DOI: 10.1016/j.jmb.2011.03.073. In Vitro DNA Tethering of HIV-1 Integrase by the Transcriptional Coactivator LEDGF/p75

In Vitro DNA Tethering of HIV-1 Integrase by the Transcriptional Coactivator LEDGF/p75

10.1016/j.jmb.2011.03.073

Crossref journal-article

Elsevier BV

Journal of Molecular Biology (78)

Bibliography

McNeely, M., Hendrix, J., Busschots, K., Boons, E., Deleersnijder, A., Gerard, M., Christ, F., & Debyser, Z. (2011). In Vitro DNA Tethering of HIV-1 Integrase by the Transcriptional Coactivator LEDGF/p75. Journal of Molecular Biology, 410(5), 811â830.

Authors 8

Melissa McNeely (first)
Jelle Hendrix (additional)
Katrien Busschots (additional)
Eline Boons (additional)
Angélique Deleersnijder (additional)
Melanie Gerard (additional)
Frauke Christ (additional)
Zeger Debyser (additional)

References 75 Referenced 29

10.1016/0092-8674(91)90297-C / Cell / HIV-1 DNA integration: mechanism of viral DNA cleavage and DNA strand transfer by Engelman (1991)
10.1073/pnas.88.4.1339 / Proc. Natl Acad. Sci. USA / Activities of human immunodeficiency virus (HIV) integration protein in vitro: specific cleavage and integration of HIV DNA by Bushman (1991)
10.1016/j.tig.2006.05.006 / Trends Genet. / Retroviral DNA integration: HIV and the role of LEDGF/p75 by Ciuffi (2006)
{'key': '10.1016/j.jmb.2011.03.073_bb0020', 'first-page': '26', 'article-title': 'HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins', 'volume': '7', 'author': 'Van Maele', 'year': '2005', 'journal-title': 'AIDS Rev.'} / AIDS Rev. / HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins by Van Maele (2005)
10.1074/jbc.M209278200 / J. Biol. Chem. / HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells by Cherepanov (2003)
10.1371/journal.ppat.1000046 / PLoS Pathog. / The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication by Engelman (2008)
10.1007/s00018-008-7540-5 / Cell. Mol. Life. Sci. / Integrase, LEDGF/p75 and HIV replication by Poeschla (2008)
10.1006/bbrc.2001.4887 / Biochem. Biophys. Res. Commun. / LEDGF binds to heat shock and stress-related element to activate the expression of stress-related genes by Singh (2001)
10.1016/S1350-9462(02)00007-1 / Prog. Retinal Eye Res. / LEDGF, a survival factor, activates stress-related genes by Shinohara (2002)
10.1016/j.jmb.2006.04.073 / J. Mol. Biol. / Identification and characterization of the chromatin-binding domains of the HIV-1 integrase interactor LEDGF/p75 by Llano (2006)
10.1074/jbc.M303594200 / J. Biol. Chem. / LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells by Maertens (2003)
10.1074/jbc.M501378200 / J. Biol. Chem. / Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication by Emiliani (2005)
10.1128/JVI.01953-06 / J. Virol. / Wild-type levels of human immunodeficiency virus type 1 infectivity in the absence of cellular emerin protein by Shun (2007)
10.1016/j.jmb.2006.10.094 / J. Mol. Biol. / Identification of the LEDGF/p75 binding site in HIV-1 integrase by Busschots (2007)
10.1016/j.virol.2006.08.011 / Virology / Structure-based mutagenesis of the integrase–LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness by Rahman (2007)
10.1128/JVI.80.4.1886-1896.2006 / J. Virol. / Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus by Vandekerckhove (2006)
10.1126/science.1132319 / Science / An essential role for LEDGF/p75 in HIV integration by Llano (2006)
10.1371/journal.pone.0001340 / PLoS One / Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting by Marshall (2007)
10.1093/nar/gkl052 / Nucleic Acids Res. / A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo by Turlure (2006)
10.1016/j.jmb.2006.04.073 / J. Mol. Biol. / Identification and characterization of the chromatin-binding domains of the HIV-1 integrase interactor LEDGF/p75 by Llano (2006)
10.1073/pnas.0506924102 / Proc. Natl. Acad. Sci. USA / Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75 by Cherepanov (2005)
10.1074/jbc.M406307200 / J. Biol. Chem. / Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase by Cherepanov (2004)
10.1038/nsmb937 / Nat. Struct. Mol. Biol. / Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75 by Cherepanov (2005)
