DOI: 10.1016/j.molcel.2006.07.012. Structural Basis for CoREST-Dependent Demethylation of Nucleosomes by the Human LSD1 Histone Demethylase

Structural Basis for CoREST-Dependent Demethylation of Nucleosomes by the Human LSD1 Histone Demethylase

10.1016/j.molcel.2006.07.012

Crossref journal-article

Elsevier BV

Molecular Cell (78)

Bibliography

Yang, M., Gocke, C. B., Luo, X., Borek, D., Tomchick, D. R., Machius, M., Otwinowski, Z., & Yu, H. (2006). Structural Basis for CoREST-Dependent Demethylation of Nucleosomes by the Human LSD1 Histone Demethylase. Molecular Cell, 23(3), 377â387.

Authors 8

Maojun Yang (first)
Christian B. Gocke (additional)
Xuelian Luo (additional)
Dominika Borek (additional)
Diana R. Tomchick (additional)
Mischa Machius (additional)
Zbyszek Otwinowski (additional)
Hongtao Yu (additional)

References 48 Referenced 294

{'key': '10.1016/j.molcel.2006.07.012_bib1', 'first-page': '87', 'article-title': 'The SANT domain: a putative DNA-binding domain in the SWI-SNF and ADA complexes, the transcriptional co-repressor N-CoR and TFIIIB', 'volume': '21', 'author': 'Aasland', 'year': '1996', 'journal-title': 'Trends Biochem. Sci.'} / Trends Biochem. Sci. / The SANT domain: a putative DNA-binding domain in the SWI-SNF and ADA complexes, the transcriptional co-repressor N-CoR and TFIIIB by Aasland (1996)
10.1016/j.cell.2005.01.001 / Cell / Genomic maps and comparative analysis of histone modifications in human and mouse by Bernstein (2005)
10.1016/S0969-2126(99)80037-9 / Structure / A 30-angstrom-long U-shaped catalytic tunnel in the crystal structure of polyamine oxidase by Binda (1999)
10.1021/bi002751j / Biochemistry / Structural bases for inhibitor binding and catalysis in polyamine oxidase by Binda (2001)
10.1016/S1097-2765(02)00634-2 / Mol. Cell / Essential role for the SANT domain in the functioning of multiple chromatin remodeling enzymes by Boyer (2002)
10.1038/nrm1314 / Nat. Rev. Mol. Cell Biol. / The SANT domain: a unique histone-tail-binding module? by Boyer (2004)
10.1107/S0907444994003112 / Acta Crystallogr. D Biol. Crystallogr. / The CCP4 suite: programs for protein crystallography (1994)
10.1016/j.cell.2006.04.024 / Cell / Structural insights into histone demethylation by JMJD2 family members by Chen (2006)
10.1107/S0907444997011980 / Acta Crystallogr. D Biol. Crystallogr. / Miscellaneous algorithms for density modification by Cowtan (1998)
10.1073/pnas.0510949103 / Proc. Natl. Acad. Sci. USA / Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes by Da (2006)
10.1016/S0022-2836(02)00386-8 / J. Mol. Biol. / Solvent mediated interactions in the structure of the nucleosome core particle at 1.9 Å resolution by Davey (2002)
10.1107/S0907444904019158 / Acta Crystallogr. D Biol. Crystallogr. / Coot: model-building tools for molecular graphics by Emsley (2004)
10.1074/jbc.M509549200 / J. Biol. Chem. / Human histone demethylase LSD1 reads the histone code by Forneris (2005)
10.1016/j.febslet.2005.03.015 / FEBS Lett. / Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process by Forneris (2005)
10.1016/S1097-2765(03)00273-9 / Mol. Cell / Crystal structure and functional analysis of a nucleosome recognition module of the remodeling factor ISWI by Grune (2003)
10.1074/jbc.M208992200 / J. Biol. Chem. / A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes by Hakimi (2003)
10.1016/j.sbi.2005.10.006 / Curr. Opin. Struct. Biol. / Structure and activity of enzymes that remove histone modifications by Holbert (2005)
10.1074/jbc.M007372200 / J. Biol. Chem. / Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1 by Humphrey (2001)
10.1126/science.1063127 / Science / Translating the histone code by Jenuwein (2001)
10.1038/nature04853 / Nature / The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36 by Klose (2006)
