DOI: 10.1016/j.lfs.2003.09.031. EP2 and EP4 prostanoid receptor signaling

EP2 and EP4 prostanoid receptor signaling

10.1016/j.lfs.2003.09.031

Crossref journal-article

Elsevier BV

Life Sciences (78)

Bibliography

Regan, J. W. (2003). EP2 and EP4 prostanoid receptor signaling. Life Sciences, 74(2â3), 143â153.

Authors 1

John W Regan (first)

References 43 Referenced 362

10.1006/bbrc.1993.2470 / Biochem. Biophys. Res. Commun. / Cloning and expression of the EP2 subtype of human receptors for prostaglandin E2 by An (1993)
{'key': '10.1016/j.lfs.2003.09.031_BIB2', 'first-page': '728', 'article-title': 'Regulation of cyclooxygenase-2 expression by the Wnt and Ras pathways', 'volume': '63', 'author': 'Araki', 'year': '2003', 'journal-title': 'Cancer Res.'} / Cancer Res. / Regulation of cyclooxygenase-2 expression by the Wnt and Ras pathways by Araki (2003)
10.1101/gad.11.24.3286 / Genes Dev. / Wnt signaling: a common theme in animal development by Cadigan (1997)
10.1016/0090-6980(94)90084-1 / Prostaglandins / A novel inhibitory receptor in piglet saphenous vein by Coleman (1994)
{'key': '10.1016/j.lfs.2003.09.031_BIB5', 'first-page': '205', 'article-title': 'VIII. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes', 'volume': '46', 'author': 'Coleman', 'year': '1994', 'journal-title': 'Pharmacol. Rev.'} / Pharmacol. Rev. / VIII. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes by Coleman (1994)
10.1124/mol.58.6.1279 / Mol. Pharmacol. / Comparison of agonist-induced internalization of the human EP2 and EP4 prostaglandin receptors: role of the carboxyl terminus in EP4 receptor sequestration by Desai (2000)
10.1016/S0165-6147(03)00162-7 / Trends Pharmacol. Sci. / Prostanoid receptors and phosphatidylinositol 3-kinase: a pathway to cancer by Fujino (2003)
10.1074/jbc.M109440200 / J. Biol. Chem. / Phosphorylation of glycogen synthase kinase-3 and stimulation of T-cell factor signaling following activation of EP2 and EP4 prostanoid receptors by prostaglandin E2 by Fujino (2002)
10.1074/jbc.M212665200 / J. Biol. Chem. / Prostaglandin E2 induced functional expression of early growth response factor-1 by EP4, but not EP2, prostanoid receptors via the phosphatidylinositol 3-kinase and extracellular signal-regulated kinases by Fujino (2003)
Fujisawa Pharm. Co., 2000. Oxazole compounds as prostaglandin E2 agonists or antagonists. Patent WO0018744.
10.1189/jlb.1002483 / J. Leuko. Biol. / Prostaglandin E2 modulates dendritic cell function via EP2 and EP4 receptor subtypes by Harizi (2003)
10.1073/pnas.96.18.10501 / Proc. Natl. Acad. Sci. USA / Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP2 by Hizaki (1999)
10.1016/S0021-9258(18)53022-2 / J. Biol. Chem. / Cloning and expression of a cDNA for mouse prostaglandin E receptor EP2 subtype by Honda (1993)
10.1074/jbc.M213290200 / J. Biol. Chem. / Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis by Kamei (2003)
10.1124/mol.54.3.584 / Mol. Pharmacol. / A single amino acid substitution in the EP2 prostaglandin receptor confers responsiveness to prostacyclin analogs by Kedzie (1998)
10.1038/7426 / Nat. Med. / Salt-sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor by Kennedy (1999)
10.1016/S0090-6980(02)00055-2 / Prostaglan. Other Lipid Mediat. / Function of prostanoid receptors: studies on knockout mice by Kobayashi (2002)
10.1210/en.141.6.2054 / Endocrinology / Knockout of the murine prostaglandin EP2 receptor impairs osteoclastogenesis in vitro by Li (2000)
10.1124/mol.60.1.36 / Mol. Pharmacol. / Prostaglandin receptor EP4 mediates the bone anabolic effects of PGE2 by Machwate (2001)
10.1172/JCI0215528 / J. Clin. Invest. / The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis by McCoy (2002)
10.1074/jbc.M003505200 / J. Biol. Chem. / Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2 by Murakami (2000)
{'key': '10.1016/j.lfs.2003.09.031_BIB22', 'first-page': '28', 'article-title': 'Involvement of prostaglandin E receptor subtype EP4 in colon carcinogenesis', 'volume': '62', 'author': 'Mutoh', 'year': '2002', 'journal-title': 'Cancer Res.'} / Cancer Res. / Involvement of prostaglandin E receptor subtype EP4 in colon carcinogenesis by Mutoh (2002)
