DOI: 10.1016/j.jmb.2008.12.048. The Chromatin of Active Genes Is Not in a Permanently Open Conformation

The Chromatin of Active Genes Is Not in a Permanently Open Conformation

10.1016/j.jmb.2008.12.048

Crossref journal-article

Elsevier BV

Journal of Molecular Biology (78)

Bibliography

Sapojnikova, N., Thorne, A., Myers, F., Staynov, D., & Crane-Robinson, C. (2009). The Chromatin of Active Genes Is Not in a Permanently Open Conformation. Journal of Molecular Biology, 386(2), 290â299.

Authors 5

Nelly Sapojnikova (first)
Alan Thorne (additional)
Fiona Myers (additional)
Dontcho Staynov (additional)
Colyn Crane-Robinson (additional)

References 45 Referenced 11

10.1126/science.948749 / Science / Chromosomal subunits in active genes have an altered conformation by Weintraub (1976)
10.1016/S0021-9258(19)68221-9 / J. Biol. Chem. / Definition of 5′ and 3′ structural boundaries of the chromatin domain containing the ovalbumin multigene family by Lawson (1982)
10.1093/nar/14.15.6085 / Nucleic Acids Res. / The DNase I sensitive domain of the chicken lysozyme gene spans 24 kb by Jantzen (1986)
10.1016/S0021-9258(19)30066-3 / J. Biol. Chem. / The limits of the DNase I-sensitive domain of the human apolipoprotein B gene coincide with the locations of chromosomal anchorage loops and define the 5′ and 3′ boundaries of the gene by Levy-Wilson (1989)
10.1016/0092-8674(80)90631-5 / Cell / Tissue-specific DNA cleavages in the globin chromatin domain introduced by DNase I by Stalder (1980)
10.1016/S0021-9258(18)34442-9 / J. Biol. Chem. / Chromatin structure of the chicken beta-globin gene region. Sensitivity to DNase I, micrococcal nuclease, and DNase II by Wood (1982)
10.1002/j.1460-2075.1994.tb06451.x / EMBO J. / Core histone hyperacetylation co-maps with generalized DNase I sensitivity in the chicken beta-globin chromosomal domain by Hebbes (1994)
10.1007/BF00285878 / Chromosoma / Nucleotide sequences and unusual electrophoretic behavior of the W chromosome-specific repeating DNA units of the domestic fowl, Gallus gallus domesticus by Kodama (1987)
10.1093/nar/28.16.3092 / Nucleic Acids Res. / DNase I digestion reveals alternating asymmetrical protection of the nucleosome by the higher order chromatin structure by Staynov (2000)
10.1128/MCB.02323-06 / Mol. Cell. Biol. / A modular enhancer is differentially regulated by GATA and NFAT elements that direct different tissue-specific patterns of nucleosome positioning and inducible chromatin remodeling by Bert (2007)
10.1128/MCB.10.6.2774 / Mol. Cell. Biol. / Developmental regulation of topoisomerase II sites and DNase I-hypersensitive sites in the chicken beta-globin locus by Reitman (1990)
10.1074/jbc.272.42.26075 / J. Biol. Chem. / The chicken lysozyme locus as a paradigm for the complex developmental regulation of eukaryotic gene loci by Bonifer (1997)
10.1093/nar/30.2.463 / Nucleic Acids Res. / The chicken lysozyme chromatin domain contains a second, widely expressed gene by Chong (2002)
10.1093/nar/11.11.3467 / Nucleic Acids Res. / Nuclease-hypersensitive sites in the chromatin domain of the chicken lysozyme gene by Fritton (1983)
10.1002/j.1460-2075.1988.tb02860.x / EMBO J. / The matrix attachment regions of the chicken lysozyme gene co-map with the boundaries of the chromatin domain by Phi-Van (1988)
10.1093/nar/22.20.4202 / Nucleic Acids Res. / Dissection of the locus control function located on the chicken lysozyme gene domain by Bonifer (1994)
10.1021/bi00305a034 / Biochemistry / DNase I sensitive domain of the gene coding for the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase by Alevy (1984)
10.1038/306709a0 / Nature / Selective unfolding of erythroid chromatin in the region of the active β-globin gene by Kimura (1983)
10.1016/0022-2836(87)90626-7 / J. Mol. Biol. / Perturbation of chromatin structure in the region of the adult beta-globin gene in chicken erythrocyte chromatin by Caplan (1987)
