DOI: 10.1016/j.molbrainres.2004.09.014. Synuclein, dopamine and oxidative stress: co-conspirators in Parkinson's disease?

Synuclein, dopamine and oxidative stress: co-conspirators in Parkinson's disease?

10.1016/j.molbrainres.2004.09.014

Crossref journal-article

Elsevier BV

Molecular Brain Research (78)

Bibliography

Maguire-Zeiss, K. A., Short, D. W., & Federoff, H. J. (2005). Synuclein, dopamine and oxidative stress: co-conspirators in Parkinsonâs disease? Molecular Brain Research, 134(1), 18â23.

Authors 3

Kathleen A. Maguire-Zeiss (first)
Douglas W. Short (additional)
Howard J. Federoff (additional)

References 65 Referenced 93

10.1093/hmg/8.4.567 / Hum. Mol. Genet. / A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease by Abbas (1999)
10.1016/S0304-3940(00)01049-1 / Neurosci. Lett. / Alpha-synuclein and the Parkinson's disease-related mutant Ala53Thr-alpha-synuclein do not undergo proteasomal degradation in HEK293 and neuronal cells by Ancolio (2000)
10.1038/nrn1434 / Nat. Med. / Oxidative stress in neurodegeneration: cause or consequence? by Andersen (2004)
10.1016/S0006-8993(98)01192-5 / Brain Res. / Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss by Brooks (1999)
10.1038/nm1001-1144 / Nat. Med. / Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease by Chung (2001)
10.1016/S0166-2236(97)01213-7 / Trends Neurosci. / The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease by Clayton (1998)
10.1126/science.1063522 / Science / Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct by Conway (2001)
10.1126/science.1101738 / Science / Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy by Cuervo (2004)
10.1016/S0896-6273(03)00568-3 / Neuron / Parkinson's disease: mechanisms and models by Dauer (2003)
10.1002/neu.10094 / J. Neurobiol. / Overexpression of Parkinson's disease-associated alpha-synucleinA53T by recombinant adeno-associated virus in mice does not increase the vulnerability of dopaminergic neurons to MPTP by Dong (2002)
10.1111/j.1749-6632.1992.tb24537.x / Ann. N. Y. Acad. Sci. / Overview of Parkinson's disease by Duvoisin (1992)
10.1006/exnr.1996.6379 / Exp. Neurol. / Dopamine synthesis, uptake, metabolism, and receptors: relevance to gene therapy of Parkinson's disease by Elsworth (1997)
10.1016/S0006-8993(02)02422-8 / Brain Res. / MPP+ increases alpha-synuclein expression and ERK/MAP-kinase phosphorylation in human neuroblastoma SH-SY5Y cells by Gomez-Santos (2002)
10.1212/WNL.50.5.1346 / Neurology / The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living by Gorell (1998)
10.1126/science.1098966 / Science / Biomedicine. Parkinson's-divergent causes, convergent mechanisms by Greenamyre (2004)
10.1038/70918 / Nat. Med. / NOS knockouts and neuroprotection by Grunewald (1999)
10.1016/S0304-3940(99)00465-6 / Neurosci. Lett. / The Ile93Met mutation in the ubiquitin carboxy-terminal-hydrolase-L1 gene is not observed in European cases with familial Parkinson's disease by Harhangi (1999)
10.1097/00001756-199903170-00011 / NeuroReport / Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro by Hashimoto (1999)
10.1073/pnas.93.5.1956 / Proc. Natl. Acad. Sci. U. S. A. / Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections by Hastings (1996)
10.1046/j.1471-4159.1998.71010338.x / J. Neurochem. / Expression pattern of synucleins (non-Abeta component of Alzheimer's disease amyloid precursor protein/alpha-synuclein) during murine brain development by Hsu (1998)