10.1074/jbc.M203618200 / J. Biol. Chem. / Transcriptional regulation of the membrane-associated prostaglandin E2 synthase gene. Essential role of the transcription factor Egr-1 by Naraba (2002)
10.1172/JCI200113455 / J. Clin. Invest. / Genetic and pharmacological analysis of prostanoid receptor function by Narumiya (2001)
10.1172/JCI200113640 / J. Clin. Invest. / Receptors for prostaglandin E2 that regulate cellular immune responses in the mouse by Nataraj (2001)
10.1038/36342 / Nature / The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth by Nguyen (1997)
{'key': '10.1016/j.lfs.2003.09.031_BIB27', 'first-page': '1031', 'article-title': 'Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist', 'volume': '50', 'author': 'Nishigaki', 'year': '1996', 'journal-title': 'Mol. Pharmacol.'} / Mol. Pharmacol. / Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist by Nishigaki (1996)
10.1097/00000542-200207000-00024 / Anesthesiology / Effects of a novel selective agonist for prostaglandin receptor subtype EP4 on hyperalgesia and inflammation in monoarthritic model by Omote (2002)
10.1073/pnas.1037343100 / Proc. Natl. Acad. Sci. USA / An EP2 receptor-selective prostaglandin E2 agonist induces bone healing by Paralkar (2003)
{'key': '10.1016/j.lfs.2003.09.031_BIB30', 'first-page': '213', 'article-title': 'Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype', 'volume': '46', 'author': 'Regan', 'year': '1994', 'journal-title': 'Mol. Pharmacol.'} / Mol. Pharmacol. / Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype by Regan (1994)
10.1128/IAI.68.12.6819-6825.2000 / Infect. Immun. / Impaired bone resorption by lipopolysaccharide in vivo in mice deficient in the prostaglandin E receptor EP4 subtype by Sakuma (2000)
{'key': '10.1016/j.lfs.2003.09.031_BIB32', 'first-page': '506', 'article-title': 'Cyclooxygenase 2- and prostaglandin E2 receptor EP2-dependent angiogenesis in ApcΔ716 mouse intestinal polyps', 'volume': '62', 'author': 'Seno', 'year': '2002', 'journal-title': 'Cancer Res.'} / Cancer Res. / Cyclooxygenase 2- and prostaglandin E2 receptor EP2-dependent angiogenesis in ApcΔ716 mouse intestinal polyps by Seno (2002)
10.1152/jappl.2000.88.6.2214 / J. Appl. Physiol. / EP2 receptor mediates bronchodilation by PGE2 in mice by Sheller (2000)
10.1016/S0006-2952(01)00586-X / Biochem. Pharmacol. / Regulation of TNFα and interleukin-10 production by prostaglandins, I2 and E2: studies with prostaglandin receptor-deficient mice and prostaglandin E-receptor subtype-selective synthetic agonists by Shinomiya (2001)
10.1146/annurev.biochem.69.1.145 / Annu. Rev. Biochem. / Cyclooxygenases: structural, cellular, and molecular biology by Smith (2000)
10.1038/nm0901-1048 / Nat. Med. / Acceleration of intestinal polyposis through prostaglandin receptor EP2 in ApcΔ716 knockout mice by Sonoshita (2001)
10.1016/S0014-2999(98)00522-6 / Eur. J. Pharmacol. / A conserved threonine in the second extracellular loop of the human EP2 and EP4 receptors is required for ligand binding by Stillman (1998)
10.1016/S0021-9258(19)50448-3 / J. Biol. Chem. / Cloning and expression of a cDNA for mouse prostaglandin E Receptor EP3 subtype by Sugimoto (1992)
10.1074/jbc.M204810200 / J. Biol. Chem. / Prostaglandin E2 suppresses chemokine production in human macrophages through the EP4 receptor by Takayama (2002)
10.1016/0014-5793(95)00129-W / FEBS Letters / Molecular evolution of receptors for eicosanoids by Toh (1995)
10.1016/S0021-9258(20)80710-8 / J. Biol. Chem. / Cloning and expression of cDNA for a mouse EP1 subtype of prostaglandin E receptor by Watabe (1993)
10.1172/JCI16492 / J. Clin. Invest. / Cancer-associated immunodeficiency and dendritic cell abnormalities mediated by the prostaglandin EP2 receptor by Yang (2003)
10.1073/pnas.062053399 / Proc. Natl. Acad. Sci. USA / Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation by Yoshida (2002)

