10.1016/j.molimm.2004.07.034
Crossref journal-article
Elsevier BV
Molecular Immunology (78)
Bibliography

Smyth, M. J., Cretney, E., Kelly, J. M., Westwood, J. A., Street, S. E. A., Yagita, H., Takeda, K., Dommelen, S. L. H. van, Degli-Esposti, M. A., & Hayakawa, Y. (2005). Activation of NK cell cytotoxicity. Molecular Immunology, 42(4), 501–510.

Authors 10
  1. Mark J. Smyth (first)
  2. Erika Cretney (additional)
  3. Janice M. Kelly (additional)
  4. Jennifer A. Westwood (additional)
  5. Shayna E.A. Street (additional)
  6. Hideo Yagita (additional)
  7. Kazuyoshi Takeda (additional)
  8. Serani L.H. van Dommelen (additional)
  9. Mariapia A. Degli-Esposti (additional)
  10. Yoshihiro Hayakawa (additional)
References 95 Referenced 544
  1. 10.1126/science.1070884 / Science / Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors by Arase (2002)
  2. 10.4049/jimmunol.149.4.1115 / J. Immunol. / Involvement of CD28 in MHC-unrestricted cytotoxicity mediated by a human natural killer leukemia cell line by Azuma (1992)
  3. 10.1007/BF00167085 / Immunogenetics / The genes encoding NK cell granule serine proteases, human tryptase-2 (TRYP2) and human granzyme A (HFSP), both map to chromosome 5q11–q12 and define a new locus for cytotoxic lymphocyte granule tryptases by Baker (1994)
  4. 10.1016/S1074-7613(00)80058-8 / Immunity / Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation by Beresford (1999)
  5. 10.1146/annurev.immunol.17.1.189 / Annu. Rev. Immunol. / Natural killer cells in antiviral defense: function and regulation by innate cytokines by Biron (1999)
  6. 10.1182/blood.V92.11.4248 / Blood / Role of spontaneous and interleukin-2-induced natural killer cell activity in the cytotoxicity and rejection of Fas+ and Fas− tumor cells by Bradley (1998)
  7. 10.4049/jimmunol.172.4.2048 / J. Immunol. / IL-21 induces the functional maturation of murine NK cells by Brady (2004)
  8. 10.1126/science.1060042 / Science / Vital involvement of a natural killer cell activation receptor in resistance to viral infection by Brown (2001)
  9. 10.1128/MCB.19.12.8604 / Mol. Cell. Biol. / Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin by Browne (1999)
  10. 10.1084/jem.185.12.2053 / J. Exp. Med. / A new mechanism of NK cell cytotoxicity activation: the CD40–CD40 ligand interaction by Carbone (1997)
  11. 10.1016/S1074-7613(00)80222-8 / Immunity / Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice by Cerwenka (2000)
  12. 10.1073/pnas.201238598 / Proc. Natl. Acad. Sci. U.S.A. / Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo by Cerwenka (2001)
  13. 10.1038/35095564 / Nat. Rev. Immunol. / Natural killer cells, viruses and cancer by Cerwenka (2001)
  14. 10.1016/S0952-7915(03)00097-9 / Curr. Opin. Immunol. / Granulysin by Clayberger (2003)
  15. 10.1016/S1074-7613(01)00095-4 / Immunity / ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor by Cosman (2001)
  16. 10.4049/jimmunol.168.3.1356 / J. Immunol. / Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice by Cretney (2002)
  17. 10.1002/1521-4141(200101)31:1<39::AID-IMMU39>3.0.CO;2-1 / Eur. J. Immunol. / Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity by Davis (2001)
  18. 10.1002/jlb.65.5.535 / J. Leukoc. Biol. / To die or not to die – the quest of the TRAIL receptors by Degli-Esposti (1999)
  19. 10.1038/77793 / Nat. Immunol. / Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages by Diefenbach (2000)
  20. 10.1038/35093109 / Nature / Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity by Diefenbach (2001)
  21. 10.1038/ni858 / Nat. Immunol. / Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D by Diefenbach (2002)
  22. 10.1038/ni714 / Nat. Immunol. / Specific and nonspecific NK cell activation during virus infection by Dokun (2001)
  23. 10.1002/j.1460-2075.1995.tb00097.x / EMBO J. / Granzyme A-deficient mice retain potent cell-mediated cytotoxicity by Ebnet (1995)
  24. 10.1038/ni885 / Nat. Immunol. / Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A by Fan (2003)