10.1016/j.jmb.2003.12.049 / J. Mol. Biol. / Physical properties of a genomic condensed chromatin fragment by Ghirlando (2004)
10.1016/j.jmb.2007.12.051 / J. Mol. Biol. / Hydrodynamic studies on defined heterochromatin fragments support a 30-nm fiber having six nucleosomes per turn by Ghirlando (2008)
10.1016/j.cell.2004.08.011 / Cell / Chromatin architecture of the human genome: gene-rich domains are enriched in open chromatin fibers by Gilbert (2004)
10.1074/jbc.M009472200 / J. Biol. Chem. / Targeted and extended acetylation of histones H4 and H3 at active and inactive genes in chicken embryo erythrocytes by Myers (2001)
10.1007/BF00330699 / Chromosoma / Structure of the chromatin axis during transcription by Bjorkroth (1988)
10.1083/jcb.200206019 / J. Cell Biol. / The transcription cycle of RNA polymerase II in living cells by Kimura (2002)
10.1038/nsmb1324 / Nat. Struct. Mol. Biol. / Gene regulation through nuclear organization by Sexton (2007)
10.1038/nsmb1280 / Nat. Struct. Mol. Biol. / In vivo dynamics of RNA polymerase II transcription by Darzacq (2007)
10.1016/j.molcel.2007.10.017 / Mol. Cell / Intranuclear distribution and local dynamics of RNA polymerase II during transcription activation by Yao (2007)
10.1016/j.molcel.2008.02.010 / Mol. Cell / Interaction of the glucocorticoid receptor with the chromatin landscape by John (2008)
10.1073/pnas.73.11.3966 / Proc. Natl Acad. Sci. USA / Selective digestion of transcriptionally active ovalbumin genes from oviduct nuclei by Garel (1976)
10.1016/0092-8674(79)90095-3 / Cell / The chromatin structure of specific genes: I. Evidence for higher order domains of defined DNA sequence by Wu (1979)
10.1016/0092-8674(79)90096-5 / Cell / The chromatin structure of specific genes: II. Disruption of chromatin structure during gene activity by Wu (1979)
10.1038/286854a0 / Nature / The 5′ ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase I by Wu (1980)
10.1016/0092-8674(78)90090-9 / Cell / Fractionation of hen oviduct chromatin into transcriptionally active and inactive regions after selective micrococcal nuclease digestion by Bloom (1978)
10.1002/j.1460-2075.1986.tb04212.x / EMBO J. / Digestion of the chicken beta-globin gene chromatin with micrococcal nuclease reveals the presence of an altered nucleosomal array characterized by an atypical ladder of DNA fragments by Sun (1986)
10.1016/j.jmb.2003.11.052 / J. Mol. Biol. / Redefinition of the cleavage sites of DNase I on the nucleosome core particle by Cousins (2004)
Santangelo, S., Cousins, D. J., Winkelmann, N. E. E., Triantaphyllopoulos, K. & Staynov, D. Z. (2008). Selective demethylation and a major disruption of the chromatin structure occurs in the IL-4 second intron after human Th2 cell differentiation. Submitted.
10.1016/j.cell.2007.12.014 / Cell / High-resolution mapping and characterization of open chromatin across the genome by Boyle (2008)
10.1016/S1097-2765(02)00459-8 / Mol. Cell. / Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4 by Cirillo (2002)
10.1126/science.1162228 / Science / Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters by Core (2008)
10.1016/S1097-2765(00)80432-3 / Mol. Cell. / Intergenic transcription and developmental remodeling of chromatin subdomains in the human beta-globin locus by Gribnau (2000)
10.1371/journal.pone.0000630 / PLoS ONE / Intergenic transcription, cell-cycle and the developmentally regulated epigenetic profile of the human beta-globin locus by Miles (2007)
10.1016/0022-2836(87)90560-2 / J. Mol. Biol. / Structural analysis of a reconstituted DNA containing three histone octamers and histone H5 by Drew (1987)
10.1002/j.1460-2075.1988.tb03250.x / EMBO J. / Footprinting of linker histones H5 and H1 on the nucleosome by Staynov (1988)
10.1073/pnas.95.24.14173 / Proc. Natl Acad. Sci. USA / Nucleosomes, linker DNA, and linker histone form a unique structural motif that directs the higher-order folding and compaction of chromatin by Bednar (1998)