Dates

Type	When
Created	21 years, 10 months ago (Oct. 28, 2003, 7:51 p.m.)
Deposited	4 years, 2 months ago (June 12, 2021, 7:24 a.m.)
Indexed	1 week ago (Aug. 29, 2025, 6:22 a.m.)
Issued	21 years, 9 months ago (Dec. 1, 2003)
Published	21 years, 9 months ago (Dec. 1, 2003)
Published Print	21 years, 9 months ago (Dec. 1, 2003)

Funders 0

None

BibTeX

@article{Regan_2003, title={EP2 and EP4 prostanoid receptor signaling}, volume={74}, ISSN={0024-3205}, url={http://dx.doi.org/10.1016/j.lfs.2003.09.031}, DOI={10.1016/j.lfs.2003.09.031}, number={2–3}, journal={Life Sciences}, publisher={Elsevier BV}, author={Regan, John W}, year={2003}, month=dec, pages={143–153} }

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      "article-title": "Regulation of cyclooxygenase-2 expression by the Wnt and Ras pathways",
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      "article-title": "Comparison of agonist-induced internalization of the human EP2 and EP4 prostaglandin receptors: role of the carboxyl terminus in EP4 receptor sequestration",
      "volume": "58",
      "author": "Desai",
      "year": "2000",
      "journal-title": "Mol. Pharmacol."
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      "article-title": "Prostanoid receptors and phosphatidylinositol 3-kinase: a pathway to cancer",
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      "author": "Fujino",
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      "author": "Fujino",
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      "volume": "73",
      "author": "Harizi",
      "year": "2003",
      "journal-title": "J. Leuko. Biol."
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      "author": "Kamei",
      "year": "2003",
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      "volume": "5",
      "author": "Kennedy",
      "year": "1999",
      "journal-title": "Nat. Med."
    },
    {
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      "doi-asserted-by": "crossref",
      "first-page": "557",
      "DOI": "10.1016/S0090-6980(02)00055-2",
      "article-title": "Function of prostanoid receptors: studies on knockout mice",
      "volume": "68\u201369",
      "author": "Kobayashi",
      "year": "2002",
      "journal-title": "Prostaglan. Other Lipid Mediat."
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      "author": "Li",
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      "volume": "60",
      "author": "Machwate",
      "year": "2001",
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      "article-title": "The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis",
      "volume": "110",
      "author": "McCoy",
      "year": "2002",
      "journal-title": "J. Clin. Invest."
    },
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      "volume": "275",
      "author": "Murakami",
      "year": "2000",
      "journal-title": "J. Biol. Chem."
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      "author": "Mutoh",
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      "volume": "277",
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      "volume": "108",
      "author": "Narumiya",
      "year": "2001",
      "journal-title": "J. Clin. Invest."
    },
    {
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      "first-page": "1229",
      "DOI": "10.1172/JCI200113640",
      "article-title": "Receptors for prostaglandin E2 that regulate cellular immune responses in the mouse",
      "volume": "108",
      "author": "Nataraj",
      "year": "2001",
      "journal-title": "J. Clin. Invest."
    },
    {
      "key": "10.1016/j.lfs.2003.09.031_BIB26",
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      "first-page": "78",
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      "article-title": "The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth",
      "volume": "390",
      "author": "Nguyen",
      "year": "1997",
      "journal-title": "Nature"
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    {
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      "first-page": "1031",
      "article-title": "Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist",
      "volume": "50",
      "author": "Nishigaki",
      "year": "1996",
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    },
    {
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      "first-page": "170",
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      "article-title": "Effects of a novel selective agonist for prostaglandin receptor subtype EP4 on hyperalgesia and inflammation in monoarthritic model",
      "volume": "97",
      "author": "Omote",
      "year": "2002",
      "journal-title": "Anesthesiology"
    },
    {
      "key": "10.1016/j.lfs.2003.09.031_BIB29",
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      "first-page": "6736",
      "DOI": "10.1073/pnas.1037343100",
      "article-title": "An EP2 receptor-selective prostaglandin E2 agonist induces bone healing",
      "volume": "100",
      "author": "Paralkar",
      "year": "2003",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.lfs.2003.09.031_BIB30",
      "first-page": "213",
