DOI: 10.1016/j.jns.2007.01.028. Homocysteine and Parkinson's disease: A dangerous liaison?

Homocysteine and Parkinson's disease: A dangerous liaison?

10.1016/j.jns.2007.01.028

Crossref journal-article

Elsevier BV

Journal of the Neurological Sciences (78)

Bibliography

Martignoni, E., Tassorelli, C., Nappi, G., Zangaglia, R., Pacchetti, C., & Blandini, F. (2007). Homocysteine and Parkinsonâs disease: A dangerous liaison? Journal of the Neurological Sciences, 257(1â2), 31â37.

Authors 6

E. Martignoni (first)
C. Tassorelli (additional)
G. Nappi (additional)
R. Zangaglia (additional)
C. Pacchetti (additional)
F. Blandini (additional)

References 77 Referenced 48

10.1016/j.advenzreg.2003.11.012 / Adv Enzyme Regul / Methylation demand and homocysteine metabolism. by Stead (2004)
10.1016/S0166-2236(03)00032-8 / Trends Neurosci / Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders by Mattson (2003)
10.1146/annurev.nutr.19.1.217 / Annu Rev Nutr / Homocysteine metabolism by Selhub (1999)
10.1002/jcp.1041460108 / J Cell Physiol / Homocysteine export from cells cultured in the presence of physiological or superfluous levels of methionine: methionine loading of non-transformed, transformed, proliferating, and quiescent cells in culture by Christensen (1991)
10.1042/bj2980415 / Biochem J / Folate-deficiency-induced homocysteinaemia in rats: disruption of S-adenosylmethionine's co-ordinate regulation of homocysteine metabolism by Miller (1994)
10.1007/s002340050119 / Neuroradiology / Hyperhomocysteinaemia; with reference to its neuroradiological aspects by van den (1995)
10.1002/ajmg.1320340320 / Am J Med Genet / Functional methionine synthase deficiency (cblE and cblG): clinical and biochemical heterogeneity by Watkins (1989)
10.1023/A:1018675624181 / J Thromb Thrombolysis / Homocysteine and risk of cardiovascular disease by Andreotti (2000)
10.1016/S0140-6736(05)65956-9 / Lancet / Serum total homocysteine concentration and risk of stroke by Perry (1996)
10.1345/aph.18457 / Ann Pharmacother / Homocysteine as a risk factor for atherosclerosis by Temple (2000)
10.1042/bst022341s / Biochem Soc Trans / Homocysteine induced endothelial cell toxicity and its protection by Blundell (1994)
10.1016/0021-9150(95)05730-7 / Atherosclerosis / Homocysteine mediated endothelial cell toxicity and its amelioration by Blundell (1996)
10.1097/00007890-200202270-00034 / Transplantation / Treatment of hyperhomocysteinemia with folic acid reduces oxidative stress in renal transplant recipients by Abdelfatah (2002)
10.1172/JCI118776 / J Clin Invest / The oxidant stress of hyperhomocyst(e)inemia by Loscalzo (1996)
10.1002/jcb.1175 / J Cell Biochem / Aru GM, Tyagi SC. Induction of oxidative stress by homocyst(e)ine impairs endothelial function by Mujumdar (2001)
10.1161/01.HYP.0000127914.94292.76 / Hypertension / Homocysteine enhances endothelial apoptosis via upregulation of Fas-mediated pathways by Suhara (2004)
10.1096/fj.00-0848com / FASEB J / Efficiency of homocysteine plus copper in inducing apoptosis is inversely proportional to gamma-glutamyl transpeptidase activity by Bessede (2001)
10.1074/jbc.M100747200 / J Biol Chem / Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response by Zhang (2001)
10.1523/JNEUROSCI.20-18-06920.2000 / J Neurosci / Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity by Kruman (2000)
10.1016/0167-5699(94)90018-3 / Immunol Today / Oxidative stress as a mediator of apoptosis by Buttke (1994)
10.1080/10715760400017269 / Free Radic Res / No evidence for oxidative stress as a mechanism of action of hyperhomocysteinemia in humans by Huerta (2004)
10.1111/j.1432-1033.2004.04070.x / Eur J Biochem / Effects of homocysteine on apoptosis-related proteins and anti-oxidant systems in isolated human lymphocytes by Mangiagalli (2004)
10.1093/jn/128.7.1204 / J Nutr / Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women by Jacob (1998)
10.1080/07315724.1998.10718790 / J Am Coll Nutr / Vitamins B6, B12, and folate: association with plasma total homocysteine and risk of coronary atherosclerosis by Siri (1998)
10.1038/ng0595-111 / Nat Genet / A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase by Frosst (1995)
10.1089/ars.2005.7.813 / Antioxid Redox Signal / The role of cystathionine beta-synthase in homocysteine metabolism by Jhee (2005)