10.1186/1471-2199-8-101 / BMC Mol. Biol. / Hepatoma-derived growth factor binds DNA through the N-terminal PWWP domain by Yang (2007)
10.1093/nar/gkm1127 / Nucleic Acids Res. / Chromatinized templates reveal the requirement for the LEDGF/p75 PWWP domain during HIV-1 integration in vitro by Botbol (2008)
10.1038/mt.2010.36 / Mol. Ther. / LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin by Gijsbers (2010)
10.1089/hum.2006.17.960 / Hum. Gene. Ther. / Modulating target site selection during human immunodeficiency virus DNA integration in vitro with an engineered tethering factor by Ciuffi (2006)
10.1101/gad.1565107 / Genes Dev. / LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration by Shun (2007)
10.1093/nar/gkq410 / Nucleic Acids Res. / High-resolution profiling of the LEDGF/p75 chromatin interaction in the ENCODE region by De Rijck (2010)
10.1074/jbc.M411681200 / J. Biol. Chem. / The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding by Busschots (2005)
10.1021/bi602387u / Biochemistry / HIV-1 integrase preassembled on donor DNA is refractory to activity stimulation by LEDGF/p75 by Yu (2007)
10.1016/j.virol.2006.12.022 / Virology / LEDGF/p75 interferes with the formation of synaptic nucleoprotein complexes that catalyze full-site HIV-1 DNA integration in vitro: implications for the mechanism of viral cDNA integration by Raghavendra (2007)
10.1128/JVI.02322-06 / J. Virol. / Transcriptional coactivator LEDGF/p75 modulates human immunodeficiency virus type 1 integrase-mediated concerted integration by Pandey (2007)
10.1074/jbc.M406307200 / J. Biol. Chem. / Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase by Cherepanov (2004)
10.1074/jbc.M805843200 / J. Biol. Chem. / Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein by McKee (2008)
10.1074/jbc.M110.114413 / J. Biol. Chem. / Structural properties of HIV integrase–LEDGF oligomers by Gupta (2010)
10.1016/j.jmb.2010.04.026 / J. Mol. Biol. / Nucleoprotein intermediates in HIV-1 DNA integration visualized by atomic force microscopy by Kotova (2010)
10.1128/JVI.00801-06 / J. Virol. / Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication by De Rijck (2006)
10.1371/journal.ppat.0030047 / PLoS Pathog. / Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV by Hombrouck (2007)
10.1093/nar/19.14.3821 / Nucleic Acids Res. / DNA binding properties of the integrase proteins of human immunodeficiency viruses types 1 and 2 by van Gent (1991)
10.1128/JVI.71.9.7005-7011.1997 / J. Virol. / Differential divalent cation requirements uncouple the assembly and catalytic reactions of human immunodeficiency virus type 1 integrase by Hazuda (1997)
10.1089/aid.1992.8.297 / AIDS Res. Hum. Retroviruses / Localization of DNA binding activity of HIV-1 integrase to the C-terminal half of the protein by Woerner (1992)
10.1093/nar/21.6.1419 / Nucleic Acids Res. / Identification of the catalytic and DNA-binding region of the human immunodeficiency virus type I integrase protein by Vink (1993)
10.1093/nar/19.4.851 / Nucleic Acids Res. / Retroviral integrase domains: DNA binding and the recognition of LTR sequences by Khan (1991)
10.1073/pnas.87.13.5119 / Proc. Natl Acad. Sci. USA / Human immunodeficiency virus integration protein expressed in Escherichia coli possesses selective DNA cleaving activity by Sherman (1990)
10.1073/pnas.91.13.5771 / Proc. Natl Acad. Sci. USA / Inhibition of human immunodeficiency virus type 1 integrase by 3′-azido-3′-deoxythymidylate by Mazumder (1994)
10.1006/bbrc.1995.2843 / Biochem. Biophys. Res. Commun. / Characterization of the DNA-binding activity of HIV-1 integrase using a filter binding assay by Haugan (1995)
10.1093/nar/22.20.4125 / Nucleic Acids Res. / Characterization of the minimal DNA-binding domain of the HIV integrase protein by Lutzke (1994)
10.1128/JVI.67.8.5041-5044.1993 / J. Virol. / Conserved residues Pro-109 and Asp-116 are required for interaction of the human immunodeficiency virus type 1 integrase protein with its viral DNA substrate by Drelich (1993)
10.1128/JVI.68.9.5911-5917.1994 / J. Virol. / The core and carboxyl-terminal domains of the integrase protein of human immunodeficiency virus type 1 each contribute to nonspecific DNA binding by Engelman (1994)
