DOI: 10.1016/j.nbd.2003.12.008. Conserved “PAL” sequence in presenilins is essential for γ-secretase activity, but not required for formation or stabilization of γ-secretase complexes

Conserved “PAL” sequence in presenilins is essential for γ-secretase activity, but not required for formation or stabilization of γ-secretase complexes

10.1016/j.nbd.2003.12.008

Crossref journal-article

Elsevier BV

Neurobiology of Disease (78)

Bibliography

Wang, J., Brunkan, A. L., Hecimovic, S., Walker, E., & Goate, A. (2004). Conserved âPALâ sequence in presenilins is essential for Î³-secretase activity, but not required for formation or stabilization of Î³-secretase complexes. Neurobiology of Disease, 15(3), 654â666.

Authors 5

Jun Wang (first)
Anne L Brunkan (additional)
Silva Hecimovic (additional)
Emily Walker (additional)
Alison Goate (additional)

References 41 Referenced 57

10.1006/nbdi.2001.0473 / Neurobiol. Dis. / A presenilin 1 mutation associated with familial frontotemporal dementia inhibits γ-secretase cleavage of APP and notch by Amtul (2002)
10.1016/S0896-6273(01)00512-8 / Neuron / Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins by Annaert (2001)
10.1242/jcs.111.24.3645 / J. Cell Sci. / The presenilin protein family member SPE-4 localizes to an ER/Golgi derived organelle and is required for proper cytoplasmic partitioning during Caenorhabditis elegans spermatogenesis by Arduengo (1998)
10.1074/jbc.273.6.3205 / J. Biol. Chem. / The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100–150-kDa molecular mass complex by Capell (1998)
10.1242/jcs.113.11.1857 / J. Cell Sci. / Proteolytic processing and cell biological functions of the amyloid precursor protein by De Strooper (2000)
10.1038/34910 / Nature / Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein by De Strooper (1998)
10.1038/19083 / Nature / A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain by De Strooper (1999)
10.1001/archneur.57.10.1454 / Arch. Neurol. / Novel presenilin 1 mutations associated with early onset of dementia in a family with both early-onset and late-onset Alzheimer disease by Devi (2000)
10.1016/S1534-5807(02)00189-2 / Dev. Cell / aph-1 and pen-2 are required for Notch pathway signaling, γ-secretase cleavage of βAPP, and presenilin protein accumulation by Francis (2002)
10.1523/JNEUROSCI.19-19-08435.1999 / J. Neurosci. / Drosophila presenilin is required for neuronal differentiation and affects notch subcellular localization and signaling by Guo (1999)
10.1073/pnas.93.4.1683 / Proc. Natl. Acad. Sci. U. S. A. / Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain by Kopan (1996)
10.1074/jbc.M208164200 / J. Biol. Chem. / Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-β precursor protein and Notch by Lee (2002)
10.1038/35015085 / Nature / Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1 by Li (2000)
10.1074/jbc.M201979200 / J. Biol. Chem. / Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain by May (2002)
10.1006/dbio.2000.9960 / Dev. Biol. / Notch signaling: from the outside in by Mumm (2000)
10.1126/science.1065412 / Science / γ-Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase by Ni (2001)
10.1002/(SICI)1098-1004(1999)13:3<256::AID-HUMU11>3.0.CO;2-P / Hum. Mutat. / Pathogenic presenilin 1 mutations (P436S and I143F) in early-onset Alzheimer's disease in the UK. Mutations in brief no. 223 Online by Palmer (1999)
