 Referenced 99

10.1523/JNEUROSCI.22-05-01738.2002 / J Neurosci / Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl by Anantharam (2002)
10.1196/annals.1332.017 / Ann NY Acad Sci / Blockade of PKCdelta proteolytic activation by loss of function mutants rescues mesencephalic dopaminergic neurons from methylcyclopentadienyl manganese tricarbonyl (MMT)-induced apoptotic cell death by Anantharam (2004)
10.3233/JAD-2004-6S602 / J Alzheimers Dis / Iron dysregulation and Parkinson's disease by Andersen (2004)
10.1111/j.1749-6632.2003.tb07470.x / Ann NY Acad Sci / Mitochondria, oxidative damage, and inflammation in Parkinson's disease by Beal (2003)
10.1602/neurorx.2.3.484 / NeuroRx / Toxin-induced models of Parkinson's disease by Bove (2005)
10.1016/S0925-4439(98)00083-0 / Biochim Biophys Acta / The Parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism by Cassarino (1999)
10.1002/(SICI)1097-4547(19990701)57:1<86::AID-JNR9>3.0.CO;2-E / J Neurosci Res / Two distinct mechanisms are involved in 6-hydroxydopamine- and MPP+-induced dopaminergic neuronal cell death: role of caspases, ROS, and JNK by Choi (1999)
10.1016/S0896-6273(03)00568-3 / Neuron / Parkinson's disease: mechanisms and models by Dauer (2003)
10.1126/science.1087753 / Science / Molecular pathways of neurodegeneration in Parkinson's disease by Dawson (2003)
10.1016/S1474-4422(03)00501-5 / Lancet Neurol / The environment and Parkinson's disease: is the nigrostriatal system preferentially targeted by neurotoxins? by Di Monte (2003)
10.1016/S0891-5849(98)00050-1 / Free Radic Biol Med / Astrocyte-enhanced neuronal survival is mediated by scavenging of extracellular reactive oxygen species by Drukarch (1998)
10.1042/BJ20050287 / Biochem J / PKCdelta mediates up-regulation of NOX1, a catalytic subunit of NADPH oxidase, via transactivation of the EGF receptor: possible involvement of PKCdelta in vascular hypertrophy by Fan (2005)
10.1111/j.1749-6632.2003.tb07469.x / Ann NY Acad Sci / Mitochondrial mechanisms of neural cell death and neuroprotective interventions in Parkinson's disease by Fiskum (2003)
10.1093/hmg/ddi308 / Hum Mol Genet / Molecular pathogenesis of Parkinson's disease by Gandhi (2005)
10.1523/JNEUROSCI.23-15-06181.2003 / J Neurosci / Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons by Gao (2003)
10.1096/fj.03-0109fje / FASEB J / Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease by Gao (2003)
10.1016/j.cardiores.2006.05.004 / Cardiovasc Res / NADPH oxidases: new kids on the block by Geiszt (2006)
10.1126/science.1098966 / Science / Biomedicine. Parkinson's—divergent causes, convergent mechanisms by Greenamyre (2004)
10.1016/j.expneurol.2005.01.013 / Exp Neurol / Oxidative stress and inflammation in Parkinson's disease: is there a causal link? by Hald (2005)
10.1152/ajplung.00015.2005 / Am J Physiol Lung Cell Mol Physiol / Effect of p47phox gene deletion on ROS production and oxygen sensing in mouse carotid body chemoreceptor cells by He (2005)
10.1111/j.1749-6632.2003.tb07478.x / Ann NY Acad Sci / The role of glial reaction and inflammation in Parkinson's disease by Hirsch (2003)
10.1007/978-3-7091-0643-3_6 / J Neural Transm Suppl / Animal models of Parkinson's disease in rodents induced by toxins: an update by Hirsch (2003)
10.1016/j.abb.2006.11.009 / Arch Biochem Biophys / Protein kinase C-alpha and -delta are required for NADPH oxidase activation in WKYMVm-stimulated IMR90 human fibroblasts by Iaccio (2006)
10.1016/j.freeradbiomed.2006.01.009 / Free Radic Biol Med / NOX1/NADPH oxidase negatively regulates nerve growth factor-induced neurite outgrowth by Ibi (2006)
10.1089/ars.2006.8.1583 / Antioxid Redox Signal / NADPH oxidases of the brain: distribution, regulation, and function by Infanger (2006)
10.1172/JCI200317638 / J Clin Invest / Oxidative stress and nitration in neurodegeneration: cause, effect, or association? by Ischiropoulos (2003)
10.1002/ana.10483 / Ann Neurol / Oxidative stress in Parkinson's disease by Jenner (2003)
10.1042/bj20021525 / Biochem J / 1-Methyl-4-phenylpyridinium (MPP+)-induced apoptosis and mitochondrial oxidant generation: role of transferrin-receptor-dependent iron and hydrogen peroxide by Kalivendi (2003)
10.1089/152308603770310275 / Antioxid Redox Signal / Role of proteolytic activation of protein kinase Cdelta in oxidative stress-induced apoptosis by Kanthasamy (2003)