10.1038/nature04021 / Nature / An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation by Lee (2005)
10.1016/S0959-437X(03)00026-1 / Curr. Opin. Genet. Dev. / Structure and dynamic behavior of nucleosomes by Luger (2003)
10.1016/j.sbi.2005.03.006 / Curr. Opin. Struct. Biol. / Nucleosome and chromatin fiber dynamics by Luger (2005)
10.1038/38444 / Nature / Crystal structure of the nucleosome core particle at 2.8 Å resolution by Luger (1997)
10.1038/nrm1761 / Nat. Rev. Mol. Cell Biol. / The diverse functions of histone lysine methylation by Martin (2005)
10.1101/gad.355405 / Genes Dev. / Histone H3 tail positioning and acetylation by the c-Myb but not the v-Myb DNA-binding SANT domain by Mo (2005)
10.1107/S0907444996012255 / Acta Crystallogr. D Biol. Crystallogr. / Refinement of macromolecular structures by the maximum-likelihood method by Murshudov (1997)
{'key': '10.1016/j.molcel.2006.07.012_bib28', 'series-title': 'Isomorphous Replacement and Anomalous Scattering', 'first-page': '80', 'article-title': 'Maximum likelihood refinement of heavy atom parameters', 'author': 'Otwinowski', 'year': '1991'} / Isomorphous Replacement and Anomalous Scattering / Maximum likelihood refinement of heavy atom parameters by Otwinowski (1991)
10.1016/S0076-6879(97)76066-X / Methods Enzymol. / Processing X-ray diffraction data collected in oscillation mode by Otwinowski (1997)
10.1038/8263 / Nat. Struct. Biol. / Automated protein model building combined with iterative structure refinement by Perrakis (1999)
10.1021/bi050983i / Biochemistry / Lys300 plays a major role in the catalytic mechanism of maize polyamine oxidase by Polticelli (2005)
10.1038/nsmb1022 / Nat. Struct. Mol. Biol. / Structure and chromosomal DNA binding of the SWIRM domain by Qian (2005)
10.1038/nature01080 / Nature / Active genes are tri-methylated at K4 of histone H3 by Santos-Rosa (2002)
10.1107/S0907444902011678 / Acta Crystallogr. D Biol. Crystallogr. / Substructure solution with SHELXD by Schneider (2002)
10.1524/zkri.217.12.644.20662 / Zeitschrift Fur Kristallographie / Macromolecular phasing with SHELXE by Sheldrick (2002)
10.1038/nature01550 / Nature / Coordinated histone modifications mediated by a CtBP co-repressor complex by Shi (2003)
10.1016/j.cell.2004.12.012 / Cell / Histone demethylation mediated by the nuclear amine oxidase homolog LSD1 by Shi (2004)
10.1016/j.molcel.2005.08.027 / Mol. Cell / Regulation of LSD1 histone demethylase activity by its associated factors by Shi (2005)
10.1038/nsmb1113 / Nat. Struct. Mol. Biol. / Crystal structure and mechanism of human lysine-specific demethylase-1 by Stavropoulos (2006)
10.1016/S0092-8674(01)00636-5 / Cell / Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter by Tahirov (2002)
10.1016/j.str.2005.12.004 / Structure / Solution structure of the SWIRM domain of human histone demethylase LSD1 by Tochio (2006)
10.1038/nature04433 / Nature / Histone demethylation by a family of JmjC domain-containing proteins by Tsukada (2006)
10.1016/S0076-6879(96)74024-7 / Methods Enzymol. / In vitro analysis of transcription factor binding to nucleosomes and nucleosome disruption/displacement by Utley (1996)
10.1016/j.cell.2006.03.028 / Cell / Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases by Whetstine (2006)
10.1016/j.cell.2005.08.022 / Cell / Taking LSD 1 to a new high by Wysocka (2005)
10.1016/j.cell.2006.03.027 / Cell / JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor by Yamane (2006)
10.1073/pnas.98.4.1454 / Proc. Natl. Acad. Sci. USA / CoREST is an integral component of the CoREST- human histone deacetylase complex by You (2001)
10.1093/emboj/cdg326 / EMBO J. / A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation by Yu (2003)

