DOI: 10.1016/j.molcel.2008.01.003. A La-Related Protein Modulates 7SK snRNP Integrity to Suppress P-TEFb-Dependent Transcriptional Elongation and Tumorigenesis

10.1016/j.molcel.2008.01.003

Crossref journal-article

Elsevier BV

Molecular Cell (78)

Bibliography

He, N., Jahchan, N. S., Hong, E., Li, Q., Bayfield, M. A., Maraia, R. J., Luo, K., & Zhou, Q. (2008). A La-Related Protein Modulates 7SK snRNP Integrity to Suppress P-TEFb-Dependent Transcriptional Elongation and Tumorigenesis. Molecular Cell, 29(5), 588â599.

Authors 8

Nanhai He (first)
Nadine S. Jahchan (additional)
Eunmee Hong (additional)
Qiang Li (additional)
Mark A. Bayfield (additional)
Richard J. Maraia (additional)
Kunxin Luo (additional)
Qiang Zhou (additional)

References 35 Referenced 199

10.1074/jbc.M102306200 / J. Biol. Chem. / Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo by Chao (2001)
10.1074/jbc.M310044200 / J. Biol. Chem. / Phosphorylated positive transcription elongation factor b (P-TEFb) is tagged for inhibition through association with 7SK snRNA by Chen (2004)
10.1016/S1046-2023(03)00032-X / Methods / Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures by Debnath (2003)
10.1002/jcp.20528 / J. Cell. Physiol. / siRNA depletion of 7SK snRNA induces apoptosis but does not affect expression of the HIV-1 LTR or P-TEFb-dependent cellular genes by Haaland (2005)
10.1128/MCB.00778-06 / Mol. Cell. Biol. / Modulation of a P-TEFb functional equilibrium for the global control of cell growth and differentiation by He (2006)
10.1038/nsmb1110 / Nat. Struct. Mol. Biol. / Separate RNA-binding surfaces on the multifunctional La protein mediate distinguishable activities in tRNA maturation by Huang (2006)
10.1016/S1097-2765(00)00034-4 / Mol. Cell / Control of transfer RNA maturation by phosphorylation of the human La antigen on serine 366 by Intine (2000)
10.1016/j.molcel.2005.06.027 / Mol. Cell / The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription by Jang (2005)
10.1016/j.molcel.2007.06.027 / Mol. Cell / Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme by Jeronimo (2007)
10.1074/jbc.M502712200 / J. Biol. Chem. / Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186 by Li (2005)
10.1016/j.molcel.2006.01.004 / Mol. Cell / The La protein-RNA complex surfaces by Maraia (2006)
10.1074/jbc.271.43.27176 / J. Biol. Chem. / Control of RNA polymerase II elongation potential by a novel carboxyl-terminal domain kinase by Marshall (1996)
10.1158/1078-0432.CCR-04-1107 / Clin. Cancer Res. / Prognostic significance of tissue transglutaminase in drug resistant and metastatic breast cancer by Mehta (2004)
10.1128/MCB.23.14.4859-4869.2003 / Mol. Cell. Biol. / MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner by Michels (2003)
{'key': '10.1016/j.molcel.2008.01.003_bib15', 'first-page': '3641', 'article-title': 'Instabilotyping reveals unique mutational spectra in microsatellite-unstable gastric cancers', 'volume': '62', 'author': 'Mori', 'year': '2002', 'journal-title': 'Cancer Res.'} / Cancer Res. / Instabilotyping reveals unique mutational spectra in microsatellite-unstable gastric cancers by Mori (2002)
10.1038/35104581 / Nature / 7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes by Nguyen (2001)
10.1016/j.molcel.2006.06.014 / Mol. Cell / Controlling the elongation phase of transcription with P-TEFb by Peterlin (2006)
10.1093/genetics/162.3.1259 / Genetics / Regulation of larval hematopoiesis in Drosophila melanogaster: a role for the multi sex combs gene by Remillieux-Leschelle (2002)
10.1038/nm778 / Nat. Med. / Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy by Sano (2002)
10.1007/s10911-004-1402-z / J. Mammary Gland Biol. Neoplasia / Use of three-dimensional basement membrane cultures to model oncogene-induced changes in mammary epithelial morphogenesis by Shaw (2004)
10.1101/gad.999002 / Genes Dev. / CDK-9/cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C. elegans embryo by Shim (2002)
10.1016/j.molcel.2005.10.027 / Mol. Cell / Structural basis for recognition and sequestration of UUU(OH) 3′ temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen by Teplova (2006)
10.1016/j.matbio.2005.09.006 / Matrix Biol. / Role of PTHrp and PTHrp-engaged pathways in MCF-7 cells migration/invasion by Torricelli (2006)
10.1002/jcp.20502 / J. Cell. Physiol. / Increased HEXIM1 expression during erythroleukemia and neuroblastoma cell differentiation by Turano (2006)
10.1073/pnas.0403954101 / Proc. Natl. Acad. Sci. USA / Cre-lox-regulated conditional RNA interference from transgenes by Ventura (2004)
{'key': '10.1016/j.molcel.2008.01.003_bib26', 'first-page': '3432', 'article-title': 'Structural analyses of the 7SK ribonucleoprotein (RNP), the most abundant human small RNP of unknown function', 'volume': '11', 'author': 'Wassarman', 'year': '1991', 'journal-title': 'Mol. Cell. Biol.'} / Mol. Cell. Biol. / Structural analyses of the 7SK ribonucleoprotein (RNP), the most abundant human small RNP of unknown function by Wassarman (1991)
10.1016/j.ejca.2003.09.027 / Eur. J. Cancer / RNA polymerase III transcription–a battleground for tumour suppressors and oncogenes by White (2004)
10.1146/annurev.biochem.71.090501.150003 / Annu. Rev. Biochem. / The La protein by Wolin (2002)
10.1093/emboj/19.7.1650 / EMBO J. / U snRNP assembly in yeast involves the La protein by Xue (2000)
10.1038/35104575 / Nature / The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription by Yang (2001)
10.1016/j.molcel.2005.06.029 / Mol. Cell / Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4 by Yang (2005)
10.1016/S1097-2765(03)00388-5 / Mol. Cell / Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA by Yik (2003)
10.1074/jbc.M500912200 / J. Biol. Chem. / Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription by Yik (2005)
10.1128/MMBR.00011-06 / Microbiol. Mol. Biol. Rev. / The Yin and Yang of P-TEFb regulation: implications for human immunodeficiency virus gene expression and global control of cell growth and differentiation by Zhou (2006)
10.1101/gad.11.20.2622 / Genes Dev. / Transcription elongation factor P-TEFb is required for HIV-1 tat transactivation in vitro by Zhu (1997)