10.1212/WNL.47.1.160 / Neurology / Clinical analysis of 17 patients in 12 Japanese families with autosomal-recessive type juvenile parkinsonism by Ishikawa (1996)
10.1002/ana.10483 / Ann. Neurol. / Oxidative stress in Parkinson's disease by Jenner (2003)
10.1038/33416 / Nature / Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism by Kitada (1998)
10.1097/00001756-200001170-00041 / NeuroReport / MPTP induces alpha-synuclein aggregation in the substantia nigra of baboons by Kowall (2000)
10.1038/ng0298-106 / Nat. Genet. / Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease by Kruger (1998)
10.1016/S0006-2952(96)00731-9 / Biochem. Pharmacol. / Dopamine- and l-beta-3,4-dihydroxyphenylalanine hydrochloride (l-Dopa)-induced cytotoxicity towards catecholaminergic neuroblastoma SH-SY5Y cells. Effects of oxidative stress and antioxidative factors by Lai (1997)
10.1046/j.1471-4159.1999.0732546.x / J. Neurochem. / Peroxynitrite- and nitrite-induced oxidation of dopamine: implications for nitric oxide in dopaminergic cell loss by LaVoie (1999)
10.1096/fj.00-0334com / FASEB J. / Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis by Lee (2001)
10.1007/s004390050845 / Hum. Genet. / Deletions in the Parkin gene and genetic heterogeneity in a Greek family with early onset Parkinson's disease by Leroy (1998)
10.1074/jbc.M306390200 / J. Biol. Chem. / Proteasomal inhibition by alpha-synuclein filaments and oligomers by Lindersson (2004)
10.1038/nrn983 / Nat. Rev., Neurosci. / Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein by Lotharius (2002)
10.1111/j.1749-6632.2003.tb07473.x / Ann. N. Y. Acad. Sci. / Convergent pathobiologic model of Parkinson's disease by Maguire-Zeiss (2003)
{'key': '10.1016/j.molbrainres.2004.09.014_bib33', 'first-page': '13', 'article-title': 'The herbicide paraquat causes upregulation and aggregation of alpha-synuclein in mice', 'volume': '13', 'author': 'Manning-Bog', 'year': '2001', 'journal-title': 'J. Biol. Chem.'} / J. Biol. Chem. / The herbicide paraquat causes upregulation and aggregation of alpha-synuclein in mice by Manning-Bog (2001)
10.1046/j.1471-4159.2002.00821.x / J. Neurochem. / Impairment of the ubiquitin–proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures by McNaught (2002)
10.1146/annurev.neuro.22.1.123 / Annu. Rev. Neurosci. / Etiology and pathogenesis of Parkinson's disease by Olanow (1999)
10.1523/JNEUROSCI.21-20-08053.2001 / J. Neurosci. / Induction of alpha-synuclein aggregation by intracellular nitrative insult by Paxinou (2001)
10.1111/j.1471-4159.2004.02423.x / J. Neurochem. / Could a loss of alpha-synuclein function put dopaminergic neurons at risk? by Perez (2004)
10.1111/j.1749-6632.2000.tb06901.x / Ann. N. Y. Acad. Sci. / Genetics of Parkinson's disease by Polymeropoulos (2000)
10.1126/science.274.5290.1197 / Science / Mapping of a gene for Parkinson's disease to chromosome 4q21–q23 by Polymeropoulos (1996)
10.1126/science.276.5321.2045 / Science / Mutation in the alpha-synuclein gene identified in families with Parkinson's disease by Polymeropoulos (1997)
10.1523/JNEUROSCI.12-05-01658.1992 / J. Neurosci. / Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity by Przedborski (1992)
10.1073/pnas.93.10.4565 / Proc. Natl. Acad. Sci. U. S. A. / Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity by Przedborski (1996)