Dates

Type	When
Created	19 years ago (Aug. 17, 2006, 1:08 p.m.)
Deposited	6 years, 4 months ago (April 20, 2019, 2:41 p.m.)
Indexed	1 month ago (July 23, 2025, 8:26 a.m.)
Issued	19 years ago (Aug. 1, 2006)
Published	19 years ago (Aug. 1, 2006)
Published Print	19 years ago (Aug. 1, 2006)

Funders 0

None

BibTeX

@article{Yang_2006, title={Structural Basis for CoREST-Dependent Demethylation of Nucleosomes by the Human LSD1 Histone Demethylase}, volume={23}, ISSN={1097-2765}, url={http://dx.doi.org/10.1016/j.molcel.2006.07.012}, DOI={10.1016/j.molcel.2006.07.012}, number={3}, journal={Molecular Cell}, publisher={Elsevier BV}, author={Yang, Maojun and Gocke, Christian B. and Luo, Xuelian and Borek, Dominika and Tomchick, Diana R. and Machius, Mischa and Otwinowski, Zbyszek and Yu, Hongtao}, year={2006}, month=aug, pages={377–387} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        7,
        23
      ]
    ],
    "date-time": "2025-07-23T12:26:53Z",
    "timestamp": 1753273613157
  },
  "reference-count": 48,
  "publisher": "Elsevier BV",
  "issue": "3",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2006,
            8,
            1
          ]
        ],
        "date-time": "2006-08-01T00:00:00Z",
        "timestamp": 1154390400000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    },
    {
      "start": {
        "date-parts": [
          [
            2013,
            8,
            22
          ]
        ],
        "date-time": "2013-08-22T00:00:00Z",
        "timestamp": 1377129600000
      },
      "content-version": "vor",
      "delay-in-days": 2578,
      "URL": "https://www.elsevier.com/open-access/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2006,
        8
      ]
    ]
  },
  "DOI": "10.1016/j.molcel.2006.07.012",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2006,
        8,
        17
      ]
    ],
    "date-time": "2006-08-17T17:08:06Z",
    "timestamp": 1155834486000
  },
  "page": "377-387",
  "source": "Crossref",
  "is-referenced-by-count": 294,
  "title": "Structural Basis for CoREST-Dependent Demethylation of Nucleosomes by the Human LSD1 Histone Demethylase",
  "prefix": "10.1016",
  "volume": "23",
  "author": [
    {
      "given": "Maojun",
      "family": "Yang",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Christian B.",
      "family": "Gocke",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Xuelian",
      "family": "Luo",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Dominika",
      "family": "Borek",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Diana R.",
      "family": "Tomchick",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Mischa",
      "family": "Machius",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Zbyszek",
      "family": "Otwinowski",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Hongtao",
      "family": "Yu",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/j.molcel.2006.07.012_bib1",
      "first-page": "87",
      "article-title": "The SANT domain: a putative DNA-binding domain in the SWI-SNF and ADA complexes, the transcriptional co-repressor N-CoR and TFIIIB",
      "volume": "21",
      "author": "Aasland",
      "year": "1996",
      "journal-title": "Trends Biochem. Sci."
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib2",
      "doi-asserted-by": "crossref",
      "first-page": "169",
      "DOI": "10.1016/j.cell.2005.01.001",
      "article-title": "Genomic maps and comparative analysis of histone modifications in human and mouse",
      "volume": "120",
      "author": "Bernstein",
      "year": "2005",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib3",
      "doi-asserted-by": "crossref",
      "first-page": "265",
      "DOI": "10.1016/S0969-2126(99)80037-9",
      "article-title": "A 30-angstrom-long U-shaped catalytic tunnel in the crystal structure of polyamine oxidase",
      "volume": "7",
      "author": "Binda",
      "year": "1999",
      "journal-title": "Structure"
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib4",
      "doi-asserted-by": "crossref",
      "first-page": "2766",
      "DOI": "10.1021/bi002751j",
      "article-title": "Structural bases for inhibitor binding and catalysis in polyamine oxidase",
      "volume": "40",
      "author": "Binda",
      "year": "2001",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "935",
      "DOI": "10.1016/S1097-2765(02)00634-2",
      "article-title": "Essential role for the SANT domain in the functioning of multiple chromatin remodeling enzymes",
      "volume": "10",
      "author": "Boyer",
      "year": "2002",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib6",