10.1021/bi971893j / Biochemistry / Displacement of viral DNA termini from stable HIV-1 integrase nucleoprotein complexes induced by secondary DNA-binding interactions by Pemberton (1998)
10.1124/mol.52.5.771 / Mol. Pharmacol. / Mode of interaction of G-quartets with the integrase of human immunodeficiency virus type 1 by Cherepanov (1997)
10.1007/s00216-008-2485-y / Anal. Bioanal. Chem. / Surface plasmon resonance study on HIV-1 integrase strand transfer activity by Vaisocherova (2009)
10.1074/jbc.M205842200 / J. Biol. Chem. / DNA-induced polymerization of HIV-1 integrase analyzed with fluorescence fluctuation spectroscopy by Vercammen (2002)
10.1074/jbc.M803257200 / J. Biol. Chem. / Insight into the integrase–DNA recognition mechanism. A specific DNA-binding mode revealed by an enzymatically labeled integrase by Delelis (2008)
10.1074/jbc.M602198200 / J. Biol. Chem. / Relationship between the oligomeric status of HIV-1 integrase on DNA and enzymatic activity by Guiot (2006)
Carayon, K., Leh, H., Henry, E., Simon, F., Mouscadet, J. F. & Deprez, E. A cooperative and specific DNA-binding mode of HIV-1 integrase depends on the nature of the metallic cofactor and involves the zinc-containing N-terminal domain. Nucleic Acids Res. 38, 3692–3708. (10.1093/nar/gkq087)
10.1074/jbc.271.3.1498 / J. Biol. Chem. / The metal ion-induced cooperative binding of HIV-1 integrase to DNA exhibits a marked preference for Mn(II) rather than Mg(II) by Pemberton (1996)
10.1021/bi982870n / Biochemistry / Divalent cations stimulate preferential recognition of a viral DNA end by HIV-1 integrase by Yi (1999)
10.1021/bi000397j / Biochemistry / Oligomeric states of the HIV-1 integrase as measured by time-resolved fluorescence anisotropy by Deprez (2000)
10.1124/mol.65.1.85 / Mol. Pharmacol. / Mechanism of HIV-1 integrase inhibition by styrylquinoline derivatives in vitro by Deprez (2004)
10.1093/nar/gki241 / Nucleic Acids Res. / HIV-1 integrase crosslinked oligomers are active in vitro by Faure (2005)
10.1128/JVI.78.17.9524-9537.2004 / J. Virol. / LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes by Llano (2004)
10.1074/jbc.M303594200 / J. Biol. Chem. / LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells by Maertens (2003)
10.1093/nar/gkq933 / Nucleic Acids Res. / The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tethering by Hendrix (2011)
10.1371/journal.ppat.1000259 / PLoS Pathog. / A novel co-crystal structure affords the design of gain-of-function lentiviral integrase mutants in the presence of modified PSIP1/LEDGF/p75 by Hare (2009)
10.3390/v1030780 / Viruses / The interaction between lentiviral integrase and LEDGF: structural and functional insights by Hare (2009)
10.1371/journal.ppat.1000515 / PLoS Pathog. / Structural basis for functional tetramerization of lentiviral integrase by Hare (2009)
10.1093/nar/gkl052 / Nucleic Acids Res. / A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo by Turlure (2006)
10.1074/jbc.M109.040121 / J. Biol. Chem. / Affinities between the binding partners of the HIV-1 integrase dimer–lens epithelium-derived growth factor (IN dimer–LEDGF) complex by Tsiang (2009)
10.1096/fj.04-3373fje / FASEB J. / Measuring protein–protein interactions inside living cells using single color fluorescence correlation spectroscopy. Application to human immunodeficiency virus type 1 integrase and LEDGF/p75 by Maertens (2005)
10.1093/nar/gnh172 / Nucleic Acids Res. / Site-directed, Ligase-Independent Mutagenesis (SLIM): a single-tube methodology approaching 100% efficiency in 4 h by Chiu (2004)
10.1016/j.jmb.2007.06.090 / J. Mol. Biol. / Differential interaction of HIV-1 integrase and JPO2 with the C terminus of LEDGF/p75 by Bartholomeeusen (2007)
10.1093/nar/26.7.1848 / Nucleic Acids Res. / An improved PCR-mutagenesis strategy for two-site mutagenesis or sequence swapping between related genes by Kirsch (1998)
10.1093/nar/28.24.4884 / Nucleic Acids Res. / Rapid microtiter assays for poxvirus topoisomerase, mammalian type IB topoisomerase and HIV-1 integrase: application to inhibitor isolation by Hwang (2000)

