DOI: 10.1016/j.molcel.2009.01.021. Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates

Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates

10.1016/j.molcel.2009.01.021

Crossref journal-article

Elsevier BV

Molecular Cell (78)

Bibliography

Korolchuk, V. I., Mansilla, A., Menzies, F. M., & Rubinsztein, D. C. (2009). Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates. Molecular Cell, 33(4), 517â527.

Authors 4

Viktor I. Korolchuk (first)
Alicia Mansilla (additional)
Fiona M. Menzies (additional)
David C. Rubinsztein (additional)

References 36 Referenced 553

10.1093/emboj/16.13.3797 / EMBO J. / β-catenin is a target for the ubiquitin-proteasome pathway by Aberle (1997)
10.1038/nature06022 / Nature / Global changes to the ubiquitin system in Huntington's disease by Bennett (2007)
10.1083/jcb.200507002 / J. Cell Biol. / p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death by Bjorkoy (2005)
10.1101/gad.436407 / Genes Dev. / HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates by Boyault (2007)
10.1038/75406 / Nat. Biotechnol. / Short-lived green fluorescent proteins for quantifying ubiquitin/proteasome-dependent proteolysis in living cells by Dantuma (2000)
10.1073/pnas.012585199 / Proc. Natl. Acad. Sci. USA / Budding yeast Dsk2p is a polyubiquitin-binding protein that can interact with the proteasome by Funakoshi (2002)
10.1074/jbc.M608787200 / J. Biol. Chem. / p62 accumulates and enhances aggregate formation in model systems of familial amyotrophic lateral sclerosis by Gal (2007)
10.1038/nature04724 / Nature / Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice by Hara (2006)
10.1038/387296a0 / Nature / Mdm2 promotes the rapid degradation of p53 by Haupt (1997)
10.1074/jbc.M508786200 / J. Biol. Chem. / HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin by Iwata (2005)
10.1074/jbc.M107190200 / J. Biol. Chem. / Cell cycle-dependent proteolysis and phosphorylation of human Mcm10 by Izumi (2001)
10.1016/S1097-2765(00)00040-X / Mol. Cell / The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome by Kleijnen (2000)
10.1111/j.1365-2443.2007.01099.x / Genes Cells / Involvement of valosin-containing protein (VCP)/p97 in the formation and clearance of abnormal protein aggregates by Kobayashi (2007)
10.1083/jcb.200412022 / J. Cell Biol. / Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice by Komatsu (2005)
10.1038/nature04723 / Nature / Loss of autophagy in the central nervous system causes neurodegeneration in mice by Komatsu (2006)
10.1016/j.cell.2007.10.035 / Cell / Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice by Komatsu (2007)
10.1038/387299a0 / Nature / Regulation of p53 stability by Mdm2 by Kubbutat (1997)
10.1083/jcb.152.4.657 / J. Cell Biol. / Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells by Mizushima (2001)
10.1111/j.1471-4159.2004.02692.x / J. Neurochem. / Increased expression of p62 in expanded polyglutamine-expressing cells and its association with polyglutamine inclusions by Nagaoka (2004)
10.1136/jmg.36.10.739 / J. Med. Genet. / A molecular investigation of true dominance in Huntington's disease by Narain (1999)
10.1083/jcb.200711108 / J. Cell Biol. / Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain by Nezis (2008)
10.1038/nature05853 / Nature / HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS by Pandey (2007)
10.1074/jbc.M212841200 / J. Biol. Chem. / Rad23 ubiquitin-associated domains (UBA) inhibit 26 S proteasome-catalyzed proteolysis by sequestering lysine 48-linked polyubiquitin chains by Raasi (2003)
10.1093/hmg/11.9.1107 / Hum. Mol. Genet. / Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy by Ravikumar (2002)
10.1016/j.cell.2004.11.013 / Cell / A series of ubiquitin binding factors connects CDC48/p97 to substrate multiubiquitylation and proteasomal targeting by Richly (2005)
10.1038/nature05291 / Nature / The roles of intracellular protein-degradation pathways in neurodegeneration by Rubinsztein (2006)
10.1074/jbc.M609532200 / J. Biol. Chem. / Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and [α]-synuclein by Sarkar (2007)
10.1016/j.febslet.2006.12.027 / FEBS Lett. / Sequestosome 1/p62–more than just a scaffold by Seibenhener (2007)
10.1016/j.tibs.2007.03.005 / Trends Biochem. Sci. / Life on the edge: a link between gene expression levels and aggregation rates of human proteins by Tartaglia (2007)
10.1074/jbc.M300227200 / J. Biol. Chem. / [α]-synuclein is degraded by both autophagy and the proteasome by Webb (2003)
10.1093/hmg/ddi426 / Hum. Mol. Genet. / Inclusion body myopathy-associated mutations in p97/VCP impair endoplasmic reticulum-associated degradation by Weihl (2006)
10.1091/mbc.E06-05-0432 / Mol. Biol. Cell / Valosin-containing protein (p97) is a regulator of endoplasmic reticulum stress and of the degradation of N-end rule and ubiquitin-fusion degradation pathway substrates in mammalian cells by Wojcik (2006)
10.1155/JBB/2006/62079 / J. Biomed. Biotechnol. / Signaling, polyubiquitination, trafficking, and inclusions: sequestosome 1/p62's role in neurodegenerative disease by Wooten (2006)
10.1038/ncb1007-1102 / Nat. Cell Biol. / Autophagosome formation: core machinery and adaptations by Xie (2007)
10.1016/j.jsb.2006.01.005 / J. Struct. Biol. / Diverse functions with a common regulator: ubiquitin takes command of an AAA ATPase by Ye (2006)
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Dates