      "article-title": "Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype",
      "volume": "46",
      "author": "Regan",
      "year": "1994",
      "journal-title": "Mol. Pharmacol."
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    {
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      "first-page": "6819",
      "DOI": "10.1128/IAI.68.12.6819-6825.2000",
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      "volume": "68",
      "author": "Sakuma",
      "year": "2000",
      "journal-title": "Infect. Immun."
    },
    {
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      "first-page": "506",
      "article-title": "Cyclooxygenase 2- and prostaglandin E2 receptor EP2-dependent angiogenesis in Apc\u0394716 mouse intestinal polyps",
      "volume": "62",
      "author": "Seno",
      "year": "2002",
      "journal-title": "Cancer Res."
    },
    {
      "key": "10.1016/j.lfs.2003.09.031_BIB33",
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      "first-page": "2214",
      "DOI": "10.1152/jappl.2000.88.6.2214",
      "article-title": "EP2 receptor mediates bronchodilation by PGE2 in mice",
      "volume": "88",
      "author": "Sheller",
      "year": "2000",
      "journal-title": "J. Appl. Physiol."
    },
    {
      "key": "10.1016/j.lfs.2003.09.031_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "1153",
      "DOI": "10.1016/S0006-2952(01)00586-X",
      "article-title": "Regulation of TNF\u03b1 and interleukin-10 production by prostaglandins, I2 and E2: studies with prostaglandin receptor-deficient mice and prostaglandin E-receptor subtype-selective synthetic agonists",
      "volume": "61",
      "author": "Shinomiya",
      "year": "2001",
      "journal-title": "Biochem. Pharmacol."
    },
    {
      "key": "10.1016/j.lfs.2003.09.031_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "145",
      "DOI": "10.1146/annurev.biochem.69.1.145",
      "article-title": "Cyclooxygenases: structural, cellular, and molecular biology",
      "volume": "69",
      "author": "Smith",
      "year": "2000",
      "journal-title": "Annu. Rev. Biochem."
    },
    {
      "key": "10.1016/j.lfs.2003.09.031_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "1048",
      "DOI": "10.1038/nm0901-1048",
      "article-title": "Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc\u0394716 knockout mice",
      "volume": "7",
      "author": "Sonoshita",
      "year": "2001",
      "journal-title": "Nat. Med."
    },
    {
      "key": "10.1016/j.lfs.2003.09.031_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "73",
      "DOI": "10.1016/S0014-2999(98)00522-6",
      "article-title": "A conserved threonine in the second extracellular loop of the human EP2 and EP4 receptors is required for ligand binding",
      "volume": "357",
      "author": "Stillman",
      "year": "1998",
      "journal-title": "Eur. J. Pharmacol."
    },
    {
      "key": "10.1016/j.lfs.2003.09.031_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "6463",
      "DOI": "10.1016/S0021-9258(19)50448-3",
      "article-title": "Cloning and expression of a cDNA for mouse prostaglandin E Receptor EP3 subtype",
      "volume": "267",
      "author": "Sugimoto",
      "year": "1992",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.lfs.2003.09.031_BIB39",
      "doi-asserted-by": "crossref",
      "first-page": "44147",
      "DOI": "10.1074/jbc.M204810200",
      "article-title": "Prostaglandin E2 suppresses chemokine production in human macrophages through the EP4 receptor",
      "volume": "277",
      "author": "Takayama",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.lfs.2003.09.031_BIB40",
      "doi-asserted-by": "crossref",
      "first-page": "17",
      "DOI": "10.1016/0014-5793(95)00129-W",
      "article-title": "Molecular evolution of receptors for eicosanoids",
      "volume": "361",
      "author": "Toh",
      "year": "1995",
      "journal-title": "FEBS Letters"
    },
    {
      "key": "10.1016/j.lfs.2003.09.031_BIB41",
      "doi-asserted-by": "crossref",
      "first-page": "20175",
      "DOI": "10.1016/S0021-9258(20)80710-8",
      "article-title": "Cloning and expression of cDNA for a mouse EP1 subtype of prostaglandin E receptor",
      "volume": "268",
      "author": "Watabe",
      "year": "1993",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.lfs.2003.09.031_BIB42",
      "doi-asserted-by": "crossref",
      "first-page": "727",
      "DOI": "10.1172/JCI16492",
      "article-title": "Cancer-associated immunodeficiency and dendritic cell abnormalities mediated by the prostaglandin EP2 receptor",
      "volume": "111",
      "author": "Yang",
      "year": "2003",
      "journal-title": "J. Clin. Invest."
    },
    {
      "key": "10.1016/j.lfs.2003.09.031_BIB43",
      "doi-asserted-by": "crossref",
      "first-page": "4580",
      "DOI": "10.1073/pnas.062053399",
      "article-title": "Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation",
      "volume": "99",
      "author": "Yoshida",
      "year": "2002",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
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