Crossref
journal-article
Elsevier BV
Journal of Molecular Biology (78)
References
43
Referenced
102
10.1073/pnas.1037392100
/ Proc. Natl Acad. Sci. USA / Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2 by Kimberly (2003)10.1038/nature01506
/ Nature / The role of presenilin cofactors in the gamma-secretase complex by Takasugi (2003)10.1038/ncb960
/ Nat. Cell Biol. / Reconstitution of gamma-secretase activity by Edbauer (2003)10.1021/bi0494976
/ Biochemistry / Purification and characterization of the human gamma-secretase complex by Fraering (2004)10.1126/science.1096187
/ Science / Intramembrane proteolysis: theme and variations by Wolfe (2004)10.1038/19077
/ Nature / Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity by Wolfe (1999)10.1038/ncb1104-1054
/ Nat. Cell Biol. / Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases by Selkoe (2004)10.1016/j.cell.2007.10.012
/ Cell / Presenilin: running with scissors in the membrane by Selkoe (2007)10.1038/nature05255
/ Nature / Crystal structure of a rhomboid family intramembrane protease by Wang (2006)10.1038/nsmb1179
/ Nat. Struct. Mol. Biol. / Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry by Wu (2006)10.1073/pnas.0609773104
/ Proc. Natl Acad. Sci. USA / Structural basis for intramembrane proteolysis by rhomboid serine proteases by Ben-Shem (2007)10.1073/pnas.0609981104
/ Proc. Natl Acad. Sci. USA / The crystal structure of the rhomboid peptidase from Haemophilus influenzae provides insight into intramembrane proteolysis by Lemieux (2007)10.1126/science.1150755
/ Science / Structure of a site-2 protease family intramembrane metalloprotease by Feng (2007)10.1016/j.sbi.2008.03.005
/ Curr. Opin. Struct. Biol. / Core principles of intramembrane proteolysis: comparison of rhomboid and site-2 family proteases by Urban (2008)10.1074/jbc.M701536200
/ J. Biol. Chem. / A C-terminal region of signal peptide peptidase defines a functional domain for intramembrane aspartic protease catalysis by Narayanan (2007)10.1093/hmg/ddg303
/ Hum. Mol. Genet. / Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs by Martoglio (2003)10.1021/bi060799c
/ Biochemistry / The gamma-secretase complex: membrane-embedded proteolytic ensemble by Wolfe (2006)10.1074/jbc.M801925200
/ J. Biol. Chem. / Direct and potent regulation of gamma-secretase by its lipid microenvironment by Osenkowski (2008)10.1021/bi035748j
/ Biochemistry / Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex by Fraering (2004)10.1073/pnas.0602321103
/ Proc. Natl Acad. Sci. USA / Electron microscopic structure of purified, active {gamma}-secretase reveals an aqueous intramembrane chamber and two pores by Lazarov (2006)10.1111/j.1471-4159.2007.05041.x
/ J. Neurochem. / Rapid purification of active gamma-secretase, an intramembrane protease implicated in Alzheimer's disease by Cacquevel (2008)10.1073/pnas.1735338100
/ Proc. Natl Acad. Sci. USA / A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis by Schroeter (2003)10.1074/jbc.M404832200
/ J. Biol. Chem. / Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins by Cervantes (2004)10.1074/jbc.M705248200
/ J. Biol. Chem. / Active gamma-secretase complexes contain only one of each component by Sato (2007)10.1073/pnas.132277899
/ Proc. Natl Acad. Sci. USA / Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation by Edbauer (2002)10.1021/bi0481702
/ Biochemistry / Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex by Evin (2005)10.1016/S0076-6879(08)36027-3
/ Methods Enzymol. / Mass mapping of large globin complexes by scanning transmission electron microscopy by Wall (2008)10.1074/jbc.M009383200
/ J. Biol. Chem. / Structural characterization of two aquaporins isolated from native spinach leaf plasma membranes by Fotiadis (2001)10.1111/j.1471-4159.2004.02447.x
/ J. Neurochem. / Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1 by Shirotani (2004)10.1074/jbc.C300435200
/ J. Biol. Chem. / Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain by Capell (2003)10.1016/j.str.2007.12.013
/ Structure / Structure of the oligosaccharyl transferase complex at 12 Å resolution by Li (2008)10.1038/nsb0497-263
/ Nat. Struct. Biol. / Molecular design of aquaporin-1 water channel as revealed by electron crystallography by Li (1997)10.1038/414872a
/ Nature / Structural basis of water-specific transport through the AQP1 water channel by Sui (2001)10.1074/jbc.M206871200
/ J. Biol. Chem. / Projection structure of P-glycoprotein by electron microscopy. Evidence for a closed conformation of the nucleotide binding domains by Lee (2002)10.1523/JNEUROSCI.3614-06.2006
/ J. Neurosci. / Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines by Sato (2006)10.1074/jbc.M802461200
/ J. Biol. Chem / Transmembrane domain 9 of presenilin determines the dynamic conformation of the catalytic site of gamma-secretase by Tolia (2008)10.1073/pnas.052436599
/ Proc. Natl Acad. Sci. USA / Activity-dependent isolation of the presenilin–gamma-secretase complex reveals nicastrin and a gamma substrate by Esler (2002)10.1006/abio.1994.1112
/ Anal. Biochem. / Analysis of molecular masses and oligomeric states of protein complexes by blue native electrophoresis and isolation of membrane protein complexes by two-dimensional native electrophoresis by Schagger (1994)10.1016/0003-2697(91)90094-A
/ Anal. Biochem. / Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form by Schagger (1991)10.1074/jbc.M303941200
/ J. Biol. Chem. / Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin by LaVoie (2003)10.1006/jsbi.1999.4174
/ J. Struct. Biol. / EMAN: semiautomated software for high-resolution single-particle reconstructions by Ludtke (1999)10.1006/jsbi.1996.0030
/ J. Struct. Biol. / SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields by Frank (1996)10.1002/jcc.20084
/ J. Comput. Chem. / UCSF Chimera—a visualization system for exploratory research and analysis by Pettersen (2004)
Dates
Type | When |
---|---|
Created | 16 years, 9 months ago (Nov. 7, 2008, 7:46 p.m.) |
Deposited | 1 year, 5 months ago (Feb. 23, 2024, 12:27 p.m.) |
Indexed | 3 weeks ago (July 30, 2025, 11:18 a.m.) |
Issued | 16 years, 7 months ago (Jan. 1, 2009) |
Published | 16 years, 7 months ago (Jan. 1, 2009) |
Published Print | 16 years, 7 months ago (Jan. 1, 2009) |
@article{Osenkowski_2009, title={Cryoelectron Microscopy Structure of Purified γ-Secretase at 12 Å Resolution}, volume={385}, ISSN={0022-2836}, url={http://dx.doi.org/10.1016/j.jmb.2008.10.078}, DOI={10.1016/j.jmb.2008.10.078}, number={2}, journal={Journal of Molecular Biology}, publisher={Elsevier BV}, author={Osenkowski, Pamela and Li, Hua and Ye, Wenjuan and Li, Dongyang and Aeschbach, Lorene and Fraering, Patrick C. and Wolfe, Michael S. and Selkoe, Dennis J. and Li, Huilin}, year={2009}, month=jan, pages={642–652} }