Dates

Type	When
Created	14 years, 1 month ago (July 22, 2011, 2:22 p.m.)
Deposited	5 years, 2 months ago (June 21, 2020, 10:34 a.m.)
Indexed	1 year ago (Aug. 15, 2024, 6:31 a.m.)
Issued	14 years, 2 months ago (July 1, 2011)
Published	14 years, 2 months ago (July 1, 2011)
Published Print	14 years, 2 months ago (July 1, 2011)

Funders 0

None

BibTeX

@article{McNeely_2011, title={In Vitro DNA Tethering of HIV-1 Integrase by the Transcriptional Coactivator LEDGF/p75}, volume={410}, ISSN={0022-2836}, url={http://dx.doi.org/10.1016/j.jmb.2011.03.073}, DOI={10.1016/j.jmb.2011.03.073}, number={5}, journal={Journal of Molecular Biology}, publisher={Elsevier BV}, author={McNeely, Melissa and Hendrix, Jelle and Busschots, Katrien and Boons, Eline and Deleersnijder, Angélique and Gerard, Melanie and Christ, Frauke and Debyser, Zeger}, year={2011}, month=jul, pages={811–830} }

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      "author": "Ciuffi",
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      "article-title": "HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins",
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      "author": "Van Maele",
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      "volume": "278",
      "author": "Cherepanov",
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      "volume": "4",
      "author": "Engelman",
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    {
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      "first-page": "1403",
      "DOI": "10.1007/s00018-008-7540-5",
      "article-title": "Integrase, LEDGF/p75 and HIV replication",
      "volume": "65",
      "author": "Poeschla",
      "year": "2008",
      "journal-title": "Cell. Mol. Life. Sci."
    },
    {
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      "volume": "283",
      "author": "Singh",
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      "volume": "365",
      "author": "Busschots",
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      "journal-title": "J. Mol. Biol."
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      "author": "Rahman",
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      "author": "Vandekerckhove",
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      "author": "Marshall",
      "year": "2007",
      "journal-title": "PLoS One"
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0095",
      "doi-asserted-by": "crossref",
      "first-page": "1653",
      "DOI": "10.1093/nar/gkl052",
      "article-title": "A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo",
      "volume": "34",
      "author": "Turlure",
      "year": "2006",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0100",
      "doi-asserted-by": "crossref",
      "first-page": "760",
      "DOI": "10.1016/j.jmb.2006.04.073",
      "article-title": "Identification and characterization of the chromatin-binding domains of the HIV-1 integrase interactor LEDGF/p75",
      "volume": "360",
      "author": "Llano",
      "year": "2006",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0105",
      "doi-asserted-by": "crossref",
      "first-page": "17308",
      "DOI": "10.1073/pnas.0506924102",
      "article-title": "Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75",
      "volume": "102",
      "author": "Cherepanov",
      "year": "2005",
      "journal-title": "Proc. Natl. Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0110",
      "doi-asserted-by": "crossref",
      "first-page": "48883",
      "DOI": "10.1074/jbc.M406307200",
      "article-title": "Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase",
      "volume": "279",
      "author": "Cherepanov",
      "year": "2004",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0115",
      "doi-asserted-by": "crossref",
      "first-page": "526",
      "DOI": "10.1038/nsmb937",
      "article-title": "Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75",
      "volume": "12",
      "author": "Cherepanov",
      "year": "2005",
      "journal-title": "Nat. Struct. Mol. Biol."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0120",
      "doi-asserted-by": "crossref",
      "first-page": "101",
      "DOI": "10.1186/1471-2199-8-101",
      "article-title": "Hepatoma-derived growth factor binds DNA through the N-terminal PWWP domain",