10.1097/00001756-199512000-00071 / NeuroReport / A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene by Perez-Tur (1995)
10.1093/hmg/11.9.1037 / Hum. Mol. Genet. / Identification of a novel family of presenilin homologues by Ponting (2002)
10.1074/jbc.272.39.24536 / J. Biol. Chem. / Endoproteolytic processing and stabilization of wild-type and mutant presenilin by Ratovitski (1997)
10.1073/pnas.96.6.3263 / Proc. Natl. Acad. Sci. U. S. A. / Evidence for a physical interaction between presenilin and Notch by Ray (1999)
10.1212/WNL.57.4.621 / Neurology / Screening for PS1 mutations in a referral-based series of AD cases: 21 novel mutations by Rogaeva (2001)
10.1083/jcb.115.3.587 / J. Cell Biol. / A conserved family of nuclear phosphoproteins localized to sites of polymerase II transcription by Roth (1991)
10.1038/30756 / Nature / Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain by Schroeter (1998)
10.1038/19866 / Nature / Translating cell biology into therapeutic advances in Alzheimer's disease by Selkoe (1999)
10.1152/physrev.2001.81.2.741 / Physiol. Rev. / Alzheimer's disease: genes, proteins, and therapy by Selkoe (2001)
10.1038/35041097 / Nat. Cell Biol. / Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases by Steiner (2000)
10.1074/jbc.C200469200 / J. Biol. Chem. / PEN-2 is an integral component of the γ-secretase complex required for coordinated expression of presenilin and nicastrin by Steiner (2002)
10.1097/00001756-199810050-00034 / NeuroReport / Two novel presenilin-1 mutations (Ser169Leu and Pro436Gln) associated with very early onset Alzheimer's disease by Taddei (1998)
10.1074/jbc.M205352200 / J. Biol. Chem. / The mechanism of γ-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals by Takasugi (2002)
10.1038/nature01506 / Nature / The role of presenilin cofactors in the γ-secretase complex by Takasugi (2003)
10.1016/S0896-6273(00)80291-3 / Neuron / Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo by Thinakaran (1996)
10.1074/jbc.272.45.28415 / J. Biol. Chem. / Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors by Thinakaran (1997)
10.1074/jbc.M011152200 / J. Biol. Chem. / The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and γ-secretase activities of presenilins by Tomita (2001)
10.1126/science.1070925 / Science / Identification of signal peptide peptidase, a presenilin-type aspartic protease by Weihofen (2002)
10.1021/bi982562p / Biochemistry / Peptidomimetic probes and molecular modeling suggest that Alzheimer's g-secretase is an intramembrane-cleaving aspartyl protease by Wolfe (1999)
10.1038/19077 / Nature / Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity by Wolfe (1999)
10.1073/pnas.97.16.9299 / Proc. Natl. Acad. Sci. U. S. A. / Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid β-protein generation by Xia (2000)
10.1073/pnas.132045399 / Proc. Natl. Acad. Sci. U. S. A. / The aspartate-257 of presenilin 1 is indispensable for mouse development and production of β-amyloid peptides through β-catenin-independent mechanisms by Xia (2002)
10.1074/jbc.273.26.16470 / J. Biol. Chem. / The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains β-catenin by Yu (1998)
10.1038/35024009 / Nature / Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing by Yu (2000)