      "doi-asserted-by": "crossref",
      "first-page": "158",
      "DOI": "10.1038/nrm1314",
      "article-title": "The SANT domain: a unique histone-tail-binding module?",
      "volume": "5",
      "author": "Boyer",
      "year": "2004",
      "journal-title": "Nat. Rev. Mol. Cell Biol."
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "760",
      "DOI": "10.1107/S0907444994003112",
      "article-title": "The CCP4 suite: programs for protein crystallography",
      "volume": "50",
      "year": "1994",
      "journal-title": "Acta Crystallogr. D Biol. Crystallogr."
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "691",
      "DOI": "10.1016/j.cell.2006.04.024",
      "article-title": "Structural insights into histone demethylation by JMJD2 family members",
      "volume": "125",
      "author": "Chen",
      "year": "2006",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "487",
      "DOI": "10.1107/S0907444997011980",
      "article-title": "Miscellaneous algorithms for density modification",
      "volume": "54",
      "author": "Cowtan",
      "year": "1998",
      "journal-title": "Acta Crystallogr. D Biol. Crystallogr."
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib10",
      "doi-asserted-by": "crossref",
      "first-page": "2057",
      "DOI": "10.1073/pnas.0510949103",
      "article-title": "Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes",
      "volume": "103",
      "author": "Da",
      "year": "2006",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib11",
      "doi-asserted-by": "crossref",
      "first-page": "1097",
      "DOI": "10.1016/S0022-2836(02)00386-8",
      "article-title": "Solvent mediated interactions in the structure of the nucleosome core particle at 1.9 \u00c5 resolution",
      "volume": "319",
      "author": "Davey",
      "year": "2002",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "2126",
      "DOI": "10.1107/S0907444904019158",
      "article-title": "Coot: model-building tools for molecular graphics",
      "volume": "60",
      "author": "Emsley",
      "year": "2004",
      "journal-title": "Acta Crystallogr. D Biol. Crystallogr."
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "41360",
      "DOI": "10.1074/jbc.M509549200",
      "article-title": "Human histone demethylase LSD1 reads the histone code",
      "volume": "280",
      "author": "Forneris",
      "year": "2005",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "2203",
      "DOI": "10.1016/j.febslet.2005.03.015",
      "article-title": "Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process",
      "volume": "579",
      "author": "Forneris",
      "year": "2005",
      "journal-title": "FEBS Lett."
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "449",
      "DOI": "10.1016/S1097-2765(03)00273-9",
      "article-title": "Crystal structure and functional analysis of a nucleosome recognition module of the remodeling factor ISWI",
      "volume": "12",
      "author": "Grune",
      "year": "2003",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "7234",
      "DOI": "10.1074/jbc.M208992200",
      "article-title": "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes",
      "volume": "278",
      "author": "Hakimi",
      "year": "2003",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "673",
      "DOI": "10.1016/j.sbi.2005.10.006",
      "article-title": "Structure and activity of enzymes that remove histone modifications",
      "volume": "15",
      "author": "Holbert",
      "year": "2005",
      "journal-title": "Curr. Opin. Struct. Biol."
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "6817",
      "DOI": "10.1074/jbc.M007372200",
      "article-title": "Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1",
      "volume": "276",
      "author": "Humphrey",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "1074",
      "DOI": "10.1126/science.1063127",
      "article-title": "Translating the histone code",
      "volume": "293",
      "author": "Jenuwein",
      "year": "2001",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib20",
      "doi-asserted-by": "crossref",
      "DOI": "10.1038/nature04853",
      "article-title": "The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36",
      "author": "Klose",
      "year": "2006",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "432",
      "DOI": "10.1038/nature04021",
      "article-title": "An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation",
      "volume": "437",
      "author": "Lee",
      "year": "2005",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "127",