10.1046/j.1471-4159.2001.00366.x / J. Neurochem. / Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice by Rathke-Hartlieb (2001)
10.1006/mcne.2002.1173 / Mol. Cell. Neurosci. / Proteasomal inhibition-induced inclusion formation and death in cortical neurons require transcription and ubiquitination by Rideout (2002)
10.1111/j.1365-2990.1995.tb01022.x / Neuropathol. Appl. Neurobiol. / Oxidative stress in Parkinson's disease by Schapira (1995)
10.1212/WNL.46.5.1275 / Neurology / Possible environmental, occupational, and other etiologic factors for Parkinson's disease: a case-control study in Germany by Seidler (1996)
10.1007/s004010100369 / Acta Neuropathol. (Berl.) / Alpha-synuclein has an altered conformation and shows a tight intermolecular interaction with ubiquitin in Lewy bodies by Sharma (2001)
10.1523/JNEUROSCI.22-16-07006.2002 / J. Neurosci. / An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage by Sherer (2002)
10.1111/j.1471-4159.1987.tb03384.x / J. Neurochem. / Biochemical events in the development of parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by Singer (1987)
10.1126/science.1090278 / Science / alpha-Synuclein locus triplication causes Parkinson's disease by Singleton (2003)
10.1523/JNEUROSCI.21-24-09549.2001 / J. Neurosci. / Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death by Stefanis (2001)
10.1038/nm1201-1280 / Nat. Med. / Alpha-synuclein and cytosolic dopamine: stabilizing a bad situation by Sulzer (2001)
10.1056/NEJM200012143432404 / N. Engl. J. Med. / Familial aggregation of Parkinson's disease in Iceland by Sveinbjornsdottir (2000)
10.1093/hmg/9.18.2683 / Hum. Mol. Genet. / Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicity by Tabrizi (2000)
10.1006/mcne.2000.0923 / Mol. Cell. Neurosci. / Reduced neuritic outgrowth and cell adhesion in neuronal cells transfected with human alpha-synuclein by Takenouchi (2001)
10.1093/hmg/10.9.919 / Hum. Mol. Genet. / Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis by Tanaka (2001)
10.1523/JNEUROSCI.20-24-09207.2000 / J. Neurosci. / The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb: implications for Parkinson's disease by Thiruchelvam (2000)
10.1016/S0006-8993(00)02496-3 / Brain Res. / Potentiated and preferential effects of combined paraquat and maneb on nigrostriatal dopamine systems: environmental risk factors for Parkinson's disease? by Thiruchelvam (2000)
10.1016/S0161-813X(02)00092-X / Neurotoxicology / Developmental exposure to the pesticides paraquat and maneb and the Parkinson's disease phenotype by Thiruchelvam (2002)
10.1111/j.0953-816X.2004.03139.x / Eur. J. Neurosci. / Risk factors for dopaminergic neuron loss in human alpha-synuclein transgenic mice by Thiruchelvam (2004)
10.1074/jbc.M308041200 / J. Biol. Chem. / Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function by Tofaris (2003)
10.1086/319522 / Am. J. Hum. Genet. / Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35–p36 by Valente (2001)
10.1126/science.1096284 / Science / Hereditary early-onset Parkinson's disease caused by mutations in PINK1 by Valente (2004)
10.1046/j.1471-4159.2000.740721.x / J. Neurochem. / Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP by Vila (2000)
10.1006/nbdi.2000.0319 / Neurobiol. Dis. / Oxidative stress and genetics in the pathogenesis of Parkinson's disease by Zhang (2000)