Dates

Type	When
Created	21 years, 6 months ago (Feb. 28, 2004, 5:31 a.m.)
Deposited	4 years, 2 months ago (June 14, 2021, 6:58 p.m.)
Indexed	3 months, 1 week ago (May 26, 2025, 11:24 a.m.)
Issued	21 years, 5 months ago (April 1, 2004)
Published	21 years, 5 months ago (April 1, 2004)
Published Print	21 years, 5 months ago (April 1, 2004)

Funders 0

None

BibTeX

@article{Wang_2004, title={Conserved “PAL” sequence in presenilins is essential for γ-secretase activity, but not required for formation or stabilization of γ-secretase complexes}, volume={15}, ISSN={0969-9961}, url={http://dx.doi.org/10.1016/j.nbd.2003.12.008}, DOI={10.1016/j.nbd.2003.12.008}, number={3}, journal={Neurobiology of Disease}, publisher={Elsevier BV}, author={Wang, Jun and Brunkan, Anne L and Hecimovic, Silva and Walker, Emily and Goate, Alison}, year={2004}, month=apr, pages={654–666} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        5,
        26
      ]
    ],
    "date-time": "2025-05-26T15:24:13Z",
    "timestamp": 1748273053700
  },
  "reference-count": 41,
  "publisher": "Elsevier BV",
  "issue": "3",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2004,
            4,
            1
          ]
        ],
        "date-time": "2004-04-01T00:00:00Z",
        "timestamp": 1080777600000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2004,
        4
      ]
    ]
  },
  "DOI": "10.1016/j.nbd.2003.12.008",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        2,
        28
      ]
    ],
    "date-time": "2004-02-28T10:31:43Z",
    "timestamp": 1077964303000
  },
  "page": "654-666",
  "source": "Crossref",
  "is-referenced-by-count": 57,
  "title": "Conserved \u201cPAL\u201d sequence in presenilins is essential for \u03b3-secretase activity, but not required for formation or stabilization of \u03b3-secretase complexes",
  "prefix": "10.1016",
  "volume": "15",
  "author": [
    {
      "given": "Jun",
      "family": "Wang",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Anne L",
      "family": "Brunkan",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Silva",
      "family": "Hecimovic",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Emily",
      "family": "Walker",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Alison",
      "family": "Goate",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "269",
      "DOI": "10.1006/nbdi.2001.0473",
      "article-title": "A presenilin 1 mutation associated with familial frontotemporal dementia inhibits \u03b3-secretase cleavage of APP and notch",
      "volume": "9",
      "author": "Amtul",
      "year": "2002",
      "journal-title": "Neurobiol. Dis."
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "579",
      "DOI": "10.1016/S0896-6273(01)00512-8",
      "article-title": "Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins",
      "volume": "32",
      "author": "Annaert",
      "year": "2001",
      "journal-title": "Neuron"
    },
    {
      "issue": "Pt 24",
      "key": "10.1016/j.nbd.2003.12.008_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "3645",
      "DOI": "10.1242/jcs.111.24.3645",
      "article-title": "The presenilin protein family member SPE-4 localizes to an ER/Golgi derived organelle and is required for proper cytoplasmic partitioning during Caenorhabditis elegans spermatogenesis",
      "volume": "111",
      "author": "Arduengo",
      "year": "1998",
      "journal-title": "J. Cell Sci."
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "3205",
      "DOI": "10.1074/jbc.273.6.3205",
      "article-title": "The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100\u2013150-kDa molecular mass complex",
      "volume": "273",
      "author": "Capell",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "issue": "Pt 11",
      "key": "10.1016/j.nbd.2003.12.008_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "1857",
      "DOI": "10.1242/jcs.113.11.1857",
      "article-title": "Proteolytic processing and cell biological functions of the amyloid precursor protein",
      "volume": "113",
      "author": "De Strooper",
      "year": "2000",
      "journal-title": "J. Cell Sci."
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "387",
      "DOI": "10.1038/34910",
      "article-title": "Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein",
      "volume": "391",
      "author": "De Strooper",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "518",
      "DOI": "10.1038/19083",
      "article-title": "A presenilin-1-dependent \u03b3-secretase-like protease mediates release of Notch intracellular domain",
      "volume": "398",
      "author": "De Strooper",
      "year": "1999",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "1454",
      "DOI": "10.1001/archneur.57.10.1454",
      "article-title": "Novel presenilin 1 mutations associated with early onset of dementia in a family with both early-onset and late-onset Alzheimer disease",
      "volume": "57",
      "author": "Devi",
      "year": "2000",
      "journal-title": "Arch. Neurol."
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "85",
      "DOI": "10.1016/S1534-5807(02)00189-2",