Dates

Type	When
Created	16 years, 8 months ago (Dec. 31, 2008, 4:25 a.m.)
Deposited	3 years, 11 months ago (Sept. 28, 2021, 11:53 p.m.)
Indexed	1 year, 2 months ago (June 22, 2024, 1:19 p.m.)
Issued	16 years, 7 months ago (Feb. 1, 2009)
Published	16 years, 7 months ago (Feb. 1, 2009)
Published Print	16 years, 7 months ago (Feb. 1, 2009)

Funders 0

None

BibTeX

@article{Sapojnikova_2009, title={The Chromatin of Active Genes Is Not in a Permanently Open Conformation}, volume={386}, ISSN={0022-2836}, url={http://dx.doi.org/10.1016/j.jmb.2008.12.048}, DOI={10.1016/j.jmb.2008.12.048}, number={2}, journal={Journal of Molecular Biology}, publisher={Elsevier BV}, author={Sapojnikova, Nelly and Thorne, Alan and Myers, Fiona and Staynov, Dontcho and Crane-Robinson, Colyn}, year={2009}, month=feb, pages={290–299} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2024,
        6,
        22
      ]
    ],
    "date-time": "2024-06-22T17:19:26Z",
    "timestamp": 1719076766698
  },
  "reference-count": 45,
  "publisher": "Elsevier BV",
  "issue": "2",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2009,
            2,
            1
          ]
        ],
        "date-time": "2009-02-01T00:00:00Z",
        "timestamp": 1233446400000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.elsevier.com/tdm/userlicense/1.0/"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2009,
        2
      ]
    ]
  },
  "DOI": "10.1016/j.jmb.2008.12.048",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2008,
        12,
        31
      ]
    ],
    "date-time": "2008-12-31T09:25:42Z",
    "timestamp": 1230715542000
  },
  "page": "290-299",
  "source": "Crossref",
  "is-referenced-by-count": 11,
  "title": "The Chromatin of Active Genes Is Not in a Permanently Open Conformation",
  "prefix": "10.1016",
  "volume": "386",
  "author": [
    {
      "given": "Nelly",
      "family": "Sapojnikova",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Alan",
      "family": "Thorne",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Fiona",
      "family": "Myers",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Dontcho",
      "family": "Staynov",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Colyn",
      "family": "Crane-Robinson",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "78",
  "reference": [
    {
      "key": "10.1016/j.jmb.2008.12.048_bib1",
      "doi-asserted-by": "crossref",
      "first-page": "848",
      "DOI": "10.1126/science.948749",
      "article-title": "Chromosomal subunits in active genes have an altered conformation",
      "volume": "193",
      "author": "Weintraub",
      "year": "1976",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib2",
      "doi-asserted-by": "crossref",
      "first-page": "1501",
      "DOI": "10.1016/S0021-9258(19)68221-9",
      "article-title": "Definition of 5\u2032 and 3\u2032 structural boundaries of the chromatin domain containing the ovalbumin multigene family",
      "volume": "257",
      "author": "Lawson",
      "year": "1982",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib3",
      "doi-asserted-by": "crossref",
      "first-page": "6085",
      "DOI": "10.1093/nar/14.15.6085",
      "article-title": "The DNase I sensitive domain of the chicken lysozyme gene spans 24\u00a0kb",
      "volume": "14",
      "author": "Jantzen",
      "year": "1986",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib4",
      "doi-asserted-by": "crossref",
      "first-page": "21196",
      "DOI": "10.1016/S0021-9258(19)30066-3",
      "article-title": "The limits of the DNase I-sensitive domain of the human apolipoprotein B gene coincide with the locations of chromosomal anchorage loops and define the 5\u2032 and 3\u2032 boundaries of the gene",
      "volume": "264",
      "author": "Levy-Wilson",
      "year": "1989",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib5",
      "doi-asserted-by": "crossref",
      "first-page": "451",
      "DOI": "10.1016/0092-8674(80)90631-5",
      "article-title": "Tissue-specific DNA cleavages in the globin chromatin domain introduced by DNase I",