10.1161/01.CIR.94.12.3074 / Circulation / Common mutation in methylenetetrahydrofolate reductase. Correlation with homocysteine metabolism and late-onset vascular disease by Deloughery (1996)
10.1161/01.CIR.94.10.2410 / Circulation / Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians by Ma (1996)
10.1182/asheducation-2003.1.62 / Hematology (Am Soc Hematol Educ Program) / Update on cobalamin, folate, and homocysteine by Carmel (2003)
10.1016/j.pnpbp.2005.06.025 / Prog Neuropsychopharmacol Biol Psychiatry / The central nervous system in animal models of hyperhomocysteinemia by Troen (2005)
{'key': '10.1016/j.jns.2007.01.028_bib31', 'first-page': '1894', 'article-title': 'Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats', 'volume': '55', 'author': 'Pogribny', 'year': '1995', 'journal-title': 'Cancer Res'} / Cancer Res / Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats by Pogribny (1995)
{'key': '10.1016/j.jns.2007.01.028_bib32', 'first-page': '2071s', 'article-title': 'Methyl groups in carcinogenesis: effects on DNA methylation and gene expression', 'volume': '52', 'author': 'Wainfan', 'year': '1992', 'journal-title': 'Cancer Res'} / Cancer Res / Methyl groups in carcinogenesis: effects on DNA methylation and gene expression by Wainfan (1992)
{'key': '10.1016/j.jns.2007.01.028_bib33', 'first-page': '471', 'article-title': 'Hyperhomocysteinemia: a new risk factor for degenerative diseases', 'volume': '48', 'author': 'Herrmann', 'year': '2002', 'journal-title': 'Clin Lab'} / Clin Lab / Hyperhomocysteinemia: a new risk factor for degenerative diseases by Herrmann (2002)
10.1515/znc-1995-9-1017 / Z Naturforsch [C] / Homocysteine-induced oxidative damage: mechanisms and possible roles in neurodegenerative and atherogenic processes by Schlussel (1995)
10.1016/S0163-7258(96)00097-6 / Pharmacol Ther / The neurotransmitter candidature of sulphur-containing excitatory amino acids in the mammalian central nervous system by Thompson (1996)
10.1002/jnr.10416 / J Neurosci Res / Multiple aspects of homocysteine neurotoxicity: glutamate excitotoxicity, kinase hyperactivation and DNA damage by Ho (2002)
10.1523/JNEUROSCI.22-05-01752.2002 / J Neurosci / Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease by Kruman (2002)
10.1073/pnas.94.11.5923 / Proc Natl Acad Sci U S A / Neurotoxicity associated with dual actions of homocysteine at the N-methyl-d-aspartate receptor by Lipton (1997)
10.1046/j.0022-3042.2001.00676.x / J Neurochem / Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease by Duan (2002)
10.1007/BF00969090 / Neurochem Res / The effects of l-dopa on the activity of methionine adenosyltransferase: relevance to l-dopa therapy and tolerance by Benson (1993)
10.1097/00002826-199702000-00007 / Clin Neuropharmacol / Effect of l-Dopa and the catechol-O-methyltransferase inhibitor Ro 41-0960 on sulfur amino acid metabolites in rats by Miller (1997)
10.1016/S0024-3205(00)00557-9 / Life Sci / Effects of l-dopa treatment on methylation in mouse brain: implications for the side effects of l-dopa by Liu (2000)
10.1097/00002826-199702000-00007 / Clin Neuropharmacol / Effect of l-Dopa and the catechol-O-methyltransferase inhibitor Ro 41-0960 on sulfur amino acid metabolites in rats by Miller (1997)
{'key': '10.1016/j.jns.2007.01.028_bib44', 'first-page': '527', 'article-title': "Sulfate and cysteine levels in the plasma of patients with Parkinson's disease", 'volume': '16', 'author': 'Allain', 'year': '1995', 'journal-title': 'Neurotoxicology'} / Neurotoxicology / Sulfate and cysteine levels in the plasma of patients with Parkinson's disease by Allain (1995)
10.1159/000007984 / Eur Neurol / Elevated plasma levels of homocysteine in Parkinson's disease by Kuhn (1998)
10.1001/archneur.60.1.59 / Arch Neurol / Elevated plasma homocysteine levels in patients treated with levodopa: association with vascular disease by Rogers (2003)
10.1002/mds.20253 / Mov Disord / Modest increase in plasma homocysteine follows levodopa initiation in Parkinson's disease by O'suilleabhain (2004)
10.1001/archneur.61.6.865 / Arch Neurol / Elevated plasma homocysteine level in patients with Parkinson disease: motor, affective, and cognitive associations by O'suilleabhain (2004)
10.1111/j.1468-1331.2004.00973.x / Eur J Neurol / Hyperhomocysteinemia in l-dopa treated Parkinson's disease patients: effect of cobalamin and folate administration by Lamberti (2005)