      "volume": "8",
      "author": "Yang",
      "year": "2007",
      "journal-title": "BMC Mol. Biol."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0125",
      "doi-asserted-by": "crossref",
      "first-page": "1237",
      "DOI": "10.1093/nar/gkm1127",
      "article-title": "Chromatinized templates reveal the requirement for the LEDGF/p75 PWWP domain during HIV-1 integration in vitro",
      "volume": "36",
      "author": "Botbol",
      "year": "2008",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0130",
      "doi-asserted-by": "crossref",
      "first-page": "552",
      "DOI": "10.1038/mt.2010.36",
      "article-title": "LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin",
      "volume": "18",
      "author": "Gijsbers",
      "year": "2010",
      "journal-title": "Mol. Ther."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0135",
      "doi-asserted-by": "crossref",
      "first-page": "960",
      "DOI": "10.1089/hum.2006.17.960",
      "article-title": "Modulating target site selection during human immunodeficiency virus DNA integration in vitro with an engineered tethering factor",
      "volume": "17",
      "author": "Ciuffi",
      "year": "2006",
      "journal-title": "Hum. Gene. Ther."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0140",
      "doi-asserted-by": "crossref",
      "first-page": "1767",
      "DOI": "10.1101/gad.1565107",
      "article-title": "LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration",
      "volume": "21",
      "author": "Shun",
      "year": "2007",
      "journal-title": "Genes Dev."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0145",
      "doi-asserted-by": "crossref",
      "first-page": "6135",
      "DOI": "10.1093/nar/gkq410",
      "article-title": "High-resolution profiling of the LEDGF/p75 chromatin interaction in the ENCODE region",
      "volume": "38",
      "author": "De Rijck",
      "year": "2010",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0150",
      "doi-asserted-by": "crossref",
      "first-page": "17841",
      "DOI": "10.1074/jbc.M411681200",
      "article-title": "The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding",
      "volume": "280",
      "author": "Busschots",
      "year": "2005",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0155",
      "doi-asserted-by": "crossref",
      "first-page": "2899",
      "DOI": "10.1021/bi602387u",
      "article-title": "HIV-1 integrase preassembled on donor DNA is refractory to activity stimulation by LEDGF/p75",
      "volume": "46",
      "author": "Yu",
      "year": "2007",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0160",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "DOI": "10.1016/j.virol.2006.12.022",
      "article-title": "LEDGF/p75 interferes with the formation of synaptic nucleoprotein complexes that catalyze full-site HIV-1 DNA integration in vitro: implications for the mechanism of viral cDNA integration",
      "volume": "360",
      "author": "Raghavendra",
      "year": "2007",
      "journal-title": "Virology"
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0165",
      "doi-asserted-by": "crossref",
      "first-page": "3969",
      "DOI": "10.1128/JVI.02322-06",
      "article-title": "Transcriptional coactivator LEDGF/p75 modulates human immunodeficiency virus type 1 integrase-mediated concerted integration",
      "volume": "81",
      "author": "Pandey",
      "year": "2007",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0170",
      "doi-asserted-by": "crossref",
      "first-page": "48883",
      "DOI": "10.1074/jbc.M406307200",
      "article-title": "Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase",
      "volume": "279",
      "author": "Cherepanov",
      "year": "2004",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0175",
      "doi-asserted-by": "crossref",
      "first-page": "31802",
      "DOI": "10.1074/jbc.M805843200",
      "article-title": "Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein",
      "volume": "283",
      "author": "McKee",
      "year": "2008",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0180",
      "doi-asserted-by": "crossref",
      "first-page": "20303",
      "DOI": "10.1074/jbc.M110.114413",