Dates

Type	When
Created	20 years, 8 months ago (Dec. 15, 2004, 1:20 p.m.)
Deposited	5 years, 4 months ago (April 4, 2020, 3:07 p.m.)
Indexed	2 months, 3 weeks ago (June 6, 2025, 2:04 a.m.)
Issued	20 years, 6 months ago (March 1, 2005)
Published	20 years, 6 months ago (March 1, 2005)
Published Print	20 years, 6 months ago (March 1, 2005)

Funders 0

None

BibTeX

@article{Maguire_Zeiss_2005, title={Synuclein, dopamine and oxidative stress: co-conspirators in Parkinson’s disease?}, volume={134}, ISSN={0169-328X}, url={http://dx.doi.org/10.1016/j.molbrainres.2004.09.014}, DOI={10.1016/j.molbrainres.2004.09.014}, number={1}, journal={Molecular Brain Research}, publisher={Elsevier BV}, author={Maguire-Zeiss, Kathleen A. and Short, Douglas W. and Federoff, Howard J.}, year={2005}, month=mar, pages={18–23} }

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      "volume": "285",
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      "article-title": "Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss",
      "volume": "823",
      "author": "Brooks",
      "year": "1999",
      "journal-title": "Brain Res."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "1144",
      "DOI": "10.1038/nm1001-1144",
      "article-title": "Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease",
      "volume": "7",
      "author": "Chung",
      "year": "2001",
      "journal-title": "Nat. Med."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib6",
      "doi-asserted-by": "crossref",
      "first-page": "249",
      "DOI": "10.1016/S0166-2236(97)01213-7",
      "article-title": "The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease",
      "volume": "21",
      "author": "Clayton",
      "year": "1998",
      "journal-title": "Trends Neurosci."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "1346",
      "DOI": "10.1126/science.1063522",
      "article-title": "Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct",
      "volume": "294",
      "author": "Conway",
      "year": "2001",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "1292",
      "DOI": "10.1126/science.1101738",
      "article-title": "Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy",
      "volume": "305",
      "author": "Cuervo",
      "year": "2004",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "889",
      "DOI": "10.1016/S0896-6273(03)00568-3",
      "article-title": "Parkinson's disease: mechanisms and models",
      "volume": "39",
      "author": "Dauer",
      "year": "2003",
      "journal-title": "Neuron"
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib10",
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      "volume": "53",
      "author": "Dong",
      "year": "2002",
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    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib11",
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      "first-page": "187",
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      "volume": "144",
      "author": "Elsworth",
      "year": "1997",
      "journal-title": "Exp. Neurol."
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      "volume": "935",
      "author": "Gomez-Santos",
      "year": "2002",
      "journal-title": "Brain Res."
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      "author": "Gorell",
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      "doi-asserted-by": "crossref",
      "first-page": "1120",
      "DOI": "10.1126/science.1098966",
      "article-title": "Biomedicine. Parkinson's-divergent causes, convergent mechanisms",
      "volume": "304",
      "author": "Greenamyre",
      "year": "2004",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "1354",
      "DOI": "10.1038/70918",
      "article-title": "NOS knockouts and neuroprotection",
      "volume": "5",
      "author": "Grunewald",
      "year": "1999",
      "journal-title": "Nat. Med."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib17",
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      "first-page": "1",
      "DOI": "10.1016/S0304-3940(99)00465-6",
      "article-title": "The Ile93Met mutation in the ubiquitin carboxy-terminal-hydrolase-L1 gene is not observed in European cases with familial Parkinson's disease",
      "volume": "270",
      "author": "Harhangi",
      "year": "1999",
      "journal-title": "Neurosci. Lett."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "717",
      "DOI": "10.1097/00001756-199903170-00011",
      "article-title": "Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro",
      "volume": "10",
      "author": "Hashimoto",
      "year": "1999",
      "journal-title": "NeuroReport"
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "1956",
      "DOI": "10.1073/pnas.93.5.1956",
      "article-title": "Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections",
      "volume": "93",
      "author": "Hastings",
      "year": "1996",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "338",
      "DOI": "10.1046/j.1471-4159.1998.71010338.x",