10.1016/j.freeradbiomed.2006.08.016 / Free Radic Biol Med / A novel peptide inhibitor targeted to caspase-3 cleavage site of a proapoptotic kinase protein kinase C delta (PKCdelta) protects against dopaminergic neuronal degeneration in Parkinson's disease models by Kanthasamy (2006)
10.1046/j.1460-9568.2003.02864.x / Eur J Neurosci / Caspase-3 dependent proteolytic activation of protein kinase C delta mediates and regulates 1-methyl-4-phenylpyridinium (MPP+)-induced apoptotic cell death in dopaminergic cells: relevance to oxidative stress in dopaminergic degeneration by Kaul (2003)
10.1016/j.molbrainres.2005.05.022 / Brain Res Mol Brain Res / Wild-type alpha-synuclein interacts with pro-apoptotic proteins PKCdelta and BAD to protect dopaminergic neuronal cells against MPP+-induced apoptotic cell death by Kaul (2005)
10.1074/jbc.M501092200 / J Biol Chem / Tyrosine phosphorylation regulates the proteolytic activation of protein kinase Cdelta in dopaminergic neuronal cells by Kaul (2005)
10.1016/S0891-5849(01)00726-2 / Free Radic Biol Med / Dieldrin-induced oxidative stress and neurochemical changes contribute to apoptopic cell death in dopaminergic cells by Kitazawa (2001)
10.1016/S0306-4522(03)00226-4 / Neuroscience / Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cdelta in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration by Kitazawa (2003)
10.1007/s00415-002-1201-7 / J Neurol / Free radicals in Parkinson's disease by Koutsilieri (2002)
10.1124/jpet.104.078469 / J Pharmacol Exp Ther / Protein kinase Cdelta is a key downstream mediator of manganese-induced apoptosis in dopaminergic neuronal cells by Latchoumycandane (2005)
10.1016/S1474-4422(04)00782-3 / Lancet Neurol / Mitochondria back in the spotlight in Parkinson's disease by Love (2004)
10.1523/JNEUROSCI.20-15-05715.2000 / J Neurosci / Delayed mitochondrial dysfunction in excitotoxic neuron death: cytochrome c release and a secondary increase in superoxide production by Luetjens (2000)
10.1007/s11064-006-9038-6 / Neurochem Res / Dopamine promotes the survival of embryonic striatal cells: involvement of superoxide and endogenous NADPH oxidase by Ma (2006)
10.1016/j.molbrainres.2004.09.014 / Brain Res Mol Brain Res / Synuclein, dopamine and oxidative stress: co-conspirators in Parkinson's disease? by Maguire-Zeiss (2005)
10.2741/2130 / Front Biosci / Mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disorders by Mancuso (2007)
10.1385/JMN:24:3:401 / J Mol Neurosci / Iron and alpha-synuclein in the substantia nigra of MPTP-treated mice: effect of neuroprotective drugs R-apomorphine and green tea polyphenol (−)-epigallocatechin-3-gallate by Mandel (2004)
10.1016/j.neuroscience.2006.03.069 / Neuroscience / Decreased susceptibility to oxidative stress underlies the resistance of specific dopaminergic cell populations to paraquat-induced degeneration by McCormack (2006)
10.1080/10715760500176866 / Free Radic Res / Rac1-NADPH oxidase-regulated generation of reactive oxygen species mediates glutamate-induced apoptosis in SH-SY5Y human neuroblastoma cells by Nikolova (2005)
10.1016/S0378-4274(02)00076-0 / Toxicol Lett / Role of hydroxyl radical formation in neurotoxicity as revealed by in vivo free radical trapping by Obata (2002)
10.1016/j.ejphar.2005.01.004 / Eur J Pharmacol / Antioxidants inhibit human endothelial cell functions through down-regulation of endothelial nitric oxide synthase activity by Polytarchou (2005)
10.1016/j.parkreldis.2004.10.012 / Parkinsonism Relat Disord / Pathogenesis of nigral cell death in Parkinson's disease by Przedborski (2005)
10.1089/ars.2005.7.685 / Antioxid Redox Signal / Reactive oxygen and nitrogen species: weapons of neuronal destruction in models of Parkinson's disease by Przedborski (2005)
10.1023/B:JOBB.0000041771.66775.d5 / J Bioenerg Biomemb / MPTP as a mitochondrial neurotoxic model of Parkinson's disease by Przedborski (2004)
10.1016/j.nbd.2006.10.008 / Neurobiol Dis / Microglial activation as a priming event leading to paraquat-induced dopaminergic cell degeneration by Purisai (2006)
10.1016/j.neurobiolaging.2005.09.036 / Neurobiol Aging / A key role for the microglial NADPH oxidase in APP-dependent killing of neurons by Qin (2006)