      "article-title": "Structural properties of HIV integrase\u2013LEDGF oligomers",
      "volume": "285",
      "author": "Gupta",
      "year": "2010",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0185",
      "doi-asserted-by": "crossref",
      "first-page": "491",
      "DOI": "10.1016/j.jmb.2010.04.026",
      "article-title": "Nucleoprotein intermediates in HIV-1 DNA integration visualized by atomic force microscopy",
      "volume": "399",
      "author": "Kotova",
      "year": "2010",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0190",
      "doi-asserted-by": "crossref",
      "first-page": "11498",
      "DOI": "10.1128/JVI.00801-06",
      "article-title": "Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication",
      "volume": "80",
      "author": "De Rijck",
      "year": "2006",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0195",
      "doi-asserted-by": "crossref",
      "first-page": "e47",
      "DOI": "10.1371/journal.ppat.0030047",
      "article-title": "Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV",
      "volume": "3",
      "author": "Hombrouck",
      "year": "2007",
      "journal-title": "PLoS Pathog."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0200",
      "doi-asserted-by": "crossref",
      "first-page": "3821",
      "DOI": "10.1093/nar/19.14.3821",
      "article-title": "DNA binding properties of the integrase proteins of human immunodeficiency viruses types 1 and 2",
      "volume": "19",
      "author": "van Gent",
      "year": "1991",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0205",
      "doi-asserted-by": "crossref",
      "first-page": "7005",
      "DOI": "10.1128/JVI.71.9.7005-7011.1997",
      "article-title": "Differential divalent cation requirements uncouple the assembly and catalytic reactions of human immunodeficiency virus type 1 integrase",
      "volume": "71",
      "author": "Hazuda",
      "year": "1997",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0210",
      "doi-asserted-by": "crossref",
      "first-page": "297",
      "DOI": "10.1089/aid.1992.8.297",
      "article-title": "Localization of DNA binding activity of HIV-1 integrase to the C-terminal half of the protein",
      "volume": "8",
      "author": "Woerner",
      "year": "1992",
      "journal-title": "AIDS Res. Hum. Retroviruses"
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0215",
      "doi-asserted-by": "crossref",
      "first-page": "1419",
      "DOI": "10.1093/nar/21.6.1419",
      "article-title": "Identification of the catalytic and DNA-binding region of the human immunodeficiency virus type I integrase protein",
      "volume": "21",
      "author": "Vink",
      "year": "1993",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0220",
      "doi-asserted-by": "crossref",
      "first-page": "851",
      "DOI": "10.1093/nar/19.4.851",
      "article-title": "Retroviral integrase domains: DNA binding and the recognition of LTR sequences",
      "volume": "19",
      "author": "Khan",
      "year": "1991",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0225",
      "doi-asserted-by": "crossref",
      "first-page": "5119",
      "DOI": "10.1073/pnas.87.13.5119",
      "article-title": "Human immunodeficiency virus integration protein expressed in Escherichia coli possesses selective DNA cleaving activity",
      "volume": "87",
      "author": "Sherman",
      "year": "1990",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0230",
      "doi-asserted-by": "crossref",
      "first-page": "5771",
      "DOI": "10.1073/pnas.91.13.5771",
      "article-title": "Inhibition of human immunodeficiency virus type 1 integrase by 3\u2032-azido-3\u2032-deoxythymidylate",
      "volume": "91",
      "author": "Mazumder",
      "year": "1994",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0235",
      "doi-asserted-by": "crossref",
      "first-page": "802",
      "DOI": "10.1006/bbrc.1995.2843",
      "article-title": "Characterization of the DNA-binding activity of HIV-1 integrase using a filter binding assay",
      "volume": "217",
      "author": "Haugan",
      "year": "1995",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0240",
      "doi-asserted-by": "crossref",
      "first-page": "4125",
      "DOI": "10.1093/nar/22.20.4125",