      "volume": "20",
      "author": "Stalder",
      "year": "1980",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib6",
      "doi-asserted-by": "crossref",
      "first-page": "7730",
      "DOI": "10.1016/S0021-9258(18)34442-9",
      "article-title": "Chromatin structure of the chicken beta-globin gene region. Sensitivity to DNase I, micrococcal nuclease, and DNase II",
      "volume": "257",
      "author": "Wood",
      "year": "1982",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib7",
      "doi-asserted-by": "crossref",
      "first-page": "1823",
      "DOI": "10.1002/j.1460-2075.1994.tb06451.x",
      "article-title": "Core histone hyperacetylation co-maps with generalized DNase I sensitivity in the chicken beta-globin chromosomal domain",
      "volume": "13",
      "author": "Hebbes",
      "year": "1994",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib8",
      "doi-asserted-by": "crossref",
      "first-page": "18",
      "DOI": "10.1007/BF00285878",
      "article-title": "Nucleotide sequences and unusual electrophoretic behavior of the W chromosome-specific repeating DNA units of the domestic fowl, Gallus gallus domesticus",
      "volume": "96",
      "author": "Kodama",
      "year": "1987",
      "journal-title": "Chromosoma"
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib9",
      "doi-asserted-by": "crossref",
      "first-page": "3092",
      "DOI": "10.1093/nar/28.16.3092",
      "article-title": "DNase I digestion reveals alternating asymmetrical protection of the nucleosome by the higher order chromatin structure",
      "volume": "28",
      "author": "Staynov",
      "year": "2000",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib10",
      "doi-asserted-by": "crossref",
      "first-page": "2870",
      "DOI": "10.1128/MCB.02323-06",
      "article-title": "A modular enhancer is differentially regulated by GATA and NFAT elements that direct different tissue-specific patterns of nucleosome positioning and inducible chromatin remodeling",
      "volume": "27",
      "author": "Bert",
      "year": "2007",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib11",
      "doi-asserted-by": "crossref",
      "first-page": "2774",
      "DOI": "10.1128/MCB.10.6.2774",
      "article-title": "Developmental regulation of topoisomerase II sites and DNase I-hypersensitive sites in the chicken beta-globin locus",
      "volume": "10",
      "author": "Reitman",
      "year": "1990",
      "journal-title": "Mol. Cell. Biol."
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib12",
      "doi-asserted-by": "crossref",
      "first-page": "26075",
      "DOI": "10.1074/jbc.272.42.26075",
      "article-title": "The chicken lysozyme locus as a paradigm for the complex developmental regulation of eukaryotic gene loci",
      "volume": "272",
      "author": "Bonifer",
      "year": "1997",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib13",
      "doi-asserted-by": "crossref",
      "first-page": "463",
      "DOI": "10.1093/nar/30.2.463",
      "article-title": "The chicken lysozyme chromatin domain contains a second, widely expressed gene",
      "volume": "30",
      "author": "Chong",
      "year": "2002",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib14",
      "doi-asserted-by": "crossref",
      "first-page": "3467",
      "DOI": "10.1093/nar/11.11.3467",
      "article-title": "Nuclease-hypersensitive sites in the chromatin domain of the chicken lysozyme gene",
      "volume": "11",
      "author": "Fritton",
      "year": "1983",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib15",
      "doi-asserted-by": "crossref",
      "first-page": "655",
      "DOI": "10.1002/j.1460-2075.1988.tb02860.x",
      "article-title": "The matrix attachment regions of the chicken lysozyme gene co-map with the boundaries of the chromatin domain",
      "volume": "7",
      "author": "Phi-Van",
      "year": "1988",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib16",
      "doi-asserted-by": "crossref",
      "first-page": "4201",