  25. 10.4049/jimmunol.161.4.1758 / J. Immunol. / Granulysin-induced apoptosis. I. Involvement of at least two distinct pathways by Gamen (1998)
  26. {'key': '10.1016/j.molimm.2004.07.034_bib26', 'first-page': '2730', 'article-title': 'Expression of B7-1 by highly metastatic mouse T lymphomas induces optimal natural killer cell-mediated cytotoxicity', 'volume': '55', 'author': 'Geldhof', 'year': '1995', 'journal-title': 'Cancer Res.'} / Cancer Res. / Expression of B7-1 by highly metastatic mouse T lymphomas induces optimal natural killer cell-mediated cytotoxicity by Geldhof (1995)
  27. 10.4049/jimmunol.168.1.73 / J. Immunol. / Requirement for NK cells in CD40 ligand-mediated rejection of Philadelphia chromosome-positive acute lymphoblastic leukemia cells by Gruber (2002)
  28. 10.4049/jimmunol.163.2.583 / J. Immunol. / Differential antitumor effects of administration of recombinant IL-18 or recombinant IL-12 are mediated primarily by Fas–Fas ligand- and perforin-induced tumor apoptosis, respectively by Hashimoto (1999)
  29. 10.4049/jimmunol.169.10.5377 / J. Immunol. / Cutting edge: tumor rejection mediated by NKG2D receptor–ligand interaction is dependent upon perforin by Hayakawa (2002)
  30. 10.4049/jimmunol.172.1.123 / J. Immunol. / NK cell TRAIL eliminates immature dendritic cells in vivo and limits dendritic cell vaccination efficacy by Hayakawa (2004)
  31. 10.1016/0092-8674(94)90376-X / Cell / Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells by Heusel (1994)
  32. 10.1038/16717 / Nature / ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28 by Hutloff (1999)
  33. 10.1016/S1074-7613(02)00333-3 / Immunity / The role of the NKG2D immunoreceptor in immune cell activation and natural killing by Jamieson (2002)
  34. 10.1038/369031a0 / Nature / Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice by Kagi (1994)
  35. 10.1038/ni746 / Nat. Immunol. / Induction of tumor-specific T cell memory by NK cell-mediated tumor rejection by Kelly (2002)
  36. 10.1007/BF02602778 / Immunogenetics / Cloning and expression of the recombinant mouse natural killer cell granzyme Met-ase-1 by Kelly (1996)
  37. 10.4049/jimmunol.168.9.4472 / J. Immunol. / A role for IFN-gamma in primary and secondary immunity generated by NK cell-sensitive tumor-expressing CD80 in vivo by Kelly (2002)
  38. 10.1074/jbc.M401670200 / J. Biol. Chem. / Granzyme M mediates a novel form of perforin-dependent cell death by Kelly (2004)
  39. 10.1038/ni799 / Nat. Immunol. / MCMV glycoprotein gp40 confers virus resistance to CD8+ T cells and NK cells in vivo by Krmpotic (2002)
  40. 10.1146/annurev.immunol.16.1.359 / Annu. Rev. Immunol. / NK cell receptors by Lanier (1998)
  41. 10.1038/ng0501-42 / Nat. Genet. / Susceptibility to mouse cytomegalovirus is associated with deletion of an activating natural killer cell receptor of the C-type lectin superfamily by Lee (2001)
  42. 10.1006/smim.1998.0154 / Semin. Immunol. / Control of lymphocyte function through CD27–CD70 interactions by Lens (1998)
  43. 10.1084/jem.20021973 / J. Exp. Med. / NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules by Lodoen (2003)
  44. 10.4049/jimmunol.162.10.5910 / J. Immunol. / Triggering of murine NK cells by CD40 and CD86 (B7-2) by Martin-Fontecha (1999)
  45. 10.1016/S1074-7613(02)00286-8 / Immunity / Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B–serglycin complexes into target cells without plasma membrane pore formation by Metkar (2002)
  46. 10.1016/S0092-8674(00)00140-9 / Cell / Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis by Motyka (2000)
  47. 10.1128/JVI.73.2.1665-1667.1999 / J. Virol. / Perforin is essential for control of ectromelia virus but not related poxviruses in mice by Mullbacher (1999)
  48. 10.1073/pnas.96.24.13950 / Proc. Natl. Acad. Sci. U.S.A. / Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes by Mullbacher (1999)
  49. 10.4049/jimmunol.161.4.1901 / J. Immunol. / Antitumor effect of CD40 ligand: elicitation of local and systemic antitumor responses by IL-12 and B7 by Nakajima (1998)