10.1002/jnr.21005 / J Neurosci Res / NADPH oxidase inhibitor diphenyliodonium abolishes lipopolysaccharide-induced down-regulation of transferrin receptor expression in N2a and BV-2 cells by Reis (2006)
{'key': '10.1016/j.neuro.2007.08.008_bib54', 'first-page': '373', 'article-title': "Role of cytokines in inflammatory process in Parkinson's disease", 'author': 'Sawada', 'year': '2006', 'journal-title': 'J Neural Transm Suppl'} / J Neural Transm Suppl / Role of cytokines in inflammatory process in Parkinson's disease by Sawada (2006)
{'key': '10.1016/j.neuro.2007.08.008_bib55', 'first-page': '15', 'article-title': "Pathogenesis of Parkinson's disease", 'volume': '6', 'author': 'Schapira', 'year': '1997', 'journal-title': 'Baillieres Clin Neurol'} / Baillieres Clin Neurol / Pathogenesis of Parkinson's disease by Schapira (1997)
10.1073/pnas.2235648100 / Proc Natl Acad Sci USA / NADPH oxidase and extracellular regulated kinases 1/2 are targets of prion protein signaling in neuronal and nonneuronal cells by Schneider (2003)
10.1007/s00441-004-0954-y / Cell Tissue Res / Neuronal pathology in Parkinson's disease by Schulz (2004)
10.1016/S0006-8993(03)03364-X / Brain Res / NADPH oxidase immunoreactivity in the mouse brain by Serrano (2003)
{'key': '10.1016/j.neuro.2007.08.008_bib59', 'first-page': '657', 'article-title': "Pathogenesis of Parkinson's disease", 'volume': '2', 'author': 'Sherer', 'year': '2001', 'journal-title': 'Curr Opin Investig Drugs'} / Curr Opin Investig Drugs / Pathogenesis of Parkinson's disease by Sherer (2001)
10.1196/annals.1332.016 / Ann NY Acad Sci / The role of alpha-synuclein in both neuroprotection and neurodegeneration by Sidhu (2004)
10.1016/j.molbrainres.2004.09.017 / Brain Res Mol Brain Res / The MPTP model of Parkinson's disease by Smeyne (2005)
10.1016/j.neuro.2006.06.006 / Neurotoxicology / Proteasome inhibitor MG-132 induces dopaminergic degeneration in cell culture and animal models by Sun (2006)
10.1111/j.1471-4159.2007.04670.x / J Neurochem / The roles of NADPH oxidase and phospholipases A(2) in oxidative and inflammatory responses in neurodegenerative diseases by Sun (2007)
10.1089/ars.2006.8.1523 / Antioxid Redox Signal / Regulation of novel superoxide-producing NAD(P)H oxidases by Takeya (2006)
10.1046/j.1460-9568.2003.02781.x / Eur J Neurosci / Age-related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotype by Thiruchelvam (2003)
10.1093/brain/awf068 / Brain / Minocycline prevents neurotoxicity induced by cerebrospinal fluid from patients with motor neurone disease by Tikka (2002)
{'key': '10.1016/j.neuro.2007.08.008_bib67', 'first-page': 're8', 'article-title': 'Localizing NADPH oxidase-derived ROS', 'volume': '349', 'author': 'Ushio-Fukai', 'year': '2006', 'journal-title': 'Sci STKE'} / Sci STKE / Localizing NADPH oxidase-derived ROS by Ushio-Fukai (2006)
10.1080/10715760500539121 / Free Radic Res / Involvement of protein kinase Cdelta in the activation of NADPH oxidase and the phagocytosis of neutrophils by Waki (2006)
10.1016/j.brainres.2006.03.060 / Brain Res / Apocynin protects against global cerebral ischemia-reperfusion-induced oxidative stress and injury in the gerbil hippocampus by Wang (2006)
{'key': '10.1016/j.neuro.2007.08.008_bib70', 'first-page': 'RA17', 'article-title': "Mechanisms of MPTP toxicity and their implications for therapy of Parkinson's disease", 'volume': '11', 'author': 'Watanabe', 'year': '2005', 'journal-title': 'Med Sci Monit'} / Med Sci Monit / Mechanisms of MPTP toxicity and their implications for therapy of Parkinson's disease by Watanabe (2005)
10.2174/092986706776055760 / Curr Med Chem / An inflammatory pathomechanism for Parkinson's disease? by Wersinger (2006)
10.1016/j.mcn.2003.11.011 / Mol Cell Neurosci / Suppression of caspase-3-dependent proteolytic activation of protein kinase C delta by small interfering RNA prevents MPP+-induced dopaminergic degeneration by Yang (2004)
10.1111/j.1460-9568.2004.03254.x / Eur J Neurosci / Neuroprotective effects of vascular endothelial growth factor (VEGF) upon dopaminergic neurons in a rat model of Parkinson's disease by Yasuhara (2004)
10.1196/annals.1306.025 / Ann NY Acad Sci / Ironing iron out in Parkinson's disease and other neurodegenerative diseases with iron chelators: a lesson from 6-hydroxydopamine and iron chelators, desferal and VK-28 by Youdim (2004)
10.1189/jlb.0504284 / J Leukoc Biol / Protein kinase Cdelta regulates p67phox phosphorylation in human monocytes by Zhao (2005)