      "article-title": "Expression pattern of synucleins (non-Abeta component of Alzheimer's disease amyloid precursor protein/alpha-synuclein) during murine brain development",
      "volume": "71",
      "author": "Hsu",
      "year": "1998",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "160",
      "DOI": "10.1212/WNL.47.1.160",
      "article-title": "Clinical analysis of 17 patients in 12 Japanese families with autosomal-recessive type juvenile parkinsonism",
      "volume": "47",
      "author": "Ishikawa",
      "year": "1996",
      "journal-title": "Neurology"
    },
    {
      "issue": "Suppl. 3",
      "key": "10.1016/j.molbrainres.2004.09.014_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "S26",
      "DOI": "10.1002/ana.10483",
      "article-title": "Oxidative stress in Parkinson's disease",
      "volume": "53",
      "author": "Jenner",
      "year": "2003",
      "journal-title": "Ann. Neurol."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "605",
      "DOI": "10.1038/33416",
      "article-title": "Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism",
      "volume": "392",
      "author": "Kitada",
      "year": "1998",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "211",
      "DOI": "10.1097/00001756-200001170-00041",
      "article-title": "MPTP induces alpha-synuclein aggregation in the substantia nigra of baboons",
      "volume": "11",
      "author": "Kowall",
      "year": "2000",
      "journal-title": "NeuroReport"
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "106",
      "DOI": "10.1038/ng0298-106",
      "article-title": "Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease",
      "volume": "18",
      "author": "Kruger",
      "year": "1998",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "363",
      "DOI": "10.1016/S0006-2952(96)00731-9",
      "article-title": "Dopamine- and l-beta-3,4-dihydroxyphenylalanine hydrochloride (l-Dopa)-induced cytotoxicity towards catecholaminergic neuroblastoma SH-SY5Y cells. Effects of oxidative stress and antioxidative factors",
      "volume": "53",
      "author": "Lai",
      "year": "1997",
      "journal-title": "Biochem. Pharmacol."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "2546",
      "DOI": "10.1046/j.1471-4159.1999.0732546.x",
      "article-title": "Peroxynitrite- and nitrite-induced oxidation of dopamine: implications for nitric oxide in dopaminergic cell loss",
      "volume": "73",
      "author": "LaVoie",
      "year": "1999",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "916",
      "DOI": "10.1096/fj.00-0334com",
      "article-title": "Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis",
      "volume": "15",
      "author": "Lee",
      "year": "2001",
      "journal-title": "FASEB J."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "424",
      "DOI": "10.1007/s004390050845",
      "article-title": "Deletions in the Parkin gene and genetic heterogeneity in a Greek family with early onset Parkinson's disease",
      "volume": "103",
      "author": "Leroy",
      "year": "1998",
      "journal-title": "Hum. Genet."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "12924",
      "DOI": "10.1074/jbc.M306390200",
      "article-title": "Proteasomal inhibition by alpha-synuclein filaments and oligomers",
      "volume": "279",
      "author": "Lindersson",
      "year": "2004",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "932",
      "DOI": "10.1038/nrn983",
      "article-title": "Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein",
      "volume": "3",
      "author": "Lotharius",
      "year": "2002",
      "journal-title": "Nat. Rev., Neurosci."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "152",
      "DOI": "10.1111/j.1749-6632.2003.tb07473.x",
      "article-title": "Convergent pathobiologic model of Parkinson's disease",
      "volume": "991",
      "author": "Maguire-Zeiss",
      "year": "2003",
      "journal-title": "Ann. N. Y. Acad. Sci."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib33",
      "first-page": "13",
      "article-title": "The herbicide paraquat causes upregulation and aggregation of alpha-synuclein in mice",
      "volume": "13",
      "author": "Manning-Bog",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "301",
      "DOI": "10.1046/j.1471-4159.2002.00821.x",
      "article-title": "Impairment of the ubiquitin\u2013proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures",
      "volume": "81",
      "author": "McNaught",
      "year": "2002",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "123",
      "DOI": "10.1146/annurev.neuro.22.1.123",
      "article-title": "Etiology and pathogenesis of Parkinson's disease",
      "volume": "22",
      "author": "Olanow",
      "year": "1999",
      "journal-title": "Annu. Rev. Neurosci."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "8053",
      "DOI": "10.1523/JNEUROSCI.21-20-08053.2001",
      "article-title": "Induction of alpha-synuclein aggregation by intracellular nitrative insult",
      "volume": "21",
      "author": "Paxinou",
      "year": "2001",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "1318",