      "DOI": "10.1016/S0959-437X(03)00026-1",
      "article-title": "Structure and dynamic behavior of nucleosomes",
      "volume": "13",
      "author": "Luger",
      "year": "2003",
      "journal-title": "Curr. Opin. Genet. Dev."
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "188",
      "DOI": "10.1016/j.sbi.2005.03.006",
      "article-title": "Nucleosome and chromatin fiber dynamics",
      "volume": "15",
      "author": "Luger",
      "year": "2005",
      "journal-title": "Curr. Opin. Struct. Biol."
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "251",
      "DOI": "10.1038/38444",
      "article-title": "Crystal structure of the nucleosome core particle at 2.8 \u00c5 resolution",
      "volume": "389",
      "author": "Luger",
      "year": "1997",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "838",
      "DOI": "10.1038/nrm1761",
      "article-title": "The diverse functions of histone lysine methylation",
      "volume": "6",
      "author": "Martin",
      "year": "2005",
      "journal-title": "Nat. Rev. Mol. Cell Biol."
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "2447",
      "DOI": "10.1101/gad.355405",
      "article-title": "Histone H3 tail positioning and acetylation by the c-Myb but not the v-Myb DNA-binding SANT domain",
      "volume": "19",
      "author": "Mo",
      "year": "2005",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "240",
      "DOI": "10.1107/S0907444996012255",
      "article-title": "Refinement of macromolecular structures by the maximum-likelihood method",
      "volume": "53",
      "author": "Murshudov",
      "year": "1997",
      "journal-title": "Acta Crystallogr. D Biol. Crystallogr."
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib28",
      "series-title": "Isomorphous Replacement and Anomalous Scattering",
      "first-page": "80",
      "article-title": "Maximum likelihood refinement of heavy atom parameters",
      "author": "Otwinowski",
      "year": "1991"
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "307",
      "DOI": "10.1016/S0076-6879(97)76066-X",
      "article-title": "Processing X-ray diffraction data collected in oscillation mode",
      "volume": "276",
      "author": "Otwinowski",
      "year": "1997",
      "journal-title": "Methods Enzymol."
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "458",
      "DOI": "10.1038/8263",
      "article-title": "Automated protein model building combined with iterative structure refinement",
      "volume": "6",
      "author": "Perrakis",
      "year": "1999",
      "journal-title": "Nat. Struct. Biol."
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "16108",
      "DOI": "10.1021/bi050983i",
      "article-title": "Lys300 plays a major role in the catalytic mechanism of maize polyamine oxidase",
      "volume": "44",
      "author": "Polticelli",
      "year": "2005",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "1078",
      "DOI": "10.1038/nsmb1022",
      "article-title": "Structure and chromosomal DNA binding of the SWIRM domain",
      "volume": "12",
      "author": "Qian",
      "year": "2005",
      "journal-title": "Nat. Struct. Mol. Biol."
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "407",
      "DOI": "10.1038/nature01080",
      "article-title": "Active genes are tri-methylated at K4 of histone H3",
      "volume": "419",
      "author": "Santos-Rosa",
      "year": "2002",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "1772",
      "DOI": "10.1107/S0907444902011678",
      "article-title": "Substructure solution with SHELXD",
      "volume": "58",
      "author": "Schneider",
      "year": "2002",
      "journal-title": "Acta Crystallogr. D Biol. Crystallogr."
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "644",
      "DOI": "10.1524/zkri.217.12.644.20662",
      "article-title": "Macromolecular phasing with SHELXE",
      "volume": "217",
      "author": "Sheldrick",
      "year": "2002",
      "journal-title": "Zeitschrift Fur Kristallographie"
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "735",
      "DOI": "10.1038/nature01550",
      "article-title": "Coordinated histone modifications mediated by a CtBP co-repressor complex",
      "volume": "422",
      "author": "Shi",
      "year": "2003",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "941",
      "DOI": "10.1016/j.cell.2004.12.012",
      "article-title": "Histone demethylation mediated by the nuclear amine oxidase homolog LSD1",
      "volume": "119",
      "author": "Shi",
      "year": "2004",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "857",
      "DOI": "10.1016/j.molcel.2005.08.027",