10.1016/S1353-8020(02)00019-6 / Parkinsonism Relat Disord / Increased dopamine turnover after partial loss of dopaminergic neurons: compensation or toxicity? by Zigmond (2002)

Dates

Type	When
Created	18 years ago (Aug. 28, 2007, 7:18 a.m.)
Deposited	1 year, 6 months ago (Feb. 17, 2024, 11:37 a.m.)
Indexed	3 months, 1 week ago (May 16, 2025, 9:04 a.m.)
Issued	17 years, 11 months ago (Sept. 1, 2007)
Published	17 years, 11 months ago (Sept. 1, 2007)
Published Print	17 years, 11 months ago (Sept. 1, 2007)

Funders 1

National Institutes of Health 10.13039/100000002
Region: Americas
gov (National government)
Labels3
1. Institutos Nacionales de la Salud
2. US National Institutes of Health
3. NIH
Awards3
1. ES10586
2. NS38644
3. NS45133

BibTeX

@article{Anantharam_2007, title={Pharmacological inhibition of neuronal NADPH oxidase protects against 1-methyl-4-phenylpyridinium (MPP+)-induced oxidative stress and apoptosis in mesencephalic dopaminergic neuronal cells}, volume={28}, ISSN={0161-813X}, url={http://dx.doi.org/10.1016/j.neuro.2007.08.008}, DOI={10.1016/j.neuro.2007.08.008}, number={5}, journal={NeuroToxicology}, publisher={Elsevier BV}, author={Anantharam, Vellareddy and Kaul, Siddharth and Song, Chunjuan and Kanthasamy, Arthi and Kanthasamy, Anumantha G.}, year={2007}, month=sep, pages={988–997} }

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      "author": "Gandhi",
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      "volume": "23",
      "author": "Gao",
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      "DOI": "10.1096/fj.03-0109fje",
      "article-title": "Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease",
      "volume": "17",
      "author": "Gao",
      "year": "2003",
      "journal-title": "FASEB J"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "289",
      "DOI": "10.1016/j.cardiores.2006.05.004",
      "article-title": "NADPH oxidases: new kids on the block",
      "volume": "71",
      "author": "Geiszt",
      "year": "2006",
      "journal-title": "Cardiovasc Res"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "1120",
      "DOI": "10.1126/science.1098966",
      "article-title": "Biomedicine. Parkinson's\u2014divergent causes, convergent mechanisms",
      "volume": "304",
      "author": "Greenamyre",
      "year": "2004",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "279",
      "DOI": "10.1016/j.expneurol.2005.01.013",
      "article-title": "Oxidative stress and inflammation in Parkinson's disease: is there a causal link?",
      "volume": "193",
      "author": "Hald",
      "year": "2005",
      "journal-title": "Exp Neurol"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "L916",
      "DOI": "10.1152/ajplung.00015.2005",
      "article-title": "Effect of p47phox gene deletion on ROS production and oxygen sensing in mouse carotid body chemoreceptor cells",
      "volume": "289",
      "author": "He",
      "year": "2005",
      "journal-title": "Am J Physiol Lung Cell Mol Physiol"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "214",
      "DOI": "10.1111/j.1749-6632.2003.tb07478.x",
      "article-title": "The role of glial reaction and inflammation in Parkinson's disease",
      "volume": "991",
      "author": "Hirsch",
      "year": "2003",
      "journal-title": "Ann NY Acad Sci"
    },
    {
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      "first-page": "89",
      "DOI": "10.1007/978-3-7091-0643-3_6",
      "article-title": "Animal models of Parkinson's disease in rodents induced by toxins: an update",
      "author": "Hirsch",
      "year": "2003",
      "journal-title": "J Neural Transm Suppl"
    },
    {
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      "doi-asserted-by": "crossref",
      "first-page": "288",
      "DOI": "10.1016/j.abb.2006.11.009",
      "article-title": "Protein kinase C-alpha and -delta are required for NADPH oxidase activation in WKYMVm-stimulated IMR90 human fibroblasts",
      "volume": "459",
      "author": "Iaccio",
      "year": "2006",
      "journal-title": "Arch Biochem Biophys"
    },
    {
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      "doi-asserted-by": "crossref",
      "first-page": "1785",
      "DOI": "10.1016/j.freeradbiomed.2006.01.009",