      "DOI": "10.1111/j.1471-4159.2004.02423.x",
      "article-title": "Could a loss of alpha-synuclein function put dopaminergic neurons at risk?",
      "volume": "89",
      "author": "Perez",
      "year": "2004",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "28",
      "DOI": "10.1111/j.1749-6632.2000.tb06901.x",
      "article-title": "Genetics of Parkinson's disease",
      "volume": "920",
      "author": "Polymeropoulos",
      "year": "2000",
      "journal-title": "Ann. N. Y. Acad. Sci."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "1197",
      "DOI": "10.1126/science.274.5290.1197",
      "article-title": "Mapping of a gene for Parkinson's disease to chromosome 4q21\u2013q23",
      "volume": "274",
      "author": "Polymeropoulos",
      "year": "1996",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "2045",
      "DOI": "10.1126/science.276.5321.2045",
      "article-title": "Mutation in the alpha-synuclein gene identified in families with Parkinson's disease",
      "volume": "276",
      "author": "Polymeropoulos",
      "year": "1997",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "1658",
      "DOI": "10.1523/JNEUROSCI.12-05-01658.1992",
      "article-title": "Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity",
      "volume": "12",
      "author": "Przedborski",
      "year": "1992",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "4565",
      "DOI": "10.1073/pnas.93.10.4565",
      "article-title": "Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity",
      "volume": "93",
      "author": "Przedborski",
      "year": "1996",
      "journal-title": "Proc. Natl. Acad. Sci. U. S. A."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "1181",
      "DOI": "10.1046/j.1471-4159.2001.00366.x",
      "article-title": "Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice",
      "volume": "77",
      "author": "Rathke-Hartlieb",
      "year": "2001",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib44",
      "doi-asserted-by": "crossref",
      "first-page": "223",
      "DOI": "10.1006/mcne.2002.1173",
      "article-title": "Proteasomal inhibition-induced inclusion formation and death in cortical neurons require transcription and ubiquitination",
      "volume": "21",
      "author": "Rideout",
      "year": "2002",
      "journal-title": "Mol. Cell. Neurosci."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib45",
      "doi-asserted-by": "crossref",
      "first-page": "3",
      "DOI": "10.1111/j.1365-2990.1995.tb01022.x",
      "article-title": "Oxidative stress in Parkinson's disease",
      "volume": "21",
      "author": "Schapira",
      "year": "1995",
      "journal-title": "Neuropathol. Appl. Neurobiol."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib46",
      "doi-asserted-by": "crossref",
      "first-page": "1275",
      "DOI": "10.1212/WNL.46.5.1275",
      "article-title": "Possible environmental, occupational, and other etiologic factors for Parkinson's disease: a case-control study in Germany",
      "volume": "46",
      "author": "Seidler",
      "year": "1996",
      "journal-title": "Neurology"
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib47",
      "doi-asserted-by": "crossref",
      "first-page": "329",
      "DOI": "10.1007/s004010100369",
      "article-title": "Alpha-synuclein has an altered conformation and shows a tight intermolecular interaction with ubiquitin in Lewy bodies",
      "volume": "102",
      "author": "Sharma",
      "year": "2001",
      "journal-title": "Acta Neuropathol. (Berl.)"
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib48",
      "doi-asserted-by": "crossref",
      "first-page": "7006",
      "DOI": "10.1523/JNEUROSCI.22-16-07006.2002",
      "article-title": "An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage",
      "volume": "22",
      "author": "Sherer",
      "year": "2002",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib49",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1111/j.1471-4159.1987.tb03384.x",
      "article-title": "Biochemical events in the development of parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine",
      "volume": "49",
      "author": "Singer",
      "year": "1987",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib50",
      "doi-asserted-by": "crossref",
      "first-page": "841",
      "DOI": "10.1126/science.1090278",
      "article-title": "alpha-Synuclein locus triplication causes Parkinson's disease",
      "volume": "302",
      "author": "Singleton",
      "year": "2003",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib51",
      "doi-asserted-by": "crossref",
      "first-page": "9549",
      "DOI": "10.1523/JNEUROSCI.21-24-09549.2001",
      "article-title": "Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death",
      "volume": "21",
      "author": "Stefanis",
      "year": "2001",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib52",
      "doi-asserted-by": "crossref",
      "first-page": "1280",
      "DOI": "10.1038/nm1201-1280",
      "article-title": "Alpha-synuclein and cytosolic dopamine: stabilizing a bad situation",