      "DOI": "10.1093/nar/22.20.4202",
      "article-title": "Dissection of the locus control function located on the chicken lysozyme gene domain",
      "volume": "22",
      "author": "Bonifer",
      "year": "1994",
      "journal-title": "Nucleic Acids Res."
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib17",
      "doi-asserted-by": "crossref",
      "first-page": "2309",
      "DOI": "10.1021/bi00305a034",
      "article-title": "DNase I sensitive domain of the gene coding for the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase",
      "volume": "23",
      "author": "Alevy",
      "year": "1984",
      "journal-title": "Biochemistry"
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib18",
      "doi-asserted-by": "crossref",
      "first-page": "709",
      "DOI": "10.1038/306709a0",
      "article-title": "Selective unfolding of erythroid chromatin in the region of the active \u03b2-globin gene",
      "volume": "306",
      "author": "Kimura",
      "year": "1983",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib19",
      "doi-asserted-by": "crossref",
      "first-page": "57",
      "DOI": "10.1016/0022-2836(87)90626-7",
      "article-title": "Perturbation of chromatin structure in the region of the adult beta-globin gene in chicken erythrocyte chromatin",
      "volume": "193",
      "author": "Caplan",
      "year": "1987",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib20",
      "doi-asserted-by": "crossref",
      "first-page": "597",
      "DOI": "10.1016/j.jmb.2003.12.049",
      "article-title": "Physical properties of a genomic condensed chromatin fragment",
      "volume": "336",
      "author": "Ghirlando",
      "year": "2004",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib21",
      "doi-asserted-by": "crossref",
      "first-page": "1417",
      "DOI": "10.1016/j.jmb.2007.12.051",
      "article-title": "Hydrodynamic studies on defined heterochromatin fragments support a 30-nm fiber having six nucleosomes per turn",
      "volume": "376",
      "author": "Ghirlando",
      "year": "2008",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib22",
      "doi-asserted-by": "crossref",
      "first-page": "555",
      "DOI": "10.1016/j.cell.2004.08.011",
      "article-title": "Chromatin architecture of the human genome: gene-rich domains are enriched in open chromatin fibers",
      "volume": "118",
      "author": "Gilbert",
      "year": "2004",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib23",
      "doi-asserted-by": "crossref",
      "first-page": "20197",
      "DOI": "10.1074/jbc.M009472200",
      "article-title": "Targeted and extended acetylation of histones H4 and H3 at active and inactive genes in chicken embryo erythrocytes",
      "volume": "276",
      "author": "Myers",
      "year": "2001",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib24",
      "doi-asserted-by": "crossref",
      "first-page": "333",
      "DOI": "10.1007/BF00330699",
      "article-title": "Structure of the chromatin axis during transcription",
      "volume": "96",
      "author": "Bjorkroth",
      "year": "1988",
      "journal-title": "Chromosoma"
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib25",
      "doi-asserted-by": "crossref",
      "first-page": "777",
      "DOI": "10.1083/jcb.200206019",
      "article-title": "The transcription cycle of RNA polymerase II in living cells",
      "volume": "159",
      "author": "Kimura",
      "year": "2002",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib26",
      "doi-asserted-by": "crossref",
      "first-page": "1049",
      "DOI": "10.1038/nsmb1324",
      "article-title": "Gene regulation through nuclear organization",
      "volume": "14",
      "author": "Sexton",
      "year": "2007",
      "journal-title": "Nat. Struct. Mol. Biol."
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib27",
      "doi-asserted-by": "crossref",
      "first-page": "796",
      "DOI": "10.1038/nsmb1280",
      "article-title": "In vivo dynamics of RNA polymerase II transcription",
      "volume": "14",