      "article-title": "NOX1/NADPH oxidase negatively regulates nerve growth factor-induced neurite outgrowth",
      "volume": "40",
      "author": "Ibi",
      "year": "2006",
      "journal-title": "Free Radic Biol Med"
    },
    {
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      "doi-asserted-by": "crossref",
      "first-page": "1583",
      "DOI": "10.1089/ars.2006.8.1583",
      "article-title": "NADPH oxidases of the brain: distribution, regulation, and function",
      "volume": "8",
      "author": "Infanger",
      "year": "2006",
      "journal-title": "Antioxid Redox Signal"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib26",
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      "first-page": "163",
      "DOI": "10.1172/JCI200317638",
      "article-title": "Oxidative stress and nitration in neurodegeneration: cause, effect, or association?",
      "volume": "111",
      "author": "Ischiropoulos",
      "year": "2003",
      "journal-title": "J Clin Invest"
    },
    {
      "issue": "Suppl 3",
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      "doi-asserted-by": "crossref",
      "first-page": "S26",
      "DOI": "10.1002/ana.10483",
      "article-title": "Oxidative stress in Parkinson's disease",
      "volume": "53",
      "author": "Jenner",
      "year": "2003",
      "journal-title": "Ann Neurol"
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    {
      "key": "10.1016/j.neuro.2007.08.008_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "151",
      "DOI": "10.1042/bj20021525",
      "article-title": "1-Methyl-4-phenylpyridinium (MPP+)-induced apoptosis and mitochondrial oxidant generation: role of transferrin-receptor-dependent iron and hydrogen peroxide",
      "volume": "371",
      "author": "Kalivendi",
      "year": "2003",
      "journal-title": "Biochem J"
    },
    {
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      "doi-asserted-by": "crossref",
      "first-page": "609",
      "DOI": "10.1089/152308603770310275",
      "article-title": "Role of proteolytic activation of protein kinase Cdelta in oxidative stress-induced apoptosis",
      "volume": "5",
      "author": "Kanthasamy",
      "year": "2003",
      "journal-title": "Antioxid Redox Signal"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "1578",
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      "article-title": "A novel peptide inhibitor targeted to caspase-3 cleavage site of a proapoptotic kinase protein kinase C delta (PKCdelta) protects against dopaminergic neuronal degeneration in Parkinson's disease models",
      "volume": "41",
      "author": "Kanthasamy",
      "year": "2006",
      "journal-title": "Free Radic Biol Med"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "1387",
      "DOI": "10.1046/j.1460-9568.2003.02864.x",
      "article-title": "Caspase-3 dependent proteolytic activation of protein kinase C delta mediates and regulates 1-methyl-4-phenylpyridinium (MPP+)-induced apoptotic cell death in dopaminergic cells: relevance to oxidative stress in dopaminergic degeneration",
      "volume": "18",
      "author": "Kaul",
      "year": "2003",
      "journal-title": "Eur J Neurosci"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "137",
      "DOI": "10.1016/j.molbrainres.2005.05.022",
      "article-title": "Wild-type alpha-synuclein interacts with pro-apoptotic proteins PKCdelta and BAD to protect dopaminergic neuronal cells against MPP+-induced apoptotic cell death",
      "volume": "139",
      "author": "Kaul",
      "year": "2005",
      "journal-title": "Brain Res Mol Brain Res"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "28721",
      "DOI": "10.1074/jbc.M501092200",
      "article-title": "Tyrosine phosphorylation regulates the proteolytic activation of protein kinase Cdelta in dopaminergic neuronal cells",
      "volume": "280",
      "author": "Kaul",
      "year": "2005",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "1473",
      "DOI": "10.1016/S0891-5849(01)00726-2",
      "article-title": "Dieldrin-induced oxidative stress and neurochemical changes contribute to apoptopic cell death in dopaminergic cells",
      "volume": "31",
      "author": "Kitazawa",
      "year": "2001",
      "journal-title": "Free Radic Biol Med"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "945",