10.1016/j.parkreldis.2004.07.008 / Parkinsonism Relat Disord / Plasma homocysteine levels in Parkinson's disease: role of antiparkinsonian medications by Zoccolella (2005)
10.1093/clinchem/47.6.1102 / Clin Chem / Plasma homocysteine and l-dopa metabolism in patients with Parkinson disease by Blandini (2001)
10.1016/S0140-6736(99)01660-8 / Lancet / Nigral endothelial dysfunction, homocysteine, and Parkinson's disease by Muller (1999)
10.1016/S0304-3940(01)01972-3 / Neurosci Lett / Decrease of methionine and S-adenosylmethionine and increase of homocysteine in treated patients with Parkinson's disease by Muller (2001)
10.1152/ajprenal.00465.2004 / Am J Physiol Renal Physiol / Effect of acute hyperhomocysteinemia on methylation potential of erythrocytes and on DNA methylation of lymphocytes in healthy male volunteers. by Fux (2005)
10.4088/JCP.v66n1210 / J Clin Psychiatry / High serum homocysteine levels in young male schizophrenic and schizoaffective patients with tardive parkinsonism and/or tardive dyskinesia by Lerner (2005)
10.1176/appi.ajp.161.9.1705 / Am J Psychiatry / Folate, homocysteine, and negative symptoms in schizophrenia by Goff (2004)
10.1176/appi.ajp.162.7.1387-a / Am J Psychiatry / The significance of homocysteine levels in schizophrenia by O’Donnell (2005)
10.1176/appi.ajp.162.7.1388 / Am J Psychiatry / Letter to the editor by Goff (2005)
10.1002/ana.20509 / Ann Neurol / Methylenetetrahydrofolate reductase C677T genotype and PD by de Lau (2005)
10.1007/s00702-002-0758-8 / J Neural Transm / Moderate hyperhomocysteinaemia and immune activation in Parkinson's disease by Widner (2002)
10.1016/j.amjmed.2005.01.052 / Am J Med / Homocysteine as a predictive factor for hip fracture in elderly women with Parkinson's disease by Sato (2005)
10.1016/0009-8981(73)90429-4 / Clin Chim Acta / The reaction of homocysteine with aldehyde: an explanation of the collagen defects in homocystinuria by Jackson (1973)
10.1212/01.wnl.0000183063.99107.5c / Neurology / Association of homocysteine with plasma amyloid beta protein in aging and neurodegenerative disease by Irizarry (2005)
10.1074/jbc.M112372200 / J Biol Chem / Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein by Sai (2002)
10.1016/S0014-5793(03)00277-1 / FEBS Lett / Presenilin 1 gene silencing by S-adenosylmethionine: a treatment for Alzheimer disease? by Scarpa (2003)
10.1093/ajcn/82.3.627 / Am J Clin Nutr / High homocysteine and low B vitamins predict cognitive decline in aging men; the Veterans Affairs Normative Aging Study by Tucker (2005)
10.1016/j.amjmed.2004.08.019 / Am J Med / Homocysteine versus the vitamins folate, B6, and B12 as predictors of cognitive function and decline in older high-functioning adults: MacArthur Studies of Successful Aging by Kado (2005)
10.1093/ajcn/82.4.866 / Am J Clin Nutr / Homocysteine, vitamin B12, and folic acid and the risk of cognitive decline in old age: the Leiden 85-Plus study by Mooijaart (2005)
10.1002/mds.20667 / Mov Disord / Homocysteine and serum markers if immune activation in primary dystonia by Muller (2005)
10.1254/jphs.CRJ05003X / J Pharmacol Sci / The high atherosclerotic risk among epileptics: the atheroprotective role of multivitamins by Hamed (2005)
10.1016/j.seizure.2005.11.002 / Seizure / Effects of common anti-epileptic drug monotherapy on serum levels of homocysteine, vitamin B12, folic acid and vitamin B6 by Sener (2006)
10.1093/ajcn/82.6.1320 / Am J Clin Nutr / Westendorp Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease by Stott (2005)
10.1016/j.archger.2005.10.002 / Arch Gerontol Geriatr / Effects of folic acid supplementation on psychomotor performance and hemorheology in healthy elderly subjects by Pathansali (2006)
10.1212/01.WNL.0000158476.74580.A8 / Neurology / Executive dysfunction in hyperhomocystinemia responds to homocysteine-lowering treatment by Boxer (2005)
10.1212/01.WNL.0000137886.74175.5A / Neurology / Homocysteine and l-Dopa: should Parkinson disease patients receive preventive therapy? by Postuma (2004)
10.1093/aje/kwh213 / Am J Epidemiol / Folate intake and risk of Parkinson's disease by Chen (2004)
10.1111/j.1365-277X.2004.00532.x / J Hum Nutr Diet / A critical evaluation of the relationship between serum vitamin B, folate and total homocysteine with cognitive impairment in the elderly by Ellinson (2004)