      "author": "Darzacq",
      "year": "2007",
      "journal-title": "Nat. Struct. Mol. Biol."
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib28",
      "doi-asserted-by": "crossref",
      "first-page": "978",
      "DOI": "10.1016/j.molcel.2007.10.017",
      "article-title": "Intranuclear distribution and local dynamics of RNA polymerase II during transcription activation",
      "volume": "28",
      "author": "Yao",
      "year": "2007",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib29",
      "doi-asserted-by": "crossref",
      "first-page": "611",
      "DOI": "10.1016/j.molcel.2008.02.010",
      "article-title": "Interaction of the glucocorticoid receptor with the chromatin landscape",
      "volume": "29",
      "author": "John",
      "year": "2008",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib30",
      "doi-asserted-by": "crossref",
      "first-page": "3966",
      "DOI": "10.1073/pnas.73.11.3966",
      "article-title": "Selective digestion of transcriptionally active ovalbumin genes from oviduct nuclei",
      "volume": "73",
      "author": "Garel",
      "year": "1976",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib31",
      "doi-asserted-by": "crossref",
      "first-page": "797",
      "DOI": "10.1016/0092-8674(79)90095-3",
      "article-title": "The chromatin structure of specific genes: I. Evidence for higher order domains of defined DNA sequence",
      "volume": "16",
      "author": "Wu",
      "year": "1979",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib32",
      "doi-asserted-by": "crossref",
      "first-page": "807",
      "DOI": "10.1016/0092-8674(79)90096-5",
      "article-title": "The chromatin structure of specific genes: II. Disruption of chromatin structure during gene activity",
      "volume": "16",
      "author": "Wu",
      "year": "1979",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib33",
      "doi-asserted-by": "crossref",
      "first-page": "854",
      "DOI": "10.1038/286854a0",
      "article-title": "The 5\u2032 ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase I",
      "volume": "286",
      "author": "Wu",
      "year": "1980",
      "journal-title": "Nature"
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib34",
      "doi-asserted-by": "crossref",
      "first-page": "141",
      "DOI": "10.1016/0092-8674(78)90090-9",
      "article-title": "Fractionation of hen oviduct chromatin into transcriptionally active and inactive regions after selective micrococcal nuclease digestion",
      "volume": "15",
      "author": "Bloom",
      "year": "1978",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib35",
      "doi-asserted-by": "crossref",
      "first-page": "293",
      "DOI": "10.1002/j.1460-2075.1986.tb04212.x",
      "article-title": "Digestion of the chicken beta-globin gene chromatin with micrococcal nuclease reveals the presence of an altered nucleosomal array characterized by an atypical ladder of DNA fragments",
      "volume": "5",
      "author": "Sun",
      "year": "1986",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib36",
      "doi-asserted-by": "crossref",
      "first-page": "1199",
      "DOI": "10.1016/j.jmb.2003.11.052",
      "article-title": "Redefinition of the cleavage sites of DNase I on the nucleosome core particle",
      "volume": "335",
      "author": "Cousins",
      "year": "2004",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib37",
      "unstructured": "Santangelo, S., Cousins, D. J., Winkelmann, N. E. E., Triantaphyllopoulos, K. & Staynov, D. Z. (2008). Selective demethylation and a major disruption of the chromatin structure occurs in the IL-4 second intron after human Th2 cell differentiation. Submitted."
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib38",
      "doi-asserted-by": "crossref",
      "first-page": "311",
      "DOI": "10.1016/j.cell.2007.12.014",
      "article-title": "High-resolution mapping and characterization of open chromatin across the genome",
      "volume": "132",
      "author": "Boyle",
      "year": "2008",