  50. 10.1128/JVI.77.8.4539-4545.2003 / J. Virol. / The human cytomegalovirus protein UL16 mediates increased resistance to natural killer cell cytotoxicity through resistance to cytolytic proteins by Odeberg (2003)
  51. 10.4049/jimmunol.169.7.3676 / J. Immunol. / Inducible costimulator costimulates cytotoxic activity and IFN-gamma production in activated murine NK cells by Ogasawara (2002)
  52. 10.1073/pnas.96.15.8627 / Proc. Natl. Acad. Sci. U.S.A. / Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo by Pham (1999)
  53. 10.1073/pnas.93.23.13090 / Proc. Natl. Acad. Sci. U.S.A. / Long-range disruption of gene expression by a selectable marker cassette by Pham (1996)
  54. 10.1097/00002030-200303070-00005 / Aids / Perforin expression in T cells and virological response to PEG-interferon alpha2b in HIV-1 infection by Portales (2003)
  55. 10.1016/j.abb.2003.12.005 / Arch. Biochem. Biophys. / Subsite specificities of granzyme M: a study of inhibitors and newly synthesized thiobenzyl ester substrates by Rukamp (2004)
  56. 10.1002/1521-4141(200111)31:11<3138::AID-IMMU3138>3.0.CO;2-B / Eur. J. Immunol. / Antiviral response by natural killer cells through TRAIL gene induction by IFN-alpha/beta by Sato (2001)
  57. 10.1084/jem.171.5.1469 / J. Exp. Med. / Cmv-1, a genetic locus that controls murine cytomegalovirus replication in the spleen by Scalzo (1990)
  58. 10.4049/jimmunol.167.4.2068 / J. Immunol. / A central role for death receptor-mediated apoptosis in the rejection of tumors by NK cells by Screpanti (2001)
  59. {'key': '10.1016/j.molimm.2004.07.034_bib59', 'first-page': '207', 'article-title': 'Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis is an important endogenous mechanism for resistance to liver metastases in murine renal cancer', 'volume': '63', 'author': 'Seki', 'year': '2003', 'journal-title': 'Cancer Res.'} / Cancer Res. / Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis is an important endogenous mechanism for resistance to liver metastases in murine renal cancer by Seki (2003)
  60. 10.1084/jem.176.6.1521 / J. Exp. Med. / Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions by Shi (1992)
  61. 10.1073/pnas.092258599 / Proc. Natl. Acad. Sci. U.S.A. / Recognition of a virus-encoded ligand by a natural killer cell activation receptor by Smith (2002)
  62. 10.4049/jimmunol.161.1.7 / J. Immunol. / Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptors by Smith (1998)
  63. 10.1084/jem.193.6.661 / J. Exp. Med. / Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis by Smyth (2001)
  64. 10.1038/nrc928 / Nat. Rev. Cancer / New aspects of natural-killer-cell surveillance and therapy of cancer by Smyth (2002)
  65. 10.4049/jimmunol.163.3.1350 / J. Immunol. / Multiple deficiencies underlie NK cell inactivity in lymphotoxin-alpha gene-targeted mice by Smyth (1999)
  66. 10.1084/jem.188.9.1611 / J. Exp. Med. / An essential role for tumor necrosis factor in natural killer cell-mediated tumor rejection in the peritoneum by Smyth (1998)
  67. 10.4049/jimmunol.154.12.6299 / J. Immunol. / Expression of recombinant human granzyme B. A processing and activation role for dipeptidyl peptidase I by Smyth (1995)
  68. 10.1002/jlb.60.5.555 / J. Leukoc. Biol. / Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies by Smyth (1996)
  69. 10.4049/jimmunol.151.11.6195 / J. Immunol. / Met-ase: cloning and distinct chromosomal location of a serine protease preferentially expressed in human natural killer cells by Smyth (1993)
  70. 10.4049/jimmunol.171.2.515 / J. Immunol. / Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection by Smyth (2003)
  71. 10.1016/S1074-7613(02)00502-2 / Immunity / Nature's TRAIL – on a path to cancer immunotherapy by Smyth (2003)
  72. 10.4049/jimmunol.165.5.2665 / J. Immunol. / The anti-tumor activity of IL-12: mechanisms of innate immunity that are model and dose dependent by Smyth (2000)
  73. 10.4049/jimmunol.162.11.6658 / J. Immunol. / Perforin is a major contributor to NK cell control of tumor metastasis by Smyth (1999)
  74. 10.1084/jem.191.4.661 / J. Exp. Med. / Differential tumor surveillance by natural killer (NK) and NKT cells by Smyth (2000)