      "article-title": "aph-1 and pen-2 are required for Notch pathway signaling, \u03b3-secretase cleavage of \u03b2APP, and presenilin protein accumulation",
      "volume": "3",
      "author": "Francis",
      "year": "2002",
      "journal-title": "Dev. Cell"
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "8435",
      "DOI": "10.1523/JNEUROSCI.19-19-08435.1999",
      "article-title": "Drosophila presenilin is required for neuronal differentiation and affects notch subcellular localization and signaling",
      "volume": "19",
      "author": "Guo",
      "year": "1999",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "1683",
      "DOI": "10.1073/pnas.93.4.1683",
      "article-title": "Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain",
      "volume": "93",
      "author": "Kopan",
      "year": "1996",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "45013",
      "DOI": "10.1074/jbc.M208164200",
      "article-title": "Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-\u03b2 precursor protein and Notch",
      "volume": "277",
      "author": "Lee",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "689",
      "DOI": "10.1038/35015085",
      "article-title": "Photoactivated \u03b3-secretase inhibitors directed to the active site covalently label presenilin 1",
      "volume": "405",
      "author": "Li",
      "year": "2000",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "18736",
      "DOI": "10.1074/jbc.M201979200",
      "article-title": "Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain",
      "volume": "277",
      "author": "May",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "151",
      "DOI": "10.1006/dbio.2000.9960",
      "article-title": "Notch signaling: from the outside in",
      "volume": "228",
      "author": "Mumm",
      "year": "2000",
      "journal-title": "Dev. Biol."
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "2179",
      "DOI": "10.1126/science.1065412",
      "article-title": "\u03b3-Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase",
      "volume": "294",
      "author": "Ni",
      "year": "2001",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "256",
      "DOI": "10.1002/(SICI)1098-1004(1999)13:3<256::AID-HUMU11>3.0.CO;2-P",
      "article-title": "Pathogenic presenilin 1 mutations (P436S and I143F) in early-onset Alzheimer's disease in the UK. Mutations in brief no. 223 Online",
      "volume": "13",
      "author": "Palmer",
      "year": "1999",
      "journal-title": "Hum. Mutat."
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "297",
      "DOI": "10.1097/00001756-199512000-00071",
      "article-title": "A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene",
      "volume": "7",
      "author": "Perez-Tur",
      "year": "1995",
      "journal-title": "NeuroReport"
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "1037",
      "DOI": "10.1093/hmg/11.9.1037",
      "article-title": "Identification of a novel family of presenilin homologues",
      "volume": "11",
      "author": "Ponting",
      "year": "2002",
      "journal-title": "Hum. Mol. Genet."
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "24536",
      "DOI": "10.1074/jbc.272.39.24536",
      "article-title": "Endoproteolytic processing and stabilization of wild-type and mutant presenilin",
      "volume": "272",
      "author": "Ratovitski",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "3263",
      "DOI": "10.1073/pnas.96.6.3263",
      "article-title": "Evidence for a physical interaction between presenilin and Notch",
      "volume": "96",
      "author": "Ray",
      "year": "1999",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "621",
      "DOI": "10.1212/WNL.57.4.621",
      "article-title": "Screening for PS1 mutations in a referral-based series of AD cases: 21 novel mutations",
      "volume": "57",
      "author": "Rogaeva",
      "year": "2001",
      "journal-title": "Neurology"
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "587",
      "DOI": "10.1083/jcb.115.3.587",
      "article-title": "A conserved family of nuclear phosphoproteins localized to sites of polymerase II transcription",
      "volume": "115",
      "author": "Roth",
      "year": "1991",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "382",
      "DOI": "10.1038/30756",
      "article-title": "Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain",
      "volume": "393",
      "author": "Schroeter",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "A23",
      "DOI": "10.1038/19866",
      "article-title": "Translating cell biology into therapeutic advances in Alzheimer's disease",
      "volume": "399",
      "author": "Selkoe",
      "year": "1999",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "741",
      "DOI": "10.1152/physrev.2001.81.2.741",
      "article-title": "Alzheimer's disease: genes, proteins, and therapy",
      "volume": "81",
      "author": "Selkoe",
      "year": "2001",
      "journal-title": "Physiol. Rev."
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "848",
      "DOI": "10.1038/35041097",
      "article-title": "Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases",