      "article-title": "Regulation of LSD1 histone demethylase activity by its associated factors",
      "volume": "19",
      "author": "Shi",
      "year": "2005",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "626",
      "DOI": "10.1038/nsmb1113",
      "article-title": "Crystal structure and mechanism of human lysine-specific demethylase-1",
      "volume": "13",
      "author": "Stavropoulos",
      "year": "2006",
      "journal-title": "Nat. Struct. Mol. Biol."
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "57",
      "DOI": "10.1016/S0092-8674(01)00636-5",
      "article-title": "Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter",
      "volume": "108",
      "author": "Tahirov",
      "year": "2002",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "457",
      "DOI": "10.1016/j.str.2005.12.004",
      "article-title": "Solution structure of the SWIRM domain of human histone demethylase LSD1",
      "volume": "14",
      "author": "Tochio",
      "year": "2006",
      "journal-title": "Structure"
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "811",
      "DOI": "10.1038/nature04433",
      "article-title": "Histone demethylation by a family of JmjC domain-containing proteins",
      "volume": "439",
      "author": "Tsukada",
      "year": "2006",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "276",
      "DOI": "10.1016/S0076-6879(96)74024-7",
      "article-title": "In vitro analysis of transcription factor binding to nucleosomes and nucleosome disruption/displacement",
      "volume": "274",
      "author": "Utley",
      "year": "1996",
      "journal-title": "Methods Enzymol."
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib44",
      "doi-asserted-by": "crossref",
      "first-page": "467",
      "DOI": "10.1016/j.cell.2006.03.028",
      "article-title": "Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases",
      "volume": "125",
      "author": "Whetstine",
      "year": "2006",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib45",
      "doi-asserted-by": "crossref",
      "first-page": "654",
      "DOI": "10.1016/j.cell.2005.08.022",
      "article-title": "Taking LSD 1 to a new high",
      "volume": "122",
      "author": "Wysocka",
      "year": "2005",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib46",
      "doi-asserted-by": "crossref",
      "first-page": "483",
      "DOI": "10.1016/j.cell.2006.03.027",
      "article-title": "JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor",
      "volume": "125",
      "author": "Yamane",
      "year": "2006",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib47",
      "doi-asserted-by": "crossref",
      "first-page": "1454",
      "DOI": "10.1073/pnas.98.4.1454",
      "article-title": "CoREST is an integral component of the CoREST- human histone deacetylase complex",
      "volume": "98",
      "author": "You",
      "year": "2001",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.molcel.2006.07.012_bib48",
      "doi-asserted-by": "crossref",
      "first-page": "3403",
      "DOI": "10.1093/emboj/cdg326",
      "article-title": "A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation",
      "volume": "22",
      "author": "Yu",
      "year": "2003",
      "journal-title": "EMBO J."
    }
  ],
  "container-title": "Molecular Cell",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S1097276506004928?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S1097276506004928?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2019,
        4,
        20
      ]
    ],
    "date-time": "2019-04-20T18:41:51Z",
    "timestamp": 1555785711000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S1097276506004928"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2006,
        8
      ]
    ]
  },
  "references-count": 48,
  "journal-issue": {
    "issue": "3",
    "published-print": {
      "date-parts": [
        [
          2006,
          8
        ]
      ]
    }
  },
  "alternative-id": [
    "S1097276506004928"
  ],
  "URL": "http://dx.doi.org/10.1016/j.molcel.2006.07.012",
  "relation": {
    "has-review": [
      {
        "id-type": "doi",
        "id": "10.3410/f.1033693.387975",
        "asserted-by": "object"
      },
      {
        "id-type": "doi",
        "id": "10.3410/f.1033693.388944",
        "asserted-by": "object"
      },
      {
        "id-type": "doi",
        "id": "10.3410/f.1033693.388892",
        "asserted-by": "object"
      }
    ]
  },
  "ISSN": [
    "1097-2765"
  ],
  "subject": [],
  "container-title-short": "Molecular Cell",
  "published": {
    "date-parts": [
      [
        2006,
        8
      ]
    ]
  }
}