Dates

Type	When
Created	18 years, 6 months ago (March 2, 2007, 12:46 p.m.)
Deposited	5 years, 4 months ago (April 20, 2020, 5:10 a.m.)
Indexed	2 months ago (June 30, 2025, 12:25 p.m.)
Issued	18 years, 3 months ago (June 1, 2007)
Published	18 years, 3 months ago (June 1, 2007)
Published Print	18 years, 3 months ago (June 1, 2007)

Funders 0

None

BibTeX

@article{Martignoni_2007, title={Homocysteine and Parkinson’s disease: A dangerous liaison?}, volume={257}, ISSN={0022-510X}, url={http://dx.doi.org/10.1016/j.jns.2007.01.028}, DOI={10.1016/j.jns.2007.01.028}, number={1–2}, journal={Journal of the Neurological Sciences}, publisher={Elsevier BV}, author={Martignoni, E. and Tassorelli, C. and Nappi, G. and Zangaglia, R. and Pacchetti, C. and Blandini, F.}, year={2007}, month=jun, pages={31–37} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        6,
        30
      ]
    ],
    "date-time": "2025-06-30T16:25:23Z",
    "timestamp": 1751300723408
  },
  "reference-count": 77,
  "publisher": "Elsevier BV",
  "issue": "1-2",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2007,
            6,
            1
          ]
        ],
        "date-time": "2007-06-01T00:00:00Z",
        "timestamp": 1180656000000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2007,
        6
      ]
    ]
  },
  "DOI": "10.1016/j.jns.2007.01.028",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2007,
        3,
        2
      ]
    ],
    "date-time": "2007-03-02T17:46:45Z",
    "timestamp": 1172857605000
  },
  "page": "31-37",
  "source": "Crossref",
  "is-referenced-by-count": 48,
  "title": "Homocysteine and Parkinson's disease: A dangerous liaison?",
  "prefix": "10.1016",
  "volume": "257",
  "author": [
    {
      "given": "E.",
      "family": "Martignoni",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "C.",
      "family": "Tassorelli",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "G.",
      "family": "Nappi",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "R.",
      "family": "Zangaglia",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "C.",
      "family": "Pacchetti",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "F.",
      "family": "Blandini",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/j.jns.2007.01.028_bib1",
      "doi-asserted-by": "crossref",
      "first-page": "321",
      "DOI": "10.1016/j.advenzreg.2003.11.012",
      "article-title": "Methylation demand and homocysteine metabolism.",
      "volume": "44",
      "author": "Stead",
      "year": "2004",
      "journal-title": "Adv Enzyme Regul"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib2",
      "doi-asserted-by": "crossref",
      "first-page": "137",
      "DOI": "10.1016/S0166-2236(03)00032-8",
      "article-title": "Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders",
      "volume": "26",
      "author": "Mattson",
      "year": "2003",
      "journal-title": "Trends Neurosci"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib3",
      "doi-asserted-by": "crossref",
      "first-page": "217",
      "DOI": "10.1146/annurev.nutr.19.1.217",
      "article-title": "Homocysteine metabolism",
      "volume": "19",
      "author": "Selhub",
      "year": "1999",
      "journal-title": "Annu Rev Nutr"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib4",
      "doi-asserted-by": "crossref",
      "first-page": "52",
      "DOI": "10.1002/jcp.1041460108",
      "article-title": "Homocysteine export from cells cultured in the presence of physiological or superfluous levels of methionine: methionine loading of non-transformed, transformed, proliferating, and quiescent cells in culture",
      "volume": "146",
      "author": "Christensen",
      "year": "1991",
      "journal-title": "J Cell Physiol"
    },
    {
      "issue": "Pt 2",
      "key": "10.1016/j.jns.2007.01.028_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "415",
      "DOI": "10.1042/bj2980415",
      "article-title": "Folate-deficiency-induced homocysteinaemia in rats: disruption of S-adenosylmethionine's co-ordinate regulation of homocysteine metabolism",
      "volume": "298",
      "author": "Miller",
      "year": "1994",
      "journal-title": "Biochem J"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib6",
      "doi-asserted-by": "crossref",
      "first-page": "403",
      "DOI": "10.1007/s002340050119",
      "article-title": "Hyperhomocysteinaemia; with reference to its neuroradiological aspects",
      "volume": "37",
      "author": "van den",
      "year": "1995",
      "journal-title": "Neuroradiology"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "427",
      "DOI": "10.1002/ajmg.1320340320",
      "article-title": "Functional methionine synthase deficiency (cblE and cblG): clinical and biochemical heterogeneity",
      "volume": "3",
      "author": "Watkins",
      "year": "1989",
      "journal-title": "Am J Med Genet"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "13",
      "DOI": "10.1023/A:1018675624181",
      "article-title": "Homocysteine and risk of cardiovascular disease",
      "volume": "9",
      "author": "Andreotti",
      "year": "2000",
      "journal-title": "J Thromb Thrombolysis"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "1526",
      "DOI": "10.1016/S0140-6736(05)65956-9",
      "article-title": "Serum total homocysteine concentration and risk of stroke",
      "volume": "348",
      "author": "Perry",
      "year": "1996",
      "journal-title": "Lancet"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib10",
      "doi-asserted-by": "crossref",
      "first-page": "57",
      "DOI": "10.1345/aph.18457",
      "article-title": "Homocysteine as a risk factor for atherosclerosis",
      "volume": "34",
      "author": "Temple",
      "year": "2000",
      "journal-title": "Ann Pharmacother"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib11",
      "doi-asserted-by": "crossref",
      "first-page": "341S",
      "DOI": "10.1042/bst022341s",
      "article-title": "Homocysteine induced endothelial cell toxicity and its protection",
      "volume": "22",
      "author": "Blundell",
      "year": "1994",