      "volume": "7",
      "author": "Sulzer",
      "year": "2001",
      "journal-title": "Nat. Med."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib53",
      "doi-asserted-by": "crossref",
      "first-page": "1765",
      "DOI": "10.1056/NEJM200012143432404",
      "article-title": "Familial aggregation of Parkinson's disease in Iceland",
      "volume": "343",
      "author": "Sveinbjornsdottir",
      "year": "2000",
      "journal-title": "N. Engl. J. Med."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib54",
      "doi-asserted-by": "crossref",
      "first-page": "2683",
      "DOI": "10.1093/hmg/9.18.2683",
      "article-title": "Expression of mutant alpha-synuclein causes increased susceptibility to dopamine toxicity",
      "volume": "9",
      "author": "Tabrizi",
      "year": "2000",
      "journal-title": "Hum. Mol. Genet."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib55",
      "doi-asserted-by": "crossref",
      "first-page": "141",
      "DOI": "10.1006/mcne.2000.0923",
      "article-title": "Reduced neuritic outgrowth and cell adhesion in neuronal cells transfected with human alpha-synuclein",
      "volume": "17",
      "author": "Takenouchi",
      "year": "2001",
      "journal-title": "Mol. Cell. Neurosci."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib56",
      "doi-asserted-by": "crossref",
      "first-page": "919",
      "DOI": "10.1093/hmg/10.9.919",
      "article-title": "Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis",
      "volume": "10",
      "author": "Tanaka",
      "year": "2001",
      "journal-title": "Hum. Mol. Genet."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib57",
      "doi-asserted-by": "crossref",
      "first-page": "9207",
      "DOI": "10.1523/JNEUROSCI.20-24-09207.2000",
      "article-title": "The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb: implications for Parkinson's disease",
      "volume": "20",
      "author": "Thiruchelvam",
      "year": "2000",
      "journal-title": "J. Neurosci."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib58",
      "doi-asserted-by": "crossref",
      "first-page": "225",
      "DOI": "10.1016/S0006-8993(00)02496-3",
      "article-title": "Potentiated and preferential effects of combined paraquat and maneb on nigrostriatal dopamine systems: environmental risk factors for Parkinson's disease?",
      "volume": "873",
      "author": "Thiruchelvam",
      "year": "2000",
      "journal-title": "Brain Res."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib59",
      "doi-asserted-by": "crossref",
      "first-page": "621",
      "DOI": "10.1016/S0161-813X(02)00092-X",
      "article-title": "Developmental exposure to the pesticides paraquat and maneb and the Parkinson's disease phenotype",
      "volume": "23",
      "author": "Thiruchelvam",
      "year": "2002",
      "journal-title": "Neurotoxicology"
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib60",
      "doi-asserted-by": "crossref",
      "first-page": "845",
      "DOI": "10.1111/j.0953-816X.2004.03139.x",
      "article-title": "Risk factors for dopaminergic neuron loss in human alpha-synuclein transgenic mice",
      "volume": "19",
      "author": "Thiruchelvam",
      "year": "2004",
      "journal-title": "Eur. J. Neurosci."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib61",
      "doi-asserted-by": "crossref",
      "first-page": "44405",
      "DOI": "10.1074/jbc.M308041200",
      "article-title": "Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function",
      "volume": "278",
      "author": "Tofaris",
      "year": "2003",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib62",
      "doi-asserted-by": "crossref",
      "first-page": "895",
      "DOI": "10.1086/319522",
      "article-title": "Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35\u2013p36",
      "volume": "68",
      "author": "Valente",
      "year": "2001",
      "journal-title": "Am. J. Hum. Genet."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib63",
      "doi-asserted-by": "crossref",
      "first-page": "1158",
      "DOI": "10.1126/science.1096284",
      "article-title": "Hereditary early-onset Parkinson's disease caused by mutations in PINK1",
      "volume": "304",
      "author": "Valente",
      "year": "2004",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib64",
      "doi-asserted-by": "crossref",
      "first-page": "721",
      "DOI": "10.1046/j.1471-4159.2000.740721.x",
      "article-title": "Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP",
      "volume": "74",
      "author": "Vila",
      "year": "2000",
      "journal-title": "J. Neurochem."
    },
    {
      "key": "10.1016/j.molbrainres.2004.09.014_bib65",
      "doi-asserted-by": "crossref",
      "first-page": "240",
      "DOI": "10.1006/nbdi.2000.0319",
      "article-title": "Oxidative stress and genetics in the pathogenesis of Parkinson's disease",
      "volume": "7",
      "author": "Zhang",
      "year": "2000",
      "journal-title": "Neurobiol. Dis."
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