Type	When
Created	16 years, 6 months ago (Feb. 27, 2009, 4:28 a.m.)
Deposited	6 years, 3 months ago (May 18, 2019, 5:21 a.m.)
Indexed	1 day, 19 hours ago (Sept. 4, 2025, 10:15 a.m.)
Issued	16 years, 7 months ago (Feb. 1, 2009)
Published	16 years, 7 months ago (Feb. 1, 2009)
Published Print	16 years, 7 months ago (Feb. 1, 2009)

Funders 0

None

BibTeX

@article{Korolchuk_2009, title={Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates}, volume={33}, ISSN={1097-2765}, url={http://dx.doi.org/10.1016/j.molcel.2009.01.021}, DOI={10.1016/j.molcel.2009.01.021}, number={4}, journal={Molecular Cell}, publisher={Elsevier BV}, author={Korolchuk, Viktor I. and Mansilla, Alicia and Menzies, Fiona M. and Rubinsztein, David C.}, year={2009}, month=feb, pages={517–527} }

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      "volume": "171",
      "author": "Bjorkoy",
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      "article-title": "HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates",
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      "author": "Boyault",
      "year": "2007",
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      "DOI": "10.1038/75406",
      "article-title": "Short-lived green fluorescent proteins for quantifying ubiquitin/proteasome-dependent proteolysis in living cells",
      "volume": "18",
      "author": "Dantuma",
      "year": "2000",
      "journal-title": "Nat. Biotechnol."
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      "volume": "99",
      "author": "Funakoshi",
      "year": "2002",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
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      "first-page": "11068",
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      "article-title": "p62 accumulates and enhances aggregate formation in model systems of familial amyotrophic lateral sclerosis",
      "volume": "282",
      "author": "Gal",
      "year": "2007",
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    },
    {
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      "author": "Kobayashi",
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      "author": "Komatsu",
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      "author": "Komatsu",
      "year": "2007",
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      "author": "Kubbutat",
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      "author": "Mizushima",
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      "first-page": "739",
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      "volume": "36",
      "author": "Narain",
      "year": "1999",
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      "volume": "180",
      "author": "Nezis",
      "year": "2008",
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      "DOI": "10.1038/nature05853",
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      "author": "Pandey",
      "year": "2007",
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      "volume": "278",
      "author": "Raasi",
      "year": "2003",
      "journal-title": "J. Biol. Chem."
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    {
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      "volume": "11",
      "author": "Ravikumar",
      "year": "2002",
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      "author": "Richly",
      "year": "2005",
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      "first-page": "780",
      "DOI": "10.1038/nature05291",
      "article-title": "The roles of intracellular protein-degradation pathways in neurodegeneration",
      "volume": "443",
      "author": "Rubinsztein",
      "year": "2006",
      "journal-title": "Nature"
    },
    {
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      "first-page": "5641",
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      "article-title": "Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and [\u03b1]-synuclein",
      "volume": "282",
      "author": "Sarkar",
      "year": "2007",
      "journal-title": "J. Biol. Chem."
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      "first-page": "175",
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      "article-title": "Sequestosome 1/p62\u2013more than just a scaffold",
      "volume": "581",
      "author": "Seibenhener",
      "year": "2007",
      "journal-title": "FEBS Lett."
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      "first-page": "204",
      "DOI": "10.1016/j.tibs.2007.03.005",
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      "volume": "32",
      "author": "Tartaglia",
      "year": "2007",
      "journal-title": "Trends Biochem. Sci."
    },
    {
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      "first-page": "25009",
      "DOI": "10.1074/jbc.M300227200",
      "article-title": "[\u03b1]-synuclein is degraded by both autophagy and the proteasome",
      "volume": "278",
      "author": "Webb",
      "year": "2003",
      "journal-title": "J.\u00a0Biol. Chem."
    },
    {
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      "doi-asserted-by": "crossref",
      "first-page": "189",
      "DOI": "10.1093/hmg/ddi426",
      "article-title": "Inclusion body myopathy-associated mutations in p97/VCP impair endoplasmic reticulum-associated degradation",
      "volume": "15",
      "author": "Weihl",
      "year": "2006",
      "journal-title": "Hum. Mol. Genet."
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      "first-page": "4606",
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      "article-title": "Valosin-containing protein (p97) is a regulator of endoplasmic reticulum stress and of the degradation of N-end rule and ubiquitin-fusion degradation pathway substrates in mammalian cells",
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      "author": "Wojcik",
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      "volume": "2006",
      "author": "Wooten",
      "year": "2006",
      "journal-title": "J. Biomed. Biotechnol."
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