      "volume": "2",
      "author": "Steiner",
      "year": "2000",
      "journal-title": "Nat. Cell Biol."
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "39062",
      "DOI": "10.1074/jbc.C200469200",
      "article-title": "PEN-2 is an integral component of the \u03b3-secretase complex required for coordinated expression of presenilin and nicastrin",
      "volume": "277",
      "author": "Steiner",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "3335",
      "DOI": "10.1097/00001756-199810050-00034",
      "article-title": "Two novel presenilin-1 mutations (Ser169Leu and Pro436Gln) associated with very early onset Alzheimer's disease",
      "volume": "9",
      "author": "Taddei",
      "year": "1998",
      "journal-title": "NeuroReport"
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "50198",
      "DOI": "10.1074/jbc.M205352200",
      "article-title": "The mechanism of \u03b3-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals",
      "volume": "277",
      "author": "Takasugi",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "438",
      "DOI": "10.1038/nature01506",
      "article-title": "The role of presenilin cofactors in the \u03b3-secretase complex",
      "volume": "422",
      "author": "Takasugi",
      "year": "2003",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "181",
      "DOI": "10.1016/S0896-6273(00)80291-3",
      "article-title": "Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo",
      "volume": "17",
      "author": "Thinakaran",
      "year": "1996",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "28415",
      "DOI": "10.1074/jbc.272.45.28415",
      "article-title": "Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors",
      "volume": "272",
      "author": "Thinakaran",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "33273",
      "DOI": "10.1074/jbc.M011152200",
      "article-title": "The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and \u03b3-secretase activities of presenilins",
      "volume": "276",
      "author": "Tomita",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "2215",
      "DOI": "10.1126/science.1070925",
      "article-title": "Identification of signal peptide peptidase, a presenilin-type aspartic protease",
      "volume": "296",
      "author": "Weihofen",
      "year": "2002",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "4720",
      "DOI": "10.1021/bi982562p",
      "article-title": "Peptidomimetic probes and molecular modeling suggest that Alzheimer's g-secretase is an intramembrane-cleaving aspartyl protease",
      "volume": "38",
      "author": "Wolfe",
      "year": "1999",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "513",
      "DOI": "10.1038/19077",
      "article-title": "Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and \u03b3-secretase activity",
      "volume": "398",
      "author": "Wolfe",
      "year": "1999",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "9299",
      "DOI": "10.1073/pnas.97.16.9299",
      "article-title": "Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid \u03b2-protein generation",
      "volume": "97",
      "author": "Xia",
      "year": "2000",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "8760",
      "DOI": "10.1073/pnas.132045399",
      "article-title": "The aspartate-257 of presenilin 1 is indispensable for mouse development and production of \u03b2-amyloid peptides through \u03b2-catenin-independent mechanisms",
      "volume": "99",
      "author": "Xia",
      "year": "2002",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "16470",
      "DOI": "10.1074/jbc.273.26.16470",
      "article-title": "The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains \u03b2-catenin",
      "volume": "273",
      "author": "Yu",
      "year": "1998",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.nbd.2003.12.008_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "48",
      "DOI": "10.1038/35024009",
      "article-title": "Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and \u03b2APP processing",
      "volume": "407",
      "author": "Yu",
      "year": "2000",
      "journal-title": "Nature"
    }
  ],
  "container-title": "Neurobiology of Disease",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0969996103002730?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0969996103002730?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        6,
        14
      ]
    ],
    "date-time": "2021-06-14T22:58:38Z",
    "timestamp": 1623711518000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0969996103002730"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2004,
        4
      ]
    ]
  },
  "references-count": 41,
  "journal-issue": {
    "issue": "3",
    "published-print": {
      "date-parts": [
        [
          2004,
          4
        ]
      ]
    }
  },
  "alternative-id": [
    "S0969996103002730"
  ],
  "URL": "http://dx.doi.org/10.1016/j.nbd.2003.12.008",
  "relation": {},
  "ISSN": [
    "0969-9961"
  ],
  "subject": [],
  "container-title-short": "Neurobiology of Disease",
  "published": {
    "date-parts": [
      [
        2004,
        4
      ]
    ]
  }
}