      "article-title": "Characterization of the minimal DNA-binding domain of the HIV integrase protein",
      "volume": "22",
      "author": "Lutzke",
      "year": "1994",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0245",
      "doi-asserted-by": "crossref",
      "first-page": "5041",
      "DOI": "10.1128/JVI.67.8.5041-5044.1993",
      "article-title": "Conserved residues Pro-109 and Asp-116 are required for interaction of the human immunodeficiency virus type 1 integrase protein with its viral DNA substrate",
      "volume": "67",
      "author": "Drelich",
      "year": "1993",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0250",
      "doi-asserted-by": "crossref",
      "first-page": "5911",
      "DOI": "10.1128/JVI.68.9.5911-5917.1994",
      "article-title": "The core and carboxyl-terminal domains of the integrase protein of human immunodeficiency virus type 1 each contribute to nonspecific DNA binding",
      "volume": "68",
      "author": "Engelman",
      "year": "1994",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0255",
      "doi-asserted-by": "crossref",
      "first-page": "2682",
      "DOI": "10.1021/bi971893j",
      "article-title": "Displacement of viral DNA termini from stable HIV-1 integrase nucleoprotein complexes induced by secondary DNA-binding interactions",
      "volume": "37",
      "author": "Pemberton",
      "year": "1998",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0260",
      "doi-asserted-by": "crossref",
      "first-page": "771",
      "DOI": "10.1124/mol.52.5.771",
      "article-title": "Mode of interaction of G-quartets with the integrase of human immunodeficiency virus type 1",
      "volume": "52",
      "author": "Cherepanov",
      "year": "1997",
      "journal-title": "Mol. Pharmacol."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0265",
      "doi-asserted-by": "crossref",
      "first-page": "1165",
      "DOI": "10.1007/s00216-008-2485-y",
      "article-title": "Surface plasmon resonance study on HIV-1 integrase strand transfer activity",
      "volume": "393",
      "author": "Vaisocherova",
      "year": "2009",
      "journal-title": "Anal. Bioanal. Chem."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0270",
      "doi-asserted-by": "crossref",
      "first-page": "38045",
      "DOI": "10.1074/jbc.M205842200",
      "article-title": "DNA-induced polymerization of HIV-1 integrase analyzed with fluorescence fluctuation spectroscopy",
      "volume": "277",
      "author": "Vercammen",
      "year": "2002",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0275",
      "doi-asserted-by": "crossref",
      "first-page": "27838",
      "DOI": "10.1074/jbc.M803257200",
      "article-title": "Insight into the integrase\u2013DNA recognition mechanism. A specific DNA-binding mode revealed by an enzymatically labeled integrase",
      "volume": "283",
      "author": "Delelis",
      "year": "2008",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0280",
      "doi-asserted-by": "crossref",
      "first-page": "22707",
      "DOI": "10.1074/jbc.M602198200",
      "article-title": "Relationship between the oligomeric status of HIV-1 integrase on DNA and enzymatic activity",
      "volume": "281",
      "author": "Guiot",
      "year": "2006",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0285",
      "doi-asserted-by": "crossref",
      "unstructured": "Carayon, K., Leh, H., Henry, E., Simon, F., Mouscadet, J. F. & Deprez, E. A cooperative and specific DNA-binding mode of HIV-1 integrase depends on the nature of the metallic cofactor and involves the zinc-containing N-terminal domain. Nucleic Acids Res. 38, 3692\u20133708.",
      "DOI": "10.1093/nar/gkq087"
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0290",
      "doi-asserted-by": "crossref",
      "first-page": "1498",
      "DOI": "10.1074/jbc.271.3.1498",
      "article-title": "The metal ion-induced cooperative binding of HIV-1 integrase to DNA exhibits a marked preference for Mn(II) rather than Mg(II)",
      "volume": "271",
      "author": "Pemberton",
      "year": "1996",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0295",
      "doi-asserted-by": "crossref",
      "first-page": "8458",
      "DOI": "10.1021/bi982870n",
      "article-title": "Divalent cations stimulate preferential recognition of a viral DNA end by HIV-1 integrase",