  75. 10.1016/0167-5699(95)80122-7 / Immunol. Today / Granzymes: exogenous proteinases that induce target cell apoptosis by Smyth (1995)
  76. 10.1016/S0021-9258(18)35783-1 / J. Biol. Chem. / Purification and cloning of a novel serine protease, RNK-Met-1, from the granules of a rat natural killer cell leukemia by Smyth (1992)
  77. 10.1126/science.282.5386.121 / Science / An antimicrobial activity of cytolytic T cells mediated by granulysin by Stenger (1998)
  78. 10.1126/science.286.5446.1957 / Science / Perforin gene defects in familial hemophagocytic lymphohistiocytosis by Stepp (1999)
  79. 10.1182/blood.V97.1.192 / Blood / Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasis by Street (2001)
  80. 10.1084/jem.20031981 / J. Exp. Med. / Innate immune surveillance of spontaneous B cell lymphomas by natural killer cells and {gamma}{delta} T cells by Street (2004)
  81. 10.1038/83416 / Nat. Med. / Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells by Takeda (2001)
  82. 10.4049/jimmunol.164.4.1741 / J. Immunol. / CD27-mediated activation of murine NK cells by Takeda (2000)
  83. 10.1084/jem.20011171 / J. Exp. Med. / Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development by Takeda (2002)
  84. 10.1006/cimm.2001.1896 / Cell. Immunol. / Involvement of tumor necrosis factor-related apoptosis-inducing ligand in NK cell-mediated and IFN-gamma-dependent suppression of subcutaneous tumor growth by Takeda (2001)
  85. 10.1128/JVI.71.1.267-275.1997 / J. Virol. / Distinct organ-dependent mechanisms for the control of murine cytomegalovirus infection by natural killer cells by Tay (1997)
  86. 10.1074/jbc.273.51.34115 / J. Biol. Chem. / Gene structure, expression pattern, and biological activity of mouse killer cell activating receptor-associated protein (KARAP)/DAP-12 by Tomasello (1998)
  87. 10.1074/jbc.271.8.4127 / J. Biol. Chem. / Localization of granzyme B in the nucleus. A putative role in the mechanism of cytotoxic lymphocyte-mediated apoptosis by Trapani (1996)
  88. 10.1016/S0952-7915(00)00094-7 / Curr. Opin. Immunol. / Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo by Trapani (2000)
  89. 10.1038/nri911 / Nat. Rev. Immunol. / Functional significance of the perforin/granzyme cell death pathway by Trapani (2002)
  90. 10.4049/jimmunol.166.1.89 / J. Immunol. / Anti-CD40 antibody induces antitumor and antimetastatic effects: the role of NK cells by Turner (2001)
  91. 10.1002/eji.1830251246 / Eur. J. Immunol. / Perforin dependence of natural killer cell-mediated tumor control in vivo by van den Broek (1995)
  92. 10.4049/jimmunol.172.2.757 / J. Immunol. / Cutting edge: novel priming of tumor-specific immunity by NKG2D-triggered NK cell-mediated tumor rejection and Th1-independent CD4+ T cell pathway by Westwood (2004)
  93. 10.1006/smim.1995.0013 / Semin. Immunol. / A family of murine NK cell receptors specific for target cell MHC class I molecules by Yokoyama (1995)
  94. 10.1038/45582 / Nature / T-cell co-stimulation through B7RP-1 and ICOS by Yoshinaga (1999)
  95. 10.1038/ni930 / Nat. Immunol. / NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases by Zompi (2003)
Dates
Type When
Created 20 years, 11 months ago (Sept. 14, 2004, 2:27 p.m.)
Deposited 2 years, 3 months ago (April 29, 2023, 5:28 a.m.)
Indexed 2 days, 12 hours ago (Aug. 23, 2025, 1 a.m.)
Issued 20 years, 6 months ago (Feb. 1, 2005)
Published 20 years, 6 months ago (Feb. 1, 2005)
Published Print 20 years, 6 months ago (Feb. 1, 2005)
Funders 0

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@article{Smyth_2005, title={Activation of NK cell cytotoxicity}, volume={42}, ISSN={0161-5890}, url={http://dx.doi.org/10.1016/j.molimm.2004.07.034}, DOI={10.1016/j.molimm.2004.07.034}, number={4}, journal={Molecular Immunology}, publisher={Elsevier BV}, author={Smyth, Mark J. and Cretney, Erika and Kelly, Janice M. and Westwood, Jennifer A. and Street, Shayna E.A. and Yagita, Hideo and Takeda, Kazuyoshi and Dommelen, Serani L.H. van and Degli-Esposti, Mariapia A. and Hayakawa, Yoshihiro}, year={2005}, month=feb, pages={501–510} }