Dates

Type	When
Created	17 years, 6 months ago (Feb. 2, 2008, 7:47 a.m.)
Deposited	3 years, 9 months ago (Nov. 3, 2021, 3:31 p.m.)
Indexed	3 weeks, 4 days ago (Aug. 6, 2025, 9:39 a.m.)
Issued	17 years, 6 months ago (March 1, 2008)
Published	17 years, 6 months ago (March 1, 2008)
Published Print	17 years, 6 months ago (March 1, 2008)

Funders 0

None

BibTeX

@article{He_2008, title={A La-Related Protein Modulates 7SK snRNP Integrity to Suppress P-TEFb-Dependent Transcriptional Elongation and Tumorigenesis}, volume={29}, ISSN={1097-2765}, url={http://dx.doi.org/10.1016/j.molcel.2008.01.003}, DOI={10.1016/j.molcel.2008.01.003}, number={5}, journal={Molecular Cell}, publisher={Elsevier BV}, author={He, Nanhai and Jahchan, Nadine S. and Hong, Eunmee and Li, Qiang and Bayfield, Mark A. and Maraia, Richard J. and Luo, Kunxin and Zhou, Qiang}, year={2008}, month=mar, pages={588–599} }

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      "volume": "279",
      "author": "Chen",
      "year": "2004",
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      "volume": "205",
      "author": "Haaland",
      "year": "2005",
      "journal-title": "J. Cell. Physiol."
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      "volume": "26",
      "author": "He",
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      "author": "Huang",
      "year": "2006",
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      "volume": "280",
      "author": "Li",
      "year": "2005",
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      "author": "Maraia",
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      "author": "Mehta",
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      "author": "Nguyen",
      "year": "2001",
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      "volume": "8",
      "author": "Sano",
      "year": "2002",
      "journal-title": "Nat. Med."
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      "author": "Shim",
      "year": "2002",
      "journal-title": "Genes Dev."
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      "volume": "21",
      "author": "Teplova",
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      "volume": "25",
      "author": "Torricelli",
      "year": "2006",
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      "first-page": "603",
      "DOI": "10.1002/jcp.20502",
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      "volume": "206",
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      "year": "2006",
      "journal-title": "J. Cell. Physiol."
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      "first-page": "10380",
      "DOI": "10.1073/pnas.0403954101",
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      "volume": "101",
      "author": "Ventura",
      "year": "2004",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.molcel.2008.01.003_bib26",
      "first-page": "3432",
      "article-title": "Structural analyses of the 7SK ribonucleoprotein (RNP), the most abundant human small RNP of unknown function",
      "volume": "11",
      "author": "Wassarman",
      "year": "1991",
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      "article-title": "RNA polymerase III transcription\u2013a battleground for tumour suppressors and oncogenes",
      "volume": "40",
      "author": "White",
      "year": "2004",
      "journal-title": "Eur. J. Cancer"
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      "doi-asserted-by": "crossref",
      "first-page": "375",
      "DOI": "10.1146/annurev.biochem.71.090501.150003",
      "article-title": "The La protein",
      "volume": "71",
      "author": "Wolin",
      "year": "2002",
      "journal-title": "Annu. Rev. Biochem."
    },
    {
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      "first-page": "1650",
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      "article-title": "U snRNP assembly in yeast involves the La protein",
      "volume": "19",
      "author": "Xue",
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      "journal-title": "EMBO J."
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    {
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      "DOI": "10.1038/35104575",
      "article-title": "The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription",
      "volume": "414",
      "author": "Yang",
      "year": "2001",
      "journal-title": "Nature"
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