      "DOI": "10.1016/S0306-4522(03)00226-4",
      "article-title": "Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cdelta in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration",
      "volume": "119",
      "author": "Kitazawa",
      "year": "2003",
      "journal-title": "Neuroscience"
    },
    {
      "issue": "Suppl 2",
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      "first-page": "II1",
      "DOI": "10.1007/s00415-002-1201-7",
      "article-title": "Free radicals in Parkinson's disease",
      "volume": "249",
      "author": "Koutsilieri",
      "year": "2002",
      "journal-title": "J Neurol"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "46",
      "DOI": "10.1124/jpet.104.078469",
      "article-title": "Protein kinase Cdelta is a key downstream mediator of manganese-induced apoptosis in dopaminergic neuronal cells",
      "volume": "313",
      "author": "Latchoumycandane",
      "year": "2005",
      "journal-title": "J Pharmacol Exp Ther"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "326",
      "DOI": "10.1016/S1474-4422(04)00782-3",
      "article-title": "Mitochondria back in the spotlight in Parkinson's disease",
      "volume": "3",
      "author": "Love",
      "year": "2004",
      "journal-title": "Lancet Neurol"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "5715",
      "DOI": "10.1523/JNEUROSCI.20-15-05715.2000",
      "article-title": "Delayed mitochondrial dysfunction in excitotoxic neuron death: cytochrome c release and a secondary increase in superoxide production",
      "volume": "20",
      "author": "Luetjens",
      "year": "2000",
      "journal-title": "J Neurosci"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "463",
      "DOI": "10.1007/s11064-006-9038-6",
      "article-title": "Dopamine promotes the survival of embryonic striatal cells: involvement of superoxide and endogenous NADPH oxidase",
      "volume": "31",
      "author": "Ma",
      "year": "2006",
      "journal-title": "Neurochem Res"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "18",
      "DOI": "10.1016/j.molbrainres.2004.09.014",
      "article-title": "Synuclein, dopamine and oxidative stress: co-conspirators in Parkinson's disease?",
      "volume": "134",
      "author": "Maguire-Zeiss",
      "year": "2005",
      "journal-title": "Brain Res Mol Brain Res"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "1107",
      "DOI": "10.2741/2130",
      "article-title": "Mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disorders",
      "volume": "12",
      "author": "Mancuso",
      "year": "2007",
      "journal-title": "Front Biosci"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "401",
      "DOI": "10.1385/JMN:24:3:401",
      "article-title": "Iron and alpha-synuclein in the substantia nigra of MPTP-treated mice: effect of neuroprotective drugs R-apomorphine and green tea polyphenol (\u2212)-epigallocatechin-3-gallate",
      "volume": "24",
      "author": "Mandel",
      "year": "2004",
      "journal-title": "J Mol Neurosci"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib44",
      "doi-asserted-by": "crossref",
      "first-page": "929",
      "DOI": "10.1016/j.neuroscience.2006.03.069",
      "article-title": "Decreased susceptibility to oxidative stress underlies the resistance of specific dopaminergic cell populations to paraquat-induced degeneration",
      "volume": "141",
      "author": "McCormack",
      "year": "2006",
      "journal-title": "Neuroscience"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib45",
      "doi-asserted-by": "crossref",
      "first-page": "1295",
      "DOI": "10.1080/10715760500176866",
      "article-title": "Rac1-NADPH oxidase-regulated generation of reactive oxygen species mediates glutamate-induced apoptosis in SH-SY5Y human neuroblastoma cells",
      "volume": "39",
      "author": "Nikolova",
      "year": "2005",
      "journal-title": "Free Radic Res"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib46",
      "doi-asserted-by": "crossref",
      "first-page": "83",
      "DOI": "10.1016/S0378-4274(02)00076-0",
      "article-title": "Role of hydroxyl radical formation in neurotoxicity as revealed by in vivo free radical trapping",
      "volume": "132",
      "author": "Obata",