      "journal-title": "Biochem Soc Trans"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "163",
      "DOI": "10.1016/0021-9150(95)05730-7",
      "article-title": "Homocysteine mediated endothelial cell toxicity and its amelioration",
      "volume": "122",
      "author": "Blundell",
      "year": "1996",
      "journal-title": "Atherosclerosis"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "663",
      "DOI": "10.1097/00007890-200202270-00034",
      "article-title": "Treatment of hyperhomocysteinemia with folic acid reduces oxidative stress in renal transplant recipients",
      "volume": "73",
      "author": "Abdelfatah",
      "year": "2002",
      "journal-title": "Transplantation"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "5",
      "DOI": "10.1172/JCI118776",
      "article-title": "The oxidant stress of hyperhomocyst(e)inemia",
      "volume": "98",
      "author": "Loscalzo",
      "year": "1996",
      "journal-title": "J Clin Invest"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "491",
      "DOI": "10.1002/jcb.1175",
      "article-title": "Aru GM, Tyagi SC. Induction of oxidative stress by homocyst(e)ine impairs endothelial function",
      "volume": "82",
      "author": "Mujumdar",
      "year": "2001",
      "journal-title": "J Cell Biochem"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "1208",
      "DOI": "10.1161/01.HYP.0000127914.94292.76",
      "article-title": "Homocysteine enhances endothelial apoptosis via upregulation of Fas-mediated pathways",
      "volume": "43",
      "author": "Suhara",
      "year": "2004",
      "journal-title": "Hypertension"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "1927",
      "DOI": "10.1096/fj.00-0848com",
      "article-title": "Efficiency of homocysteine plus copper in inducing apoptosis is inversely proportional to gamma-glutamyl transpeptidase activity",
      "volume": "15",
      "author": "Bessede",
      "year": "2001",
      "journal-title": "FASEB J"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "35867",
      "DOI": "10.1074/jbc.M100747200",
      "article-title": "Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response",
      "volume": "276",
      "author": "Zhang",
      "year": "2001",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "6920",
      "DOI": "10.1523/JNEUROSCI.20-18-06920.2000",
      "article-title": "Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity",
      "volume": "20",
      "author": "Kruman",
      "year": "2000",
      "journal-title": "J Neurosci"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "7",
      "DOI": "10.1016/0167-5699(94)90018-3",
      "article-title": "Oxidative stress as a mediator of apoptosis",
      "volume": "15",
      "author": "Buttke",
      "year": "1994",
      "journal-title": "Immunol Today"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "1215",
      "DOI": "10.1080/10715760400017269",
      "article-title": "No evidence for oxidative stress as a mechanism of action of hyperhomocysteinemia in humans",
      "volume": "38",
      "author": "Huerta",
      "year": "2004",
      "journal-title": "Free Radic Res"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "1671",
      "DOI": "10.1111/j.1432-1033.2004.04070.x",
      "article-title": "Effects of homocysteine on apoptosis-related proteins and anti-oxidant systems in isolated human lymphocytes",
      "volume": "271",
      "author": "Mangiagalli",
      "year": "2004",
      "journal-title": "Eur J Biochem"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "1204",
      "DOI": "10.1093/jn/128.7.1204",
      "article-title": "Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women",
      "volume": "128",
      "author": "Jacob",
      "year": "1998",
      "journal-title": "J Nutr"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "435",
      "DOI": "10.1080/07315724.1998.10718790",
      "article-title": "Vitamins B6, B12, and folate: association with plasma total homocysteine and risk of coronary atherosclerosis",
      "volume": "17",
      "author": "Siri",
      "year": "1998",
      "journal-title": "J Am Coll Nutr"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "111",
      "DOI": "10.1038/ng0595-111",
      "article-title": "A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase",
      "volume": "10",
      "author": "Frosst",
      "year": "1995",
      "journal-title": "Nat Genet"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "813",
      "DOI": "10.1089/ars.2005.7.813",
      "article-title": "The role of cystathionine beta-synthase in homocysteine metabolism",
      "volume": "7",
      "author": "Jhee",
      "year": "2005",
      "journal-title": "Antioxid Redox Signal"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "3074",
      "DOI": "10.1161/01.CIR.94.12.3074",
      "article-title": "Common mutation in methylenetetrahydrofolate reductase. Correlation with homocysteine metabolism and late-onset vascular disease",
      "volume": "94",
      "author": "Deloughery",
      "year": "1996",
      "journal-title": "Circulation"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "2410",
      "DOI": "10.1161/01.CIR.94.10.2410",
      "article-title": "Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians",
      "volume": "94",
      "author": "Ma",
      "year": "1996",
      "journal-title": "Circulation"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "62",
      "DOI": "10.1182/asheducation-2003.1.62",
      "article-title": "Update on cobalamin, folate, and homocysteine",
      "author": "Carmel",
      "year": "2003",
      "journal-title": "Hematology (Am Soc Hematol Educ Program)"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "1140",
      "DOI": "10.1016/j.pnpbp.2005.06.025",
      "article-title": "The central nervous system in animal models of hyperhomocysteinemia",
      "volume": "29",
      "author": "Troen",
      "year": "2005",
      "journal-title": "Prog Neuropsychopharmacol Biol Psychiatry"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib31",
      "first-page": "1894",
      "article-title": "Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats",