      "journal-title": "Cell"
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib39",
      "doi-asserted-by": "crossref",
      "first-page": "279",
      "DOI": "10.1016/S1097-2765(02)00459-8",
      "article-title": "Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4",
      "volume": "9",
      "author": "Cirillo",
      "year": "2002",
      "journal-title": "Mol. Cell."
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib40",
      "doi-asserted-by": "crossref",
      "first-page": "1845",
      "DOI": "10.1126/science.1162228",
      "article-title": "Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters",
      "volume": "322",
      "author": "Core",
      "year": "2008",
      "journal-title": "Science"
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib41",
      "doi-asserted-by": "crossref",
      "first-page": "377",
      "DOI": "10.1016/S1097-2765(00)80432-3",
      "article-title": "Intergenic transcription and developmental remodeling of chromatin subdomains in the human beta-globin locus",
      "volume": "5",
      "author": "Gribnau",
      "year": "2000",
      "journal-title": "Mol. Cell."
    },
    {
      "issue": "7",
      "key": "10.1016/j.jmb.2008.12.048_bib42",
      "doi-asserted-by": "crossref",
      "first-page": "e630",
      "DOI": "10.1371/journal.pone.0000630",
      "article-title": "Intergenic transcription, cell-cycle and the developmentally regulated epigenetic profile of the human beta-globin locus",
      "volume": "2",
      "author": "Miles",
      "year": "2007",
      "journal-title": "PLoS ONE"
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib43",
      "doi-asserted-by": "crossref",
      "first-page": "485",
      "DOI": "10.1016/0022-2836(87)90560-2",
      "article-title": "Structural analysis of a reconstituted DNA containing three histone octamers and histone H5",
      "volume": "197",
      "author": "Drew",
      "year": "1987",
      "journal-title": "J. Mol. Biol."
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib44",
      "doi-asserted-by": "crossref",
      "first-page": "3685",
      "DOI": "10.1002/j.1460-2075.1988.tb03250.x",
      "article-title": "Footprinting of linker histones H5 and H1 on the nucleosome",
      "volume": "7",
      "author": "Staynov",
      "year": "1988",
      "journal-title": "EMBO J."
    },
    {
      "key": "10.1016/j.jmb.2008.12.048_bib45",
      "doi-asserted-by": "crossref",
      "first-page": "14173",
      "DOI": "10.1073/pnas.95.24.14173",
      "article-title": "Nucleosomes, linker DNA, and linker histone form a unique structural motif that directs the higher-order folding and compaction of chromatin",
      "volume": "95",
      "author": "Bednar",
      "year": "1998",
      "journal-title": "Proc. Natl Acad. Sci. USA"
    }
  ],
  "container-title": "Journal of Molecular Biology",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0022283608015684?httpAccept=text/xml",
      "content-type": "text/xml",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://api.elsevier.com/content/article/PII:S0022283608015684?httpAccept=text/plain",
      "content-type": "text/plain",
      "content-version": "vor",
      "intended-application": "text-mining"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2021,
        9,
        29
      ]
    ],
    "date-time": "2021-09-29T03:53:17Z",
    "timestamp": 1632887597000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://linkinghub.elsevier.com/retrieve/pii/S0022283608015684"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2009,
        2
      ]
    ]
  },
  "references-count": 45,
  "journal-issue": {
    "issue": "2",
    "published-print": {
      "date-parts": [
        [
          2009,
          2
        ]
      ]
    }
  },
  "alternative-id": [
    "S0022283608015684"
  ],
  "URL": "http://dx.doi.org/10.1016/j.jmb.2008.12.048",
  "relation": {},
  "ISSN": [
    "0022-2836"
  ],
  "subject": [],
  "container-title-short": "Journal of Molecular Biology",
  "published": {
    "date-parts": [
      [
        2009,
        2
      ]
    ]
  }
}