      "volume": "38",
      "author": "Yi",
      "year": "1999",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0300",
      "doi-asserted-by": "crossref",
      "first-page": "9275",
      "DOI": "10.1021/bi000397j",
      "article-title": "Oligomeric states of the HIV-1 integrase as measured by time-resolved fluorescence anisotropy",
      "volume": "39",
      "author": "Deprez",
      "year": "2000",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0305",
      "doi-asserted-by": "crossref",
      "first-page": "85",
      "DOI": "10.1124/mol.65.1.85",
      "article-title": "Mechanism of HIV-1 integrase inhibition by styrylquinoline derivatives in vitro",
      "volume": "65",
      "author": "Deprez",
      "year": "2004",
      "journal-title": "Mol. Pharmacol."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0310",
      "doi-asserted-by": "crossref",
      "first-page": "977",
      "DOI": "10.1093/nar/gki241",
      "article-title": "HIV-1 integrase crosslinked oligomers are active in vitro",
      "volume": "33",
      "author": "Faure",
      "year": "2005",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0315",
      "doi-asserted-by": "crossref",
      "first-page": "9524",
      "DOI": "10.1128/JVI.78.17.9524-9537.2004",
      "article-title": "LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes",
      "volume": "78",
      "author": "Llano",
      "year": "2004",
      "journal-title": "J. Virol."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0320",
      "doi-asserted-by": "crossref",
      "first-page": "33528",
      "DOI": "10.1074/jbc.M303594200",
      "article-title": "LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells",
      "volume": "278",
      "author": "Maertens",
      "year": "2003",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0325",
      "doi-asserted-by": "crossref",
      "first-page": "1310",
      "DOI": "10.1093/nar/gkq933",
      "article-title": "The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tethering",
      "volume": "39",
      "author": "Hendrix",
      "year": "2011",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0330",
      "doi-asserted-by": "crossref",
      "first-page": "e1000259",
      "DOI": "10.1371/journal.ppat.1000259",
      "article-title": "A novel co-crystal structure affords the design of gain-of-function lentiviral integrase mutants in the presence of modified PSIP1/LEDGF/p75",
      "volume": "5",
      "author": "Hare",
      "year": "2009",
      "journal-title": "PLoS Pathog."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0335",
      "doi-asserted-by": "crossref",
      "first-page": "780",
      "DOI": "10.3390/v1030780",
      "article-title": "The interaction between lentiviral integrase and LEDGF: structural and functional insights",
      "volume": "1",
      "author": "Hare",
      "year": "2009",
      "journal-title": "Viruses"
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0340",
      "doi-asserted-by": "crossref",
      "first-page": "e1000515",
      "DOI": "10.1371/journal.ppat.1000515",
      "article-title": "Structural basis for functional tetramerization of lentiviral integrase",
      "volume": "5",
      "author": "Hare",
      "year": "2009",
      "journal-title": "PLoS Pathog."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0345",
      "doi-asserted-by": "crossref",
      "first-page": "1653",
      "DOI": "10.1093/nar/gkl052",
      "article-title": "A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo",
      "volume": "34",
      "author": "Turlure",
      "year": "2006",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/j.jmb.2011.03.073_bb0350",
      "doi-asserted-by": "crossref",
      "first-page": "33580",
      "DOI": "10.1074/jbc.M109.040121",
      "article-title": "Affinities between the binding partners of the HIV-1 integrase dimer\u2013lens epithelium-derived growth factor (IN dimer\u2013LEDGF) complex",
      "volume": "284",
      "author": "Tsiang",
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      "author": "Maertens",
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      "volume": "32",
      "author": "Chiu",
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      "author": "Kirsch",
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