      "volume": "55",
      "author": "Pogribny",
      "year": "1995",
      "journal-title": "Cancer Res"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib32",
      "first-page": "2071s",
      "article-title": "Methyl groups in carcinogenesis: effects on DNA methylation and gene expression",
      "volume": "52",
      "author": "Wainfan",
      "year": "1992",
      "journal-title": "Cancer Res"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib33",
      "first-page": "471",
      "article-title": "Hyperhomocysteinemia: a new risk factor for degenerative diseases",
      "volume": "48",
      "author": "Herrmann",
      "year": "2002",
      "journal-title": "Clin Lab"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "699",
      "DOI": "10.1515/znc-1995-9-1017",
      "article-title": "Homocysteine-induced oxidative damage: mechanisms and possible roles in neurodegenerative and atherogenic processes",
      "volume": "50",
      "author": "Schlussel",
      "year": "1995",
      "journal-title": "Z Naturforsch [C]"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "25",
      "DOI": "10.1016/S0163-7258(96)00097-6",
      "article-title": "The neurotransmitter candidature of sulphur-containing excitatory amino acids in the mammalian central nervous system",
      "volume": "72",
      "author": "Thompson",
      "year": "1996",
      "journal-title": "Pharmacol Ther"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "694",
      "DOI": "10.1002/jnr.10416",
      "article-title": "Multiple aspects of homocysteine neurotoxicity: glutamate excitotoxicity, kinase hyperactivation and DNA damage",
      "volume": "70",
      "author": "Ho",
      "year": "2002",
      "journal-title": "J Neurosci Res"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib37",
      "doi-asserted-by": "crossref",
      "first-page": "1752",
      "DOI": "10.1523/JNEUROSCI.22-05-01752.2002",
      "article-title": "Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease",
      "volume": "22",
      "author": "Kruman",
      "year": "2002",
      "journal-title": "J Neurosci"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "5923",
      "DOI": "10.1073/pnas.94.11.5923",
      "article-title": "Neurotoxicity associated with dual actions of homocysteine at the N-methyl-d-aspartate receptor",
      "volume": "94",
      "author": "Lipton",
      "year": "1997",
      "journal-title": "Proc Natl Acad Sci U S A"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "101",
      "DOI": "10.1046/j.0022-3042.2001.00676.x",
      "article-title": "Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease",
      "volume": "80",
      "author": "Duan",
      "year": "2002",
      "journal-title": "J Neurochem"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "325",
      "DOI": "10.1007/BF00969090",
      "article-title": "The effects of l-dopa on the activity of methionine adenosyltransferase: relevance to l-dopa therapy and tolerance",
      "volume": "18",
      "author": "Benson",
      "year": "1993",
      "journal-title": "Neurochem Res"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "55",
      "DOI": "10.1097/00002826-199702000-00007",
      "article-title": "Effect of l-Dopa and the catechol-O-methyltransferase inhibitor Ro 41-0960 on sulfur amino acid metabolites in rats",
      "volume": "20",
      "author": "Miller",
      "year": "1997",
      "journal-title": "Clin Neuropharmacol"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "2277",
      "DOI": "10.1016/S0024-3205(00)00557-9",
      "article-title": "Effects of l-dopa treatment on methylation in mouse brain: implications for the side effects of l-dopa",
      "volume": "66",
      "author": "Liu",
      "year": "2000",
      "journal-title": "Life Sci"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "55",
      "DOI": "10.1097/00002826-199702000-00007",
      "article-title": "Effect of l-Dopa and the catechol-O-methyltransferase inhibitor Ro 41-0960 on sulfur amino acid metabolites in rats",
      "volume": "20",
      "author": "Miller",
      "year": "1997",
      "journal-title": "Clin Neuropharmacol"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib44",
      "first-page": "527",
      "article-title": "Sulfate and cysteine levels in the plasma of patients with Parkinson's disease",
      "volume": "16",
      "author": "Allain",
      "year": "1995",
      "journal-title": "Neurotoxicology"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib45",
      "doi-asserted-by": "crossref",
      "first-page": "225",
      "DOI": "10.1159/000007984",
      "article-title": "Elevated plasma levels of homocysteine in Parkinson's disease",
      "volume": "40",
      "author": "Kuhn",
      "year": "1998",
      "journal-title": "Eur Neurol"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib46",
      "doi-asserted-by": "crossref",
      "first-page": "59",
      "DOI": "10.1001/archneur.60.1.59",
      "article-title": "Elevated plasma homocysteine levels in patients treated with levodopa: association with vascular disease",
      "volume": "60",
      "author": "Rogers",
      "year": "2003",
      "journal-title": "Arch Neurol"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib47",
      "doi-asserted-by": "crossref",
      "first-page": "1403",
      "DOI": "10.1002/mds.20253",
      "article-title": "Modest increase in plasma homocysteine follows levodopa initiation in Parkinson's disease",
      "volume": "19",
      "author": "O'suilleabhain",
      "year": "2004",
      "journal-title": "Mov Disord"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib48",
      "doi-asserted-by": "crossref",
      "first-page": "865",
      "DOI": "10.1001/archneur.61.6.865",
      "article-title": "Elevated plasma homocysteine level in patients with Parkinson disease: motor, affective, and cognitive associations",
      "volume": "61",
      "author": "O'suilleabhain",
      "year": "2004",
      "journal-title": "Arch Neurol"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib49",
      "doi-asserted-by": "crossref",
      "first-page": "365",
      "DOI": "10.1111/j.1468-1331.2004.00973.x",