      "year": "2002",
      "journal-title": "Toxicol Lett"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib47",
      "doi-asserted-by": "crossref",
      "first-page": "31",
      "DOI": "10.1016/j.ejphar.2005.01.004",
      "article-title": "Antioxidants inhibit human endothelial cell functions through down-regulation of endothelial nitric oxide synthase activity",
      "volume": "510",
      "author": "Polytarchou",
      "year": "2005",
      "journal-title": "Eur J Pharmacol"
    },
    {
      "issue": "Suppl 1",
      "key": "10.1016/j.neuro.2007.08.008_bib48",
      "doi-asserted-by": "crossref",
      "first-page": "S3",
      "DOI": "10.1016/j.parkreldis.2004.10.012",
      "article-title": "Pathogenesis of nigral cell death in Parkinson's disease",
      "volume": "11",
      "author": "Przedborski",
      "year": "2005",
      "journal-title": "Parkinsonism Relat Disord"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib49",
      "doi-asserted-by": "crossref",
      "first-page": "685",
      "DOI": "10.1089/ars.2005.7.685",
      "article-title": "Reactive oxygen and nitrogen species: weapons of neuronal destruction in models of Parkinson's disease",
      "volume": "7",
      "author": "Przedborski",
      "year": "2005",
      "journal-title": "Antioxid Redox Signal"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib50",
      "doi-asserted-by": "crossref",
      "first-page": "375",
      "DOI": "10.1023/B:JOBB.0000041771.66775.d5",
      "article-title": "MPTP as a mitochondrial neurotoxic model of Parkinson's disease",
      "volume": "36",
      "author": "Przedborski",
      "year": "2004",
      "journal-title": "J Bioenerg Biomemb"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib51",
      "doi-asserted-by": "crossref",
      "first-page": "392",
      "DOI": "10.1016/j.nbd.2006.10.008",
      "article-title": "Microglial activation as a priming event leading to paraquat-induced dopaminergic cell degeneration",
      "volume": "25",
      "author": "Purisai",
      "year": "2006",
      "journal-title": "Neurobiol Dis"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib52",
      "doi-asserted-by": "crossref",
      "first-page": "1577",
      "DOI": "10.1016/j.neurobiolaging.2005.09.036",
      "article-title": "A key role for the microglial NADPH oxidase in APP-dependent killing of neurons",
      "volume": "27",
      "author": "Qin",
      "year": "2006",
      "journal-title": "Neurobiol Aging"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib53",
      "doi-asserted-by": "crossref",
      "first-page": "1047",
      "DOI": "10.1002/jnr.21005",
      "article-title": "NADPH oxidase inhibitor diphenyliodonium abolishes lipopolysaccharide-induced down-regulation of transferrin receptor expression in N2a and BV-2 cells",
      "volume": "84",
      "author": "Reis",
      "year": "2006",
      "journal-title": "J Neurosci Res"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib54",
      "first-page": "373",
      "article-title": "Role of cytokines in inflammatory process in Parkinson's disease",
      "author": "Sawada",
      "year": "2006",
      "journal-title": "J Neural Transm Suppl"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib55",
      "first-page": "15",
      "article-title": "Pathogenesis of Parkinson's disease",
      "volume": "6",
      "author": "Schapira",
      "year": "1997",
      "journal-title": "Baillieres Clin Neurol"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib56",
      "doi-asserted-by": "crossref",
      "first-page": "13326",
      "DOI": "10.1073/pnas.2235648100",
      "article-title": "NADPH oxidase and extracellular regulated kinases 1/2 are targets of prion protein signaling in neuronal and nonneuronal cells",
      "volume": "100",
      "author": "Schneider",
      "year": "2003",
      "journal-title": "Proc Natl Acad Sci USA"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib57",
      "doi-asserted-by": "crossref",
      "first-page": "135",
      "DOI": "10.1007/s00441-004-0954-y",
      "article-title": "Neuronal pathology in Parkinson's disease",
      "volume": "318",
      "author": "Schulz",
      "year": "2004",
      "journal-title": "Cell Tissue Res"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib58",
      "doi-asserted-by": "crossref",