      "article-title": "Hyperhomocysteinemia in l-dopa treated Parkinson's disease patients: effect of cobalamin and folate administration",
      "volume": "12",
      "author": "Lamberti",
      "year": "2005",
      "journal-title": "Eur J Neurol"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib50",
      "doi-asserted-by": "crossref",
      "first-page": "131",
      "DOI": "10.1016/j.parkreldis.2004.07.008",
      "article-title": "Plasma homocysteine levels in Parkinson's disease: role of antiparkinsonian medications",
      "volume": "11",
      "author": "Zoccolella",
      "year": "2005",
      "journal-title": "Parkinsonism Relat Disord"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib51",
      "doi-asserted-by": "crossref",
      "first-page": "1102",
      "DOI": "10.1093/clinchem/47.6.1102",
      "article-title": "Plasma homocysteine and l-dopa metabolism in patients with Parkinson disease",
      "volume": "47",
      "author": "Blandini",
      "year": "2001",
      "journal-title": "Clin Chem"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib52",
      "doi-asserted-by": "crossref",
      "first-page": "126",
      "DOI": "10.1016/S0140-6736(99)01660-8",
      "article-title": "Nigral endothelial dysfunction, homocysteine, and Parkinson's disease",
      "volume": "354",
      "author": "Muller",
      "year": "1999",
      "journal-title": "Lancet"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib53",
      "doi-asserted-by": "crossref",
      "first-page": "54",
      "DOI": "10.1016/S0304-3940(01)01972-3",
      "article-title": "Decrease of methionine and S-adenosylmethionine and increase of homocysteine in treated patients with Parkinson's disease",
      "volume": "308",
      "author": "Muller",
      "year": "2001",
      "journal-title": "Neurosci Lett"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib54",
      "doi-asserted-by": "crossref",
      "first-page": "F786",
      "DOI": "10.1152/ajprenal.00465.2004",
      "article-title": "Effect of acute hyperhomocysteinemia on methylation potential of erythrocytes and on DNA methylation of lymphocytes in healthy male volunteers.",
      "volume": "289",
      "author": "Fux",
      "year": "2005",
      "journal-title": "Am J Physiol Renal Physiol"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib55",
      "doi-asserted-by": "crossref",
      "first-page": "1558",
      "DOI": "10.4088/JCP.v66n1210",
      "article-title": "High serum homocysteine levels in young male schizophrenic and schizoaffective patients with tardive parkinsonism and/or tardive dyskinesia",
      "volume": "66",
      "author": "Lerner",
      "year": "2005",
      "journal-title": "J Clin Psychiatry"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib56",
      "doi-asserted-by": "crossref",
      "first-page": "1705",
      "DOI": "10.1176/appi.ajp.161.9.1705",
      "article-title": "Folate, homocysteine, and negative symptoms in schizophrenia",
      "volume": "161",
      "author": "Goff",
      "year": "2004",
      "journal-title": "Am J Psychiatry"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib57",
      "doi-asserted-by": "crossref",
      "first-page": "1387",
      "DOI": "10.1176/appi.ajp.162.7.1387-a",
      "article-title": "The significance of homocysteine levels in schizophrenia",
      "volume": "162",
      "author": "O\u2019Donnell",
      "year": "2005",
      "journal-title": "Am J Psychiatry"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib58",
      "doi-asserted-by": "crossref",
      "first-page": "1388",
      "DOI": "10.1176/appi.ajp.162.7.1388",
      "article-title": "Letter to the editor",
      "volume": "162",
      "author": "Goff",
      "year": "2005",
      "journal-title": "Am J Psychiatry"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib59",
      "doi-asserted-by": "crossref",
      "first-page": "927",
      "DOI": "10.1002/ana.20509",
      "article-title": "Methylenetetrahydrofolate reductase C677T genotype and PD",
      "volume": "57",
      "author": "de Lau",
      "year": "2005",
      "journal-title": "Ann Neurol"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib60",
      "doi-asserted-by": "crossref",
      "first-page": "1445",
      "DOI": "10.1007/s00702-002-0758-8",
      "article-title": "Moderate hyperhomocysteinaemia and immune activation in Parkinson's disease",
      "volume": "109",
      "author": "Widner",
      "year": "2002",
      "journal-title": "J Neural Transm"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib61",
      "doi-asserted-by": "crossref",
      "first-page": "1250",
      "DOI": "10.1016/j.amjmed.2005.01.052",
      "article-title": "Homocysteine as a predictive factor for hip fracture in elderly women with Parkinson's disease",
      "volume": "118",
      "author": "Sato",
      "year": "2005",
      "journal-title": "Am J Med"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib62",
      "doi-asserted-by": "crossref",
      "first-page": "215",
      "DOI": "10.1016/0009-8981(73)90429-4",
      "article-title": "The reaction of homocysteine with aldehyde: an explanation of the collagen defects in homocystinuria",
      "volume": "45",
      "author": "Jackson",
      "year": "1973",
      "journal-title": "Clin Chim Acta"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib63",
      "doi-asserted-by": "crossref",
      "first-page": "1402",
      "DOI": "10.1212/01.wnl.0000183063.99107.5c",
      "article-title": "Association of homocysteine with plasma amyloid beta protein in aging and neurodegenerative disease",
      "volume": "65",
      "author": "Irizarry",
      "year": "2005",
      "journal-title": "Neurology"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib64",
      "doi-asserted-by": "crossref",
      "first-page": "12915",
      "DOI": "10.1074/jbc.M112372200",
      "article-title": "Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein",
      "volume": "277",
      "author": "Sai",
      "year": "2002",
      "journal-title": "J Biol Chem"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib65",
      "doi-asserted-by": "crossref",
      "first-page": "145",
      "DOI": "10.1016/S0014-5793(03)00277-1",
      "article-title": "Presenilin 1 gene silencing by S-adenosylmethionine: a treatment for Alzheimer disease?",
      "volume": "541",
      "author": "Scarpa",
      "year": "2003",
      "journal-title": "FEBS Lett"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib66",
      "doi-asserted-by": "crossref",
      "first-page": "627",
      "DOI": "10.1093/ajcn/82.3.627",
      "article-title": "High homocysteine and low B vitamins predict cognitive decline in aging men; the Veterans Affairs Normative Aging Study",
      "volume": "82",
      "author": "Tucker",
      "year": "2005",
      "journal-title": "Am J Clin Nutr"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib67",
      "doi-asserted-by": "crossref",
      "first-page": "161",
      "DOI": "10.1016/j.amjmed.2004.08.019",
      "article-title": "Homocysteine versus the vitamins folate, B6, and B12 as predictors of cognitive function and decline in older high-functioning adults: MacArthur Studies of Successful Aging",
      "volume": "118",
      "author": "Kado",
      "year": "2005",
      "journal-title": "Am J Med"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib68",
      "doi-asserted-by": "crossref",
      "first-page": "866",
      "DOI": "10.1093/ajcn/82.4.866",
      "article-title": "Homocysteine, vitamin B12, and folic acid and the risk of cognitive decline in old age: the Leiden 85-Plus study",
      "volume": "82",
      "author": "Mooijaart",
      "year": "2005",
      "journal-title": "Am J Clin Nutr"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib69",
      "doi-asserted-by": "crossref",
      "first-page": "1663",
      "DOI": "10.1002/mds.20667",
      "article-title": "Homocysteine and serum markers if immune activation in primary dystonia",
      "volume": "20",
      "author": "Muller",
      "year": "2005",
      "journal-title": "Mov Disord"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib70",
      "doi-asserted-by": "crossref",
      "first-page": "340",
      "DOI": "10.1254/jphs.CRJ05003X",
      "article-title": "The high atherosclerotic risk among epileptics: the atheroprotective role of multivitamins",
      "volume": "98",
      "author": "Hamed",
      "year": "2005",
      "journal-title": "J Pharmacol Sci"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib71",
      "doi-asserted-by": "crossref",
      "first-page": "79",
      "DOI": "10.1016/j.seizure.2005.11.002",
      "article-title": "Effects of common anti-epileptic drug monotherapy on serum levels of homocysteine, vitamin B12, folic acid and vitamin B6",
      "volume": "15",
      "author": "Sener",
      "year": "2006",
      "journal-title": "Seizure"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib72",
      "doi-asserted-by": "crossref",
      "first-page": "1320",
      "DOI": "10.1093/ajcn/82.6.1320",
      "article-title": "Westendorp Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease",
      "volume": "82",
      "author": "Stott",
      "year": "2005",
      "journal-title": "Am J Clin Nutr"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib73",
      "doi-asserted-by": "crossref",
      "first-page": "127",
      "DOI": "10.1016/j.archger.2005.10.002",
      "article-title": "Effects of folic acid supplementation on psychomotor performance and hemorheology in healthy elderly subjects",
      "volume": "43",
      "author": "Pathansali",
      "year": "2006",
      "journal-title": "Arch Gerontol Geriatr"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib74",
      "doi-asserted-by": "crossref",
      "first-page": "1431",
      "DOI": "10.1212/01.WNL.0000158476.74580.A8",
      "article-title": "Executive dysfunction in hyperhomocystinemia responds to homocysteine-lowering treatment",
      "volume": "64",
      "author": "Boxer",
      "year": "2005",
      "journal-title": "Neurology"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib75",
      "doi-asserted-by": "crossref",
      "first-page": "886",
      "DOI": "10.1212/01.WNL.0000137886.74175.5A",
      "article-title": "Homocysteine and l-Dopa: should Parkinson disease patients receive preventive therapy?",
      "volume": "63",
      "author": "Postuma",
      "year": "2004",
      "journal-title": "Neurology"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib76",
      "doi-asserted-by": "crossref",
      "first-page": "368",
      "DOI": "10.1093/aje/kwh213",
      "article-title": "Folate intake and risk of Parkinson's disease",
      "volume": "160",
      "author": "Chen",
      "year": "2004",
      "journal-title": "Am J Epidemiol"
    },
    {
      "key": "10.1016/j.jns.2007.01.028_bib77",
      "doi-asserted-by": "crossref",
      "first-page": "371",
      "DOI": "10.1111/j.1365-277X.2004.00532.x",
      "article-title": "A critical evaluation of the relationship between serum vitamin B, folate and total homocysteine with cognitive impairment in the elderly",
      "volume": "17",
      "author": "Ellinson",
      "year": "2004",
      "journal-title": "J Hum Nutr Diet"
    }
  ],
  "container-title": "Journal of the Neurological Sciences",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0022510X07000548?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0022510X07000548?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2020,
        4,
        20
      ]
    ],
    "date-time": "2020-04-20T09:10:54Z",
    "timestamp": 1587373854000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0022510X07000548"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2007,
        6
      ]
    ]
  },
  "references-count": 77,
  "journal-issue": {
    "issue": "1-2",
    "published-print": {
      "date-parts": [
        [
          2007,
          6
        ]
      ]
    }
  },
  "alternative-id": [
    "S0022510X07000548"
  ],
  "URL": "http://dx.doi.org/10.1016/j.jns.2007.01.028",
  "relation": {},
  "ISSN": [
    "0022-510X"
  ],
  "subject": [],
  "container-title-short": "Journal of the Neurological Sciences",
  "published": {
    "date-parts": [
      [
        2007,
        6
      ]
    ]
  }
}