      "first-page": "193",
      "DOI": "10.1016/S0006-8993(03)03364-X",
      "article-title": "NADPH oxidase immunoreactivity in the mouse brain",
      "volume": "988",
      "author": "Serrano",
      "year": "2003",
      "journal-title": "Brain Res"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib59",
      "first-page": "657",
      "article-title": "Pathogenesis of Parkinson's disease",
      "volume": "2",
      "author": "Sherer",
      "year": "2001",
      "journal-title": "Curr Opin Investig Drugs"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib60",
      "doi-asserted-by": "crossref",
      "first-page": "250",
      "DOI": "10.1196/annals.1332.016",
      "article-title": "The role of alpha-synuclein in both neuroprotection and neurodegeneration",
      "volume": "1035",
      "author": "Sidhu",
      "year": "2004",
      "journal-title": "Ann NY Acad Sci"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib61",
      "doi-asserted-by": "crossref",
      "first-page": "57",
      "DOI": "10.1016/j.molbrainres.2004.09.017",
      "article-title": "The MPTP model of Parkinson's disease",
      "volume": "134",
      "author": "Smeyne",
      "year": "2005",
      "journal-title": "Brain Res Mol Brain Res"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib62",
      "doi-asserted-by": "crossref",
      "first-page": "807",
      "DOI": "10.1016/j.neuro.2006.06.006",
      "article-title": "Proteasome inhibitor MG-132 induces dopaminergic degeneration in cell culture and animal models",
      "volume": "27",
      "author": "Sun",
      "year": "2006",
      "journal-title": "Neurotoxicology"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib63",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1111/j.1471-4159.2007.04670.x",
      "article-title": "The roles of NADPH oxidase and phospholipases A(2) in oxidative and inflammatory responses in neurodegenerative diseases",
      "volume": "103",
      "author": "Sun",
      "year": "2007",
      "journal-title": "J Neurochem"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib64",
      "doi-asserted-by": "crossref",
      "first-page": "1523",
      "DOI": "10.1089/ars.2006.8.1523",
      "article-title": "Regulation of novel superoxide-producing NAD(P)H oxidases",
      "volume": "8",
      "author": "Takeya",
      "year": "2006",
      "journal-title": "Antioxid Redox Signal"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib65",
      "doi-asserted-by": "crossref",
      "first-page": "589",
      "DOI": "10.1046/j.1460-9568.2003.02781.x",
      "article-title": "Age-related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotype",
      "volume": "18",
      "author": "Thiruchelvam",
      "year": "2003",
      "journal-title": "Eur J Neurosci"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib66",
      "doi-asserted-by": "crossref",
      "first-page": "722",
      "DOI": "10.1093/brain/awf068",
      "article-title": "Minocycline prevents neurotoxicity induced by cerebrospinal fluid from patients with motor neurone disease",
      "volume": "125",
      "author": "Tikka",
      "year": "2002",
      "journal-title": "Brain"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib67",
      "first-page": "re8",
      "article-title": "Localizing NADPH oxidase-derived ROS",
      "volume": "349",
      "author": "Ushio-Fukai",
      "year": "2006",
      "journal-title": "Sci STKE"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib68",
      "doi-asserted-by": "crossref",
      "first-page": "359",
      "DOI": "10.1080/10715760500539121",
      "article-title": "Involvement of protein kinase Cdelta in the activation of NADPH oxidase and the phagocytosis of neutrophils",
      "volume": "40",
      "author": "Waki",
      "year": "2006",
      "journal-title": "Free Radic Res"
    },
    {
      "key": "10.1016/j.neuro.2007.08.008_bib69",
      "doi-asserted-by": "crossref",
      "first-page": "182",
      "DOI": "10.1016/j.brainres.2006.03.060",
      "article-title": "Apocynin protects against global cerebral ischemia-reperfusion-induced oxidative stress and injury in the gerbil hippocampus",
      "volume": "1090",
      "author": "Wang",
      "year": "2006",
      "journal-title": "Brain Res"
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